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Conserved domains on  [gi|568916233|ref|XP_006499198|]
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glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 176-387 4.44e-55

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


:

Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 188.55  E-value: 4.44e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 176 FLNVQLHKGQMKMVQKAVQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFLPPEV 255
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 256 NlsldnsEGILARAVVRATVEELLTSGQPLLIFLEEPPGSPG-PRLSALGQAWlgVVIQAVQAGIISDATLVPVAIAYDL 334
Cdd:cd07993   81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGkLLPPKLGLLS--VVVEAYLKGSVPDVLIVPVSISYDR 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568916233 335 VPDAPCNMNHDLAPLGLWTGALAvFRRLCNcWGCNRRVCVRVHLAQPFSLQEY 387
Cdd:cd07993  153 VLEEELYAEELLGPPKPKESLSG-LLGASK-ILRENFGRIRVDFGEPISLREY 203
ZF_RNaseIII_KREN_KREPB-like super family cl49632
C2H2 zinc finger and Ribonuclease III-like domain of RNA-editing catalytic complex (RECC) ...
 469-526 1.93e-04

C2H2 zinc finger and Ribonuclease III-like domain of RNA-editing catalytic complex (RECC) proteins KREN1-3, KREPB4-KREPB10, and related proteins; KREN1-3 (KREPB1-3) and KREPB4-KREPB10 are components of the RNA-editing catalytic complex (RECC) involved in U-insertion/deletion mRNA editing during kinetoplast RNA processing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastid species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. The RECC core complex comprises a U-insertion subcomplex (KRET2 TUTase, KREPA1 zinc-finger protein, and KREL2 RNA ligase), a U-deletion subcomplex (KREX2 exonuclease, KREPA2 zinc-finger protein, and KREL1 RNA ligase), and six structural and/or RNA-binding proteins (KREPA3, KREPA4, KREPA5, KREPA6, KREPB4, and KREPB5). This core complex interacts with one of three RNase III family endonucleases (KREN1, KREN2, and KREN3) that may partner with one or more partner protein(s) with divergent RNase III domains, such as KREN1/KREPB8, KREN2/KREPB7, KREN3/KREPB6. KREPB4-KREPB10 have divergent RNase III domains. RECC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and the RNA-editing substrate-binding complex (RESC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing.


The actual alignment was detected with superfamily member cd23383:

Pssm-ID: 483972  Cd Length: 195  Bit Score: 43.10  E-value: 1.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568916233 469 LLLKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVLLRV 526
Cdd:cd23383  126 LLSFHRKGDFVRALIGELHWALIRREGIPPPPSDSARLRVLAQFVLRSLVAELIYLRL 183
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 176-387 4.44e-55

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 188.55  E-value: 4.44e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 176 FLNVQLHKGQMKMVQKAVQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFLPPEV 255
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 256 NlsldnsEGILARAVVRATVEELLTSGQPLLIFLEEPPGSPG-PRLSALGQAWlgVVIQAVQAGIISDATLVPVAIAYDL 334
Cdd:cd07993   81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGkLLPPKLGLLS--VVVEAYLKGSVPDVLIVPVSISYDR 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568916233 335 VPDAPCNMNHDLAPLGLWTGALAvFRRLCNcWGCNRRVCVRVHLAQPFSLQEY 387
Cdd:cd07993  153 VLEEELYAEELLGPPKPKESLSG-LLGASK-ILRENFGRIRVDFGEPISLREY 203
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 131-547 1.69e-18

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 90.37  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 131 AAGEGQAPELVKKEVQRILGHIQTTPRPFLLRLFSWALLWFLNRLFLNVQLHkgQMKMVQKAVQeGSPLVFLSTHKSLLD 210
Cdd:COG2937  140 AKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAK-GHEIVYVPCHRSHMD 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 211 GFLLPFVLFSQGLGVVRVA----LDsrtcSPALRALLRKLGGLFL-------PpevnlsldnsegiLARAVVRATVEELL 279
Cdd:COG2937  217 YLLLSYVLYHNGLVPPHIAaginLN----FWPLGPILRRGGAFFIrrsfkgnK-------------LYSAVFREYLAELF 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 280 TSGQPLLIFLEeppG--SpgpRLSALGQAWLGV---VIQAVQAGIISDATLVPVAIAYDLVPDAPcNMNHDLA-----PL 349
Cdd:COG2937  280 ERGYSVEYFIE---GgrS---RTGRLLPPKTGMlsmTVQAFLRGARRPVVFVPVYIGYERVLEVG-SYAKELRggekkKE 352

