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Conserved domains on  [gi|768017218|ref|XP_011527132|]
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nociceptin receptor isoform X4 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-249 3.47e-158

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15092:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 279  Bit Score: 441.61  E-value: 3.47e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15092   31 MKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15092  111 RTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15092  191 LRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAF 270

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15092  271 LDENFKACF 279
 
Name Accession Description Interval E-value
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
1-249 3.47e-158

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 441.61  E-value: 3.47e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15092   31 MKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15092  111 RTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15092  191 LRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAF 270

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15092  271 LDENFKACF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-238 1.64e-60

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 192.90  E-value: 1.64e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218    1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:pfam00001  15 LRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGdWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYK 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQV--EDEEIECLVEIPTPQDYWgPVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:pfam00001  95 RRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTvpEGNVTVCFIDFPEDLSKP-VSYTLLISVLGFLLPLLVILVCYTL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  157 MIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAV-AILRFCTALGYVNSCLNP 235
Cdd:pfam00001 174 IIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLdKALSVTLWLAYVNSCLNP 253

                  ...
gi 768017218  236 ILY 238
Cdd:pfam00001 254 IIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
2-251 1.49e-28

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 111.41  E-value: 1.49e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:PHA03087  71 KTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKIN 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRl 161
Cdd:PHA03087 151 TVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILIT- 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 rgvrlLSGSREKDRNLRRItRLVLVVVAVFVGCWTP--VQVFVL-AQGLGVQPSSETAVAI---LRFCTALGYVNSCLNP 235
Cdd:PHA03087 230 -----LKGINKSKKNKKAI-KLVLIIVILFVIFWLPfnVSVFVYsLHILHFKSGCKAVKYIqyaLHVTEIISLSHCCINP 303
                        250
                 ....*....|....*.
gi 768017218 236 ILYAFLDENFKACFRK 251
Cdd:PHA03087 304 LIYAFVSEFFNKHKKK 319
 
Name Accession Description Interval E-value
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
1-249 3.47e-158

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 441.61  E-value: 3.47e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15092   31 MKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15092  111 RTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15092  191 LRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAF 270

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15092  271 LDENFKACF 279
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
1-249 3.06e-121

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 348.13  E-value: 3.06e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14970   31 MKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQV-EDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd14970  111 RTPRKAKLVSLCVWALSLVLGLPVIIFARTLQeEGGTISCNLQWPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLS--GSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd14970  191 RLRSSRNLStsGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFCIALSYANSCLNPIL 270
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd14970  271 YAFLDENFRKSF 282
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
1-249 1.28e-108

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 316.12  E-value: 1.28e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15091   31 MKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVE--DEEIECLVEIPTPQ-DYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15091  111 RTPLKAKIINICIWLLSSSVGISAIVLGGTKVRedVDSTECSLQFPDDDySWWDTFMKICVFIFAFVIPVLIIIVCYTLM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15091  191 ILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPIL 270
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15091  271 YAFLDENFKRCF 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
1-249 4.82e-107

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 312.27  E-value: 4.82e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15089   31 MKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDE-EIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15089  111 RTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDgAVVCMLQFPSPSWYWDTVTKICVFIFAFVVPILVITVCYGLMIL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGL-GVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15089  191 RLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLvDIDRRNPLVVAALHLCIALGYANSSLNPVLY 270
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15089  271 AFLDENFKRCF 281
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
1-249 4.99e-104

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 304.61  E-value: 4.99e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15090   31 MKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15090  111 RTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLLKICVFIFAFIMPVLIITVCYGLMILR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15090  191 LKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 270

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15090  271 LDENFKRCF 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 1.15e-65

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 206.93  E-value: 1.15e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15093   31 MKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIM-GSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15093  111 RRPRVAKVVNLAVWVASLLVILPVVVFaGTRENQDGSSACNMQWPEPAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15093  191 KVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPETPALVGVYHFVVILSYANSCANPILYG 270
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15093  271 FLSDNFKKSF 280
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
1-249 4.46e-63

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 200.14  E-value: 4.46e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15970   31 MKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAARY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGS-AQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15970  111 RRPTVAKMVNLGVWVFSILVILPIIIFSNtAPNSDGSVACNMQMPEPSQRWLAVFVVYTFLMGFLLPVIAICLCYILIIV 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPvqvFVLAQGLGVQPSSETAvAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15970  191 KMRVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMP---FYVVQLVSVFVGQHDA-TVSQLSVILGYANSCANPILYG 266
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15970  267 FLSDNFKRSF 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-238 1.64e-60

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 192.90  E-value: 1.64e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218    1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:pfam00001  15 LRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGdWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYK 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQV--EDEEIECLVEIPTPQDYWgPVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:pfam00001  95 RRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTvpEGNVTVCFIDFPEDLSKP-VSYTLLISVLGFLLPLLVILVCYTL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  157 MIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAV-AILRFCTALGYVNSCLNP 235
Cdd:pfam00001 174 IIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLdKALSVTLWLAYVNSCLNP 253

                  ...
gi 768017218  236 ILY 238
Cdd:pfam00001 254 IIY 256
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
1-249 1.02e-59

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 191.22  E-value: 1.02e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15973   31 MKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIM-GSAQVEDEEIECLVEIPTPQdyWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15973  111 RRPTVAKMINICVWILSLLVISPIIIFaDTATRKGQAVACNLIWPHPA--WSAAFVIYTFLLGFLLPVLAIGLCYILIIG 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPvqvFVLAQGLGVQPSSETAvAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15973  189 KMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMP---FYVVQLLNLFLPRLDA-TVNHASLILSYANSCANPILYG 264
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15973  265 FLSDNFRRSF 274
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
1-249 2.66e-57

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 185.43  E-value: 2.66e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15971   31 MKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15971  111 RKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIK 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15971  191 VKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAF 270

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15971  271 LSDNFKKSF 279
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
1-249 6.44e-57

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 184.22  E-value: 6.44e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15094   31 MKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIP-TPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15094  111 RTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPdSSAVNGQKAFTLYTFLLGFAIPLLLISVFYTLVIL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTP---VQVFVLAQGLGVQPSSETaVAILRFCTALGYVNSCLNPI 236
Cdd:cd15094  191 RLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPywaFQVHLIFLPPGTDMPKWE-ILMFLLLTVLSYANSMVNPL 269
                        250
                 ....*....|...
gi 768017218 237 LYAFLDENFKACF 249
Cdd:cd15094  270 LYAFLSENFRKSF 282
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
1-249 3.96e-56

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 182.31  E-value: 3.96e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15974   31 MKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMgsAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15974  111 RRPRVAKLINATVWTLSFLVVLPVIIF--SDVQPDLNTCNISWPEPVSVWSTAFIIYTAVLGFFGPLLVICLCYLLIVIK 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15974  189 VKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVILPEEPAFVGVYFFVVVLSYANSCANPILYGF 268

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15974  269 LSDNFKQSF 277
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
1-249 2.65e-54

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 177.62  E-value: 2.65e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRA--L 78
Cdd:cd15087   31 MKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVMSVDRYLVVLATVRSrrM 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI-ECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15087  111 PYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNELGRkSCVLSFPSPESLWFKASRIYTLVLGFAIPVSTICILYTMM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15087  191 LYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALTTDLPQTPLVIGISYFITSLSYANSCLNPFL 270
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15087  271 YAFLDDSFRKSF 282
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
1-249 7.20e-54

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 176.72  E-value: 7.20e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15096   31 MRSTTNILILNLAVADlLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE----CLveIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15096  111 IRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEaysyCT--FLTEVGTAAQTFFTSFFLFSYLIPLTLICVLYM 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLR--GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCL 233
Cdd:cd15096  189 LMLRRLRrqKSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLKYYGVLPETVLYVVIQILSNCLAYGNSCV 268
                        250
                 ....*....|....*.
gi 768017218 234 NPILYAFLDENFKACF 249
Cdd:cd15096  269 NPILYAFLSQNFRKAF 284
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
1-249 2.21e-53

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 175.35  E-value: 2.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd14971   31 MRSTTNLFILNLAVADlTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd14971  111 IRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RL-RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd14971  191 HLwRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLTYATYALRIWAHCLAYSNSAVNPVLY 270
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd14971  271 AFLSEHFRKAF 281
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
1-249 5.73e-51

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 168.83  E-value: 5.73e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15972   31 SESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMgsAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15972  111 RKPPVAKTVNATVWALSFLVVLPVVIF--SGVPGGMGTCHIAWPEPAQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVK 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LR--GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15972  189 VRssGRRVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPSLFGLYFFVVVLSYANSCANPIIY 268
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15972  269 GFLSDNFKQGF 279
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
1-246 8.63e-51

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 168.40  E-value: 8.63e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILL-GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15088   31 LRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIdGQWYFGEVMCKIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSA-QVEDEEIECLVEIPTPQD-YWgpvFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15088  111 YRTRFVAKLVNVGLWAASFLSILPVWVYSSLiYFPDGTTFCYVSLPSPDDlYW---FTIYHFILGFAVPLVVITVCYILI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRL-RGVRLLSGSREKDRnLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVA-ILRFCtaLGYVNSCLNP 235
Cdd:cd15088  188 LHRLaRGVAPGNQSHGSSR-TKRVTKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAyFLSIC--LGYANSCLNP 264
                        250
                 ....*....|.
gi 768017218 236 ILYAFLDENFK 246
Cdd:cd15088  265 FVYILVSENFR 275
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
5-249 1.68e-49

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 165.28  E-value: 1.68e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLVLL-TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15098   37 TNVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVGVPVA----IMGSAQVEDEEIeCLVEIPTPQdyWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15098  117 RNALLGVLVIWVLSLAMASPVAvhqdLVHHWTASNQTF-CWENWPEKQ--QKPVYVVCTFVFGYLLPLLLITFCYAKVLN 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVrLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15098  194 HLHKK-LKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYA 272
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15098  273 FLSENFRKAY 282
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
1-241 6.73e-49

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 163.61  E-value: 6.73e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd00637   29 LRTVTNYFILNLAVADLLVgLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGsaQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd00637  109 RFTRRRAKLLIALIWLLSLLLALPPLLGW--GVYDYGGYCCCCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFR 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLR-------GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGvQPSSETAVAILRFCTALGYVNSC 232
Cdd:cd00637  187 KLRrhrrrirSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFG-PDPSPLPRILYFLALLLAYLNSA 265

                 ....*....
gi 768017218 233 LNPILYAFL 241
Cdd:cd00637  266 INPIIYAFF 274
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
2-247 8.41e-49

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 163.59  E-value: 8.41e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGT-DILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14982   32 RSPTTIYMINLALADLLFVLTLPFRIYyYLNGGWWPFGDFLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE-CLVEIPTPQDYWGPVFaICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd14982  112 RRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTtCFEFLSEWLASAAPIV-LIALVVGFLIPLLIILVCYSLIIR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSgsrEKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQ------PSSETAVAILRFCTALGYVNSCL 233
Cdd:cd14982  191 ALRRRSKQS---QKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRLsfiadcSARNSLYKAYRITLCLASLNSCL 267
                        250
                 ....*....|....
gi 768017218 234 NPILYAFLDENFKA 247
Cdd:cd14982  268 DPLIYYFLSKTFRK 281
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
1-249 2.08e-48

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 162.77  E-value: 2.08e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd14993   31 MRTVTNYFLVNLAVADLLVsLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE-------CLVEIPTPQDYWGpvFAICIFLFSFIVPVLVISV 152
Cdd:cd14993  111 VSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPgtitiyiCTEDWPSPELRKA--YNVALFVVLYVLPLLIISV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRL--------RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTP---VQVFVLAQGLGVQPSSETAVAILR 221
Cdd:cd14993  189 AYSLIGRRLwrrkppgdRGSANSTSSRRILRSKKKVARMLIVVVVLFALSWLPyyvLSILLDFGPLSSEESDENFLLILP 268
                        250       260
                 ....*....|....*....|....*...
gi 768017218 222 FCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd14993  269 FAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
2-249 3.73e-48

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 161.31  E-value: 3.73e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14974   31 RTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHhWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWAQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPT--PQDYWG--PVFAIcIFLFSFIVPVLVISVCYSL 156
Cdd:cd14974  111 RTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEdyDLRRSRhkALTVI-RFLCGFLLPLLIIAICYSV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLRGVRLLSGSREkdrnLRRITRLVLVVVAvfvgCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPI 236
Cdd:cd14974  190 IAVKLRRKRLAKSSKP----LRVLLAVVVAFFL----CWLPYHVFALLELVAAAGLPEVVLLGLPLATGLAYFNSCLNPI 261
                        250
                 ....*....|...
gi 768017218 237 LYAFLDENFKACF 249
Cdd:cd14974  262 LYVFMGQDFRKRL 274
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
1-249 1.57e-46

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 157.83  E-value: 1.57e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTViaidYYNM---FTST-FTLTAMSVDRYVAICHPI 75
Cdd:cd15095   31 MRTVTNYYIVNLAVTDLAFLVCcVPFTAALYATPSWVFGDFMCKFV----NYMMqvtVQATcLTLTALSVDRYYAIVHPI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  76 RALDVRTSSKAQAVNVAIWALASVVGVPVAI-MGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15095  107 RSLRFRTPRVAVVVSACIWIVSFLLSIPVAIyYRLEEGYWYGPQTYCREVWPSKAFQKAYMIYTVLLTYVIPLAIIAVCY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGVRLLS------GSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQ-PSSETAVAILRFCTALG 227
Cdd:cd15095  187 GLILRRLWRRSVDGnnqseqLSERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQRFDPNfPETYATYALKIAALCLS 266
                        250       260
                 ....*....|....*....|..
gi 768017218 228 YVNSCLNPILYAFLDENFKACF 249
Cdd:cd15095  267 YANSAVNPFVYAFMGENFRKYF 288
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
2-246 2.10e-43

