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Conserved domains on  [gi|4504665|ref|NP_000869|]
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interleukin-2 receptor subunit beta precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL2RB_N1 pfam18707
Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I ...
 32-123 7.41e-48

Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I cytokine receptor superfamily. It carries a cytokine-binding homology region, which is divided in two fibronectin type-III (FN-III) domains termed D1 and D2. Each domain contains seven beta-strands that form a sandwich of two antiparallel beta-sheets. The N-terminal D1 domain of IL-2Rbeta includes two highly conserved disulfide bridges. This entry describes D1 of the N-terminal region of IL2Rbeta.


:

Pssm-ID: 465844  Cd Length: 92  Bit Score: 161.41  E-value: 7.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665     32 SQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCR 111
Cdd:pfam18707   1 SSLTCFYNSRANISCVWSHDGTLQVTSCHLHAKSNIRSWNKSCELIPVEPASWSCNLILGSPNSQKFTSADTLDLSVMCS 80

                          90
                  ....*....|..
gi 4504665    112 EGVRWRVMAIQD 123
Cdd:pfam18707  81 EGEEWRGVKTQD 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 134-216 9.01e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 9.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665     134 APISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEaplLTLKQKQEWICLETLTPDTQYEFQVRVKPL 213
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKE---VNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ...
gi 4504665     214 QGE 216
Cdd:smart00060  80 AGE 82
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
386-531 2.23e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665   386 PYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDdlllfSPSLLGGPSPPSTAPGgsgageERMPPSLQERVPR 465
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA-----APAAAPAPADDDPPPW------EELPPEFASPAPA 512

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665   466 DWDPQPLGPPTPGVPDLVDFQPPPElvlREAGEEVPDAGPREGVS-----FPWSRPPGQGEFR----------ALNARLP 530
Cdd:PRK12323 513 QPDAAPAGWVAESIPDPATADPDDA---FETLAPAPAAAPAPRAAaatepVVAPRPPRASASGlpdmfdgdwpALAARLP 589


                 .
gi 4504665   531 L 531
Cdd:PRK12323 590 V 590
 
Name Accession Description Interval E-value
IL2RB_N1 pfam18707
Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I ...
 32-123 7.41e-48

Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I cytokine receptor superfamily. It carries a cytokine-binding homology region, which is divided in two fibronectin type-III (FN-III) domains termed D1 and D2. Each domain contains seven beta-strands that form a sandwich of two antiparallel beta-sheets. The N-terminal D1 domain of IL-2Rbeta includes two highly conserved disulfide bridges. This entry describes D1 of the N-terminal region of IL2Rbeta.


Pssm-ID: 465844  Cd Length: 92  Bit Score: 161.41  E-value: 7.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665     32 SQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCR 111
Cdd:pfam18707   1 SSLTCFYNSRANISCVWSHDGTLQVTSCHLHAKSNIRSWNKSCELIPVEPASWSCNLILGSPNSQKFTSADTLDLSVMCS 80

                          90
                  ....*....|..
gi 4504665    112 EGVRWRVMAIQD 123
Cdd:pfam18707  81 EGEEWRGVKTQD 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 134-216 9.01e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 9.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665     134 APISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEaplLTLKQKQEWICLETLTPDTQYEFQVRVKPL 213
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKE---VNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ...
gi 4504665     214 QGE 216
Cdd:smart00060  80 AGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 134-231 2.55e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 2.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665  134 APISLQVVHVETHRCNISWE-----ISQASHYferHLEFEARTLSPGHTWEEAPLLTLKQKqewicLETLTPDTQYEFQV 208
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTppeddGGPITGY---VVEYREKGSGDWKEVEVTPGSETSYT-----LTGLKPGTEYEFRV 74

                        90       100
                ....*....|....*....|...
gi 4504665  209 RVKPLQGefttWSPWSQPLAFRT 231
Cdd:cd00063  75 RAVNGGG----ESPPSESVTVTT 93
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
386-531 2.23e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665   386 PYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDdlllfSPSLLGGPSPPSTAPGgsgageERMPPSLQERVPR 465
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA-----APAAAPAPADDDPPPW------EELPPEFASPAPA 512

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665   466 DWDPQPLGPPTPGVPDLVDFQPPPElvlREAGEEVPDAGPREGVS-----FPWSRPPGQGEFR----------ALNARLP 530
Cdd:PRK12323 513 QPDAAPAGWVAESIPDPATADPDDA---FETLAPAPAAAPAPRAAaatepVVAPRPPRASASGlpdmfdgdwpALAARLP 589


                 .
gi 4504665   531 L 531
Cdd:PRK12323 590 V 590
 
Name Accession Description Interval E-value
IL2RB_N1 pfam18707
Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I ...
 32-123 7.41e-48

Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I cytokine receptor superfamily. It carries a cytokine-binding homology region, which is divided in two fibronectin type-III (FN-III) domains termed D1 and D2. Each domain contains seven beta-strands that form a sandwich of two antiparallel beta-sheets. The N-terminal D1 domain of IL-2Rbeta includes two highly conserved disulfide bridges. This entry describes D1 of the N-terminal region of IL2Rbeta.


Pssm-ID: 465844  Cd Length: 92  Bit Score: 161.41  E-value: 7.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665     32 SQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCR 111
Cdd:pfam18707   1 SSLTCFYNSRANISCVWSHDGTLQVTSCHLHAKSNIRSWNKSCELIPVEPASWSCNLILGSPNSQKFTSADTLDLSVMCS 80

                          90
                  ....*....|..
gi 4504665    112 EGVRWRVMAIQD 123
Cdd:pfam18707  81 EGEEWRGVKTQD 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 134-216 9.01e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 9.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665     134 APISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEaplLTLKQKQEWICLETLTPDTQYEFQVRVKPL 213
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKE---VNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ...
gi 4504665     214 QGE 216
Cdd:smart00060  80 AGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 134-231 2.55e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 2.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665  134 APISLQVVHVETHRCNISWE-----ISQASHYferHLEFEARTLSPGHTWEEAPLLTLKQKqewicLETLTPDTQYEFQV 208
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTppeddGGPITGY---VVEYREKGSGDWKEVEVTPGSETSYT-----LTGLKPGTEYEFRV 74

                        90       100
                ....*....|....*....|...
gi 4504665  209 RVKPLQGefttWSPWSQPLAFRT 231
Cdd:cd00063  75 RAVNGGG----ESPPSESVTVTT 93
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
386-531 2.23e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665   386 PYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDdlllfSPSLLGGPSPPSTAPGgsgageERMPPSLQERVPR 465
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA-----APAAAPAPADDDPPPW------EELPPEFASPAPA 512

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504665   466 DWDPQPLGPPTPGVPDLVDFQPPPElvlREAGEEVPDAGPREGVS-----FPWSRPPGQGEFR----------ALNARLP 530
Cdd:PRK12323 513 QPDAAPAGWVAESIPDPATADPDDA---FETLAPAPAAAPAPRAAaatepVVAPRPPRASASGlpdmfdgdwpALAARLP 589


                 .
gi 4504665   531 L 531
Cdd:PRK12323 590 V 590
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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