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Conserved domains on  [gi|251823957|ref|NP_082451|]
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volume-regulated anion channel subunit LRRC8E [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-330 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 560.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENISGAPCQQLLPQGI--- 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPtqs 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957   78 -----SEQMGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  153 LGKCFDSPWTTRALSEVSGENHKGPASGRAM------VTTVTTTGAGSGKVGEGEKEKVLIEPEKVVSE-PPVVTLLDKK 225
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGntvlpkVSSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  226 EGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLIYVEKISFLVACRVETSEITGYASFCCNHTKA 305
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 251823957  306 HLFSKLAFCYISFVCVYGITCLYTL 330
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
508-771 4.90e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 4.90e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 508 LEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELE 587
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 588 LVACGLerIPHAIFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETL 667
Cdd:COG4886   82 LSLLLL--GLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 668 PTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALS 747
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLE 231

                        250       260
                 ....*....|....*....|....
gi 251823957 748 RLELKGNRLETLPeELGDCKGLKK 771
Cdd:COG4886  232 TLDLSNNQLTDLP-ELGNLTNLEE 254
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-330 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 560.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENISGAPCQQLLPQGI--- 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPtqs 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957   78 -----SEQMGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  153 LGKCFDSPWTTRALSEVSGENHKGPASGRAM------VTTVTTTGAGSGKVGEGEKEKVLIEPEKVVSE-PPVVTLLDKK 225
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGntvlpkVSSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  226 EGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLIYVEKISFLVACRVETSEITGYASFCCNHTKA 305
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 251823957  306 HLFSKLAFCYISFVCVYGITCLYTL 330
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
508-771 4.90e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 4.90e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 508 LEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELE 587
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 588 LVACGLerIPHAIFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETL 667
Cdd:COG4886   82 LSLLLL--GLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 668 PTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALS 747
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLE 231

                        250       260
                 ....*....|....*....|....
gi 251823957 748 RLELKGNRLETLPeELGDCKGLKK 771
Cdd:COG4886  232 TLDLSNNQLTDLP-ELGNLTNLEE 254
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 606-754 1.61e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 79.06  E-value: 1.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 606 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSHNKLETLpTQLGQCFGLRLLDLSHN 685
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 686 glrSLPPE----------LGLLQSLQHLALSYNALESLpDELFFCHKLRTLLLGYNHLT---QLSPDVAALQALSRLELK 752
Cdd:cd21340  101 ---RLPPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 251823957 753 GN 754
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
585-763 3.89e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.74  E-value: 3.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 585 ELELVACGLERIPHAI--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 645
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 646 EHVRKlrSLEQLYLSHNKLETLPTQLGQcfGLRLLDLSHNGLRSLPPELGllQSLQHLALSYNALESLPDELffCHKLRT 725
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 251823957 726 LLLGYNHLTQLSPDVAAlqALSRLELKGNRLETLPEEL 763
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
LRR_8 pfam13855
Leucine rich repeat;
676-733 2.73e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.73e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  676 GLRLLDLSHNGLRSLPPELGL-LQSLQHLALSYNALESLPDELFFC-HKLRTLLLGYNHL 733
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-330 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 560.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENISGAPCQQLLPQGI--- 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPtqs 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957   78 -----SEQMGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  153 LGKCFDSPWTTRALSEVSGENHKGPASGRAM------VTTVTTTGAGSGKVGEGEKEKVLIEPEKVVSE-PPVVTLLDKK 225
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGntvlpkVSSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  226 EGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLIYVEKISFLVACRVETSEITGYASFCCNHTKA 305
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 251823957  306 HLFSKLAFCYISFVCVYGITCLYTL 330
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
508-771 4.90e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 4.90e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 508 LEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELE 587
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 588 LVACGLerIPHAIFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETL 667
Cdd:COG4886   82 LSLLLL--GLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 668 PTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALS 747
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLE 231

