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Conserved domains on  [gi|4557617|ref|NP_000811|]
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growth arrest-specific protein 6 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 298-450 1.50e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 1.50e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617  298 GRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRyNGVGRVT-SSGPVINH 376
Cdd:cd00110   1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYD-LGSGSLVlSSKTPLND 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4557617  377 GMWQTISVEELARNLVIKVNRDAVMKIAvagdlfqPERGLYHLN----LTVGGIPFHEKDLVQPINPRLDGCMRSWNW 450
Cdd:cd00110  80 GQWHSVSVERNGRSVTLSVDGERVVESG-------SPGGSALLNldgpLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 53-92 3.61e-21

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


:

Pssm-ID: 459861  Cd Length: 41  Bit Score: 86.82  E-value: 3.61e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4557617     53 FEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRY 92
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 160-195 4.36e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 60.72  E-value: 4.36e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4557617    160 CSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 195
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 513-644 2.38e-10

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 58.59  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617    513 IRPAADTGVLFalWAPDLRAVPLSVALVDyhstKKLKKQlVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDG 592
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVN----GRLVLR-YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4557617    593 TRgqsevsaaQLQERLAVLERHLRSPVLTFAGGLP-DVPVTSAPVTAFYRGCM 644
Cdd:pfam02210  74 QT--------VVSSLPPGESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCI 118
EGF_CA smart00179
Calcium-binding EGF-like domain;
197-227 2.22e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 2.22e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557617     197 DIDECADSEACGE-ARCKNLPGSYSCLCDEGF 227
Cdd:smart00179   1 DIDECASGNPCQNgGTCVNTVGSYRCECPPGY 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 245-277 6.75e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 6.75e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4557617    245 GRCEQVCVNSPGSYTCHCdgRGGLKLSQDMDTC 277
Cdd:pfam14670   6 GGCSHLCLNTPGGYTCSC--PEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 298-450 1.50e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 1.50e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617  298 GRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRyNGVGRVT-SSGPVINH 376
Cdd:cd00110   1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYD-LGSGSLVlSSKTPLND 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4557617  377 GMWQTISVEELARNLVIKVNRDAVMKIAvagdlfqPERGLYHLN----LTVGGIPFHEKDLVQPINPRLDGCMRSWNW 450
Cdd:cd00110  80 GQWHSVSVERNGRSVTLSVDGERVVESG-------SPGGSALLNldgpLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
322-454 1.72e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 1.72e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617     322 EFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRY-NGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAv 400
Cdd:smart00282   3 SFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGN- 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4557617     401 mkiAVAGDLFQPERGL-YHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWnWLNGE 454
Cdd:smart00282  82 ---RVSGESPGGLTILnLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNL-KVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
325-452 1.41e-21

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 90.84  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617    325 FRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRyNGVGR-VTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKI 403
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYD-LGSGAaVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 4557617    404 AvagdlfQPERGLYHLNLT----VGGIP-FHEKDLVQPINPRLDGCMRSWNWLN 452
Cdd:pfam00054  80 E------SPLGATTDLDVDgplyVGGLPsLGVKKRRLAISPSFDGCIRDVIVNG 127
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 53-92 3.61e-21

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 86.82  E-value: 3.61e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4557617     53 FEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRY 92
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 40-92 1.78e-19

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 82.74  E-value: 1.78e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 4557617      40 QFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRY 92
Cdd:smart00069  12 KVLRRQRRANAFLLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRY 64
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 160-195 4.36e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 60.72  E-value: 4.36e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4557617    160 CSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 195
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 513-644 2.38e-10

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 58.59  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617    513 IRPAADTGVLFalWAPDLRAVPLSVALVDyhstKKLKKQlVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDG 592
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVN----GRLVLR-YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4557617    593 TRgqsevsaaQLQERLAVLERHLRSPVLTFAGGLP-DVPVTSAPVTAFYRGCM 644
Cdd:pfam02210  74 QT--------VVSSLPPGESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCI 118
LamG smart00282
Laminin G domain;
513-651 2.05e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.19  E-value: 2.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617     513 IRPAADTGVLFAlWAPDLRAVPLSVALVDyhstKKLkkQLVVLAVEHTALALME-IKVCDGQEHVVTVSLRDGEATLEVD 591
Cdd:smart00282   6 FRTTSPNGLLLY-AGSKGGGDYLALELRD----GRL--VLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557617     592 GTRGQSEVSAAQLQerlavlERHLRSPVltFAGGLPDVPVTSA-PVTAFYRGCM-TLEVNRR 651
Cdd:smart00282  79 GGNRVSGESPGGLT------ILNLDGPL--YLGGLPEDLKLPPlPVTPGFRGCIrNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 484-644 9.22e-09

