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Conserved domains on  [gi|2029126891|ref|NP_001381449|]
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protein THEMIS isoform 5 [Homo sapiens]

Protein Classification

CABIT domain-containing protein( domain architecture ID 12119421)

CABIT domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CABIT pfam12736
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ...
3-239 1.01e-54

Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.


:

Pssm-ID: 463686  Cd Length: 261  Bit Score: 186.88  E-value: 1.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891   3 GNECCFSTGEVIKITGLK-VKKIIAEICEQiEGCESLQPFELPMNFPGtfvkrskecLFKIVADKTPYLTMEEITRTIHI 81
Cdd:pfam12736  15 GSVYCLSKGDVLLIHGLKqAKKVVAQEVEE-GRGVVGPKLLIPLSYPG---------LFKLLADEGPFESVEELARSFPI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891  82 -------GPSRLGHPCFYHQKDIKLENLIIKQGEQIMLNSVEEIDGE----------IMVSCAVarNHQTHSFNLPLSQE 144
Cdd:pfam12736  85 rvlakeeGPDSVGVPMFRSSDDMSLANFTLQAGEELTLLGVEESSGGkeelasvtvgDYLICLV--NQTGESVLLPLSCR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 145 GEFYE-CEDERIYTLKEIVE-WKIPKNRTRTVNLTDFSNKwdstnpfpKDFYGTLILKPVYEIQGVMK--------FRKD 214
Cdd:pfam12736 163 GRFSEeCEDEGEYTLREIVEkFKLPLNVKVVVGDPPRGDL--------DAFTGELRLEPVYEEQAVVAspllipvpFRKL 234
                         250       260
                  ....*....|....*....|....*..
gi 2029126891 215 IIRILPSLDVEVKDIT--DSYDANWFL 239
Cdd:pfam12736 235 EVPIPSDLDVEVAEVTsaDNKDYEEFL 261
CABIT pfam12736
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ...
255-503 2.45e-40

Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.


:

Pssm-ID: 463686  Cd Length: 261  Bit Score: 147.98  E-value: 2.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 255 FPIVTEVIEAPEGnHLPQSILQPGKTIVIHKKYQASRILASEIRSNF--PKRHFLIPTSYKGKFKRRPRE--FPTAYDL- 329
Cdd:pfam12736   1 LPQVVKVTSGIYG-EGSVYCLSKGDVLLIHGLKQAKKVVAQEVEEGRgvVGPKLLIPLSYPGLFKLLADEgpFESVEELa 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 330 ------EIAKSE-------------------------KEPLHVVATKAFHSPHDKLSSVSVGDqflvhqsettevlcegi 378
Cdd:pfam12736  80 rsfpirVLAKEEgpdsvgvpmfrssddmslanftlqaGEELTLLGVEESSGGKEELASVTVGD----------------- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 379 kkvvnVLACEKilKKSYEAALLPLYMEGGFVEVIHDKKQYPISELCKQFRLPFNVKVSVRDLSIEEDVlAATPGLQLEED 458
Cdd:pfam12736 143 -----YLICLV--NQTGESVLLPLSCRGRFSEECEDEGEYTLREIVEKFKLPLNVKVVVGDPPRGDLD-AFTGELRLEPV 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2029126891 459 ITDSYLLISDFANPTECWEIPVG-RLNMTVQLVSNFSRDAEPFLVR 503
Cdd:pfam12736 215 YEEQAVVASPLLIPVPFRKLEVPiPSDLDVEVAEVTSADNKDYEEF 260
 
Name Accession Description Interval E-value
CABIT pfam12736
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ...
3-239 1.01e-54

Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.


Pssm-ID: 463686  Cd Length: 261  Bit Score: 186.88  E-value: 1.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891   3 GNECCFSTGEVIKITGLK-VKKIIAEICEQiEGCESLQPFELPMNFPGtfvkrskecLFKIVADKTPYLTMEEITRTIHI 81
Cdd:pfam12736  15 GSVYCLSKGDVLLIHGLKqAKKVVAQEVEE-GRGVVGPKLLIPLSYPG---------LFKLLADEGPFESVEELARSFPI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891  82 -------GPSRLGHPCFYHQKDIKLENLIIKQGEQIMLNSVEEIDGE----------IMVSCAVarNHQTHSFNLPLSQE 144
Cdd:pfam12736  85 rvlakeeGPDSVGVPMFRSSDDMSLANFTLQAGEELTLLGVEESSGGkeelasvtvgDYLICLV--NQTGESVLLPLSCR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 145 GEFYE-CEDERIYTLKEIVE-WKIPKNRTRTVNLTDFSNKwdstnpfpKDFYGTLILKPVYEIQGVMK--------FRKD 214
Cdd:pfam12736 163 GRFSEeCEDEGEYTLREIVEkFKLPLNVKVVVGDPPRGDL--------DAFTGELRLEPVYEEQAVVAspllipvpFRKL 234
                         250       260
                  ....*....|....*....|....*..
gi 2029126891 215 IIRILPSLDVEVKDIT--DSYDANWFL 239
Cdd:pfam12736 235 EVPIPSDLDVEVAEVTsaDNKDYEEFL 261
CABIT pfam12736
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ...
255-503 2.45e-40

Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.