                        250       260
                 ....*....|....*....|....
gi 251823957 748 RLELKGNRLETLPeELGDCKGLKK 771
Cdd:COG4886  232 TLDLSNNQLTDLP-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
350-720 7.50e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 7.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 350 TGMNDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNMRGRLELSLCMLPGLP 429
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 430 DTVFELSEVEALrleaicDISFPPGLSQLVNLQELSLLHSparlpfssqiflrdrlkvicvkfeELREVPLWVFGLRGLE 509
Cdd:COG4886   90 TDLGDLTNLTEL------DLSGNEELSNLTNLESLDLSGN------------------------QLTDLPEELANLTNLK 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 510 ELHLEG----LFPpemargatlESLRELKQLKVLSLRSNA-GKVPASVTDVAgHLQRLSLHNDgaRLLAL-NSLKKLAVL 583
Cdd:COG4886  140 ELDLSNnqltDLP---------EPLGNLTNLKSLDLSNNQlTDLPEELGNLT-NLKELDLSNN--QITDLpEPLGNLTNL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 584 RELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQhcrKLVTLRLWHNQIAYVPEhVRKLRSLEQLYLSHNK 663
Cdd:COG4886  208 EELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 251823957 664 LETLP-TQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFC 720
Cdd:COG4886  284 LTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 606-754 1.61e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 79.06  E-value: 1.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 606 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSHNKLETLpTQLGQCFGLRLLDLSHN 685
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 686 glrSLPPE----------LGLLQSLQHLALSYNALESLpDELFFCHKLRTLLLGYNHLT---QLSPDVAALQALSRLELK 752
Cdd:cd21340  101 ---RLPPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 251823957 753 GN 754
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
585-763 3.89e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.74  E-value: 3.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 585 ELELVACGLERIPHAI--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 645
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 646 EHVRKlrSLEQLYLSHNKLETLPTQLGQcfGLRLLDLSHNGLRSLPPELGllQSLQHLALSYNALESLPDELffCHKLRT 725
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 251823957 726 LLLGYNHLTQLSPDVAAlqALSRLELKGNRLETLPEEL 763
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 450-769 2.12e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.58  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 450 SFPPGLSQLVNLQELSLLHSPARLPFSSQIFlrDRLKVICVKFEELR---EVPLWVFGLRGLEELHLeglFPPEMArGAT 526
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSlsgEIPELVIQLQNLEILHL---FSNNFT-GKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 527 LESLRELKQLKVLSLRSN--AGKVPASvtdvaghlqrLSLHNDGARL-LALNSLKKlavlrelelvacgleRIPHAIFSL 603
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNkfSGEIPKN----------LGKHNNLTVLdLSTNNLTG---------------EIPEGLCSS 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 604 GALQELDLKDNHLRSiEEILSFQHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE--------TLPT----- 669
Cdd:PLN00113 380 GNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMPSlqmls 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 670 --------QLGQCFG---LRLLDLSHNGLR-SLPPELGLLQSLQHLALSYNALES-LPDELFFCHKLRTLLLGYNHLT-Q 735
Cdd:PLN00113 459 larnkffgGLPDSFGskrLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQ 538

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 251823957 736 LSPDVAALQALSRLELKGNRLE-TLPEELGDCKGL 769
Cdd:PLN00113 539 IPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 412-756 2.79e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 2.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 412 RNMRGRLELSLCMLP--------------GLPDTVFELSEveALRLEAICDISFPPGLSQ--LVNLQELSLLHSPARLPF 475
Cdd:PLN00113  79 KNISGKISSAIFRLPyiqtinlsnnqlsgPIPDDIFTTSS--SLRYLNLSNNNFTGSIPRgsIPNLETLDLSNNMLSGEI 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 476 SSQIFLRDRLKVICVKFEELR-EVPLWVFGLRGLEEL-----HLEGLFPPEMARgatleslreLKQLKVLSLRSN--AGK 547
Cdd:PLN00113 157 PNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLtlasnQLVGQIPRELGQ---------MKSLKWIYLGYNnlSGE 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 548 VPASVTDVAG--HLQRLSLHNDGARLLALNSLKKLAVLRELELVACGleRIPHAIFSLGALQELDLKDNHLR-SIEEILS 624
Cdd:PLN00113 228 IPYEIGGLTSlnHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG--PIPPSIFSLQKLISLDLSDNSLSgEIPELVI 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 625 fqHCRKLVTLRLWHNQI-AYVPEHVRKLRSLEQLYLSHNKLE-TLPTQLGQCFGLRLLDLSHNGLRSLPPElGLLQS--L 700
Cdd:PLN00113 306 --QLQNLEILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPE-GLCSSgnL 382

