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Conserved domains on  [gi|29171745|ref|NP_803545|]
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phospholipid phosphatase 2 isoform 2 [Homo sapiens]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 38-184 2.12e-74

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 222.12  E-value: 2.12e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  38 AVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLE---KVCRGNPADVTEARLSFYSGHSS 114
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIadcTCCTGDPDLIREARLSFPSGHAS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745 115 FGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:cd03384  81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 38-184 2.12e-74

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 222.12  E-value: 2.12e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  38 AVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLE---KVCRGNPADVTEARLSFYSGHSS 114
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIadcTCCTGDPDLIREARLSFPSGHAS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745 115 FGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:cd03384  81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
47-184 2.12e-26

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 98.57  E-value: 2.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745     47 LFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPdwsrvncsvyvqlekVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALY 126
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA---------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 29171745    127 vqarlcwKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:smart00014  66 -------LPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 46-187 2.16e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 2.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745    46 FLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSrvncsvyvqlekvcrgNPADVTEARLSFYSGHSSFGMYCMVFLAL 125
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29171745   126 YVqARLCWKWARLLRptvqFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYI 187
Cdd:pfam01569  66 LL-RRLRKIVRVLLA----LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 40-196 3.36e-18

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 81.51  E-value: 3.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745   40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLekVCRGNPADVTEARLSFYSGHSSFGMYC 119
Cdd:PLN02250  98 HAILG-LLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVTTDV--LCTGAKSVIKEGHKSFPSGHTSWSFAG 174

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171745  120 MVFLALYV--QARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAalTVCYISdFFkarPP 196
Cdd:PLN02250 175 LGFLSLYLsgKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA--SFCYLQ-FF---PP 247
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 42-184 1.83e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 49.65  E-value: 1.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  42 VLGTFLFGAAVSQSLTDLAKYMIGRLRPNFlavcdpdwsrvncsvyvqlekVCRGNPADVTEARLSFYSGHSSFGMYCMV 121
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFV---------------------VPDLELLLGTAGGYSFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171745 122 FLALYVQARLCWkwarllrptvqFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:COG0671 133 VLALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 38-184 2.12e-74

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 222.12  E-value: 2.12e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  38 AVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLE---KVCRGNPADVTEARLSFYSGHSS 114
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIadcTCCTGDPDLIREARLSFPSGHAS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745 115 FGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:cd03384  81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 45-186 2.77e-29

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 108.46  E-value: 2.77e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  45 TFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDwsRVNCSVYVQLEKVCR-GNPADVTEARLSFYSGHSSFGMYCMVFL 123
Cdd:cd03390  50 GLLLSVSLNGVITNVLKNYAGRPRPDFLARCFPD--GGTPSDTLVGIDICCtGDPGVLKEGRKSFPSGHSSFAFAGLGFL 127

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29171745 124 ALYVQARL-CWKWA-RLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCY 186
Cdd:cd03390 128 SLYLAGKLhIFDPRgSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
acidPPc smart00014
Acid phosphatase homologues;
47-184 2.12e-26

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 98.57  E-value: 2.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745     47 LFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPdwsrvncsvyvqlekVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALY 126
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA---------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 29171745    127 vqarlcwKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:smart00014  66 -------LPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 40-184 2.53e-23

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 90.60  E-value: 2.53e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  40 YKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDwsrvncsvyvqlekvcrGNPADVTEARLSFYSGHSSFGMYC 119
Cdd:cd01610   2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFAL 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29171745 120 MVFLALYVqarlcwkWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:cd01610  65 ALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 46-187 2.16e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 2.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745    46 FLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSrvncsvyvqlekvcrgNPADVTEARLSFYSGHSSFGMYCMVFLAL 125
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29171745   126 YVqARLCWKWARLLRptvqFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYI 187
Cdd:pfam01569  66 LL-RRLRKIVRVLLA----LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 40-196 3.36e-18

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 81.51  E-value: 3.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745   40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLekVCRGNPADVTEARLSFYSGHSSFGMYC 119
Cdd:PLN02250  98 HAILG-LLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVTTDV--LCTGAKSVIKEGHKSFPSGHTSWSFAG 174

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171745  120 MVFLALYV--QARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAalTVCYISdFFkarPP 196
Cdd:PLN02250 175 LGFLSLYLsgKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA--SFCYLQ-FF---PP 247
PLN02715 PLN02715
lipid phosphate phosphatase
 40-186 1.32e-17

