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Conserved domains on  [gi|188536110|ref|NP_689824|]
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leucine-rich repeat neuronal protein 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-314 2.40e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  77 LRSLDASHNllralstSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGpALSSLRALALAGN 156
Cdd:COG4886   98 LTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNN 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 157 PLRALqPRAFACFPALQLLNLSCTALGRgaqggiAEAAFAGedgapLVTLEVLDLSGTFLERVeSGWIRDLPKLTSLYLR 236
Cdd:COG4886  170 QLTDL-PEELGNLTNLKELDLSNNQITD------LPEPLGN-----LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLS 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 188536110 237 KMpRLTTLegdifkmtPNLQQLdcqdspalasvathifqdtPHLQVLLFQNCNLSSFPPwTLDSSQVLSINLFGNPLT 314
Cdd:COG4886  237 NN-QLTDL--------PELGNL-------------------TNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 580-676 3.30e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 580 PDPPR-LQgVTETTDTSALVHWCAP---NSVVHGYQIRYSAEGwAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAAN 655
Cdd:cd00063    1 PSPPTnLR-VTDVTSTSVTLSWTPPeddGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90       100
                 ....*....|....*....|.
gi 188536110 656 RAGLSQPrssgwrSPCAAFTT 676
Cdd:cd00063   79 GGGESPP------SESVTVTT 93
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-314 2.40e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  77 LRSLDASHNllralstSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGpALSSLRALALAGN 156
Cdd:COG4886   98 LTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNN 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 157 PLRALqPRAFACFPALQLLNLSCTALGRgaqggiAEAAFAGedgapLVTLEVLDLSGTFLERVeSGWIRDLPKLTSLYLR 236
Cdd:COG4886  170 QLTDL-PEELGNLTNLKELDLSNNQITD------LPEPLGN-----LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLS 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 188536110 237 KMpRLTTLegdifkmtPNLQQLdcqdspalasvathifqdtPHLQVLLFQNCNLSSFPPwTLDSSQVLSINLFGNPLT 314
Cdd:COG4886  237 NN-QLTDL--------PELGNL-------------------TNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 580-676 3.30e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 580 PDPPR-LQgVTETTDTSALVHWCAP---NSVVHGYQIRYSAEGwAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAAN 655
Cdd:cd00063    1 PSPPTnLR-VTDVTSTSVTLSWTPPeddGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90       100
                 ....*....|....*....|.
gi 188536110 656 RAGLSQPrssgwrSPCAAFTT 676
Cdd:cd00063   79 GGGESPP------SESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
581-662 3.61e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  581 DPPRLQGVTETTDTSALVHWCAP---NSVVHGYQIRYSAEGwAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAANRA 657
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  ....*
gi 188536110  658 GLSQP 662
Cdd:pfam00041  80 GEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 580-660 7.45e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 7.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110   580 PDPPRLQGVTETTDTSALVHWCAPNS-VVHGYQIRYSAEGWAGNQSVVGVIY-ATARQHPLYGLSPGTTYRVCVLAANRA 657
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGSEWKEVNVtPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 188536110   658 GLS 660
Cdd:smart00060  81 GEG 83
LRR_8 pfam13855
Leucine rich repeat;
123-178 2.06e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.06e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 188536110  123 GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLS 178
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-178 1.56e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  38 SSGSNATDSPCEGLPAADATALTLANRNLErLPGCLPRTLRSLDASHNLLRALSTSelgHLEQLQVLTLRHNRIAALrwg 117
Cdd:PRK15370 226 YANSNQLTSIPATLPDTIQEMELSINRITE-LPERLPSALQSLDLFHNKISCLPEN---LPEELRYLSVYDNSIRTL--- 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188536110 118 PGG-PAGLHTLDLSYNQLAALPPCTGPALSSLRAlalAGNPLRALqPRAFAcfPALQLLNLS 178
Cdd:PRK15370 299 PAHlPSGITHLNVQSNSLTALPETLPPGLKTLEA---GENALTSL-PASLP--PELQVLDVS 354
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-213 7.88e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 7.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  69 LPGCLPRtLRSLDASHNLLRALST----SELGHLEQLQVLTLRHNRI---AALRWGPGGPA--GLHTLDLSYN------- 132
Cdd:cd00116  132 LKDLPPA-LEKLVLGRNRLEGASCealaKALRANRDLKELNLANNGIgdaGIRALAEGLKAncNLEVLDLNNNgltdega 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 133 -QLAALPpctgPALSSLRALALAGNPLRALQPRAFA-----CFPALQLLNLSCTALGRGAQGGIAEAAFAGEDgaplvtL 206
Cdd:cd00116  211 sALAETL----ASLKSLEVLNLGDNNLTDAGAAALAsallsPNISLLTLSLSCNDITDDGAKDLAEVLAEKES------L 280