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 251823957 701 QHLALSYNALES-LPDELFFCHKLRTLLLGYNHLT-QLSPDVAALQALSRLELKGNRL 756
Cdd:PLN00113 383 FKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 536-771 2.57e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 2.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 536 LKVLSLRSNA--GKVPASVTDVAGhLQRLSLhndgarllALNSL-----KKLAVLRELELVACGLE----RIPHAIFSLG 604
Cdd:PLN00113 166 LKVLDLGGNVlvGKIPNSLTNLTS-LEFLTL--------ASNQLvgqipRELGQMKSLKWIYLGYNnlsgEIPYEIGGLT 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 605 ALQELDLKDNHLrsIEEI-LSFQHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPTQLGQCFGLRLLD 681
Cdd:PLN00113 237 SLNHLDLVYNNL--TGPIpSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILH 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 682 LSHNGLR-SLPPELGLLQSLQHLALSYNALE-SLPDELFFCHKLRTLLLGYNHLTQLSPD-VAALQALSRLELKGNRLET 758
Cdd:PLN00113 315 LFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSSGNLFKLILFSNSLEG 394

                        250
                 ....*....|....
gi 251823957 759 -LPEELGDCKGLKK 771
Cdd:PLN00113 395 eIPKSLGACRSLRR 408
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
630-789 2.83e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 2.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 630 KLVTLRLWHNQIAYVPEHVRKlrSLEQLYLSHNKLETLPTQLGQCfgLRLLDLSHNGLRSLPPELGllQSLQHLALSYNA 709
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPDT--IQEMELSINRITELPERLP--SALQSLDLFHNK 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 710 LESLPDELffCHKLRTLLLGYNHLTQLSPDVAAlqALSRLELKGNRLETLPEELGdcKGLKksgLLVED-----TLYEGL 784
Cdd:PRK15370 274 ISCLPENL--PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLK---TLEAGenaltSLPASL 344


                 ....*
gi 251823957 785 PAEVR 789
Cdd:PRK15370 345 PPELQ 349
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 479-756 6.07e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.03  E-value: 6.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 479 IFLRDRLKVICVKFEELREVPLWvfglrglEELHLEGLFPPEMAR--GATLESLRELKQLKVLSLRSNAGKVPASVTDVa 556
Cdd:COG5238   84 AFPTQLLVVDWEGAEEVSPVALA-------ETATAVATPPPDLRRimAKTLEDSLILYLALPRRINLIQVLKDPLGGNA- 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 557 ghlQRLSLHNDGARLLALNSLKKLAVLRELELVAC--------GLERIPHAIFSLGALQELDLKDNHL--RSIEEILS-F 625
Cdd:COG5238  156 ---VHLLGLAARLGLLAAISMAKALQNNSVETVYLgcnqigdeGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaL 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 626 QHCRKLVTLRLWHNQI-----AYVPEHVRKLRSLEQLYLSHNKL-----ETLPTQLGQCFGLRLLDLSHNGLRSlPPELG 695
Cdd:COG5238  233 KGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGD-EGAIA 311

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 251823957 696 LLQSLQHlalsynaleslpdelffCHKLRTLLLGYNhltQLSPD-----VAALQA---LSRLELKGNRL 756
Cdd:COG5238  312 LAEGLQG-----------------NKTLHTLNLAYN---GIGAQgaialAKALQEnttLHSLDLSDNQI 360
LRR_8 pfam13855
Leucine rich repeat;
676-733 2.73e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.73e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  676 GLRLLDLSHNGLRSLPPELGL-LQSLQHLALSYNALESLPDELFFC-HKLRTLLLGYNHL 733
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 596-692 2.18e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 596 IPHAIFSLGALQELDLKDNHLRS-IEEILSfqHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPTQLG 672
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSGeIPDELS--SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLG 568

