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Conserved domains on  [gi|1057866996|ref|NP_001317263|]
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polycomb protein EED isoform d [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-358 8.10e-20

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 8.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319    89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEV------------LSASCENAIVCWkpgk 255
Cdd:COG2319   160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVrsvafspdgkllASGSADGTVRLW---- 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 256 medDIDKIKPsesnVTILGRFDYSqcdIWYMRFSMDfwQKMLALGNQVGKLYVWDLEvedpHKAKCTTLTHHkcGAAIRQ 335
Cdd:COG2319   232 ---DLATGKL----LRTLTGHSGS---VRSVAFSPD--GRLLASGSADGTVRLWDLA----TGELLRTLTGH--SGGVNS 293

                         250       260
                  ....*....|....*....|...
gi 1057866996 336 TSFSRDSSILIAVCDDASIWRWD 358
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWD 316
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-358 8.10e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 8.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319    89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEV------------LSASCENAIVCWkpgk 255
Cdd:COG2319   160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVrsvafspdgkllASGSADGTVRLW---- 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 256 medDIDKIKPsesnVTILGRFDYSqcdIWYMRFSMDfwQKMLALGNQVGKLYVWDLEvedpHKAKCTTLTHHkcGAAIRQ 335
Cdd:COG2319   232 ---DLATGKL----LRTLTGHSGS---VRSVAFSPD--GRLLASGSADGTVRLWDLA----TGELLRTLTGH--SGGVNS 293

                         250       260
                  ....*....|....*....|...
gi 1057866996 336 TSFSRDSSILIAVCDDASIWRWD 358
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-358 3.77e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 230 ggvEGHRDEVLSASCENA--IVCWKPGKMEDDIDKIKPSESNVTILGRfdysQCDIWYMRFSMDfwQKMLALGNQVGKLY 307
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCLTTLRGH----TDWVNSVAFSPD--GTFVASSSQDGTIK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1057866996 308 VWDLEvedphKAKC-TTLTHHKCGaaIRQTSFSRDSSILIAVCDDASIWRWD 358
Cdd:cd00200   161 LWDLR-----TGKCvATLTGHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 5.07e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1057866996  179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 2.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1057866996 180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-358 8.10e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 8.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319    89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEV------------LSASCENAIVCWkpgk 255
Cdd:COG2319   160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVrsvafspdgkllASGSADGTVRLW---- 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 256 medDIDKIKPsesnVTILGRFDYSqcdIWYMRFSMDfwQKMLALGNQVGKLYVWDLEvedpHKAKCTTLTHHkcGAAIRQ 335
Cdd:COG2319   232 ---DLATGKL----LRTLTGHSGS---VRSVAFSPD--GRLLASGSADGTVRLWDLA----TGELLRTLTGH--SGGVNS 293

                         250       260
                  ....*....|....*....|...
gi 1057866996 336 TSFSRDSSILIAVCDDASIWRWD 358
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
162-359 2.71e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEV-- 239
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVrs 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 240 ----------LSASCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVW 309
Cdd:COG2319   252 vafspdgrllASGSADGTVRLW-------DLATGEL-------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLW 315

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1057866996 310 DLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWDR 359
Cdd:COG2319   316 DLATGKLLR----TLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
83-358 1.10e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996  83 KCVNSLKEdHNQPLFGVQFnwhSKEGDPLvfATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshp 161
Cdd:COG2319   153 KLLRTLTG-HSGAVTSVAF---SPDGKLL--ASGSDdGTVRLWDLATGKLLRTLTGHTGA-----VRSVAFSPDGKL--- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 162 lLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFGGvegHRDEVLS 241
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG---HSGGVNS 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 242 ascenaiVCWKP-GKM-----ED------DIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVW 309
Cdd:COG2319   294 -------VAFSPdGKLlasgsDDgtvrlwDLATGKL-------LRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLW 357

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1057866996 310 DLEVedphKAKCTTLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWD 358
Cdd:COG2319   358 DLAT----GELLRTLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-358 3.77e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 230 ggvEGHRDEVLSASCENA--IVCWKPGKMEDDIDKIKPSESNVTILGRfdysQCDIWYMRFSMDfwQKMLALGNQVGKLY 307
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCLTTLRGH----TDWVNSVAFSPD--GTFVASSSQDGTIK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1057866996 308 VWDLEvedphKAKC-TTLTHHKCGaaIRQTSFSRDSSILIAVCDDASIWRWD 358
Cdd:cd00200   161 LWDLR-----TGKCvATLTGHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-358 6.61e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 6.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 148 YTCAWtydsNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVA 227
Cdd:cd00200    97 SSVAF----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 228 IFggvEGHRDEV------------LSASCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSmdFWQK 295
Cdd:cd00200   172 TL---TGHTGEVnsvafspdgeklLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS--PDGY 232

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1057866996 296 MLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 358
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-244 5.11e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 5.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996  81 SFKCVNSLKeDHNQPLFGVQFNWHSKegdplvFATVGS--NRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNT 158
Cdd:cd00200   124 TGKCLTTLR-GHTDWVNSVAFSPDGT------FVASSSqdGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEK 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 159 shplLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDE 238
Cdd:cd00200   192 ----LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNS 263


                  ....*.
gi 1057866996 239 VLSASC 244
Cdd:cd00200   264 VTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
90-222 1.68e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996  90 EDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSR 169
Cdd:COG2319   285 TGHSGGVNSVAF---SPDGKLLASGS-DDGTVRLWDLATGKLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSDD 351

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1057866996 170 GIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQT 222
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-358 3.25e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 3.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 182 CIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEV------------LSASCENAIV 249
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVrdvaasadgtylASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 250 CWKPGKmeddidkikpSESNVTILGrfdySQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPhkakCTTLTHHKc 329
Cdd:cd00200    77 LWDLET----------GECVRTLTG----HTSYVSSVAFSPD--GRILSSSSRDKTIKVWDVETGKC----LTTLRGHT- 135

                         170       180
                  ....*....|....*....|....*....
gi 1057866996 330 gAAIRQTSFSRDSSILIAVCDDASIWRWD 358
Cdd:cd00200   136 -DWVNSVAFSPDGTFVASSSQDGTIKLWD 163
WD40 COG2319
WD40 repeat [General function prediction only];
162-358 1.99e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEV-- 239
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVrs 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996 240 ----------LSASCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVW 309
Cdd:COG2319   126 vafspdgktlASGSADGTVRLW-------DLATGKL-------LRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLW 189

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1057866996 310 DLEvedphKAKC-TTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 358
Cdd:COG2319   190 DLA-----TGKLlRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-219 2.52e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866996  81 SFKCVNSLkEDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSyvdadADENFYTCAWTYDSNtsh 160
Cdd:cd00200   166 TGKCVATL-TGHTGEVNSVAF---SPDGEKLLSSS-SDGTIKLWDLSTGKCLGTLRG-----HENGVNSVAFSPDGY--- 232

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1057866996 161 pLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:cd00200   233 -LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 5.07e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1057866996  179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 2.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1057866996 180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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