                 ....*..
gi 188536110 207 EVLDLSG 213
Cdd:cd00116  281 LELDLRG 287
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-314 2.40e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  77 LRSLDASHNllralstSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGpALSSLRALALAGN 156
Cdd:COG4886   98 LTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNN 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 157 PLRALqPRAFACFPALQLLNLSCTALGRgaqggiAEAAFAGedgapLVTLEVLDLSGTFLERVeSGWIRDLPKLTSLYLR 236
Cdd:COG4886  170 QLTDL-PEELGNLTNLKELDLSNNQITD------LPEPLGN-----LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLS 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 188536110 237 KMpRLTTLegdifkmtPNLQQLdcqdspalasvathifqdtPHLQVLLFQNCNLSSFPPwTLDSSQVLSINLFGNPLT 314
Cdd:COG4886  237 NN-QLTDL--------PELGNL-------------------TNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-325 7.80e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 7.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  63 NRNLERLPGCLPR--TLRSLDASHNLLRALStSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPC 140
Cdd:COG4886  122 GNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 141 TGpALSSLRALALAGNPLRALqPRAFACFPALQLLNLSCTALGRgaqggIAEaaFAGedgapLVTLEVLDLSGTFLERVE 220
Cdd:COG4886  201 LG-NLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD-----LPE--LGN-----LTNLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 221 SgwIRDLPKLTSLYLRKMP----RLTTLEGDIFKMTPNLQQLDCQDSPALAS--VATHIFQDTPHLQVLLFQNCNLSSFP 294
Cdd:COG4886  267 P--LANLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILllLLTTLLLLLLLLKGLLVTLTTLALSL 344

                        250       260       270
                 ....*....|....*....|....*....|.
gi 188536110 295 PWTLDSSQVLSINLFGNPLTCSCDLSWLLTD 325
Cdd:COG4886  345 SLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 580-676 3.30e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 580 PDPPR-LQgVTETTDTSALVHWCAP---NSVVHGYQIRYSAEGwAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAAN 655
Cdd:cd00063    1 PSPPTnLR-VTDVTSTSVTLSWTPPeddGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90       100
                 ....*....|....*....|.
gi 188536110 656 RAGLSQPrssgwrSPCAAFTT 676
Cdd:cd00063   79 GGGESPP------SESVTVTT 93
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-322 3.76e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 3.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  75 RTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNR-IAALrwgpggpAGLHTLDLSYNQLAALPPCTGpALSSLRALAL 153
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNL-------TNLESLDLSGNQLTDLPEELA-NLTNLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 154 AGNPLRALQPrafacfpalqllnlsctALGRgaqggiaeaafagedgapLVTLEVLDLSGTFLERVeSGWIRDLPKLTSL 233
Cdd:COG4886  144 SNNQLTDLPE-----------------PLGN------------------LTNLKSLDLSNNQLTDL-PEELGNLTNLKEL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 234 YLRKmPRLTTLEGDIFKMTpNLQQLDCqdspalasvathifqdtphlqvllfQNCNLSSFPPWTLDSSQVLSINLFGNPL 313
Cdd:COG4886  188 DLSN-NQITDLPEPLGNLT-NLEELDL-------------------------SGNQLTDLPEPLANLTNLETLDLSNNQL 240