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 149.29  E-value: 2.10e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd14984   32 RSMTDVYLLNLALADLLFVLTLPFWAVYAADG-WVFGSFLCKLVSALYTINFYSGILFLACISIDRYLAIVHAVSALRAR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPT-PQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd14984  111 TLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEdTATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRT 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LrgvrLLSGSREKDRNLRRItrlvLVVVAVFVGCWTPVQVFVLAQGL----GVQPSSETA----VAILrFCTALGYVNSC 232
Cdd:cd14984  191 L----LRARNHKKHRALRVI----FAVVVVFFLCWLPYNIVLLLDTLqllgIISRSCELSksldYALQ-VTESLAFSHCC 261
                        250
                 ....*....|....
gi 768017218 233 LNPILYAFLDENFK 246
Cdd:cd14984  262 LNPVLYAFVGVKFR 275
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
1-249 5.55e-42

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 146.21  E-value: 5.55e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRalD 79
Cdd:cd15203   31 MQTVTNIFILNLAVSDlLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTR--P 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE------CLVEipTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15203  109 RMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILpycgyfCTES--WPSSSSRLIYTISVLVLQFVIPLLIISFC 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLR-------GVRLLSGSREKDRNLR--RITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCT 224
Cdd:cd15203  187 YFRISLKLRkrvkkkrGKRTLSSRRRRSELRRkrRTNRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPQIDGRHFYLIFLI 266
                        250       260
                 ....*....|....*....|....*..
gi 768017218 225 A--LGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15203  267 ChlIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
2-247 3.45e-41

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 143.67  E-value: 3.45e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14985   32 KRVADIFIANLAAADLVFVLTLPLWATYTANQYdWPFGAFLCKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQ-VEDEEI-ECLVEIPTPQdyWGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd14985  112 RRRRQARVTCALIWVVACLLSLPTFLLRSLQaIENLNKtACIMLYPHEA--WHFGLSLELNILGFVLPLLIILTCYFHIA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRgvRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVF----VLAQgLGVQPSSETAVAI---LRFCTALGYVNS 231
Cdd:cd14985  190 RSLR--KRYERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFkfldFLAQ-LGAIRPCFWELFLdlgLPIATCLAFTNS 266
                        250
                 ....*....|....*.
gi 768017218 232 CLNPILYAFLDENFKA 247
Cdd:cd14985  267 CLNPFIYVFVDRRFRQ 282
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
6-249 4.55e-40

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 141.10  E-value: 4.55e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd14976   38 NKFVFNLALTDLIFVLTLPFWAVEYALDFvWPFGTAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAF 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE-CLVEIP-----TPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd14976  118 GAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTlCLLRFPknssvTRWYNWLGMYQLQKVVLGFFLPLGIITLSYLLLL 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRgvRLLSGSRekdRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLG---VQPSSETAVAILRF----CTALGYVNS 231
Cdd:cd14976  198 RFLQ--RKRGGSK---RRKSRVTKSVFIVVLSFFICWLPNQALSLWSALIkfdDVPFSDAFFAFQTYafpvAICLAHSNS 272
                        250
                 ....*....|....*...
gi 768017218 232 CLNPILYAFLDENFKACF 249
Cdd:cd14976  273 CLNPVLYCLVRREFRDAL 290
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
2-247 5.94e-39

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 138.36  E-value: 5.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15190   43 RRSADTFIANLALADLTFVVTLPLWAVYTALGYhWPFGSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKL 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECL-------VEIPTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15190  123 RSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVIcdmdysgVVSNESEWAWIAGLGLSSTVLGFLLPFLIMLTC 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YsLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTP---VQVFVLAQGLGVQPSS----ETAVAILRFCTAL 226
Cdd:cd15190  203 Y-FFIGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPfhlVKTLYALMYLGILPFScgfdLFLMNAHPYATCL 281
                        250       260
                 ....*....|....*....|.
gi 768017218 227 GYVNSCLNPILYAFLDENFKA 247
Cdd:cd15190  282 AYVNSCLNPFLYAFFDPRFRQ 302
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
5-249 7.31e-39

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 137.65  E-value: 7.31e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15097   36 TNLFILNLSVADlCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTP 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVGVP-VAIMGSAQVEDEEIeClveIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRL- 161
Cdd:cd15097  116 RNAVAAIALIWGLSLLFAGPyLSYYDLIDYANSTV-C---MPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLw 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFL 241
Cdd:cd15097  192 TAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALV 271

                 ....*...
gi 768017218 242 DENFKACF 249
Cdd:cd15097  272 SKHFRKGF 279
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
1-249 1.02e-38

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 137.18  E-value: 1.02e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15192   31 LKTVANIFLLNLALADLCFLITLPLWAAYTAMEYhWPFGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSA-QVEDEEIE-CLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15192  111 RRTLVVARVTCIVIWLLAGVASLPAIIHRDVfFIENTNITvCAFHYPSQNSTLLVGLGLMKNLLGFLIPFLIILTCYTLI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGSREKDRNlrrITRLVLVVVAVFVGCWTPVQVF----VLAQGLGVQ--PSSETAVAILRFCTALGYVNS 231
Cdd:cd15192  191 GKALKKAYEIQRNKPRNDE---IFKMIMAVVLFFFFCWIPHQIFtfldVLIQLKVIQdcHIADIVDTAMPFTICIAYFNS 267
                        250
                 ....*....|....*...
gi 768017218 232 CLNPILYAFLDENFKACF 249
Cdd:cd15192  268 CLNPILYGFVGKNFRKKF 285
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
3-249 1.10e-38

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 136.54  E-value: 1.10e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd14967   32 TVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLM 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTpqdywGPVFAICIFLFSFIVPVLVISVCYSLMIRRL 161
Cdd:cd14967  112 TKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTP-----NKIYVLVSSVISFFIPLLIMIVLYARIFRVA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 RgvrllsgsREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgvQPSSETAVAILRFCTALGYVNSCLNPILYAFL 241
Cdd:cd14967  187 R--------RE-----LKAAKTLAIIVGAFLLCWLPFFIIYLVSAF--CPPDCVPPILYAVFFWLGYLNSALNPIIYALF 251

                 ....*...
gi 768017218 242 DENFKACF 249
Cdd:cd14967  252 NRDFRRAF 259
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
2-247 2.12e-38

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 136.05  E-value: 2.12e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILL-GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15115   31 RTVNTIWFLNLAVADLLCCLSLPFSIAHLLLnGHWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVeiptpqDYWGpVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15115  111 RSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGY------DFLV-AITITRAVFGFLLPLLIIAACYSFIAFR 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRgvrllSGSREKDRNlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15115  184 MQ-----RGRFAKSQS--KTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVF 256

                 ....*..
gi 768017218 241 LDENFKA 247
Cdd:cd15115  257 MGKDFKK 263
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
2-249 9.93e-37

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 132.24  E-value: 9.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDIL-LGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15338   35 QTVPDIFIFNLSIVDLLFLLGMPFLIHQLLgNGVWHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKI 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAI-MGSAQVEDEEIECLVEIPTPQD--YWgpvFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15338  115 RTPRVAVAVICLVWILSLLSITPVWMyAGLMPLPDGSVGCALLLPNPETdtYW---FTLYQFFLAFALPLVVICVVYFKI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQgLGVQPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15338  192 LQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAH-LSIDRPSLAFLYAYNVAISMGYANSCINPFL 270
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15338  271 YIMLSETFKRQF 282
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
1-249 9.64e-36

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 128.93  E-value: 9.64e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15001   30 MRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISIERYYVILHPMKAKS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAImgSAQVEDEEIECLVEIPTPQDYWG-----PVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15001  110 FCTIGRARKVALLIWILSAILASPVLF--GQGLVRYESENGVTVYHCQKAWPstlysRLYVVYLAIVIFFIPLIVMTFAY 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLmIRRLRGVRLLsgsrekdrnlrritrlvLVVVAVFVGCWTPVQVFVLAQGLGV-QPSSETAVAILRFC-TALGYVNSC 232
Cdd:cd15001  188 AR-DTRKQVIKML-----------------ISVVVLFAVCWGPLLIDNLLVSFDViSTLHTQALKYMRIAfHLLSYANSC 249
                        250
                 ....*....|....*..
gi 768017218 233 LNPILYAFLDENFKACF 249
Cdd:cd15001  250 INPIIYAFMSKNFRSSF 266
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
3-246 1.63e-35

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 128.68  E-value: 1.63e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLL-TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDvR 81
Cdd:cd15002   34 SLIDSLILNLSAADLLLLLfSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVT-I 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRL 161
Cdd:cd15002  113 KQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQC 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFL 241
Cdd:cd15002  193 QRRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVAWLWLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLM 272

                 ....*
gi 768017218 242 DENFK 246
Cdd:cd15002  273 SEEFR 277
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
1-249 5.27e-35

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 127.74  E-value: 5.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRalD 79
Cdd:cd15207   31 MRTVTNYFILNLAVSDLLVgVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPTE--P 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMgsAQVEDEEIECLVEIPTPQDYWGPV-----FAICIFLFSFIVPVLVISVCY 154
Cdd:cd15207  109 KLTNRQAFVIIVAIWVLALAIMIPQALV--LEVKEYQFFRGQTVHICVEFWPSDeyrkaYTTSLFVLCYVAPLLIIAVLY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRL---RGVRLLSGSREKD----RNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLG-VQPSSETAVAILRFCTA- 225
Cdd:cd15207  187 VRIGYRLwfkPVPGGGSASREAQaavsKKKVRVIKMLIVVVVLFALSWLPLHTVTMLDDFGnLSPNQREVLYVYIYPIAh 266
                        250       260
                 ....*....|....*....|....*
gi 768017218 226 -LGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15207  267 wLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
2-246 1.20e-34

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 126.93  E-value: 1.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15926   33 KSSINLFVTSLAVTDFQFVLTLPFWAVENALDFtWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIP---TPQDYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15926  113 RGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPdnrGNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLL 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGvRLLSGSREKDRNlrRITRLVLVVVAVFVGCWTPVQVF----VLAQGLGVQPSSE---TAVAILRFCTALGYVN 230
Cdd:cd15926  193 VRFITD-KNITGSSTKRRS--KVTKSVTIVVLSFFLCWLPNQALttwgILIKLNVVHFSYEyftTQVYIFPITVCLAHSN 269
                        250
                 ....*....|....*.
gi 768017218 231 SCLNPILYAFLDENFK 246
Cdd:cd15926  270 SCLNPILYCLMRREFR 285
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
7-247 1.42e-34

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 126.40  E-value: 1.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDvRTSSKA 86
Cdd:cd14999   36 VYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  87 QAVNVAIWALASVVGVPVAIMGSAQVEDEEI----ECLVEIPTPQDYwgPVFAICIFLFSFIVPVLVISVCYSLMIRRLR 162
Cdd:cd14999  115 KLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSggskRICLPTWSEESY--KVYLTLLFSTSIVIPGLVIGYLYIRLARKYW 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 163 GVRLLSGSREKDRNL-RRITRLVLVVVAVFVGCWTPVQV-FVLAQGLGVQPSSETAVAILRFCTA-LGYVNSCLNPILYA 239
Cdd:cd14999  193 LSQAAASNSSRKRLPkQKVLKMIFTIVLVFWACFLPFWIwQLLYLYSPSLSLSPRTTTYVNYLLTcLTYSNSCINPFLYT 272

                 ....*...
gi 768017218 240 FLDENFKA 247
Cdd:cd14999  273 LLTKNYKE 280
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
1-249 3.02e-34

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 125.62  E-value: 3.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd14992   31 LRGATNYFIASLAISDLLMaLFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVE-----DEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd14992  111 RQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLfsvknQEKIFCCQIPPVDNKTYEKVYFLLIFVVIFVLPLIVMTLAY 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGvRLLSGSREKDRNL------RRITRLVLVVVAVFVGCWTPVQVFVLAQglGVQPSSETAVAILR---FCTA 225
Cdd:cd14992  191 ARISRELWF-RKVPGFSIKEVERkrlkckRRVIKMLVCVVVLFVICWLPFHLFFLLR--DFFPLIMKEKHTLQvyyFLHW 267
                        250       260
                 ....*....|....*....|....
gi 768017218 226 LGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd14992  268 IAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
1-249 4.61e-34

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 125.46  E-value: 4.61e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15927   31 MRNVPNIFILSLALGDLLLLLTcVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEI----PTPQDYWGP-VFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15927  111 SQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQIcypyPQELGPNYPkIMVLLRFLVYYLIPLLIIGVFY 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRL------RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSET-----AVAILRFC 223
Cdd:cd15927  191 VLMARHLirstrnIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHVFMLWFHFAPNGLVDYnafwhVLKIVGFC 270
                        250       260
                 ....*....|....*....|....*.
gi 768017218 224 taLGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15927  271 --LSFINSCVNPVALYLLSGSFRRHF 294
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
2-246 3.86e-33

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 122.62  E-value: 3.86e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15339   31 KTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLTSL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE-CLVEIPTPQD-YWgpvFAICIFLFSFIVPVLVISVCYSL-- 156
Cdd:cd15339  111 RTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLEsCAFNLTSPDDvLW---YTLYQTITTFFFPLPLILICYILil 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 -----MIRRLRGVRLLSGSREKDRnLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI-LRFCtaLGYVN 230
Cdd:cd15339  188 cytweMYRKNKKAGRYNTSIPRQR-VMRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVSQPTLAFYVSYyLSIC--LSYAS 264
                        250
                 ....*....|....*.
gi 768017218 231 SCLNPILYAFLDENFK 246
Cdd:cd15339  265 SSINPFLYILLSGNFR 280
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
3-246 4.91e-33

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 122.29  E-value: 4.91e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15925   34 PPIDVFVFNLALADFGFALTLPFWAVESALDFhWPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSA-QVEDEEIeCLVEIPTpqDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15925  114 STFWAKIITLALWAAALLATVPTAIFATEgEVCGVEL-CLLKFPS--NYWLGAYHLQRVVVAFVVPLGVITTSYLLLLSF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDrnlRRITRLVLVVVAVFVGCWTPVQVF----VLAQGLGVQPSSE---TAVAILRFCTALGYVNSCL 233
Cdd:cd15925  191 LQQHKVNQNNRQRQ---SVIARSVRLVVASFFLCWFPNHVVtfwgVLVKFRAVPWNSTfyfIHTYVFPVTTCLAHSNSCL 267
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd15925  268 NPVLYCLMRREFR 280
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
1-247 5.13e-33