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 80.10  E-value: 1.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745   40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVncsvYVQLEKV-CRGNPADVTEARLSFYSGHSSFGMY 118
Cdd:PLN02715 123 HSILG-LLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKEL----YDALGGViCHGKAAEVKEGHKSFPSGHTSWSFA 197

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  119 CMVFLALYVQARLCW--KWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALtvCY 186
Cdd:PLN02715 198 GLTFLSLYLSGKIKAfnGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAF--CY 265
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 40-198 2.15e-17

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 79.69  E-value: 2.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745   40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSrvncSVYVQL-EKVCRGNPADVTEARLSFYSGHSSFGMY 118
Cdd:PLN02731 117 HAVLG-LLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGK----ALYDSLgDVICHGDKSVIREGHKSFPSGHTSWSFS 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  119 CMVFLALYVQARLCW--KWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALvaALTVCYISdFFKarPP 196
Cdd:PLN02731 192 GLGFLSLYLSGKIQAfdGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLA--ISTICYLQ-FFP--PP 266


                 ..
gi 29171745  197 QH 198
Cdd:PLN02731 267 YH 268
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-184 9.62e-10

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 54.26  E-value: 9.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  40 YKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNflavCDPDWSRvncsvyvqlekvcrgnpadvtearlSFYSGHSSfgmyc 119
Cdd:cd03394   2 REGLLILAEAAALTAAVTEGLKFAVGRARPD----GSNNGYR-------------------------SFPSGHTA----- 47

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29171745 120 MVF-LALYVQARLCWKWArllrptvqfFLVAFAL--YVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:cd03394  48 SAFaAATFLQYRYGWRWY---------GIPAYALasLVGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 42-184 1.83e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 49.65  E-value: 1.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  42 VLGTFLFGAAVSQSLTDLAKYMIGRLRPNFlavcdpdwsrvncsvyvqlekVCRGNPADVTEARLSFYSGHSSFGMYCMV 121
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFV---------------------VPDLELLLGTAGGYSFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171745 122 FLALYVQARLCWkwarllrptvqFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV 184
Cdd:COG0671 133 VLALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 32-183 8.08e-07

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 47.60  E-value: 8.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  32 FNNYVAAVYkVLGTFLFGAAVSQSLtdlaKYMIGRLRP-NFLAVCDPDWsrvncsvyvqlekvcrgnpadvtearlSFYS 110
Cdd:cd03392  58 KRRRRAALF-LLLALLGGGALNTLL----KLLVQRPRPpLHLLVPEGGY---------------------------SFPS 105

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171745 111 GHSSFGMYCMVFLALYVQARLcwkWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALT 183
Cdd:cd03392 106 GHAMGATVLYGFLAYLLARRL---PRRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALL 175
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 7-183 5.47e-05

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 42.69  E-value: 5.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745   7 TATVILVSAGEAYLVYTDRlYSRSDFNNYVAAVYKV--LGTFLFGA-AVSQSLTDLAKYMIGRLRPNFLavcdpdwsrvn 83
Cdd:cd03389  33 KSGWYLIPSLLLFLLFRFG-DLRGLSAPSRARFPKAawAGLFLFATvALSGILVNLLKFIIGRARPKLL----------- 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171745  84 csvyvqLEKVCRG-NPADVTEARLSFYSGHSSFGMYCMVFLALyvqarlcwkwarlLRPTVQFFLVAFALYVGYTRVSDY 162
Cdd:cd03389 101 ------FDDGLYGfDPFHADYAFTSFPSGHSATAGAAAAALAL-------------LFPRYRWAFILLALLIAFSRVIVG 161

                       170       180
                ....*....|....*....|.
gi 29171745 163 KHHWSDVLVGLLQGALVAALT 183
Cdd:cd03389 162 AHYPSDVIAGSLLGAVTALAL 182
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 110-182 6.59e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 41.88  E-value: 6.59e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171745 110 SGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAAL 182
Cdd:cd03382  85 SSHSQFMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 107-182 2.48e-03

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 37.63  E-value: 2.48e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29171745 107 SFYSGHSSFGMYCMVFLALYVqarlcwkWARLLRPtvqfFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAAL 182
Cdd:cd03395 105 SFASSHAANSFALALFIWLFF-------RRGLFSP----VLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLL 169
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 107-182 5.42e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 36.53  E-value: 5.42e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29171745 107 SFYSGHSSFGMYCMVFLALYvqarlcWKWARLLRPTVqfflVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAAL 182
Cdd:cd03391  92 SFPSGHASRAAFVARFLLNH------LVLAVPLRVLL----VLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALL 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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