                         90       100
                 ....*....|....*....|.
gi 251823957 673 QCFGLRLLDLSHNGLR-SLPP 692
Cdd:PLN00113 569 NVESLVQVNISHNHLHgSLPS 589
PLN03150 PLN03150
hypothetical protein; Provisional
 643-710 2.65e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.05  E-value: 2.65e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 643 YVPEHVRKLRSLEQLYLSHNKLE-TLPTQLGQCFGLRLLDLSHNGLR-SLPPELGLLQSLQHLALSYNAL 710
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
698-756 1.22e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251823957  698 QSLQHLALSYNALESLPDELFF-CHKLRTLLLGYNHLTQLSPDV-AALQALSRLELKGNRL 756
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
527-717 1.64e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 527 LESLRELKQ--LKVLSLRSNA-GKVPASVTDVAGHLQrlslhndgarlLALNSLKKL-----AVLRELELVACGLERIPH 598
Cdd:PRK15370 211 LKSLPENLQgnIKTLYANSNQlTSIPATLPDTIQEME-----------LSINRITELperlpSALQSLDLFHNKISCLPE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 599 AIFSlgALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVPEHV-RKLRSLEQ------------------LYL 659
Cdd:PRK15370 280 NLPE--ELRYLSVYDNSIRTLPAHLP----SGITHLNVQSNSLTALPETLpPGLKTLEAgenaltslpaslppelqvLDV 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 251823957 660 SHNKLETLPTQLGQCfgLRLLDLSHNGLRSLPPELGllQSLQHLALSYNALESLPDEL 717
Cdd:PRK15370 354 SKNQITVLPETLPPT--ITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
629-687 1.67e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251823957  629 RKLVTLRLWHNQIAYVPEHV-RKLRSLEQLYLSHNKLETLPTQLGQCF-GLRLLDLSHNGL 687
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
583-641 1.92e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.92e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  583 LRELELVACGLERI-PHAIFSLGALQELDLKDNHLRSIEEIlSFQHCRKLVTLRLWHNQI 641
Cdd:pfam13855   3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 526-790 8.77e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 8.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 526 TLESLRELKQLKVLSLRSNagkvpaSVTDVAGHLQRLSLHNDGARLLALNSLKKLA-VLRELELVACGLERIPhaifslg 604
Cdd:cd00116   15 ATELLPKLLCLQVLRLEGN------TLGEEAAKALASALRPQPSLKELCLSLNETGrIPRGLQSLLQGLTKGC------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 605 ALQELDLKDNHLrSIEEILSFQHCRKLVTLRLWH-NQIAYVPEHVRKL--------RSLEQLYLSHNKLE-TLPTQLGQC 674
Cdd:cd00116   82 GLQELDLSDNAL-GPDGCGVLESLLRSSSLQELKlNNNGLGDRGLRLLakglkdlpPALEKLVLGRNRLEgASCEALAKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 675 F----GLRLLDLSHN-----GLRSLPPELGLLQSLQHLALSYNALESLPDElFFCH------KLRTLLLGYNHLTqlSPD 739
Cdd:cd00116  161 LranrDLKELNLANNgigdaGIRALAEGLKANCNLEVLDLNNNGLTDEGAS-ALAEtlaslkSLEVLNLGDNNLT--DAG 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 251823957 740 VAAL--------QALSRLELKGNRLE-----TLPEELGDCKGLKKSGLLVEDTLYEG--LPAEVRE 790
Cdd:cd00116  238 AAALasallspnISLLTLSLSCNDITddgakDLAEVLAEKESLLELDLRGNKFGEEGaqLLAESLL 303
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
583-773 4.09e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 583 LRELELVACGLERIPhaIFSLGALqELDLKDNHLRSIEEILSfqhcrKLVTLRLWHNQIAYVPEHVRklrSLEQLYLSHN 662
Cdd:PRK15387 244 LRTLEVSGNQLTSLP--VLPPGLL-ELSIFSNPLTHLPALPS-----GLCKLWIFGNQLTSLPVLPP---GLQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 663 KLETLPTQLGQcfgLRLLDLSHNGLRSLPPelgLLQSLQHLALSYNALESLPDelfFCHKLRTLLLGYNHLTQLSpdvAA 742
Cdd:PRK15387 313 QLASLPALPSE---LCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPT---LPSELYKLWAYNNRLTSLP---AL 380