                 ....*....
gi 188536110 314 TcscDLSWL 322
Cdd:COG4886  241 T---DLPEL 246
fn3 pfam00041
Fibronectin type III domain;
581-662 3.61e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  581 DPPRLQGVTETTDTSALVHWCAP---NSVVHGYQIRYSAEGwAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAANRA 657
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  ....*
gi 188536110  658 GLSQP 662
Cdd:pfam00041  80 GEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 580-660 7.45e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 7.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110   580 PDPPRLQGVTETTDTSALVHWCAPNS-VVHGYQIRYSAEGWAGNQSVVGVIY-ATARQHPLYGLSPGTTYRVCVLAANRA 657
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGSEWKEVNVtPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 188536110   658 GLS 660
Cdd:smart00060  81 GEG 83
LRR_8 pfam13855
Leucine rich repeat;
123-178 2.06e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.06e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 188536110  123 GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLS 178
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
169-314 9.00e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 9.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 169 FPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLervesgwIRDLPKLTSLYLRKMpRLTTLEGDI 248
Cdd:COG4886   61 LLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGN-QLTDLPEEL 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 188536110 249 FKMTpNLQQLDCQDSPaLASVATHIFQdTPHLQVLLFQNCNLSSFPPWTLDSSQVLSINLFGNPLT 314
Cdd:COG4886  133 ANLT-NLKELDLSNNQ-LTDLPEPLGN-LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-178 1.56e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  38 SSGSNATDSPCEGLPAADATALTLANRNLErLPGCLPRTLRSLDASHNLLRALSTSelgHLEQLQVLTLRHNRIAALrwg 117
Cdd:PRK15370 226 YANSNQLTSIPATLPDTIQEMELSINRITE-LPERLPSALQSLDLFHNKISCLPEN---LPEELRYLSVYDNSIRTL--- 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188536110 118 PGG-PAGLHTLDLSYNQLAALPPCTGPALSSLRAlalAGNPLRALqPRAFAcfPALQLLNLS 178
Cdd:PRK15370 299 PAHlPSGITHLNVQSNSLTALPETLPPGLKTLEA---GENALTSL-PASLP--PELQVLDVS 354
LRR_8 pfam13855
Leucine rich repeat;
100-158 2.77e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  100 QLQVLTLRHNRIAALRWGP-GGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPL 158
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
75-134 4.18e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.18e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 188536110   75 RTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGP-GGPAGLHTLDLSYNQL 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
170-236 1.00e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188536110  170 PALQLLNLSCTALGrgaqgGIAEAAFAGedgapLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLR 236
Cdd:pfam13855   1 PNLRSLDLSNNRLT-----SLDDGAFKG-----LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57
LRR_8 pfam13855
Leucine rich repeat;
146-214 5.17e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 5.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188536110  146 SSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRgaqggIAEAAFAGedgapLVTLEVLDLSGT 214
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----LSPGAFSG-----LPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-213 7.88e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 7.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  69 LPGCLPRtLRSLDASHNLLRALST----SELGHLEQLQVLTLRHNRI---AALRWGPGGPA--GLHTLDLSYN------- 132
Cdd:cd00116  132 LKDLPPA-LEKLVLGRNRLEGASCealaKALRANRDLKELNLANNGIgdaGIRALAEGLKAncNLEVLDLNNNgltdega 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 133 -QLAALPpctgPALSSLRALALAGNPLRALQPRAFA-----CFPALQLLNLSCTALGRGAQGGIAEAAFAGEDgaplvtL 206
Cdd:cd00116  211 sALAETL----ASLKSLEVLNLGDNNLTDAGAAALAsallsPNISLLTLSLSCNDITDDGAKDLAEVLAEKES------L 280


                 ....*..
gi 188536110 207 EVLDLSG 213
Cdd:cd00116  281 LELDLRG 287
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-316 8.31e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 8.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  86 LLRALSTSELGHLEQLQVLTLRHNRI--AALRWGPG---GPAGLHTLDLSYNQLAALPPCTG------PALSSLRALALA 154
Cdd:cd00116   10 LKTERATELLPKLLCLQVLRLEGNTLgeEAAKALASalrPQPSLKELCLSLNETGRIPRGLQsllqglTKGCGLQELDLS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 155 GNPLRALQPRAFACF---PALQLLNLSCTALGRGAQGGIAEAAfagedGAPLVTLEVLDLSGTfleRVESGWIRDLPKLt 231
Cdd:cd00116   90 DNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAKGL-----KDLPPALEKLVLGRN---RLEGASCEALAKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 232 slyLRKMPRLTTLE--------------GDIFKMTPNLQQLDCQDS---PALASVATHIFQDTPHLQVLLFQNCNLSSFP 294
Cdd:cd00116  161 ---LRANRDLKELNlanngigdagiralAEGLKANCNLEVLDLNNNgltDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260
                 ....*....|....*....|....*...
gi 188536110 295 PWTLDSS------QVLSINLFGNPLTCS 316
Cdd:cd00116  238 AAALASAllspniSLLTLSLSCNDITDD 265
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
63-150 9.52e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 9.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  63 NRNLERLPGCLPRTLRSLDASHNLLRALSTSelgHLEQLQVLTLRHNRIAALrwgPGG-PAGLHTLDLSYNQLAALPPCT 141
Cdd:PRK15370 313 SNSLTALPETLPPGLKTLEAGENALTSLPAS---LPPELQVLDVSKNQITVL---PETlPPTITTLDVSRNALTNLPENL 386


                 ....*....
gi 188536110 142 GPALSSLRA 150
Cdd:PRK15370 387 PAALQIMQA 395
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-259 1.30e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  65 NLERLPG--CLPRtLRSLDASHNLLRALStsELGHLEQLQVLTLRHNRIAALRwGPGGPAGLHTLDLSYNQLA-----AL 137
Cdd:cd21340   35 KITKIENleFLTN-LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE-GLENLTNLEELHIENQRLPpgeklTF 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 138 PPCTGPALS-SLRALALAGNPLRALQPrafacfpalqllnLSCtalgrgaqggiaeaafagedgapLVTLEVLDLSGTFL 216
Cdd:cd21340  111 DPRSLAALSnSLRVLNISGNNIDSLEP-------------LAP-----------------------LRNLEQLDASNNQI 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 188536110 217 ERVE--SGWIRDLPKLTSLYLR-----KMPRlttLEGDIFKMTPNLQQLD 259
Cdd:cd21340  155 SDLEelLDLLSSWPSLRELDLTgnpvcKKPK---YRDKIILASKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 87-165 2.49e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  87 LRALSTSELGHLEQLQVLTLRHNRI-AALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRA 165
Cdd:PLN03150 430 LRGFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAA 509
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-182 4.43e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 4.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  41 SNATDSPcEGLPAADATALTLANRnLERLPGCLPRTLRSLDASHNLLRALSTselgHL-EQLQVLTLRHNRIAALrwgPG 119
Cdd:PRK15370 251 NRITELP-ERLPSALQSLDLFHNK-ISCLPENLPEELRYLSVYDNSIRTLPA----HLpSGITHLNVQSNSLTAL---PE 321