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 122.22  E-value: 5.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQgTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15187   31 LRSMTDVYLLNLAASDLLFVFSLPFQ-AYYLLDQWVFGNAMCKIVSGAYYIGFYSSMFFITLMSIDRYLAIVHAVYALKV 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15187  110 RTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGNSWKVFTNFEVNILGLLIPFSILIFCYHNILRN 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGL-------GVQPSSETAVAiLRFCTALGYVNSCL 233
Cdd:cd15187  190 LRRC--------HNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLhslhiidGCQNSQRLTLA-LHLTETISFTHCCL 260
                        250
                 ....*....|....
gi 768017218 234 NPILYAFLDENFKA 247
Cdd:cd15187  261 NPVIYAFVGEKFKK 274
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
2-246 5.38e-33

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 122.54  E-value: 5.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15117   31 RTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFhWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEI----PTPQDyWGPVFAICI----------FLFSFIVP 146
Cdd:cd15117  111 RTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFdpwnETAED-PVLWLETVVqrlsaqvitrFVLGFLVP 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 147 VLVISVCYSLMIRRLRGVRLLSGSREKdrnlrritRLVLVVVAVFVGCWTPVQVFV---LAQGLGVQPSSETAVAIL-RF 222
Cdd:cd15117  190 LVIIGGCYGLIAARLWREGWVHSSRPF--------RVLTAVVAAFFLCWFPFHLVSlleLVVILNQKEDLNPLLILLlPL 261
                        250       260
                 ....*....|....*....|....
gi 768017218 223 CTALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15117  262 SSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
1-249 9.41e-33

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 121.75  E-value: 9.41e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAld 79
Cdd:cd15393   31 MRTVTNIFIANLAVADIIIgLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKA-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vRTSSKAQAVNVA-IWALASVVGVPVAIMGSAqVEDEEIECLVEIP-----TPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15393  109 -RCSKKSAKIIILiIWILALLVALPVALALRV-EELTDKTNNGVKPfclpvGPSDDWWKIYNLYLVCVQYFVPLVIICYA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRL---LSGSREKD--RNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTA-LG 227
Cdd:cd15393  187 YTRIAVKIWGTKApgnAQDVRDDEilKNKKKVIKMLIIVVALFALCWLPLQTYNLLNEIKPEINKYKYINIIWFCSHwLA 266
                        250       260
                 ....*....|....*....|..
gi 768017218 228 YVNSCLNPILYAFLDENFKACF 249
Cdd:cd15393  267 MSNSCYNPFIYGLYNEKFKREF 288
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
1-246 1.09e-32

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 121.23  E-value: 1.09e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALDV 80
Cdd:cd15178   31 SRSSTDVYLLHLAIADLLFALTLPFWAVSVVKG-WIFGTFMCKLVSLLQEANFYSGILLLACISVDRYLAI---VHATRA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKA--QAVNVAIWALASVVGVPVAIMGSAQVE--DEEIECLVEI-PTPQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15178  107 LTQKRHlvKFVCAGVWLLSLLLSLPALLNRDAFKPpnSGRTVCYENLgNESADKWRVVLRILRHTLGFLLPLVVMLFCYG 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRllsgSREKDRNLRRITRLVLVVVAvfvgCWTPVQVFVLAQGL----GVQPSSETAVAI---LRFCTALGY 228
Cdd:cd15178  187 FTIKTLLQTR----SFQKHRAMRVIFAVVLAFLL----CWLPYNVTVLIDTLmrtkLITETCELRNHVdvaLYVTQILGF 258
                        250
                 ....*....|....*...
gi 768017218 229 VNSCLNPILYAFLDENFK 246
Cdd:cd15178  259 LHSCINPVLYAFIGQKFR 276
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
1-249 1.18e-32

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 121.46  E-value: 1.18e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAld 79
Cdd:cd15202   31 MRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLKP-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vRTSSKAQAVNVA-IWALASVVGVPVAIMGS--AQVEDEEIE---CLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15202  109 -RISKTKAKFIIAvIWTLALAFALPHAICSKleTFKYSEDIVrslCLEDWPERADLFWKYYDLALFILQYFLPLLVISFA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRLLSGSR-----EKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETaVAILRFCTA-LG 227
Cdd:cd15202  188 YARVGIKLWASNMPGDATteryfALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLLSSKPDYLIKT-INAVYFAFHwLA 266
                        250       260
                 ....*....|....*....|..
gi 768017218 228 YVNSCLNPILYAFLDENFKACF 249
Cdd:cd15202  267 MSSTCYNPFIYCWLNERFRIEF 288
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
1-249 1.71e-32

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 121.24  E-value: 1.71e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd14997   31 MRTPTNIFLVNLSVADLLVLLVcMPVALVETWAREpWLLGEFMCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEE-----IECLVEIPTPqdyWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd14997  111 YVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNdgtpvAVCRTPADTF---WKVAYILSTIVVFFVVPLAILSGL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRLL------SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVL---------AQGLGvqpsSETAVA 218
Cdd:cd14997  188 YSVICRRLVGHPALesrradAANRHTLRSRRQVVYMLITVVVLFFVCLLPFRVVTLwiifapdedLQALG----LEGYLN 263
                        250       260       270
                 ....*....|....*....|....*....|.
gi 768017218 219 ILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd14997  264 LLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
6-247 2.82e-32

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 120.24  E-value: 2.82e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15193   36 DTFVLNLAVADLVFVLTLPFWAASTALGGqWLFGEGLCKLSSFIIAVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRR 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEclveipTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRgv 164
Cdd:cd15193  116 CALITCCIIWAVSLVLGIPSLVYRNLINESVCVE------DSSSRFFQGISLATLFLTFVLPLIVILFCYCSILVRLR-- 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 165 RLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQ----VFVLAQGLGVQPSSETAVAI---LRFCTALGYVNSCLNPIL 237
Cdd:cd15193  188 RHFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNtlkaVRLLLELGGGVLPCHTTVAIrqgLTITACLAFVNSCVNPLI 267
                        250
                 ....*....|
gi 768017218 238 YAFLDENFKA 247
Cdd:cd15193  268 YSLLDRHFRR 277
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
2-247 4.14e-32

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 119.85  E-value: 4.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15119   31 KTVNTLWFLNLAIADFVFVLFLPLHITYVALDFhWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIM-GSAQVEDEEIECLVEIPTPQDYWGPVFAICI----FLFSFIVPVLVISVCYS 155
Cdd:cd15119  111 RTLKSALILCGIVWLSAAAISGPALYFrDTMELSINVTICFNNFHKHDGDLIVMRHTILvwvrFFFGFLFPLLTMVVCYS 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSrekdrnlrRITRLVLVVVAVFVGCWTPVQVFVLAQgLGVQPSS---ETAVAILRFCTALGYVNSC 232
Cdd:cd15119  191 LLAIKVKRRTLLISS--------KFFWTISAVIVAFFVCWTPYHIFSILE-LSIHHSSylhNVLRAGIPLATSLAFINSC 261
                        250
                 ....*....|....*
gi 768017218 233 LNPILYAFLDENFKA 247
Cdd:cd15119  262 LNPILYVLIGKKFKA 276
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
2-247 8.20e-32

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 119.10  E-value: 8.20e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15116   31 KTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIM-GSAQVEDEE-IECLVEIPTPQDYWGP-----------VFAICIFLFSFIVPV 147
Cdd:cd15116  111 RSVRLASLVSLAVWVVAFFLSSPSFIFrDTAPSQNNNkIICFNNFSLSGDNSSPevnqlrnmrhqVMTITRFLLGFLIPF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 148 LVISVCYSLMIRRLRGVRLLSGSREkdrnlrriTRLVLVVVAVFVGCWTPVQVFVLAQgLGVQPSSETAVAI-LRFCTAL 226
Cdd:cd15116  191 TIIICCYAAIVLKLKRNRLAKSSKP--------FKIIAAVIVTFFLCWAPYHILNLLE-MEATRSPASVFKIgLPITSSL 261
                        250       260
                 ....*....|....*....|.
gi 768017218 227 GYVNSCLNPILYAFLDENFKA 247
Cdd:cd15116  262 AFINSCLNPILYVFMGQDFKK 282
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
1-249 5.96e-31

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 117.07  E-value: 5.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLL-TLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd14979   31 LRTTTNYYLFSLAVSDLLILLvGLPVELYNFWWQYpWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVE------IPTPQDYWGPVFAICIFLFsFIVPVLVISV 152
Cdd:cd14979  111 TLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVPdsavctLVVDRSTFKYVFQVSTFIF-FVLPMFVISI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRLRGVRLL-----------SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQvfvlAQGLGVQPSSETAVAILR 221
Cdd:cd14979  190 LYFRIGVKLRSMRNIkkgtraqgtrnVELSLSQQARRQVVKMLGAVVIAFFVCWLPFH----AQRLMFSYASKEDTFLFD 265
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768017218 222 FC-------TALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd14979  266 FYqylypisGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
1-249 7.49e-31

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 116.69  E-value: 7.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDIL-LGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15392   31 MRTVTNYFIVNLALSDILMaVFCVPFSFIALLiLQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAISIDRYVAIMWPLRPR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 dvRTSSKAQAVNVAIWALASVVGVPVAIMgSAQVEDEEIECLVEIPT---PQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15392  111 --MTKRQALLLIAVIWIFALATALPIAIT-SRLFEDSNASCGQYICTeswPSDTNRYIYSLVLMILQYFVPLAVLVFTYT 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRL---LSGSREKD--RNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCT-ALGYV 229
Cdd:cd15392  188 RIGIVVWAKRTpgeAENNRDQRmaESKRKLVKMMITVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLAAhWLAMS 267
                        250       260
                 ....*....|....*....|
gi 768017218 230 NSCLNPILYAFLDENFKACF 249
Cdd:cd15392  268 HCCYNPFIYCWMNAKFRNGF 287
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
3-249 1.95e-30

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 115.49  E-value: 1.95e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15168   33 NSSAIYMFNLAVSDLLYLLSLPFLIYYYANGdHWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECL-VEIPTPQDYWGPvFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15168  113 KKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYdTTSPEELNDYVI-YSMVLTGLGFLLPLLIILACYGLIVRA 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 L-RGVRLLSGSREKDRNLRRItrlvLVVVAVFVGCWTPVQV----FVLAQGLGVQPSSETAVAILRF---CTALGYVNSC 232
Cdd:cd15168  192 LiRKLGEGVTSALRRKSIRLV----IIVLALFAVCFLPFHVtrtiNLAARLLSGTASCATLNGIYVAykvTRPLASLNSC 267
                        250
                 ....*....|....*..
gi 768017218 233 LNPILYAFLDENFKACF 249
Cdd:cd15168  268 LNPLLYFLAGDKFRRRL 284
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
5-240 2.19e-30

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 115.27  E-value: 2.19e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd14975   35 TMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVPVaiMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGV 164
Cdd:cd14975  115 LAHKVLAIIWLLAVLLATPV--IAFRHVEETVENGMCKYRHYSDGQLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRR 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 165 RLLSGsrekdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILR--------FCTALGYVNSCLNPI 236
Cdd:cd14975  193 RFRRR--------RRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAGTLGkvaeagrpIAGALAFLSSSINPL 264

                 ....
gi 768017218 237 LYAF 240
Cdd:cd14975  265 LYAF 268
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
1-246 2.37e-30

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 115.24  E-value: 2.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILlGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15184   31 LKSMTDIYLLNLAISDLLFLLTLPFWAHYAA-NEWVFGNAMCKLLTGLYHIGFFSGIFFIILLTIDRYLAIVHAVFALKA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQ-DYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15184  110 RTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQyQFWKNFQTLKMNILGLVLPLLVMIICYSGILK 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgvRLLSGSREKDRNlrRITRLVLVVVAVFVGCWTPVQVFVLAQ------GLGVQPSSETAVAILRFCTALGYVNSCL 233
Cdd:cd15184  190 -----TLLRCRNEKKRH--KAVRLIFTIMIVYFLFWAPYNIVLLLNtfqeffGLNNCSSSNRLDQAMQVTETLGMTHCCI 262
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd15184  263 NPVIYAFVGEKFR 275
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
2-246 2.41e-30

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 115.19  E-value: 2.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILL-GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15114   31 RSVNAVWFLNLAVADLLCCLSLPILAVPIAQdGHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVE--DEEIECLVeiptpqDYWGPV-----FAICIFLFSFIVPVLVISVC 153
Cdd:cd15114  111 RRARLAWIACGAAWLLALLLTVPSFIYRRIHQEhfPEKTVCVV------DYGGSTgvewaVAIIRFLLGFLGPLVVIASC 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRllsgsREKDrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQgLGVQPSSETAVAILR---FCTALGYVN 230
Cdd:cd15114  185 HGVLLVRTWSRR-----RQKS---RRTLKVVTAVVVGFFLCWTPYHVVGLII-AASAPNSRLLANALKadpLTVSLAYIN 255
                        250
                 ....*....|....*.
gi 768017218 231 SCLNPILYAFLDENFK 246
Cdd:cd15114  256 SCLNPIIYVVAGRGFR 271
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
2-246 4.44e-30

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 114.46  E-value: 4.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAlDV 80
Cdd:cd15191   32 KTVASIYIFNLAVADLLFLATLPLWATYYSYGYnWLFGSVMCKICGSLLTLNLFASIFFITCMSVDRYLAVVYPLRS-QR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQ-VEDEEIE-CLVEIPTPQ-DYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15191  111 RRSWQARLVCLLVWVLACLSSLPTFYFRDTYyIEELGVNaCIMAFPNEKyAQWSAGLALMKNTLGFLIPLIVIATCYFGI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRllsGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGL---GVQPSSETAVAI---LRFCTALGYVNS 231
Cdd:cd15191  191 GRHLLKTK---GFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALarmGVINNCWVITVIdkaLPFAICLGFSNS 267
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15191  268 CINPFLYCFVGNHFR 282
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
3-246 5.95e-30