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 350 GLWtGALAVFRRLCNCWGcnrrvcvRVHL--AQPFSLQEYtinarscwdsrqtlehLLQpivlgecVVPDTEKEQEWTPp 427
Cdd:COG2937  353 SLG-GLLRALRKLRRRFG-------RVYVnfGEPISLSEY----------------LDQ-------HVPDWRESEDLRP- 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 428 tglllalkEEDQLLVRRLSRHVLSASVASSAVMSTAIMATLLLLKHQKGvvlsqllgefswLTEETLLRgfdvgfsgQLR 507
Cdd:COG2937  401 --------EWLRPAVDKLAFEIMVRINRAAAVNPVNLVALALLASPKRA------------LTEAELLA--------QLD 452

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 568916233 508 CLaqhtLSLLRahvvllRVHQGDLVVVPRPGP--GLTHLARL 547
Cdd:COG2937  453 LY----LDLLR------NVPYSLSVTLPELTPeeLLEHLLSL 484
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 199-333 2.17e-11

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 61.60  E-value: 2.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233   199 LVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFlppevnlsLDNSEGILARAVVRATVeEL 278
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIF--------IDRSNGRKARAALREAV-EL 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568916233   279 LTSGQPLLIFLEeppgspGPRLS--ALGQAWLGVVIQAVQAGiisdATLVPVAIAYD 333
Cdd:smart00563  72 LKEGEWLLIFPE------GTRSRpgKLLPFKKGAARLALEAG----VPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 193-330 9.25e-09

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 54.59  E-value: 9.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233  193 VQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFLppevnlsldNSEGILARAVVR 272
Cdd:pfam01553  10 LPRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFI---------DRKNRKDAAGTL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233  273 ATVEELLTSGQPLLIFLEeppgspGPRLSA--LGQAWLGVVIQAVQAGIisdaTLVPVAI 330
Cdd:pfam01553  81 EYLVELLREGKLVVIFPE------GTRSREgeLLPFKKGAFRLAIEAGV----PIVPVAI 130
ZF_RNaseIII_KREN_KREPB-like cd23383
C2H2 zinc finger and Ribonuclease III-like domain of RNA-editing catalytic complex (RECC) ...
 469-526 1.93e-04

C2H2 zinc finger and Ribonuclease III-like domain of RNA-editing catalytic complex (RECC) proteins KREN1-3, KREPB4-KREPB10, and related proteins; KREN1-3 (KREPB1-3) and KREPB4-KREPB10 are components of the RNA-editing catalytic complex (RECC) involved in U-insertion/deletion mRNA editing during kinetoplast RNA processing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastid species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. The RECC core complex comprises a U-insertion subcomplex (KRET2 TUTase, KREPA1 zinc-finger protein, and KREL2 RNA ligase), a U-deletion subcomplex (KREX2 exonuclease, KREPA2 zinc-finger protein, and KREL1 RNA ligase), and six structural and/or RNA-binding proteins (KREPA3, KREPA4, KREPA5, KREPA6, KREPB4, and KREPB5). This core complex interacts with one of three RNase III family endonucleases (KREN1, KREN2, and KREN3) that may partner with one or more partner protein(s) with divergent RNase III domains, such as KREN1/KREPB8, KREN2/KREPB7, KREN3/KREPB6. KREPB4-KREPB10 have divergent RNase III domains. RECC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and the RNA-editing substrate-binding complex (RESC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing.


Pssm-ID: 469560  Cd Length: 195  Bit Score: 43.10  E-value: 1.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568916233 469 LLLKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVLLRV 526
Cdd:cd23383  126 LLSFHRKGDFVRALIGELHWALIRREGIPPPPSDSARLRVLAQFVLRSLVAELIYLRL 183
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
131-335 2.31e-03

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 41.37  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 131 AAGEGQAPELVKKEVQRILGHIQTTPRPFLLRLFSWALLWFLNRLFLNVQLHkgQMKMVQKAVQEGSPLVFLSTHKSLLD 210
Cdd:PRK04974 238 AKSKKISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVH--NAERVRQLAQDGHEIVYVPCHRSHMD 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 211 GFLLPFVLFSQGLGVVRVA----LDsrtcSPALRALLRKLGGLFlppevnlsldnsegI--------LARAVVRATVEEL 278
Cdd:PRK04974 316 YLLLSYVLYHQGLVPPHIAaginLN----FWPAGPIFRRGGAFF--------------IrrsfkgnkLYSTVFREYLGEL 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568916233 279 LTSGQPLLIFLEeppG--SPGPRLSALGQAWLGVVIQAVQAGIISDATLVPVAIAYDLV 335
Cdd:PRK04974 378 FARGYSVEYFVE---GgrSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHV 433
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 176-387 4.44e-55