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 54.73  E-value: 9.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617  484 GFAFYSLDYMRTPLDVGTESTWEVEVvaHIRPAADTGVLFAlWAPDLRAVPLSVALVDYHstkklkkqlVVLAVEHTALA 563
Cdd:cd00110   1 GVSFSGSSYVRLPTLPAPRTRLSISF--SFRTTSPNGLLLY-AGSQNGGDFLALELEDGR---------LVLRYDLGSGS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617  564 LM---EIKVCDGQEHVVTVSLRDGEATLEVDGTRgqsevsaaQLQERLAVLERHLRSPVLTFAGGLPDVP-VTSAPVTAF 639
Cdd:cd00110  69 LVlssKTPLNDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGPLYLGGLPEDLkSPGLPVSPG 140


                ....*
gi 4557617  640 YRGCM 644
Cdd:cd00110 141 FVGCI 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-196 1.72e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 1.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 4557617     156 DVNECSQENG-GCLQICHNKPGSFHCSCHSGFElssDGRTCQ 196
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
197-227 2.22e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 2.22e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557617     197 DIDECADSEACGE-ARCKNLPGSYSCLCDEGF 227
Cdd:smart00179   1 DIDECASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 197-227 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 5.18e-07
                        10        20        30
                ....*....|....*....|....*....|..
gi 4557617  197 DIDECADSEACGE-ARCKNLPGSYSCLCDEGF 227
Cdd:cd00054   1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-196 9.88e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 9.88e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 4557617  156 DVNECSQENGgCL--QICHNKPGSFHCSCHSGFElssdGRTCQ 196
Cdd:cd00054   1 DIDECASGNP-CQngGTCVNTVGSYRCSCPPGYT----GRNCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 245-277 6.75e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 6.75e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4557617    245 GRCEQVCVNSPGSYTCHCdgRGGLKLSQDMDTC 277
Cdd:pfam14670   6 GGCSHLCLNTPGGYTCSC--PEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 232-273 3.38e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.76  E-value: 3.38e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 4557617  232 QEKACRDVDECLQGR--CEQVCVNSPGSYTCHCdgRGGLKLSQD 273
Cdd:cd01475 180 QGKICVVPDLCATLShvCQQVCISTPGSYLCAC--TEGYALLED 221
EGF_CA smart00179
Calcium-binding EGF-like domain;
238-263 5.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 5.82e-04
                           10        20
                   ....*....|....*....|....*....
gi 4557617     238 DVDECLQG---RCEQVCVNSPGSYTCHCD 263
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
197-226 5.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 5.61e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 4557617    197 DIDECADSEA-CGE-ARCKNLPGSYSCLCDEG 226
Cdd:pfam07645   1 DVDECATGTHnCPAnTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 298-450 1.50e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 1.50e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617  298 GRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRyNGVGRVT-SSGPVINH 376
Cdd:cd00110   1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYD-LGSGSLVlSSKTPLND 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4557617  377 GMWQTISVEELARNLVIKVNRDAVMKIAvagdlfqPERGLYHLN----LTVGGIPFHEKDLVQPINPRLDGCMRSWNW 450
Cdd:cd00110  80 GQWHSVSVERNGRSVTLSVDGERVVESG-------SPGGSALLNldgpLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
322-454 1.72e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 1.72e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617     322 EFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRY-NGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAv 400
Cdd:smart00282   3 SFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGN- 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4557617     401 mkiAVAGDLFQPERGL-YHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWnWLNGE 454
Cdd:smart00282  82 ---RVSGESPGGLTILnLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNL-KVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
325-452 1.41e-21