                        170       180       190
                 ....*....|....*....|....*....|.
gi 251823957 743 LQALSRLELKGNRLETLPEELGDCKGLKKSG 773
Cdd:PRK15387 381 PSGLKELIVSGNRLTSLPVLPSELKELMVSG 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 527-667 5.66e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 527 LESLRELKQLKVLSLRSNagkvpaSVTDVAGhLQRLS----LHNDGARL-----LALN--SLKKLAV-LRELELVACGLE 594
Cdd:cd21340   61 IENLENLVNLKKLYLGGN------RISVVEG-LENLTnleeLHIENQRLppgekLTFDprSLAALSNsLRVLNISGNNID 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 251823957 595 RIpHAIFSLGALQELDLKDNHLRSIEEIL-SFQHCRKLVTLRLWHNQIAyvpeHVRKLRslEQLYLSHNKLETL 667
Cdd:cd21340  134 SL-EPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC----KKPKYR--DKIILASKSLEVL 200
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
631-760 1.56e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 631 LVTLRLWHNQIAYVPEHVRKLRsleQLYLSHNKLETLPTQLGqcfGLRLLDLSHNGLRSLPPelgLLQSLQHLALSYNAL 710
Cdd:PRK15387 304 LQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLPTLPS---GLQELSVSDNQLASLPT---LPSELYKLWAYNNRL 374

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 251823957 711 ESLPDelfFCHKLRTLLLGYNHLTQLsPDVAAlqALSRLELKGNRLETLP 760
Cdd:PRK15387 375 TSLPA---LPSGLKELIVSGNRLTSL-PVLPS--ELKELMVSGNRLTSLP 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 532-669 3.24e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 532 ELKQLKVLSLRSNA--GKVPASVTdvAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLE-RIPHAIFSLGALQE 608
Cdd:PLN00113 450 DMPSLQMLSLARNKffGGLPDSFG--SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVS 527

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251823957 609 LDLKDNHLrSIEEILSFQHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPT 669
Cdd:PLN00113 528 LDLSHNQL-SGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPS 589
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 583-760 7.58e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 7.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  583 LRELELVACGLERIPHAIFSLGALQELDLKDNhlRSIEEILSFQHCRKLVTLRLWH-NQIAYVPEHVRKLRSLEQLYLSH 661
Cdd:PLN03210  613 LVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGS--KNLKEIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMSR 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957  662 -NKLETLPT----------QLGQCFGLRL----------LDLSHNGLRSLPPELGlLQSLQHLALSYNALESLPDEL--- 717
Cdd:PLN03210  691 cENLEILPTginlkslyrlNLSGCSRLKSfpdistniswLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVqpl 769

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 251823957  718 -----FFCHKLRTLLLGYN-HLTQLSPDVAALQALSRLELKGNR-LETLP 760
Cdd:PLN03210  770 tplmtMLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLETLP 819
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 525-685 9.74e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 525 ATLESLRELKQLKVLSLRSNagkvpasvtdvaghlqrlSLHNDGARLLALnSLKKLAVLRELELVACGLER-----IPHA 599
Cdd:cd00116  156 ALAKALRANRDLKELNLANN------------------GIGDAGIRALAE-GLKANCNLEVLDLNNNGLTDegasaLAET 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823957 600 IFSLGALQELDLKDNHLRS--IEEILS--FQHCRKLVTLRLWHNQIAY-----VPEHVRKLRSLEQLYLSHNKL----ET 666
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDagAAALASalLSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKFgeegAQ 296

                        170       180
                 ....*....|....*....|.
gi 251823957 667 LPTQLGQCFG--LRLLDLSHN 685
Cdd:cd00116  297 LLAESLLEPGneLESLWVKDD 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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