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 188.55  E-value: 4.44e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 176 FLNVQLHKGQMKMVQKAVQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFLPPEV 255
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 256 NlsldnsEGILARAVVRATVEELLTSGQPLLIFLEEPPGSPG-PRLSALGQAWlgVVIQAVQAGIISDATLVPVAIAYDL 334
Cdd:cd07993   81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGkLLPPKLGLLS--VVVEAYLKGSVPDVLIVPVSISYDR 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568916233 335 VPDAPCNMNHDLAPLGLWTGALAvFRRLCNcWGCNRRVCVRVHLAQPFSLQEY 387
Cdd:cd07993  153 VLEEELYAEELLGPPKPKESLSG-LLGASK-ILRENFGRIRVDFGEPISLREY 203
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 131-547 1.69e-18

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 90.37  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 131 AAGEGQAPELVKKEVQRILGHIQTTPRPFLLRLFSWALLWFLNRLFLNVQLHkgQMKMVQKAVQeGSPLVFLSTHKSLLD 210
Cdd:COG2937  140 AKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAK-GHEIVYVPCHRSHMD 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 211 GFLLPFVLFSQGLGVVRVA----LDsrtcSPALRALLRKLGGLFL-------PpevnlsldnsegiLARAVVRATVEELL 279
Cdd:COG2937  217 YLLLSYVLYHNGLVPPHIAaginLN----FWPLGPILRRGGAFFIrrsfkgnK-------------LYSAVFREYLAELF 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 280 TSGQPLLIFLEeppG--SpgpRLSALGQAWLGV---VIQAVQAGIISDATLVPVAIAYDLVPDAPcNMNHDLA-----PL 349
Cdd:COG2937  280 ERGYSVEYFIE---GgrS---RTGRLLPPKTGMlsmTVQAFLRGARRPVVFVPVYIGYERVLEVG-SYAKELRggekkKE 352

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 350 GLWtGALAVFRRLCNCWGcnrrvcvRVHL--AQPFSLQEYtinarscwdsrqtlehLLQpivlgecVVPDTEKEQEWTPp 427
Cdd:COG2937  353 SLG-GLLRALRKLRRRFG-------RVYVnfGEPISLSEY----------------LDQ-------HVPDWRESEDLRP- 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 428 tglllalkEEDQLLVRRLSRHVLSASVASSAVMSTAIMATLLLLKHQKGvvlsqllgefswLTEETLLRgfdvgfsgQLR 507
Cdd:COG2937  401 --------EWLRPAVDKLAFEIMVRINRAAAVNPVNLVALALLASPKRA------------LTEAELLA--------QLD 452

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 568916233 508 CLaqhtLSLLRahvvllRVHQGDLVVVPRPGP--GLTHLARL 547
Cdd:COG2937  453 LY----LDLLR------NVPYSLSVTLPELTPeeLLEHLLSL 484
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 199-333 2.17e-11

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 61.60  E-value: 2.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233   199 LVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFlppevnlsLDNSEGILARAVVRATVeEL 278
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIF--------IDRSNGRKARAALREAV-EL 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568916233   279 LTSGQPLLIFLEeppgspGPRLS--ALGQAWLGVVIQAVQAGiisdATLVPVAIAYD 333
Cdd:smart00563  72 LKEGEWLLIFPE------GTRSRpgKLLPFKKGAARLALEAG----VPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 193-330 9.25e-09

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 54.59  E-value: 9.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233  193 VQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFLppevnlsldNSEGILARAVVR 272
Cdd:pfam01553  10 LPRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFI---------DRKNRKDAAGTL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233  273 ATVEELLTSGQPLLIFLEeppgspGPRLSA--LGQAWLGVVIQAVQAGIisdaTLVPVAI 330
Cdd:pfam01553  81 EYLVELLREGKLVVIFPE------GTRSREgeLLPFKKGAFRLAIEAGV----PIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 158-332 2.50e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 52.32  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 158 PFLLRLFSWALLWFLNRLFLNVQLHKGQMKMVQKAVQEGsPLVFLSTHKSLLDGFLLPFVLFSQglgvVR-VALDSRTCS 236
Cdd:COG0204    5 FLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADG-PVLIVANHQSWLDILLLLAALPRP----VRfVAKKELFKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 237 PALRALLRKLGGLFlppevnlsLDNSEGILARAVVRATVeELLTSGQPLLIFLEeppG--SPGPRLSAL--GQAWLgvvi 312
Cdd:COG0204   80 PLLGWLLRALGAIP--------VDRSKRRAALRALRQAV-EALKAGESLVIFPE---GtrSPDGRLLPFktGAARL---- 143