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 114.02  E-value: 5.95e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRT 82
Cdd:cd15180   33 SVTDTFILHLALADILLLVTLPFWAVQAVHG-WIFGTGLCKLAGAVFKINFYCGIFLLACISFDRYLSIVHAVQMYSRKK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  83 SSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEE--IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15180  112 PMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQnkTECVHNFPQSDTYWWLALRLLYHIVGFLLPLAVMVYCYTSILLR 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRgvrllsgSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLA------QGLGVQPSSETAVAILRFCTA-LGYVNSCL 233
Cdd:cd15180  192 LL-------RSSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVdtlidlSVLDRNCGTESRLDIALSVTSsLGYFHCCL 264
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd15180  265 NPLLYAFVGVKFR 277
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
2-246 1.53e-29

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 112.93  E-value: 1.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15162   32 KAPAVIYMANLAIADLLLVIWLPFKIAYHIHGnNWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVP---------VAIMGSAQVEDEEIECLVEiptpqDYWGPVFaICIFLFSFIVPVLVIS 151
Cdd:cd15162  112 RARRYALGTCLAIWLLALLVTLPlylvkqtifLPALDITTCHDVLPEQLLV-----GDWFYYF-LSLAIVGFLIPFILTA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 152 VCYSLMIRRLRGVRLLSGSREKDRNLrritRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAV-AILRFCTALGYVN 230
Cdd:cd15162  186 SCYVATIRTLAALEDENSEKKKKRAI----KLAATVLAIFIICFAPSNLLLLAHYSLISSSGTGHLyFAYLLALCLSTLN 261
                        250
                 ....*....|....*.
gi 768017218 231 SCLNPILYAFLDENFK 246
Cdd:cd15162  262 SCIDPFIYYFVSKEFR 277
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
3-247 1.95e-29

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 112.97  E-value: 1.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15380   33 TIAEIYLANLAASDLVFVLGLPFWAENIRNQFnWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQ-VEDEEIE-CLVEIPTPqdYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15380  113 SRRQAQVICLLIWVFGGLLSIPTFLFRSVKhVPDLNISaCILLFPHE--AWHFARRVELNIVGFLLPLAAIVFFNFHIIA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFV----LAQGLGVQPS--SETAVAILRFCTALGYVNSCL 233
Cdd:cd15380  191 SLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAfldfLFQVEVIQGCfwEEFIDLGLQLANFFAFANSCL 270
                        250
                 ....*....|....
gi 768017218 234 NPILYAFLDENFKA 247
Cdd:cd15380  271 NPVIYVFAGKLFRT 284
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
1-247 4.58e-29

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 112.05  E-value: 4.58e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAld 79
Cdd:cd15389   31 MHTATNLFIVNLAVSDILItLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHPLKP-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vR-TSSKAQAVNVAIWALASVVGVPVAIMGSA-----QVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15389  109 -RiTPCQGVVVIAIIWIMASCLSLPHAIYQKLvefeySNERTRSRCLPSFPEPSDLFWKYLDLATFILQYVLPLLIIGVA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRLLSGSREK-----DRNLRRITRLVLVVVAVFVGCWTPVQVFVLAqgLGVQPSSETAVAILrFCTALGY 228
Cdd:cd15389  188 YTRVAKKLWLRNAIGDVTTEqyvaqRRKKKKTIKMLMLVVLLFAICWLPLNCYHVL--LSSHPIRSNSALFF-AFHWLAM 264
                        250
                 ....*....|....*....
gi 768017218 229 VNSCLNPILYAFLDENFKA 247
Cdd:cd15389  265 SSTCYNPFIYCWLNDSFRS 283
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
3-246 5.67e-29

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 111.79  E-value: 5.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15189   33 TVAEIYLGNLAAADLVFVSGLPFWAMNILNQFnWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQ-VEDEEI-ECLVEIptPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15189  113 RRRYAKLICVLIWVVGLLLSIPTFLLRKIKaIPDLNItACVLLY--PHEAWHFAHIVLLNIVGFLLPLLVITFCNYNILQ 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSRekDRNLRRITRLVLVVVAVFVGCWTPVQVFV---LAQGLGVQPSSETAVAI---LRFCTALGYVNSCL 233
Cdd:cd15189  191 ALRTREESTRCE--DRNDSKATALVLAVTLLFLVCWGPYHFFTfldFLFDVGVLDECFWEHFIdigLQLAVFLAFSNSCL 268
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd15189  269 NPVLYVFVGRYFR 281
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
1-246 9.32e-29

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 110.73  E-value: 9.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15183   31 LRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQ-DYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15183  111 RTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSlIRWKRFQALKLNLLGLILPLLVMIICYTGIIN 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRgvrllsgsREKDRNLRRITRLVLVVVAVFVGCWTP--VQVFVLA-QGLGVQPSSETAVAI---LRFCTALGYVNSCL 233
Cdd:cd15183  191 ILL--------RRPNEKKAKAVRLIFVITLLFFLLWTPynLAAFVSAfQDVLFTPSCEQSQQLdlaLQVTEVIAYTHCCV 262
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd15183  263 NPVIYVFVGERFR 275
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
1-249 1.06e-28

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 110.85  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAld 79
Cdd:cd15390   31 MRTVTNYFLVNLAVADLLIsAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHPLRP-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vRTSSK-AQAVNVAIWALASVVGVPVAIMG-----SAQVEDEEIECLVEIP-TPQDYWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15390  109 -RLSRRtTKIAIAVIWLASFLLALPQLLYSttetyYYYTGSERTVCFIAWPdGPNSLQDFVYNIVLFVVTYFLPLIIMAV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRLRGVRLLSGSR----EKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgvQPSSETAVAILRFCTA--- 225
Cdd:cd15390  188 AYTRVGVELWGSKTIGENTprqlESVRAKRKVVKMMIVVVVIFAICWLPYHLYFILTYL--YPDINSWKYIQQIYLAiyw 265
                        250       260
                 ....*....|....*....|....
gi 768017218 226 LGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15390  266 LAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
1-246 1.45e-28

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 110.14  E-value: 1.45e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15182   31 LKTLTNIFILNLAISDLLFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMgSAQVEDEEIECLVEIPTPQDYWGPVFAICIFlfsFIVPVLVISVCYSLMIRR 160
Cdd:cd15182  110 RKLRYASLVSVAVWVISILASLPELIL-STVMKSDEDGSLCEYSSIKWKLGYYYQQNLF---FLIPLGIIVYCYVRILQT 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRllsgSREKDRNLRRItrlvLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVA-----ILRFCTALGYVNSCLNP 235
Cdd:cd15182  186 LMRTR----TMRKHRTVKLI----FVIVLVFFLSWAPYNIVIFLRSLKDLTIPICECSkqldyAFYICRNIAFSHCCLNP 257
                        250
                 ....*....|.
gi 768017218 236 ILYAFLDENFK 246
Cdd:cd15182  258 VFYVFVGVKFR 268
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
2-251 1.49e-28

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 111.41  E-value: 1.49e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:PHA03087  71 KTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKIN 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRl 161
Cdd:PHA03087 151 TVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILIT- 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 rgvrlLSGSREKDRNLRRItRLVLVVVAVFVGCWTP--VQVFVL-AQGLGVQPSSETAVAI---LRFCTALGYVNSCLNP 235
Cdd:PHA03087 230 -----LKGINKSKKNKKAI-KLVLIIVILFVIFWLPfnVSVFVYsLHILHFKSGCKAVKYIqyaLHVTEIISLSHCCINP 303
                        250
                 ....*....|....*.
gi 768017218 236 ILYAFLDENFKACFRK 251
Cdd:PHA03087 304 LIYAFVSEFFNKHKKK 319
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
3-246 1.81e-28

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 110.24  E-value: 1.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15381   33 TVAEIYLGNLAAADLLLVCCLPFWAINISNGFnWPFGEFLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEE--IECLVEIPTPqdYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15381  113 RPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYniTACVLDYPSE--GWHVALNILLNVVGFLIPLSIITFCSTQIIQ 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRllSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVL---AQGLGVQPSS------ETAVAILRFCtalGYVN 230
Cdd:cd15381  191 VLRNNK--MQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFldtLHKLGLISGCrwedilDIGTQIATFL---AYSN 265
                        250
                 ....*....|....*.
gi 768017218 231 SCLNPILYAFLDENFK 246
Cdd:cd15381  266 SCLNPLLYVIVGKHFR 281
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
2-246 3.17e-28

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 109.47  E-value: 3.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15179   32 RTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN-WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEClvEIPTPQDY---WGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15179  111 KLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYIC--DRIYPEDTfelWVVAFRFQHILVGLVLPGLVILTCYCIII 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLrgvrllsgSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQG---LGVQPSS---ETAVAILRFCT-ALGYVNS 231
Cdd:cd15179  189 SKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTfmlLEIIKQScemEQTVHKWISITeALAFFHC 260
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15179  261 CLNPILYAFLGAKFK 275
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
2-247 7.82e-28

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 108.26  E-value: 7.82e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15157   32 KTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGsHWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEiECLvEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15157  112 TSIKYARILCAVIWIFVMAASSPLLSKGTSKYNSQT-KCL-DLHPSKIDKLLILNYIVLVVGFILPFCTLSICYILIIKA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSgSREKDRNlRRITRLVLVVVAVFVGCWTP------VQVFVLAQGLGVQPSSETAVAILrfctALGYVNSCLN 234
Cdd:cd15157  190 LLKPRVPQ-SKLRVSH-KKALLTIIITLILFLLCFLPyhilrtVHLMQWSEGQCNLRLHKAVVITL----CLAAANSCLD 263
                        250
                 ....*....|...
gi 768017218 235 PILYAFLDENFKA 247
Cdd:cd15157  264 PLLYYFAGENFKE 276
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
1-246 1.32e-27

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 107.99  E-value: 1.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15185   31 LRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDY-WGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15185  111 RTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDsWKRFHALRMNIFGLALPLLIMVICYTGIIK 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLrgvrLLSGSREKDRNLRRITRLVLVVVAVfvgcWTPVQVFVLAQ-------GLGVQPSSETAVAILrFCTALGYVNSC 232
Cdd:cd15185  191 TL----LRCPSKKKYKAIRLIFVIMVVFFIF----WTPYNLVLLLSafqsiffETDCERSKHLDLAMQ-VTEVIAYTHCC 261
                        250
                 ....*....|....
gi 768017218 233 LNPILYAFLDENFK 246
Cdd:cd15185  262 INPVIYAFVGERFR 275
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
2-249 1.52e-27

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 107.97  E-value: 1.52e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILL-GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15921   32 QTPVSVLMVNLAISDLLLVCTLPLRLTYYVLnSHWPFGDIACRIILYVLYVNMYSSIYFLTALSVFRYLALVWPYLYLRV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15921  112 QTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCL-ELAHDAVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKN 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQVF----------VLAQGLGVQPSSETAVAILRFCTAlgyvN 230
Cdd:cd15921  191 LLKPSPALGRTRPSR--RKACALIIISLGIFLVCFLPYHIVrtihliterqIKESCGYILRVRKAAVITLCLAAS----N 264
                        250
                 ....*....|....*....
gi 768017218 231 SCLNPILYAFLDENFKACF 249
Cdd:cd15921  265 SCFDPLLYFFVGENFRSRL 283
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
2-249 2.10e-27

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 107.56  E-value: 2.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15120   31 RTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNhWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVP-VAIMGSAQVEDEEIECLV-----------EIPTPQDYWGPVFAICIFLFSFIVPVL 148
Cdd:cd15120  111 RTNRWASAIVLGVWISAILLSIPyLAFRETRLDEKGKTICQNnyalstnwesaEVQASRQWIHVAMFVFRFLLGFLLPFL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 149 VISVCYSLMirrlrgvrllsGSREKDRNLRRITRLVLVVVAVFVG---CWTPVQVFvlaQGL----GVQPSSETAVAILR 221
Cdd:cd15120  191 IITFCYVRM-----------ALKMKERGLARSSKPFKVMFTAVVSffvCWLPYHLH---SGLvltrGRPPSLTDITLLLT 256
                        250       260
                 ....*....|....*....|....*...
gi 768017218 222 FCTALgyVNSCLNPILYAFLDENFKACF 249
Cdd:cd15120  257 VGTTC--FNTCFTPVLYLFVGENFKKVL 282
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
4-238 2.14e-27

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 107.58  E-value: 2.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   4 ATNIYIFNLALADTLVLLTLPfqgTDILL----GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15374   34 PTTVYMFHLALSDTLYVLSLP---TLIYYyadhNHWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRALR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQDYWGPV-FAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15374  111 WVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCH-DTTRPEEFDHYVhYSSAVMVLLFGIPCLVIVVCYGLMA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQV----FVLAQGLGVQPSSETAVAILRFCT-ALGYVNSCL 233
Cdd:cd15374  190 RRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHItrtlYYVARLLKADCDTLNIINVTYKVTrPLASANSCL 269

                 ....*
gi 768017218 234 NPILY 238
Cdd:cd15374  270 DPILY 274
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
1-249 3.78e-27

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 107.03  E-value: 3.78e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15134   31 MHTATNYYLFSLAVSDLLLLILgLPFELYTIWQQYpWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQ-----------VEDEEIeCLVEIPTPQDYwgPVFAICIFLFsFIVPV 147
Cdd:cd15134  111 TMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVyleypptsgeaLEESAF-CAMLNEIPPIT--PVFQLSTFLF-FIIPM 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 148 LVISVCYSLM---IRRLRGVRLLSGSREKDRN----LRRITRLVLVVVAVFVGCWTP--VQVFVLAQGLGVQPSSETAVA 218
Cdd:cd15134  187 IAIIVLYVLIglqLRRSTLLRRGQRSVSGGRRssqsRRTVLRMLVAVVVAFFICWAPfhAQRLLTVYAKNMTPPYLFINR 266
                        250       260       270
                 ....*....|....*....|....*....|..
gi 768017218 219 ILRFCTA-LGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15134  267 ILFYISGvLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
2-240 6.73e-27