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 90.84  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617    325 FRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRyNGVGR-VTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKI 403
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYD-LGSGAaVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 4557617    404 AvagdlfQPERGLYHLNLT----VGGIP-FHEKDLVQPINPRLDGCMRSWNWLN 452
Cdd:pfam00054  80 E------SPLGATTDLDVDgplyVGGLPsLGVKKRRLAISPSFDGCIRDVIVNG 127
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 53-92 3.61e-21

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 86.82  E-value: 3.61e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4557617     53 FEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRY 92
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 40-92 1.78e-19

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 82.74  E-value: 1.78e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 4557617      40 QFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRY 92
Cdd:smart00069  12 KVLRRQRRANAFLLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRY 64
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 325-454 3.80e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.93  E-value: 3.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617    325 FRTFDPEGILLFAGGHQdSTWIVLALRAGRLELQLRY-NGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKI 403
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLgSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4557617    404 AVAG--DLFQPERGLYhlnltVGGIPFHEKDLVQPINPRLDGCMRSWNwLNGE 454
Cdd:pfam02210  80 LPPGesLLLNLNGPLY-----LGGLPPLLLLPALPVRAGFVGCIRDVR-VNGE 126
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 160-195 4.36e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 60.72  E-value: 4.36e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4557617    160 CSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTC 195
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 513-644 2.38e-10

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 58.59  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617    513 IRPAADTGVLFalWAPDLRAVPLSVALVDyhstKKLKKQlVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDG 592
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVN----GRLVLR-YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4557617    593 TRgqsevsaaQLQERLAVLERHLRSPVLTFAGGLP-DVPVTSAPVTAFYRGCM 644
Cdd:pfam02210  74 QT--------VVSSLPPGESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCI 118
LamG smart00282
Laminin G domain;
513-651 2.05e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.19  E-value: 2.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617     513 IRPAADTGVLFAlWAPDLRAVPLSVALVDyhstKKLkkQLVVLAVEHTALALME-IKVCDGQEHVVTVSLRDGEATLEVD 591
Cdd:smart00282   6 FRTTSPNGLLLY-AGSKGGGDYLALELRD----GRL--VLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557617     592 GTRGQSEVSAAQLQerlavlERHLRSPVltFAGGLPDVPVTSA-PVTAFYRGCM-TLEVNRR 651
Cdd:smart00282  79 GGNRVSGESPGGLT------ILNLDGPL--YLGGLPEDLKLPPlPVTPGFRGCIrNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 484-644 9.22e-09

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 54.73  E-value: 9.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617  484 GFAFYSLDYMRTPLDVGTESTWEVEVvaHIRPAADTGVLFAlWAPDLRAVPLSVALVDYHstkklkkqlVVLAVEHTALA 563
Cdd:cd00110   1 GVSFSGSSYVRLPTLPAPRTRLSISF--SFRTTSPNGLLLY-AGSQNGGDFLALELEDGR---------LVLRYDLGSGS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617  564 LM---EIKVCDGQEHVVTVSLRDGEATLEVDGTRgqsevsaaQLQERLAVLERHLRSPVLTFAGGLPDVP-VTSAPVTAF 639
Cdd:cd00110  69 LVlssKTPLNDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGPLYLGGLPEDLkSPGLPVSPG 140


                ....*
gi 4557617  640 YRGCM 644
Cdd:cd00110 141 FVGCI 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-196 1.72e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 1.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 4557617     156 DVNECSQENG-GCLQICHNKPGSFHCSCHSGFElssDGRTCQ 196
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
197-227 2.22e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 2.22e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557617     197 DIDECADSEACGE-ARCKNLPGSYSCLCDEGF 227
Cdd:smart00179   1 DIDECASGNPCQNgGTCVNTVGSYRCECPPGY 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 179-200 4.39e-07