                        170       180
                 ....*....|....*....|
gi 568916233 313 qAVQAGiisdATLVPVAIAY 332
Cdd:COG0204  144 -ALEAG----VPIVPVAIDG 158
ZF_RNaseIII_KREN_KREPB-like cd23383
C2H2 zinc finger and Ribonuclease III-like domain of RNA-editing catalytic complex (RECC) ...
 469-526 1.93e-04

C2H2 zinc finger and Ribonuclease III-like domain of RNA-editing catalytic complex (RECC) proteins KREN1-3, KREPB4-KREPB10, and related proteins; KREN1-3 (KREPB1-3) and KREPB4-KREPB10 are components of the RNA-editing catalytic complex (RECC) involved in U-insertion/deletion mRNA editing during kinetoplast RNA processing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastid species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. The RECC core complex comprises a U-insertion subcomplex (KRET2 TUTase, KREPA1 zinc-finger protein, and KREL2 RNA ligase), a U-deletion subcomplex (KREX2 exonuclease, KREPA2 zinc-finger protein, and KREL1 RNA ligase), and six structural and/or RNA-binding proteins (KREPA3, KREPA4, KREPA5, KREPA6, KREPB4, and KREPB5). This core complex interacts with one of three RNase III family endonucleases (KREN1, KREN2, and KREN3) that may partner with one or more partner protein(s) with divergent RNase III domains, such as KREN1/KREPB8, KREN2/KREPB7, KREN3/KREPB6. KREPB4-KREPB10 have divergent RNase III domains. RECC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and the RNA-editing substrate-binding complex (RESC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing.


Pssm-ID: 469560  Cd Length: 195  Bit Score: 43.10  E-value: 1.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568916233 469 LLLKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVLLRV 526
Cdd:cd23383  126 LLSFHRKGDFVRALIGELHWALIRREGIPPPPSDSARLRVLAQFVLRSLVAELIYLRL 183
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 170-332 2.33e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 42.64  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 170 WFLNRLFLNVQLHKgqmkmvQKAVQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRtcsPALRALLRKLGGL 249
Cdd:cd07989    3 LLLRLLGVRVRVEG------LENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKI---PFLGWLLRLLGAI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 250 FlppevnlsLDNSEGILARAVVRAtVEELLTSGQPLLIFLEeppG--SPGPRLSALGqawLGVVIQAVQAGiisdATLVP 327
Cdd:cd07989   74 P--------IDRGNGRSAREALRE-AIEALKEGESVVIFPE---GtrSRDGELLPFK---SGAFRLAKEAG----VPIVP 134


                 ....*
gi 568916233 328 VAIAY 332
Cdd:cd07989  135 VAISG 139
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
131-335 2.31e-03

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 41.37  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 131 AAGEGQAPELVKKEVQRILGHIQTTPRPFLLRLFSWALLWFLNRLFLNVQLHkgQMKMVQKAVQEGSPLVFLSTHKSLLD 210
Cdd:PRK04974 238 AKSKKISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVH--NAERVRQLAQDGHEIVYVPCHRSHMD 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 211 GFLLPFVLFSQGLGVVRVA----LDsrtcSPALRALLRKLGGLFlppevnlsldnsegI--------LARAVVRATVEEL 278
Cdd:PRK04974 316 YLLLSYVLYHQGLVPPHIAaginLN----FWPAGPIFRRGGAFF--------------IrrsfkgnkLYSTVFREYLGEL 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568916233 279 LTSGQPLLIFLEeppG--SPGPRLSALGQAWLGVVIQAVQAGIISDATLVPVAIAYDLV 335
Cdd:PRK04974 378 FARGYSVEYFVE---GgrSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHV 433
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 166-333 3.76e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 39.32  E-value: 3.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 166 WALLWFLNRLFLNVQlHKGQmkmvqKAVQEGSPLVFLSTHKSLLDGFLLPFVLF----SQGLGVVRVALDSRtcspalRA 241
Cdd:cd06551    1 FRYLLLNFFGFVRLE-VKGP-----PPPPGGGPVLFVSNHSSWWDGLILFLLLErglrRDVYGLMDEELLER------YP 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916233 242 LLRKLgGLFlppevnlSLDNSEGILARAVVRATVEELLTSGQPLLIFLE---EPPGSPGPRLSAlgqawlGVVIQAVQAG 318
Cdd:cd06551   69 FFTRL-GAF-------SVDRDSPRSAAKSLKYVARLLSKPGSVVWIFPEgtrTRRDKRPLQFKP------GVAHLAEKAG 134

                        170
                 ....*....|....*
gi 568916233 319 iisdATLVPVAIAYD 333
Cdd:cd06551  135 ----VPIVPVALRYT 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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