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 106.04  E-value: 6.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15122   34 RSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQvEDEEIECLVEIPTpqdYWGPVFAICIFLF----SFIVPVLVISVCYSLM 157
Cdd:cd15122  114 KKALVRKILLAIWLLALLLALPAFVYRHVW-KDEGMNDRICEPC---HASRGHAIFHYTFetlvAFVLPFGVILFSYSVI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGSrekdrnlrRITRLVLVVVAVFVGCWTP------VQVFV-LAQGLGVQPSSETAVAILRFCTALGYVN 230
Cdd:cd15122  190 LVRLKGARFRRRA--------RVEKLIAAIVVAFALLWVPyhvvnlLQVVAnLAPGEVLEKLGGAAKAARAGATALAFFS 261
                        250
                 ....*....|
gi 768017218 231 SCLNPILYAF 240
Cdd:cd15122  262 SSVNPLLYVF 271
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
1-249 7.35e-27

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 105.54  E-value: 7.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQG-TDILLGF--WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRA 77
Cdd:cd14995   31 MRTPTNCYLVSLAVADLMVLVAAGLPNeIESLLGPdsWIYGYAGCLLITYLQYLGINASSLSITAFTIERYIAICHPMKA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDE--EIECLVEIPTPQDYWGPVFAICIFLFsFIVPVLVISVCYS 155
Cdd:cd14995  111 QFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYgdDIVVRCGYKVSRHYYLPIYLADFVLF-YVIPLLLAIVLYG 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMirrlrgVRLLSGSRekdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVaiLRFCTALGYVNSCLNP 235
Cdd:cd14995  190 LI------GRILFSSR------KQVTKMLAVVVVLFALLWMPYRTLVVYNSFASPPYLDLWF--LLFCRTCIYLNSAINP 255
                        250
                 ....*....|....
gi 768017218 236 ILYAFLDENFKACF 249
Cdd:cd14995  256 ILYNLMSQKFRAAF 269
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
6-242 1.65e-26

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 104.94  E-value: 1.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTLP-FQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15194   36 DIFISNLAASDFIFLVTLPlWVDKEVVLGPWRSGSFLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKH 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYwgpVFAICIFLFSFIVPVLVISVCYSLMIRRLrgV 164
Cdd:cd15194  116 NAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPSKV---IFSLVSLIVAFFLPLLSILTCYCTIIWKL--C 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 165 RLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVF---VLAQGLGVQPSSETAVAI---LRFCTALGYVNSCLNPILY 238
Cdd:cd15194  191 HHYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFkalAIASGLQVEVTCLPYTLAqlgMEVSAPLAFANSCANPFIY 270

                 ....
gi 768017218 239 AFLD 242
Cdd:cd15194  271 YFFD 274
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
2-246 3.44e-26

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 104.06  E-value: 3.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15181   32 RRTTENYLLHLALADLLLLLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCSSLLLACISVDRYLAIVHAIHSYRHR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIP---TPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15181  111 RLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSCSFHqygIHESNWWLTSRFLYHVVGFFLPLLIMGYCYATIV 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRgvrllSGSREKDRnlRRITRLVLVVVAVFVGCWTP----------VQVFVLAQGLGVQPSSETAVAIlrfCTALGY 228
Cdd:cd15181  191 VTLC-----QSSRRLQK--QKAIRVAILVTLVFCLCWLPynivifldtlDDLKAVVKNCKLNDLLDAAITV---TESLGF 260
                        250
                 ....*....|....*...
gi 768017218 229 VNSCLNPILYAFLDENFK 246
Cdd:cd15181  261 SHCCLNPILYAFIGVKFR 278
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
1-249 8.30e-26

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 102.81  E-value: 8.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQG-TDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15053   31 LQTATNYFIVSLAVADLLVaILVMPFAVyVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTpqdywgpvFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15053  111 RQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNPD--------FIIYSSISSFYIPCIVMLLLYYRIF 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRgvrllsgsREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGL---GVQPSSETAVAILRFCTALGYVNSCLNP 235
Cdd:cd15053  183 RALR--------RE-----KKATKTLAIVLGVFLFCWLPFFTLNILNAIcpkLQNQSCHVGPALFSLTTWLGYVNSFLNP 249
                        250
                 ....*....|....
gi 768017218 236 ILYAFLDENFKACF 249
Cdd:cd15053  250 IIYTIFNIEFRKAF 263
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
1-249 1.55e-25

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 102.08  E-value: 1.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15206   31 MRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15206  111 WQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKCREVWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISW 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRllsgsrekdrnlRRITRLVLVVVAVFVGCWTP---VQVFVLAQGLGVQPS-SETAVAILRFctaLGYVNSCLNP 235
Cdd:cd15206  191 TLLEAK------------KRVIRMLFVIVVEFFICWTPlyvINTWKAFDPPSAARYvSSTTISLIQL---LAYISSCVNP 255
                        250
                 ....*....|....
gi 768017218 236 ILYAFLDENFKACF 249
Cdd:cd15206  256 ITYCFMNKRFRQAF 269
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
2-245 2.13e-25

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 102.19  E-value: 2.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15118   31 RTVISIWILNLALSDLLATLSLPFFTYYLASGHtWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSA-QVEDEEIEC----LVEIPTPQD------YWGPVFAICIFLFSFIVPVLV 149
Cdd:cd15118  111 RNVAAAKKICGVIWAMALINTIPYFVFRDViERKDGRKLCyynfALFSPSPDNnhpickQRQEGLAISKLLLAFLIPLVI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 150 ISVCYSlmirrlrGVRLLSGSREKDRNLrRITRLVLVVVAVFVGCWTPVQVFVLAQGLG-VQPSSETAV-AILRFCTALG 227
Cdd:cd15118  191 IAVSYA-------VVSLIIRHRCRRRPG-RFVRLVVSVVVSFALCWAPYHIFSIIEVMAhNQHSLRPLViQGLPFATTLA 262
                        250
                 ....*....|....*...
gi 768017218 228 YVNSCLNPILYAFLDENF 245
Cdd:cd15118  263 FLNSVLNPVLYVFSCPDF 280
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
2-247 2.30e-25

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 102.21  E-value: 2.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALdv 80
Cdd:cd15391   32 RTDLNYYLINLAVSDlIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSR-- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE----CLVEIPTPqDYWGPVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd15391  110 HTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEgrvlCGESWPGP-DTSRSAYTVFVMLLTYIIPLLILTSTYGY 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLRGvRLLSGSREKDRNL------RRITRLVLVVVAVFVGCWTPVQVFVLAQGLG--VQPSSE-TAVAILRFCTALG 227
Cdd:cd15391  189 VGFRLWN-RTAPGNADKGRDDmqikskRKVIKMLVFVVLMFGICWLPLHLFNLVQDFStvFRNMPQhTTRLIYGACHWIA 267
                        250       260
                 ....*....|....*....|
gi 768017218 228 YVNSCLNPILYAFLDENFKA 247
Cdd:cd15391  268 MSNSFVNPIIYLFMNDSFRS 287
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
2-246 2.40e-25

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 101.71  E-value: 2.40e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15161   32 GTPSNVFLMHLAVADLSYVLILPMRLVYHLSGnHWPFGEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIM-GSAQVEDEEIECLVEIPTPqdywgPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15161  112 RKPLYAHVVCGFLWVIVTVAMAPLLVSpQTVEVNNTTVCLQLYREKA-----SRGALVSLAVAFTIPFVTTVTCYLLIIR 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRgvrllSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQV-----FVLAQGLGVQPSSETAVAIL-RFCTALGYVNSCL 233
Cdd:cd15161  187 SLR-----TGKREEKPLKDKAIKMIILVLTIFLICFVPYHIsryiyILSHNGAGASCSSRRGLALAnRITSCLTCLNGAL 261
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd15161  262 DPVMYFFVAEKFR 274
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
1-246 2.52e-25

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 101.78  E-value: 2.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICH--PIRAL 78
Cdd:cd15177   31 LRSMTDVYLLNLALADLLLLLTLPFAAAETLQG-WIFGNAMCKLIQGLYAINFYSGFLFLTCISVDRYVVIVRatSAHRL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPV-FAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15177  110 RPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSRTVKGaTALTQVVLGFAIPLIVMAVCYAAI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRllsgSREKDRNLRRITRLVLVVVAVFvgcwTPVQVFVLAQGLGVQPSSETAVA-------ILRFCTALGYVN 230
Cdd:cd15177  190 GRTLLAAR----GWERHRALRVIAALVVAFVLFQ----LPYSVVLLLDTADLLATLELSCSqskrkdiALLVTSGLAYVR 261
                        250
                 ....*....|....*.
gi 768017218 231 SCLNPILYAFLDENFK 246
Cdd:cd15177  262 CCLNPLLYAFVGVRFR 277
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
3-249 2.83e-25

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 101.38  E-value: 2.83e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRT 82
Cdd:cd15923   33 TETNIYMTNLAVADLLLLISLPFKMHSYRRE-SAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRARELRS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  83 SSKAQAVNVAIWALASVVGVPVAIMGSAQvedEEIECLVEIptpQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLR 162
Cdd:cd15923  112 PRKAAVVCAVIWVLVVTISIPYFLLDSSN---EKTMCFQRT---KQTESLKVFLLLEIFGFLLPLIIMTFCSARVIHTLQ 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 163 GVRLLSGSREKdrnLRRITRLVLVVVAVFVGCWTPVQV--FV--LAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15923  186 KRLDDVGSRSE---TKQCIRVIMANLIVFIVCFLPVHVgfFVkfIVGKSYSCDSKLIIHFFLQSAFCLSDMNCCLDAFCY 262
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15923  263 YFATKEFREAY 273
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
2-248 9.31e-25

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 100.21  E-value: 9.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTD-ILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15158   32 KSAFHIYMLNLAVSDLLCVCTLPLRVVYyVHKGQWLFGDFLCRISSYALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQDYWGPVFAICIF--LFSFIVPVLVISVCYSLMI 158
Cdd:cd15158  112 VTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCF-EPPQSNQQLTKLLVLNYIslVVGFIIPFLVILICYAMII 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLrgVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRF------CTALGYVNSC 232
Cdd:cd15158  191 RTL--LKNTMKARKQQSSRKKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFLSRKDSTCEEVLYMqksvviTLCLAAANCC 268
                        250
                 ....*....|....*.
gi 768017218 233 LNPILYAFLDENFKAC 248
Cdd:cd15158  269 FDPLLYFFSGENFRRR 284
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
3-247 1.11e-24

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 100.24  E-value: 1.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15968   33 TRTAIYMVNLALADLLYALSLPLLIYNYAMRdRWLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKE 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQDYWGPV-FAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15968  113 TRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCY-DLAPPALFPHYVpYGMALTVSGFLLPFSIILWCYCLVVRT 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LrgVRLLSGSREKDRNLRRIT-RLVLVVVAVFVGCWTPVQV-----FVLAQGLGVQPSSETAVAILRFCT-ALGYVNSCL 233
Cdd:cd15968  192 L--CRTLGPAEPPAQARRRKSiRTIVTVTLLFALCFLPFHItrtiyLAVRVTPGVPCHVLEAVAACYKITrPLASANSVL 269
                        250
                 ....*....|....
gi 768017218 234 NPILYAFLDENFKA 247
Cdd:cd15968  270 NPLLYFLTKKKFGR 283
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
7-246 1.26e-24

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 99.82  E-value: 1.26e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15372   36 IFLINLAVADLLLILVLPFKISYHFLGnNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRF 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQV--EDEEIECLVEIPTPQD--YWGPVFaICIFLFSFIVPVLVISVCYSLMIrrl 161
Cdd:cd15372  116 ALCMCTAIWLIAAALTLPLTLQRQSYPleRLNITLCHDVLPLDEQdtYLFYYF-ACLAVLGFLLPLVVILFCYGSVL--- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 rgvRLLSGSREKDRNLRRITrlvLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRF-CTALGYVNSCLNPILYAF 240
Cdd:cd15372  192 ---HTLLRSGQRYGHAMKLT---VLVLVSFVLCFTPSNLLLLLHYSDPTLDDGGNLYIVYMvSLAISTLNSCVDPFIYYY 265

                 ....*.
gi 768017218 241 LDENFK 246
Cdd:cd15372  266 VSEEFR 271
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
1-247 1.40e-24

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 99.87  E-value: 1.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15928   31 MRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRpWRFGDLLCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIM-----GSAQVEDEEIEClveipTPQDYWGPVFAICIFLFS--FIVPVLVISV 152
Cdd:cd15928  111 LVTRGRVKLLIAVIWAVAIVSAGPALVLvgvehIQGQQTPRGFEC-----TVVNVSSGLLSVMLWVSTsfFFVPMVCLSL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRL---RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQV------FVLAQGLGVQPSSEtAVAILRFc 223
Cdd:cd15928  186 LYGLIGRALwdrRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVgrvifnHSRASTKHLHYVSQ-YFNLVSF- 263
                        250       260
                 ....*....|....*....|....
gi 768017218 224 tALGYVNSCLNPILYAFLDENFKA 247
Cdd:cd15928  264 -VLFYLSAAINPILYNLMSKRYRY 286
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
4-246 1.70e-24