Pssm-ID: 463686  Cd Length: 261  Bit Score: 147.98  E-value: 2.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 255 FPIVTEVIEAPEGnHLPQSILQPGKTIVIHKKYQASRILASEIRSNF--PKRHFLIPTSYKGKFKRRPRE--FPTAYDL- 329
Cdd:pfam12736   1 LPQVVKVTSGIYG-EGSVYCLSKGDVLLIHGLKQAKKVVAQEVEEGRgvVGPKLLIPLSYPGLFKLLADEgpFESVEELa 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 330 ------EIAKSE-------------------------KEPLHVVATKAFHSPHDKLSSVSVGDqflvhqsettevlcegi 378
Cdd:pfam12736  80 rsfpirVLAKEEgpdsvgvpmfrssddmslanftlqaGEELTLLGVEESSGGKEELASVTVGD----------------- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 379 kkvvnVLACEKilKKSYEAALLPLYMEGGFVEVIHDKKQYPISELCKQFRLPFNVKVSVRDLSIEEDVlAATPGLQLEED 458
Cdd:pfam12736 143 -----YLICLV--NQTGESVLLPLSCRGRFSEECEDEGEYTLREIVEKFKLPLNVKVVVGDPPRGDLD-AFTGELRLEPV 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2029126891 459 ITDSYLLISDFANPTECWEIPVG-RLNMTVQLVSNFSRDAEPFLVR 503
Cdd:pfam12736 215 YEEQAVVASPLLIPVPFRKLEVPiPSDLDVEVAEVTSADNKDYEEF 260
 
Name Accession Description Interval E-value
CABIT pfam12736
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ...
3-239 1.01e-54

Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.


Pssm-ID: 463686  Cd Length: 261  Bit Score: 186.88  E-value: 1.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891   3 GNECCFSTGEVIKITGLK-VKKIIAEICEQiEGCESLQPFELPMNFPGtfvkrskecLFKIVADKTPYLTMEEITRTIHI 81
Cdd:pfam12736  15 GSVYCLSKGDVLLIHGLKqAKKVVAQEVEE-GRGVVGPKLLIPLSYPG---------LFKLLADEGPFESVEELARSFPI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891  82 -------GPSRLGHPCFYHQKDIKLENLIIKQGEQIMLNSVEEIDGE----------IMVSCAVarNHQTHSFNLPLSQE 144
Cdd:pfam12736  85 rvlakeeGPDSVGVPMFRSSDDMSLANFTLQAGEELTLLGVEESSGGkeelasvtvgDYLICLV--NQTGESVLLPLSCR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 145 GEFYE-CEDERIYTLKEIVE-WKIPKNRTRTVNLTDFSNKwdstnpfpKDFYGTLILKPVYEIQGVMK--------FRKD 214
Cdd:pfam12736 163 GRFSEeCEDEGEYTLREIVEkFKLPLNVKVVVGDPPRGDL--------DAFTGELRLEPVYEEQAVVAspllipvpFRKL 234
                         250       260
                  ....*....|....*....|....*..
gi 2029126891 215 IIRILPSLDVEVKDIT--DSYDANWFL 239
Cdd:pfam12736 235 EVPIPSDLDVEVAEVTsaDNKDYEEFL 261
CABIT pfam12736
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ...
255-503 2.45e-40

Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.


Pssm-ID: 463686  Cd Length: 261  Bit Score: 147.98  E-value: 2.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 255 FPIVTEVIEAPEGnHLPQSILQPGKTIVIHKKYQASRILASEIRSNF--PKRHFLIPTSYKGKFKRRPRE--FPTAYDL- 329
Cdd:pfam12736   1 LPQVVKVTSGIYG-EGSVYCLSKGDVLLIHGLKQAKKVVAQEVEEGRgvVGPKLLIPLSYPGLFKLLADEgpFESVEELa 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 330 ------EIAKSE-------------------------KEPLHVVATKAFHSPHDKLSSVSVGDqflvhqsettevlcegi 378
Cdd:pfam12736  80 rsfpirVLAKEEgpdsvgvpmfrssddmslanftlqaGEELTLLGVEESSGGKEELASVTVGD----------------- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126891 379 kkvvnVLACEKilKKSYEAALLPLYMEGGFVEVIHDKKQYPISELCKQFRLPFNVKVSVRDLSIEEDVlAATPGLQLEED 458
Cdd:pfam12736 143 -----YLICLV--NQTGESVLLPLSCRGRFSEECEDEGEYTLREIVEKFKLPLNVKVVVGDPPRGDLD-AFTGELRLEPV 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2029126891 459 ITDSYLLISDFANPTECWEIPVG-RLNMTVQLVSNFSRDAEPFLVR 503
Cdd:pfam12736 215 YEEQAVVASPLLIPVPFRKLEVPiPSDLDVEVAEVTSADNKDYEEF 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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