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188536110 120 G-PAGLHTLDLSYNQLAALPPCTGPAlssLRALALAGNPLRALqPRAFAcfPALQLLNLSCTAL 182
Cdd:PRK15370 322 TlPPGLKTLEAGENALTSLPASLPPE---LQVLDVSKNQITVL-PETLP--PTITTLDVSRNAL 379
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-311 6.44e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 6.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  76 TLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAalrwGPGGPA-----GLHTLDLSYNQLAALPPCTGPALSSLRA 150
Cdd:PLN00113 237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS----GPIPPSifslqKLISLDLSDNSLSGEIPELVIQLQNLEI 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 151 LALAGNPLRALQPRAFACFPALQLLNLSCTALgrgaQGGIAeaafagEDGAPLVTLEVLDLSGTFLE-RVESGwIRDLPK 229
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKF----SGEIP------KNLGKHNNLTVLDLSTNNLTgEIPEG-LCSSGN 381

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 230 LTSLYLRKmprlTTLEGDIFK---MTPNLQQLDCQDSpALASVATHIFQDTPHLQVLLFQNCNLS---SFPPWTLDSSQV 303
Cdd:PLN00113 382 LFKLILFS----NSLEGEIPKslgACRSLRRVRLQDN-SFSGELPSEFTKLPLVYFLDISNNNLQgriNSRKWDMPSLQM 456

                        250
                 ....*....|.
gi 188536110 304 LSI---NLFGN 311
Cdd:PLN00113 457 LSLarnKFFGG 467
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 74-192 1.48e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  74 PRTLRSLDASHNLL-----RALSTSeLGHLEQLQVLTLRHNRI-----AALRWGPGGPAGLHTLDLSYNQL--------- 134
Cdd:COG5238  263 NTTVETLYLSGNQIgaegaIALAKA-LQGNTTLTSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIgaqgaiala 341

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 188536110 135 AALPpcTGPALSSLRalaLAGNPLRALQPRAFACFPA----LQLLNLSCTALG-RGAQGGIAE 192
Cdd:COG5238  342 KALQ--ENTTLHSLD---LSDNQIGDEGAIALAKYLEgnttLRELNLGKNNIGkQGAEALIDA 399
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 206-246 1.89e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 188536110  206 LEVLDLSGTFLERVESgwIRDLPKLTSLYLRKMPRLTTLEG 246
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-182 1.90e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  80 LDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLR 159
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 188536110 160 ALQPR------------------------AFACFPALQLLNLSCTAL 182
Cdd:PLN00113 513 GEIPDelssckklvsldlshnqlsgqipaSFSEMPVLSQLDLSQNQL 559
AFD_class_I cd04433
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...
 131-254 7.91e-03

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341228 [Multi-domain]  Cd Length: 336  Bit Score: 39.19  E-value: 7.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110 131 YNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNL-------SCTALGRGAqggiAEAAFAGEDGAPL 203
Cdd:cd04433   99 LARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGIKLVNGygltetgGTVATGPPD----DDARKPGSVGRPV 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 188536110 204 --VTLEVLDLSGTFLERVESG--WIRDlPKLTSLYLrKMPRLTTLE--------GDIFKMTPN 254
Cdd:cd04433  175 pgVEVRIVDPDGGELPPGEIGelVVRG-PSVMKGYW-NNPEATAAVdedgwyrtGDLGRLDED 235
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 591-676 9.25e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 36.23  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536110  591 TTDTSALVHWcAPNSVVHGYQIRYSAEGWAGNQSVVGVI--YATARQHPLY-------GLSPGTTYRVCVLAANRaglsq 661
Cdd:pfam16656  10 GDSTSMTVSW-VTPSAVTSPVVQYGTSSSALTSTATATSstYTTGDGGTGYihratltGLEPGTTYYYRVGDDNG----- 83

                          90
                  ....*....|....*
gi 188536110  662 pRSSGWRSpcaaFTT 676
Cdd:pfam16656  84 -GWSEVYS----FTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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