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 99.73  E-value: 1.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   4 ATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRT 82
Cdd:cd15159   34 STTLYLINLAVSDILFTLALPGRIAYYALGFdWPFGDWLCRLTALLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  83 SSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQDYWG-PVFAICIFLFSFIVPVLVISVCYSLMIRRL 161
Cdd:cd15159  114 VKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCM-EYPNFEKIKRlPLILLGACVIGFGVPVGIILFCYSQITLKL 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLA---QGLGVQPSSETAVAI---LRFCTALGYVNSCLNP 235
Cdd:cd15159  193 CRTAKENPLTEKSGHHKKACNVILLVLLVFVVCFSPYHLNIIQfmiRKLLYQPSCSELKAFkisLQITVCLMNLNCCLDP 272
                        250
                 ....*....|.
gi 768017218 236 ILYAFLDENFK 246
Cdd:cd15159  273 FIYFFACKGYK 283
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
1-249 2.66e-24

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 98.45  E-value: 2.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15327   31 LQTVTNYFIVNLAIADLLLSTTvLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGV-PVAIMGSAQVEDEEIECLVEIPTpqdywgpvFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15327  111 IMTERKAGVILVLLWVSSMVISIgPLLGWKEPPPPDESICSITEEPG--------YALFSSLFSFYLPLMVILVMYFRVY 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 rrlrgVRLLSGSREKdrnlrRITRLVLVVVAVFVGCWTPVqVFVLAQGlGVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15327  183 -----VVALKFSREK-----KAAKTLAIVVGVFILCWFPF-FFVLPLG-SFFPALKPSEMVFKVIFWLGYFNSCVNPIIY 250
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15327  251 PCSSKEFKRAF 261
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
2-246 2.67e-24

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 99.06  E-value: 2.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15174   32 KTMTDVYLLNLAIADLLFLCTLPFWATAASSG-WVFGTFLCKVVNSMYKINFYSCMLLLTCISVDRYIAIVQATKAHNSK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSS--KAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICI-FLFSFIVPVLVISVCYSLMI 158
Cdd:cd15174  111 NKRllYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESNRFKVAVLALkVTVGFFLPFVVMVICYTLII 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRGVRllsgSREKDRNLRRITrlvlvvvavfvgcwTPVQVFVLAQ----GLGVQPSSETAVAILRFCT---------- 224
Cdd:cd15174  191 HTLLQAK----RFQKHKALKVII--------------AVVTVFVLSQlpynSILLIKTINAYNITITDCAtsqnldiagq 252
                        250       260
                 ....*....|....*....|....*
gi 768017218 225 ---ALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15174  253 vtqSIAFLHSCLNPFLYVFVGVRFR 277
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
1-249 4.02e-24

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 98.56  E-value: 4.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15051   31 LRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVpVAIM-------GSAQVEDEEIECLVEiptpqdyWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15051  111 RVTPRRVAIALAAIWVVSLAVSF-LPIHlgwntpdGRVQNGDTPNQCRFE-------LNPPYVLLVAIGTFYLPLLIMCG 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIR-------RLRGVRLLSGSREKDRNL----RRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILr 221
Cdd:cd15051  183 VYLRIFRiareqakRINALTPASTANSSKSAAtareHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGDNINETALSVV- 261
                        250       260
                 ....*....|....*....|....*...
gi 768017218 222 fcTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15051  262 --LWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-249 4.86e-24

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 98.04  E-value: 4.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15326   31 LRIPTNYFIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEClvEIPTPqdywgPVFAICIFLFSFIVPVLVISVCYSLMIr 159
Cdd:cd15326  111 IVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVC--EITEE-----PFYALFSSLGSFYIPLIVILVMYCRVY- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgVRLLSGSREKdrnlrRITRLVLVVVAVFVGCWTPvqvFVLAQGLGVQPSSET-AVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15326  183 ----IVALKFSREK-----KAAKTLGIVVGMFILCWLP---FFIALPLGSLFSHLKpPETLFKIIFWLGYFNSCLNPIIY 250
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15326  251 PCSSKEFKRAF 261
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 1.60e-23

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 97.46  E-value: 1.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRalD 79
Cdd:cd15208   31 MRTVTNYFIVNLSLADFLVIIIcLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLM--F 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMgsaqvedeeIECLVEIPTPQDY---------WGP-----VFAICIFLFSFIV 145
Cdd:cd15208  109 KSTAKRARVSILIIWIVSLLIMIPQAIV---------MECSRVVPLANKTilltvcderWSDsiyqkVYHICFFLVTYLL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 146 PVLVISVCYSLMIRRL------------------RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVF-VLAQG 206
Cdd:cd15208  180 PLCLMILAYFQIFRKLwcrqipgtssvvqrkwnkPRKSAVAAEEKQLRSRRKTAKMLIVVVIMFAICYLPVHLLnILRYV 259
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 768017218 207 LGVQPSS-ETAVAILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15208  260 FGLFTVDrETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
2-240 2.30e-23

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 96.42  E-value: 2.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15121   32 RSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSaqVEDEEIECLVEIPTpqdYWGPVFAICIFLFS----FIVPVLVISVCYSLM 157
Cdd:cd15121  112 TKRSVRALLLAIWIVAFLLSLPMPFYRT--VLKKNINMKLCIPY---HPSVGHEAFQYLFEtitgFLLPFTAIVTCYSTI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLlsgsrekdRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILR-------FCTALGYVN 230
Cdd:cd15121  187 GRRLRSARF--------RRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASVLKaaklarpNVTALAFLS 258
                        250
                 ....*....|
gi 768017218 231 SCLNPILYAF 240
Cdd:cd15121  259 SSVNPVLYAF 268
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
1-246 2.78e-23

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 96.37  E-value: 2.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDIlLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15175   31 LKTMTDIYLLNLALADILFLLTLPFWAASA-AKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIVQAASAHRH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSK--AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVfAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15175  110 RSRAVfiSKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTLSVKI-QISQMVLGFLVPLVVMSFCYSVII 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLrgvrLLSGSREKDRNLRRITRLVLVVVAVFVgcwtPVQVFVLAQGLGVQPSSETAVAI---LRFCT----ALGYVNS 231
Cdd:cd15175  189 KTL----LQARNFEKNKAIKVIIAVVVVFVVFQL----PYNSVMLVSTLSSFKGNTTDCDYsknLDFALdvtySLACFRC 260
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15175  261 CLNPFLYAFIGVKFR 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
2-249 3.79e-23

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 95.74  E-value: 3.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14969   32 RTPLNLFLLNLALADLLMsVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVnVAIWALASVVGVPVAI-MGSAQVEDEEIECLVEIpTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd14969  112 SKRRALILI-AFIWLYGLFWALPPLFgWSSYVPEGGGTSCSVDW-YSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGV-------RLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILrfcTAL-GYVNS 231
Cdd:cd14969  190 TLRKMskraarrKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSFGGESTIPPLLATI---PALfAKSST 266
                        250
                 ....*....|....*...
gi 768017218 232 CLNPILYAFLDENFKACF 249
Cdd:cd14969  267 IYNPIIYVFMNKQFRRAL 284
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 4.22e-23

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 96.17  E-value: 4.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPiraLD 79
Cdd:cd15125   31 MRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNP---MD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSS---KAQAVNVAIWALASVVGVPVAIMGS-AQVEDEEIECLVE-IPTPQ--DYWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15125  108 IQTSSavlRTCLKAIAIWVVSVLLAVPEAVFSEvAHIMPDDNTTFTAcIPYPQtdEMHPKIHSVLIFLVYFLIPLAIISI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRL-RGVRLLSG-----SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQP--SSETAVAILRFCT 224
Cdd:cd15125  188 YYYHIAKTLiKSAHNIPGeysehSKRQMETRKRLAKIVLVFVGLFAFCWFPNHVLYMYRSFNYNEidSSLGHMIVTLVAR 267
                        250       260
                 ....*....|....*....|....*
gi 768017218 225 ALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15125  268 VLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
1-246 6.18e-23

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 95.20  E-value: 6.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAldV 80
Cdd:cd15176   31 LKTKTDVYILNLAVADLLLLFTLPFWAADAVNG-WVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVAITKATSR--Q 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIptPQDYWGPVFA---ICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15176  108 FTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVF--PPSLVTSAKAtiqILEVLLGFVLPFLVMVFCYSRV 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVrllSGSReKDRNLRRITrlvlvvvavfvgcwTPVQVFVLAQ------------------GLGVQPSSETAVAI 219
Cdd:cd15176  186 ARALSRT---PNVK-KSRALKVLL--------------AVVGVFIVTQlpynvvkfyraidviyllITDCSMSKTLDIAI 247
                        250       260
                 ....*....|....*....|....*..
gi 768017218 220 lRFCTALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15176  248 -QVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
1-249 6.34e-23

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 95.62  E-value: 6.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15205   31 MRTATNIFICSLALSDLLItFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPV----FAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15205  111 QYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKYDFLYEKRHVCCLERWYSPTqqkiYTTFILVILFLLPLTTMLFLYS 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRL--------RGVRLLSGSREKDRNLRRITRLVLVVVAVFV---GCWTPVQVFVLA---QGLGVQPSSETAVAILR 221
Cdd:cd15205  191 RIGYELwikkrvgdASVLQTIHGIEMSKISRKKKRAVKMMVTVVLlfaVCWAPFHVVHMMieySNLENKYDGVTIKLIFA 270
                        250       260
                 ....*....|....*....|....*...
gi 768017218 222 FCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15205  271 IVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
2-246 7.56e-23

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 94.90  E-value: 7.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQgTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15186   32 KSITDIYLLNLALSDLLFVATLPFW-THYLINEWGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPvAIMGSAQVEDeeiECLVEIPTP-QDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15186  111 TVQHGVTISLGVWAAAILVAVP-QFMFTKMKEN---ECLGDYPEVlQEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQT 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LrgvrLLSGSREKDRNLRRITRLVLVVVAVfvgcWTPVQVFVLAQGL---------GVQPSSETAVAILRfctALGYVNS 231
Cdd:cd15186  187 L----FSCKNHKKARAIKLILLVVIVFFLF----WTPYNVMIFLETLklydffpscDMKKDLRLALSVTE---TIAFSHC 255
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15186  256 CLNPLIYAFAGEKFR 270
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
1-249 8.46e-23

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 94.84  E-value: 8.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD- 79
Cdd:cd15173   31 LRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHE-WIFGTVMCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNc 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 -VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEiptPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15173  110 hAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVY---PPDAIEVVVNIIQMTVGFFLPLLAMIICYSVII 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLrgvrLLSGSREKDRNLRRItrlvLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCT-ALGYVNSCLNPIL 237
Cdd:cd15173  187 KTL----LHAKGFQKHKSLKII----FVVVAVFILTQLPYNIMKLIRTLHIENTDSTNFKYAILITeAIAYLHACLNPIL 258
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15173  259 YAFVGVKFRKNF 270
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
1-246 9.41e-23

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 94.95  E-value: 9.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFqgtDILLGF----WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15131   31 MRTTTNLYLSSMAFSDLLIFLCMPL---DLYRLWqyrpWNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFPLR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  77 ALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVED--EEIECLVEIPTPQDYWGPVFAICIFLFS--FIVPVLVISV 152
Cdd:cd15131  108 AKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENgtNPIDTNECKATEYAVRSGLLTIMVWVSSvfFFLPVFCLTV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRL---RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFC----TA 225
Cdd:cd15131  188 LYSLIGRKLwrrRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEAGSLEIALISQYCnlvsFV 267
                        250       260
                 ....*....|....*....|.
gi 768017218 226 LGYVNSCLNPILYAFLDENFK 246
Cdd:cd15131  268 LFYLSAAINPILYNIMSKKYR 288
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
2-240 1.10e-22

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 94.80  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFqgTDILLGF---WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15197   32 KSRMNFFITQLAIADLCVGLINVL--TDIIWRItveWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 dvRTSSKAQAVNVAIWALASVVGVPVAIM-GSAQVEDEEIECLVEIPTPQdYWGPVFAICIFLFsFIVPVLVISVCYSLM 157
Cdd:cd15197  110 --QSGRQARVLICVAWILSALFSIPMLIIfEKTGLSNGEVQCWILWPEPW-YWKVYMTIVAFLV-FFIPATIISICYIII 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRL-----RGVRLLSGSREKDRNLRRITR------------LVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAIL 220
Cdd:cd15197  186 VRTIwkkskIQVTINKAGLHDGSSRRSSSRgiiprakiktikMTFVIVTVFIICWSPYFVFDLLDVFGLLPRSKTKIAAA 265
                        250       260
                 ....*....|....*....|
gi 768017218 221 RFCTALGYVNSCLNPILYAF 240
Cdd:cd15197  266 TFIQSLAPLNSAINPLIYCL 285
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
3-245 1.21e-22

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 94.32  E-value: 1.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRT 82
Cdd:cd15165   33 TESTIYMINLALNDLLLLLSLPFKMHSSKKQ-WPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  83 SSKAQAVNVAIWALASVVGVPVaimgsAQVEDE---EIECLVEIptPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15165  112 PRKAAIVCLTIWVFVWAGSIPI-----YSFHDKptnNTRCFHGF--SNKTWSKKVIVVVEEFGFLIPMAVMVFCSVQIIR 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRNLRRITRLVLVVVAVfvgCWTPVQV-----FVLAQGLGVQPSSETAVAI-LRFCTALGYVNSCL 233
Cdd:cd15165  185 TLLDMRRPEQPKVKQNKSVKIVLSNLVVFLV---CFTPYHLgiflqFLVKNDIINDCSTKQSIRLfVQVSMCLANVNCCL 261
                        250
                 ....*....|..
gi 768017218 234 NPILYAFLDENF 245
Cdd:cd15165  262 DAICYYFILKEF 273
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
1-249 1.38e-22

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 94.60  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15155   31 MRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTI 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQDYWGPVFAICIFL--FSFIVPVLVISVCYSLMI 158
Cdd:cd15155  111 RTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCF-EGFSKSIWKTYLSKITIFIevVGFIIPLLLNLTCSSLVL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRGVRLLSgsrEKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgVQPSSETAVAILRFCTA-------LGYVNS 231
Cdd:cd15155  190 RTLRKPATLS---QIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYAL-VRSQAIANCGVERFARTmypitlcLATLNC 265
                        250
                 ....*....|....*...
gi 768017218 232 CLNPILYAFLDENFKACF 249
Cdd:cd15155  266 CFDPFVYYFTSESFQKSF 283
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
4-238 1.98e-22

