Conserved Protein Domain Family
CNNM

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pfam01595: CNNM 
Cyclin M transmembrane N-terminal domain
This transmembrane domain is found in metal transporter proteins such as cyclin M 1/2 (CNNM). CNNMs are integral membrane proteins that are conserved from bacteria to humans. CNNM family members influence metal ion homeostasis through mechanisms that may not involve direct membrane transport of the ions. Structurally, CNNMs are complex proteins that contain an extracellular N-terminal domain preceding a transmembrane domain, a 'Bateman module', which consists of two cystathionine- beta-synthase (CBS) domains pfam00571, and a C-terminal cNMP (cyclic nucleotide monophosphate) binding domain. This entry describes the CNNM transmembrane domain which contains four hydrophobic regions and forms a dimer through hydrophobic contacts between TM2 and TM3, in which each chain is composed of three transmembrane helices (TM1-3), a pair of short helices exposed on the intracellular side, and a juxtamembrane (JM) helix that forms a belt-like structure. The homodimer adopts an inward-facing conformation with a negatively charged cavity containing a conserved pi-helical turn in TM3 that coordinates a Mg2 ion.
Statistics
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PSSM-Id: 460260
Aligned: 82 rows
Threshold Bit Score: 41.4327
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
tigr:CLC_2805   9 FLiLILI-IINAFFSSAEMAIISLNKNKLntiidnaeeENSSSRKT---KKAKI--LLNLLKEPSKFLATIQVGITLAGF 82 
jgi:Nmar_1007   9 AL-AGLI-GLSGFFSGLEVALVGTSQATI---------ERLVKDNV---KGAKS--LQKLKANPGWMMSSVNLGNNLVNI 72 
Q18E42         39 FViFLLI-GFSAFFSSSEIAMFSLAKHRV---------DALVDDNV---PGADV--VDELKSNPHRLLVTILVGNNIVNI 103 Haloquadratum ...
Q2FTJ8          9 IIfILCL-ILSGFFSGSEVALFSITRAKV---------RTLVNEKE---PGSEA--LATLKKNPDRFLITILIGNNIVNI 73  Methanospirill...
Q3Z6L6          9 ILfFLCI-VFSAFFASSETAFISIQRFRL---------QNMVQSKV---KGADK--VSQLMERPEKFLSTVLLGNNFVNT 73  Dehalococcoide...
WP_012065371    9 LFiLAILlTLSAFFSASETSLMALSKIRI---------RNMVEKKV---EGADI--INSLIKNPGQLLSSILVGNNIVNI 74  Alkaliphilus m...
Q63QL6         11 GAvFLLL-LCSSFFSISETAMMALNRHRL---------KHLASHGA---LGAKT--TQRLLARTDQLLSVILIGNNLFNT 75  Burkholderia p...
Q9HXP6         12 LL-VLLV-ACSAFFSCVETALLNLDRYRL---------RLQAKQGL---RGARR--SSWLLLHDDRLRGTLLFGRTLVNV 75  Pseudomonas ae...
Q5NH00          8 IIiFILI-CISAFFSSSETAMIALNKYKL---------KHLAKKNH---RAAKR--SLSLVRNPERLLVAILIGNTFANI 72  Francisella tu...
jgi:Fnod_1002  13 IIaFLII--LSAFFSASETALTSVSKHKL---------RTLARKKEdeeEKTEIhlF-------NKLLTALLISNNIVNI 74 
tigr:CLC_2805  83 LASASAATSISKYIEIffkhlnipksssialflttLLLSYLTLVFGELLPKRIALNNSEKIALFSIKPIIIFMKISLPFV 162
jgi:Nmar_1007  73 GSASLATIVAIEIFgdngv------------giavGIMTFLVIIFGEVTPKTYCNANATKVALRCSRILLTFSYVFYPAV 140
Q18E42        104 AMSSLATALVSLYFDpgsav-----------lvstFGITSLVLLFGESAPKSYAVEHTESWALRIARPLKYSEYVLLPLV 172 Haloquadratum ...
Q2FTJ8         74 LAASVATAVAIGFLGEtgiav----------tvstIIVVLLLLVFGEIWPKMYASRNATSFSLRFSPIILFLSRIFSPVI 143 Methanospirill...
Q3Z6L6         74 AASALGTVLAVSIWGnergv-----------liatAGVTIILLVFGETTPKTLATQHSEKIAFAVAPAVEVISKIFAPIV 142 Dehalococcoide...
WP_012065371   75 GASALATSIAFQVEAFrynpv----------giatVIMTILVLIFAEITPKSIAAQHSEKLALKVAKPIRWVVVVLNPIV 144 Alkaliphilus m...
Q63QL6         76 IIPVLTTSIALRTFGHdnfvl----------siatGIVAFLIIVFAEITPKIVGATFPERIALPASVVIAPLMRVMMPVV 145 Burkholderia p...
Q9HXP6         76 SAAALASWAALRHWgvigl------------avaiPGMTLLLLLFGALLPRRYGALRSERVALPLSLPLLILQRLCWPLL 143 Pseudomonas ae...
Q5NH00         73 FAGTVISSYSEDHFgdlgl------------liatIVVTILVLVFGEIIPKSFAAIYPQRLAFPFSLPLKIIMLILYPAV 140 Francisella tu...
jgi:Fnod_1002  75 LASSIAAVMFSKIIVYeslst----------ivstFVMTFLLLIFGEITPKILSRQNSEKFFEISMKLVVPISKLLSPLV 144
tigr:CLC_2805 163 NILTYSTNFLLKVLGIDy--ENIEEKISEEEIKKMIDLGEETGVF-NSTE 209
jgi:Nmar_1007 141 WILEKITRGIIKITGs----DYQPPALTEDEIKGIIAQGHRDEAL-EKSE 185
Q18E42        173 IVFDRLTRVINRITGGRs--EIETSYVTRDEIQDLIQTGEREGVI-EEDE 219 Haloquadratum walsbyi DSM 16790
Q2FTJ8        144 FIFNKIAGKMTma------gAFAHHMITEEEIKEWIDVGQEEGTI-EKDE 186 Methanospirillum hungatei JF-1
Q3Z6L6        143 ALLGWISSGFTKLFGGp---ALKSSLVAEDDIRAMITVGHKEGTV-EEDK 188 Dehalococcoides mccartyi 195
WP_012065371  145 IILNRITSILIRMLGGKk--AYDKPFITEEELRTMVNVSHEEGVL-EVEE 191 Alkaliphilus metalliredigens
Q63QL6        146 WFVNTLSGAILaalr-intkAGRDQRLSTEELRSLVLES---GSFmPTKH 191 Burkholderia pseudomallei
Q9HXP6        144 WLLTLLSNALLRLLGVAaaeQDDSGRSRDEEALHPADNPQAS----EVNR 189 Pseudomonas aeruginosa
Q5NH00        141 IFLSMVSKVTLKLFGVKi-eAVNNESLDKEEIQTVVNESNAK--L-GAKN 186 Francisella tularensis subsp. tularensis
jgi:Fnod_1002 145 SFFVTVSNYFVKLFGGQk--VAEAPFITMDDIASYLEMGREEGTI-DHEE 191
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