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 46.25  E-value: 4.39e-07
                          10        20
                  ....*....|....*....|..
gi 4557617    179 HCSCHSGFELSSDGRTCQDIDE 200
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 197-227 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 5.18e-07
                        10        20        30
                ....*....|....*....|....*....|..
gi 4557617  197 DIDECADSEACGE-ARCKNLPGSYSCLCDEGF 227
Cdd:cd00054   1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-196 9.88e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 9.88e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 4557617  156 DVNECSQENGgCL--QICHNKPGSFHCSCHSGFElssdGRTCQ 196
Cdd:cd00054   1 DIDECASGNP-CQngGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 160-195 2.01e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 2.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4557617    160 CSQENGGC--LQICHNKPGSFHCSCHSGFELssDGRTC 195
Cdd:pfam12947   1 CSDNNGGChpNATCTNTGGSFTCTCNDGYTG--DGVTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 150-194 1.77e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 46.61  E-value: 1.77e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 4557617  150 GRLCdKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRT 194
Cdd:cd01475 181 GKIC-VVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 245-277 6.75e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 6.75e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4557617    245 GRCEQVCVNSPGSYTCHCdgRGGLKLSQDMDTC 277
Cdd:pfam14670   6 GGCSHLCLNTPGGYTCSC--PEGYELQDDGRTC 36
Laminin_G_1 pfam00054
Laminin G domain;
513-654 2.64e-04

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557617    513 IRPAADTGVLFALwAPDLRAVPLSVALVDYHStkklkkqLVVLAVEHTALALM-EIKVCDGQEHVVTVSLRDGEATLEVD 591
Cdd:pfam00054   1 FRTTEPSGLLLYN-GTQTERDFLALELRDGRL-------EVSYDLGSGAAVVRsGDKLNDGKWHSVELERNGRSGTLSVD 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4557617    592 GT---RGQSEVSAAQlqerlavlerHLRSPVLTFAGGLPDVPVTS--APVTAFYRGCM-TLEVNRRLLD 654
Cdd:pfam00054  73 GEarpTGESPLGATT----------DLDVDGPLYVGGLPSLGVKKrrLAISPSFDGCIrDVIVNGKPLD 131
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 232-273 3.38e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.76  E-value: 3.38e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 4557617  232 QEKACRDVDECLQGR--CEQVCVNSPGSYTCHCdgRGGLKLSQD 273
Cdd:cd01475 180 QGKICVVPDLCATLShvCQQVCISTPGSYLCAC--TEGYALLED 221
EGF_CA smart00179
Calcium-binding EGF-like domain;
238-263 5.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 5.82e-04
                           10        20
                   ....*....|....*....|....*....
gi 4557617     238 DVDECLQG---RCEQVCVNSPGSYTCHCD 263
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECP 29
EGF smart00181
Epidermal growth factor-like domain;
200-227 6.20e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 6.20e-04
                           10        20
                   ....*....|....*....|....*...
gi 4557617     200 ECADSEACGEARCKNLPGSYSCLCDEGF 227
Cdd:smart00181   1 ECASGGPCSNGTCINTPGSYTCSCPPGY 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 238-263 2.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.10e-03
                        10        20
                ....*....|....*....|....*....
gi 4557617  238 DVDECLQG---RCEQVCVNSPGSYTCHCD 263
Cdd:cd00054   1 DIDECASGnpcQNGGTCVNTVGSYRCSCP 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 200-227 3.05e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.05e-03
                        10        20
                ....*....|....*....|....*....
gi 4557617  200 ECADSEACGE-ARCKNLPGSYSCLCDEGF 227
Cdd:cd00053   1 ECAASNPCSNgGTCVNTPGSYRCVCPPGY 29
EGF_CA pfam07645
Calcium-binding EGF domain;
238-263 3.36e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.36e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 4557617    238 DVDECLQGR--CEQ--VCVNSPGSYTCHCD 263
Cdd:pfam07645   1 DVDECATGThnCPAntVCVNTIGSFECRCP 30
EGF smart00181
Epidermal growth factor-like domain;
159-196 3.79e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4557617     159 ECSqENGGCLQ-ICHNKPGSFHCSCHSGFELSsdgRTCQ 196
Cdd:smart00181   1 ECA-SGGPCSNgTCINTPGSYTCSCPPGYTGD---KRCE 35
EGF_CA pfam07645
Calcium-binding EGF domain;
197-226 5.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 5.61e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 4557617    197 DIDECADSEA-CGE-ARCKNLPGSYSCLCDEG 226
Cdd:pfam07645   1 DVDECATGTHnCPAnTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 159-196 5.91e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 34.76  E-value: 5.91e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 4557617  159 ECSQeNGGCL--QICHNKPGSFHCSCHSGFELSsdgRTCQ 196
Cdd:cd00053   1 ECAA-SNPCSngGTCVNTPGSYRCVCPPGYTGD---RSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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