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 94.05  E-value: 1.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   4 ATNIYIFNLALADTLVLLTLPF------QGTDillgfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRA 77
Cdd:cd15373   34 ASTTYMFNLAISDTLYVLSLPLlvyyyaDEND-----WPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRS 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEClvEIPTPQDYWGP--VFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15373  109 LRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITC--HDTSSPELFDQfvVYSSVMLVLLFCVPFVVILVCYA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQV----FVLAQGLGVQPSSETAVAILRFCT-ALGYVN 230
Cdd:cd15373  187 LMVRKLLKPSAGTSTNSRSK--KKSVKMIIIVLAVFILCFLPFHVtrtlYYSFRSMDLSCGTLNAINLAYKVTrPLASAN 264

                 ....*...
gi 768017218 231 SCLNPILY 238
Cdd:cd15373  265 SCLDPILY 272
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
1-243 2.36e-22

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 93.76  E-value: 2.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15156   31 VRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKTL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGS--AQVEDEEIECLVEIptPQDYWGPVFA---ICIFLFSFIVPVLVISVCYS 155
Cdd:cd15156  111 RTKRNAKIVCAAVWLTVLAGSLPASFFQStnNQLNNNSETCFENF--SSKTWKTYLSkivIFIEIVGFFIPLILNVTCST 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSRekdRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLG-----VQPSSETAVAIL---RFCTALG 227
Cdd:cd15156  189 MVLKTLRRPNTLSRSK---LNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVrtqtfKNCSVVAAVRTMypiTLCIAVS 265
                        250
                 ....*....|....*.
gi 768017218 228 yvNSCLNPILYAFLDE 243
Cdd:cd15156  266 --NCCFDPIVYYFTSE 279
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
6-246 3.09e-22

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 93.59  E-value: 3.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTss 84
Cdd:cd14986   36 NIFILNLAIADLVVaFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSLDRYQAIVKPMSSLKPRK-- 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVP-VAIMGSAQVEDEEIECLVEIPTPqdyWGP-VFAICIFLFSFIVPVLVISVCYSLMIR--- 159
Cdd:cd14986  114 RARLMIVVAWVLSFLFSIPqLVIFVERELGDGVHQCWSSFYTP---WQRkVYITWLATYVFVIPLIILSYCYGRILRtiw 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 -RLRGVRLLSGSREKDRNLR----------------RITRLVLVVVAVFVGCWTP-VQVFVLAQGLGVQPSSETAVAILR 221
Cdd:cd14986  191 iRSRQKTDRPIAPTAMSCRSvscvssrvslisrakiKTIKMTLVIILAFILCWTPyFIVQLLDVYAGMQQLENDAYVVSE 270
                        250       260
                 ....*....|....*....|....*
gi 768017218 222 fctALGYVNSCLNPILYAFLDENFK 246
Cdd:cd14986  271 ---TLASLNSALNPLIYGFFSSHLS 292
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
1-249 4.14e-22

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 92.90  E-value: 4.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDiLLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15172   31 TKSMTDVYLLNMAIADILFVLTLPFWAVY-EAHQWIFGNFSCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKA--QAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDY----WGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15172  110 RSRTLAysKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVCEPKYPKNStaimWKLLVLSLQVSLGFFIPLLVMIFCY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLrgVRLLSGSREKdrnlrrITRLVLVVVAVFVGCWTPVQVFVLAQ----GLGVQPSSETAVAILRFCT-ALGYV 229
Cdd:cd15172  190 SFIIKTL--LQAQNSQRHK------AVRVVVAVVLVFLVCQVPYNIVLLIEainlGEQQSCSSEKAVAYAKTITeCLAFF 261
                        250       260
                 ....*....|....*....|
gi 768017218 230 NSCLNPILYAFLDENFKACF 249
Cdd:cd15172  262 HCCLNPVLYAFIGVKFRNYF 281
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-249 6.43e-22

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 92.02  E-value: 6.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15059   31 LRAPQNWFLVSLAVADILVgLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIM--GSAQVEDEEIECLVeiptpQDYWGPVFAICIflFSFIVPVLVISVCYslm 157
Cdd:cd15059  111 KRTPRRAKAMIAAVWIISAVISLPPLFGwkDEQPWHGAEPQCEL-----SDDPGYVLFSSI--GSFYIPLLIMIIVY--- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 irrlrgVRLLSGSREKDrnlRRITRLVLVVVAVFVGCWTPvqVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15059  181 ------ARIYRAAKRKE---RRFTLVLGVVMGAFVLCWLP--FFFTYPLVVVCKTCGVPELLFKFFFWLGYCNSALNPVI 249
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15059  250 YTIFNKDFRRAF 261
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-249 6.46e-22

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 92.26  E-value: 6.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15325   31 LQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGV-PVAIMGSAQVEDEEIECLVEIPTpqdywgpvFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15325  111 IMTERRGLLALLCVWVLSLVISIgPLFGWKEPAPEDETICQITEEPG--------YALFSALGSFYLPLAIILVMYCRVY 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 rrlrgVRLLSGSREKdrnlrRITRLVLVVVAVFVGCWTPvqvFVLAQGLG-VQPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15325  183 -----VVALKFSREK-----KAAKTLGIVVGCFVLCWLP---FFLVMPIGsIFPAYKPSDTVFKITFWLGYFNSCINPII 249
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15325  250 YPCSSQEFKKAF 261
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
7-247 6.72e-22

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 92.45  E-value: 6.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15160   37 VYLLNLSLSDLLYILTLPLWIDYTANHHnWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRF 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEiPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVR 165
Cdd:cd15160  117 ALKVSASIWVLELGTHSVFLGHDELFRDEPNHTLCYE-KYPMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSP 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 166 LLSGSREkdrnlRRITRLVLVVVAVFVGCWTPVQV--FVLAQGLGVQP---SSETAVAIL-RFCTALGYVNSCLNPILYA 239
Cdd:cd15160  196 SLEREEK-----RKIIGLLLSIVVIFLLCFLPYHVvlLVRSVIELVQNglcGFEKRVFTAyQISLCLTSLNCVADPILYI 270

                 ....*...
gi 768017218 240 FLDENFKA 247
Cdd:cd15160  271 FVTEDVRQ 278
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
3-249 7.17e-22

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 92.01  E-value: 7.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15064   33 TPANYLIASLAVADLLVaVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEiptpQDYWGPVFAICIflfSFIVPVLVISVCYSLMIRrl 161
Cdd:cd15064  113 TPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLIS----QDIGYTIFSTFG---AFYIPLLLMLILYWKIYR-- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 rgvrllSGSREkdrnlRRITRLVLVVVAVFVGCWTPVqvFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFL 241
Cdd:cd15064  184 ------AAARE-----RKAAKTLGIILGAFIVCWLPF--FLVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFF 250

                 ....*...
gi 768017218 242 DENFKACF 249
Cdd:cd15064  251 NKDFRKAF 258
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
1-247 7.18e-22

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 92.50  E-value: 7.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDIL-LGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAl 78
Cdd:cd15394   31 MHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFePRGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIAVDRYYVTVYPLRR- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 dvRTSSKAQA-VNVAIWALASVVGVPVAIMG-SAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd15394  110 --RISRRTCAyIVAAIWLLSCGLALPAAAHTyYVEFKGLDFSICEEFWFGQEKQRLAYACSTLLITYVLPLLAISLSYLR 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLRGvRLLSGS-----REKDRNLRRIT-RLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRF-CTALGYV 229
Cdd:cd15394  188 ISVKLRN-RVVPGSmtqsqAEWDRARRRKTfRLLVVVVVAFAICWLPLHIFNVIRDIDIDLIDKQYFNLIQLlCHWLAMS 266
                        250
                 ....*....|....*...
gi 768017218 230 NSCLNPILYAFLDENFKA 247
Cdd:cd15394  267 SACYNPFLYAWLHDSFRG 284
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
7-240 7.72e-22

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 92.52  E-value: 7.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15369   37 IYMLNLACADLLFVLLLPFKIAYHFSGNdWLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSA-QVEDEEIECLVEIPTPQD---YWGPVFAICIFLFsFIVPVLVISVCYSLMIRRL 161
Cdd:cd15369  117 ASFTCAAIWLLSIAGVVPLLLSEQTiQIPDLGITTCHDVLNEQLlmgYYVYYFSIFSCLF-FFVPLIITTVCYVSIIRCL 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 RGVRLLSGSREKDRNLrritRLVLVVVAVFVGCWTPVQVFVLAQ--GLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15369  196 SSSSDVANSSKKTRAL----FMAVAVFCVFVICFGPTNVLLLAHyvRFAYTSTNDASYFAYLLCVCVGSISCCLDPLIYY 271

                 .
gi 768017218 240 F 240
Cdd:cd15369  272 Y 272
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
1-249 8.46e-22

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 91.65  E-value: 8.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15061   30 LRTITNCYIVSLATADLLVgVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRT 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEClvEIPTPQDYwgpvfAICIFLFSFIVPVLVISVCYslmir 159
Cdd:cd15061  110 KRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSC--YYTYDKGY-----RIYSSMGSFFLPLLLMLFVY----- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rLRGVRLLsgSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSEtavAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15061  178 -LRIFRVI--AKE-----RKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCDCQFSE---ALSTAFTWLGYFNSVINPFIYA 246
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15061  247 FYNKDFRRAF 256
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
1-249 1.03e-21

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 92.29  E-value: 1.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15123   31 MQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMG-----SAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15123  111 SDAVLKTCCKAGCVWIVSMLFAIPEAVFSdlysfRDPEKNTTFEACAPYPVSEKILQEIHSLLCFLVFYIIPLSIISVYY 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGVRL------LSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGL----GVQPSSETAVAILrFCT 224
Cdd:cd15123  191 FLIARTLYKSTFnmpaeeHSHARKQIESRKRVAKTVLVLVALFAFCWLPNHILYLYRSFtyhtSVDSSAFHLIATI-FSR 269
                        250       260
                 ....*....|....*....|....*
gi 768017218 225 ALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15123  270 VLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
1-249 1.26e-21

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 91.18  E-value: 1.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15329   31 LRTPSNYLIVSLAVSDLLVaLLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIECLVEiptpQDYWGPVFAIcifLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15329  111 KRTPKRMALMIAIVWLLSALISIP-PLFGWKNKVNDPGVCQVS----QDFGYQIYAT---FGAFYIPLIVMLVLYYKIYR 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgvrllSGSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQG-LGVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15329  183 --------AAKSE-----RKAIKTLGIIMGAFTLCWLPFFILALLRPfLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIY 249
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15329  250 AKFNREFRTPF 260
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
2-246 1.31e-21

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 91.77  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILlGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15188   33 KKMTEVYLLNLAVSDLLFLVTLPFWAMYVA-WHWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAI-MGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSlmirr 160
Cdd:cd15188  112 TRRKSLLVLVAVWVLSIALSVPDMVfVQTHHTNNGVWVCHADYGGHHTIWKLVFQFQQNLLGFLFPLLAMVFFYS----- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 lRGVRLLSGSREKdrNLRRITRLVLVVVAVFVGCWTPVQVFV---LAQGLGVQPSSETAVAI---LRFCTALGYVNSCLN 234
Cdd:cd15188  187 -RIACVLTRLRPP--GQGRALRFVAALVVVFFVLWFPYNLTLflhSLQDLHVIGNCERSRHLdyaLQVTESLAFVHCCLN 263
                        250
                 ....*....|..
gi 768017218 235 PILYAFLDENFK 246
Cdd:cd15188  264 PLLYAFVSKRFR 275
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
5-246 1.38e-21

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 91.74  E-value: 1.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLVLLTLPFQGTDIL-LGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd14987   35 THLYILNLAIADLCVVATLPVWVVSLVqHNQWPMGEFTCKITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDY---WGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd14987  115 IVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEESfkeWLIGMELVSIVLGFVIPFPIIAVFYFLLARA 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRgvrllSGSREKDRNLRRITRLVLVVVAVfvgCWTPVQVFVLAQG---LGVQPSS---ETAV-AILRFCTALGYVNSCL 233
Cdd:cd14987  195 IS-----ASSDQERKSSRKIIFSYVVVFLV---CWLPYHTVVLLDIlsfLHLIPFScqlENFLyAALHVTQCFSLVHCCV 266
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd14987  267 NPILYSFINRNYR 279
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
1-246 1.54e-21

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 93.54  E-value: 1.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQgtdILLGF--WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:PHA02638 128 IKTITDIYIFNLAISDLIFVIDFPFI---IYNEFdqWIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQ 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIM-------GSAQVEDEEI---ECLVEIPTPQD---YWGPVFAICIFLFSFIV 145
Cdd:PHA02638 205 KYRTFNIGIILCIISWILSLIITSPAYFIfeasniiFSAQDSNETIsnyQCTLIEDNEKNnisFLGRILQFEINILGMFI 284
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 146 PVLVISVCYSLMIRRLRGVRllsgSREKDRNLRRITRLVLVVVAvfvgCWTPVQVFVLAQGLGVQPS-----SETAVAIL 220
Cdd:PHA02638 285 PIIIFAFCYIKIILKLKQLK----KSKKTKSIIIVSIIIICSLI----CWIPLNIVILFATMYSFKGfnsiiSEHICGFI 356
                        250       260       270
                 ....*....|....*....|....*....|..
gi 768017218 221 R------FCTALGYVNSCLNPILYAFLDENFK 246
Cdd:PHA02638 357 KlgyammLAEAISLTHCCINPLIYTLIGENFR 388
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
3-246 2.95e-21

