Conserved Protein Domain Family
PLC_epsilon_RA
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cd01780: PLC_epsilon_RA (this model, PSSM-Id:176375 is obsolete and has been replaced by 340478)
Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
PLC_epsilon_RA Phosphatidylinositide-specific phospholipase C (PLC) is a signaling enzyme that hydrolyzes membrane phospholipids to generate inositol triphosphate. PLC-epsilon represents a novel forth class of PLC that has a PLC catalytic core domain, a CDC25 guanine nucleotide exchange factor domain and two RA (Ras-association) domains of which the second is critical for Ras activation of the enzyme.
Links
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Statistics
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PSSM-Id: 176375
Aligned: 5 rows
Threshold Bit Score: 146.572
Created: 2-Aug-2004
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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Feature 1:putative Ras interaction site [polypeptide binding site]
Evidence:
  • Comment:interacts with the switch I and switch II regions of Ras
  • Citation:PMID 9628477
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       # #         ## ##   ##       #  ##                                             
AAG17145  2137 FFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAkysysilsnpNPSDYVLLEEVVKDttnkktttpkssQRVLLdqe 2216 human
NP_446210 2116 FFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAkysysilnnpNPCDYVLLEEVMKDapnkksstpkssQRILLdqe 2195 Norway rat
7500213   1817 FLVCVHNVSEDQPYAILRAGIHSTAADIIRQVFVKArrs-----nvDDSEFVLVEETCDDpklnq--gqsmlQALSLark 1889 Caenorhabditis e...
CAG12626  1495 LLDVIHEVSPEQPHTVIKAPRYSTAQDIIQQTLSKAkysysivshpNPCDYVLMEEVTKDvgskkssttkppQRVLLdhe 1574 Tetraodon nigrov...
XP_312409  771 FLVCVYNVSQDIPYAILRVPMKSTAQDVLAQALLKArr------ldNPNNFVLVEELNYStkgn-----dtmQRILLdde 839  Anopheles gambia...

Feature 1                          
AAG17145  2217 cvfqaqskwkgagKFILKLK 2236 human
NP_446210 2196 cvfqaqskwkgagKFILKLK 2215 Norway rat
7500213   1890 rsn----drrplrCFALYIH 1905 Caenorhabditis elegans
CAG12626  1575 cvyqaqsrwrgtgKFILKLK 1594 Tetraodon nigroviridis
XP_312409  840 nvyvtqanwktigRFVIHER 859  Anopheles gambiae str. PEST

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