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 90.97  E-value: 2.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTD-ILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd16001   33 TCSTIYLVNLAVADLLYVCSLPLLIVNyAMRDRWPFGDFLCKLVRFLFYTNLYGSILFLTCISVHRFLGVCYPIRSLAYR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQDYWGP-VFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd16001  113 TRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCY-DLTSPDNFGNYfPYGMVLTVTGFLIPFLIILLCYCLMIKS 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 L--RGVRLLSGSREKDRNLRRITRLVLVVVAvfvgCWTPVQV------FVLAQGLGVQPSSETAVAILRFCTALGYVNSC 232
Cdd:cd16001  192 LirSEEAAGVGKAARAKSIRTILLVCGLFAL----CFVPFHItrtiylFVRVYLVQDCPLLQFVSLAYKIWRPLVSFNSC 267
                        250
                 ....*....|....
gi 768017218 233 LNPILYAFLDENFK 246
Cdd:cd16001  268 INPLLYFLSGDSNR 281
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
2-246 5.76e-21

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 89.85  E-value: 5.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15153   32 KNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHPFKARDWK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAqAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIF--LFSFIVPVLVISVCYSLMIR 159
Cdd:cd15153  112 RRYDV-GISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFGAAIAMMTVaeLFGFVIPLFIIAWCTWKTEN 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLR-GVRLLSGSREKDRNLRRITRLVLVVVAvfvgCWTPVQV---FVLAQGLGVQPSSETAVAILRF---CTALGYVNSC 232
Cdd:cd15153  191 SLRqRNKQQQSTSEKQKALRMVRMCAAVFFI----CFAPYHInflFYLMVSESIITNCEVSQVILQFhpiSLCLASLNCC 266
                        250
                 ....*....|....
gi 768017218 233 LNPILYAFLDENFK 246
Cdd:cd15153  267 LDPILYYFMTSEFQ 280
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-249 5.82e-21

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 89.47  E-value: 5.82e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15062   31 LRTPTHYFIVNLAVADLLLSFTvLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPtpqdywgPVFAICIFLFSFIVPVLVISVCYSLMIr 159
Cdd:cd15062  111 IVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGVNEE-------PGYVLFSSLGSFYLPLAIILVMYCRVY- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgVRLLSGSREKdrnlrRITRLVLVVVAVFVGCWTPvqvFVLAQGLG-VQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15062  183 ----VVAFKFSREK-----KAAKTLGIVVGAFVLCWFP---FFVVLPLGsLFSTLKPPEPVFKVVFWLGYFNSCLNPIIY 250
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15062  251 PCSSREFKRAF 261
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
3-251 1.54e-20

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 89.03  E-value: 1.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGnALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15057   34 KVTNYFIVSLAVSDLLVaILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIMCSTASILNLCVISVDRYWAISSPFRYERRM 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVpVAIMGSAQVEDEEIECLVEIPTPQD---YWGPVFAICIFLFSFIVPVLVISVCYSLM- 157
Cdd:cd15057  113 TRRRAFIMIAVAWTLSALISF-IPVQLGWHRADDTSEALALYADPCQcdsSLNRTYAISSSLISFYIPVAIMIVTYTRIy 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 ------IRRL-----RGVRLLSGSREKDRNLRRITRLVLVVVAVF---VGCWTPVqvFVLAQGL---GVQPSSETAV--A 218
Cdd:cd15057  192 riarrqIRRIaalerAAQESTNPDSSLRSSLRRETKALKTLSIIMgvfVCCWLPF--FILNCVLpfcDLRTAQFPCVpdT 269
                        250       260       270
                 ....*....|....*....|....*....|...
gi 768017218 219 ILRFCTALGYVNSCLNPILYAfldenFKACFRK 251
Cdd:cd15057  270 TFIVFVWLGWANSSLNPIIYA-----FNADFRK 297
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
1-249 2.10e-20

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 88.39  E-value: 2.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15978   31 MRTVTNIFLLSLAVSDlMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTFNLVAISLERYSAICKPLKSRV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSA---QVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd15978  111 WQTKSHALKVIAATWCLSFTIMLPYPIYSNLvpfTRINNSTGNMCRLLWPNDVTQQSWYIFLLLILFLIPGIVMMTAYGL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRL-RGVRLLSGSrekdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLG-VQPSSETAVAILRFCTALGYVNSCLN 234
Cdd:cd15978  191 ISLELyRGIKFLMAK-------KRVIRMLIVIVILFFLCWTPIFSANAWRAFDtRSADRLLSGAPISFIHLLSYTSACVN 263
                        250
                 ....*....|....*
gi 768017218 235 PILYAFLDENFKACF 249
Cdd:cd15978  264 PIIYCFMNKRFRMGF 278
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-244 2.44e-20

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 88.49  E-value: 2.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQgTD---ILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15204   31 LRTLTNLLIANLALSDFLVaVFCLPFE-MDyyvVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLK 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  77 ALDVRTSskAQAVNVAIWALASVVGVPVAIMGSA--QVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15204  110 PRMKRRT--ACVVIALVWVVSLLLAIPSAVYSKTtpYANQGKIFCGQIWPVDQQAYYKAYYLFLFVLEFVLPVLIMTLCY 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGvRLLSGS-----REKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGL--GVQPSSETAVAILRFCTALG 227
Cdd:cd15204  188 LRIVRKVWF-RRVPGQqteqiRRRLRRRRRKVRLLVVILTAFVLCWAPYYGYAIVRDFfpTLLSKEKLNTTIFYIVEALA 266
                        250
                 ....*....|....*..
gi 768017218 228 YVNSCLNPILYAFLDEN 244
Cdd:cd15204  267 MSNSMINTVVYVAFNNN 283
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
1-249 2.51e-20

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 88.25  E-value: 2.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIC--HPIRA 77
Cdd:cd14977   31 MRSVPNILIASLALGDLLLLLLcVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVnsMPMQT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKAQAvnVAIWALASVVGVPVAImgsaqvedeeiecLVEIPTPQDYWGPVFAICI------------------- 138
Cdd:cd14977  111 IGACLSTCVKL--AVIWVGSVLLAVPEAV-------------LSTVARESSLDNSSLTVCImkpstpfaetypkarswwl 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 139 FLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDR--NLRRITRLVLVVVAVFVGCWTPVQV-----FVLAQGLGVQP 211
Cdd:cd14977  176 FGCYFCLPLAFTAVCYLLMARTLIRAAKEYTRGTKKHmkQRRQLAKTVLCLVLVFAFCWLPEHIsnilrATLYNEVLIDT 255
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 768017218 212 SSETAVAILrFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd14977  256 RSTLDILDL-IGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
1-249 4.05e-20

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 87.56  E-value: 4.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15979   31 LRTVTNSFLLSLALSDLMLaVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQ---VEDEEI--ECLVEIPTPQDYwgPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15979  111 WQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVpvpVGDRPRghQCRHAWPSAQVR--QAWYVLLLLILFFIPGVVMIVAY 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMirrlrgvrllsgSREKDRNL---RRITRLVLVVVAVFVGCWTPVQVFVLAQGLGvQPSSETAV--AILRFCTALGYV 229
Cdd:cd15979  189 GLI------------SRELYRGLlakKRVIRMLVVIVAMFFLCWLPIFSANTWRAFD-PLSAHRALsgAPISFIHLLSYT 255
                        250       260
                 ....*....|....*....|
gi 768017218 230 NSCLNPILYAFLDENFKACF 249
Cdd:cd15979  256 SACVNPLVYCFMNRRFRKAF 275
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
1-248 5.18e-20

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 87.11  E-value: 5.18e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15012   30 MRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPsWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVP-------VAIMGSAQVEDEEIECLVEiptpQDYWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15012  110 LLTAARLRVTIVTVWLTSAVYNTPyfvfsqtVEILVTQDGQEEEICVLDR----EMFNSKLYDTINFIVWYLIPLLIMTV 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMirrlrGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGV-QPSSETAVAILRFCTAL-GYVN 230
Cdd:cd15012  186 LYSKI-----SIVLWKSSSIEAR--RKVVRLLVAVVVSFALCNLPYHARKMWQYWSEpYRCDSNWNALLTPLTFLvLYFN 258
                        250
                 ....*....|....*...
gi 768017218 231 SCLNPILYAFLDENFKAC 248
Cdd:cd15012  259 SAVNPLLYAFLSKRFRQS 276
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
4-249 5.51e-20

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 86.98  E-value: 5.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   4 ATNIYIFNLALADTLV-LLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15052   34 VTNYFLMSLAIADLLVgLLVMPLSILTELFGGvWPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVED--EEIECLVEIPtpqdywgpVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15052  114 SRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNvlNNGTCVLFNP--------NFVIYGSIVAFFIPLLIMVVTYALTIR 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRgvrllsgsrekdrNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15052  186 LLS-------------NEQKASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRISPWLLSVFVWLGYVSSTINPIIYT 252
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15052  253 IFNKTFRRAF 262
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
4-248 5.75e-20

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 87.33  E-value: 5.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   4 ATNIYIFNLALADTLVLLTL-PFQGTDILLGFWPFGNALCKtviaidYYNMFTSTF------TLTAMSVDRYVAICHPIR 76
Cdd:cd15074   34 PAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGCV------FYGFCGFLFgccsinTLTAISIYRYLKICHPPY 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  77 ALDVrTSSKAQAVNVAIWALASVVGV-PVAIMGSAQVEDEEIECLVEIPTPQDYW-GPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15074  108 GPKL-SRRHVCIVIVAIWLYALFWAVaPLVGWGSYGPEPFGTSCSIDWTGASASVgGMSYIISIFIFCYLLPVLIIVFSY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGVRLL---SGSREKDRNL--RRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILrfCTALGYV 229
Cdd:cd15074  187 VKIIRKVKSSRKRvagFDSRSKRQHKieRKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDSVPILASIL--PALFAKS 264
                        250
                 ....*....|....*....
gi 768017218 230 NSCLNPILYAFLDENFKAC 248
Cdd:cd15074  265 SCMYNPIIYLLFSSKFRQD 283
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
1-249 6.42e-20

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 87.13  E-value: 6.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15154   31 LHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSA---QVEDEEIECLVEIPTPQDyWGPVFAICIF--LFSFIVPVLVISVCYS 155
Cdd:cd15154  111 RRPKVARLLCLAVWALILGGSVPAAIVHSSsdcLLHGEKVYRCFESFSDND-WKGLLPLVVLaeILGFLLPLAAVLYCSC 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGL-------GVQPSSETAVAILRFCTALGY 228
Cdd:cd15154  190 RIFVELCRTQEPQQGRR-----RKTVRLLLVNLVIFLICFVPYNTTLAVYGLlranlveDTWNIKDTLRKVLSVTVLLAS 264
                        250       260
                 ....*....|....*....|.
gi 768017218 229 VNSCLNPILYAFLDENFKACF 249
Cdd:cd15154  265 TNCALDPLVYYFSTEGFRNTL 285
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 1.26e-19

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 86.14  E-value: 1.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAld 79
Cdd:cd16003   31 MRTVTNYFLVNLAFSDaSMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPLKP-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vRTSSKAQAVNV-AIWALASVVGVPVAIMGSAQVEDEEIECLVEIP-TPQDYWgpVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd16003  109 -RLSATATKVVIgSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPgGPDQHF--TYHIIVIVLVYCLPLLVMGITYTIV 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGS----REKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTA-LGYVNSC 232
Cdd:cd16003  186 GITLWGGEIPGDTsdkyHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQLNRWKYIQQVYLASFwLAMSSTM 265
                        250
                 ....*....|....*..
gi 768017218 233 LNPILYAFLDENFKACF 249
Cdd:cd16003  266 YNPIIYCCLNKRFRAGF 282
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
2-247 1.77e-19

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 85.60  E-value: 1.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15365   32 KNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDnWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVpVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSlmiRR 160
Cdd:cd15365  112 RTIRTALSVSVAIWLLEICFNA-VILTWEDSFHESSSHTLCYDKFPLEDWQARLNLFRICLGYLLPLLIILFCYW---KI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGL---GVQPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15365  188 YQAVRSNQATEDQEK--KKIFKLLLLITVTFVICFTPYHVVLLIRSIvepCDCRNAKWLYTLYKITVALTSLNCIADPFL 265
                        250
                 ....*....|
gi 768017218 238 YAFLDENFKA 247
Cdd:cd15365  266 YCFVTESGRA 275
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
1-251 1.87e-19

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 85.77  E-value: 1.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15307   31 LQNVTNYFLMSLAITDLMVaVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPqdywgpVFAICIFLFSFIVPVLVISVCYSLMir 159
Cdd:cd15307  111 NKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIPDP------VYKLVGSIVCFYIPLGVMLLTYCLT-- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgVRLLSGSREKD-RNLR---RITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNP 235
Cdd:cd15307  183 ----VRLLARQRSRHgRIIRleqKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNP 258
                        250
                 ....*....|....*.
gi 768017218 236 ILYAFLDENFKACFRK 251
Cdd:cd15307  259 IFYTIFNKVFRQAFKK 274
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
1-249 2.11e-19

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 85.68  E-value: 2.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLL-TLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15357   31 MKTPTNYYLFSLAVSDLLVLLfGMPLEVYEMWSNYpFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAILHPFRAK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVP-VAIMGSAQ--------VEDEEIECLVEiptPQDYWGPVFAICIFLFsFIVPVLV 149
Cdd:cd15357  111 LNSTRERALKIIVVLWVLSVLFSIPnTSIHGIKLqyfpngtlIPDSATCTVVK---PLWIYNLIIQITSLLF-YVLPMGV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 150 ISVCYSLMIRRLRGVRLLSgSREKDRNLRR-----ITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVA---ILR 221
Cdd:cd15357  187 ISVLYYLMGLKLRGDKSLE-ADEMNVNIQRpsrksVTKMLFVLVLVFAICWAPFHVDRLFFSFVVEWTEPLANVfnlIHV 265
                        250       260
                 ....*....|....*....|....*...
gi 768017218 222 FCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15357  266 VSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-249 3.42e-19

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 84.97  E-value: 3.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15321   37 LRAPQNLFLVSLAAADILVaTLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNS 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQveDEEIECLVEIPTPQDYWgpvFAICIFLFSFIVPVLVISVCYslmir 159
Cdd:cd15321  117 KRTPRRIKCIILIVWLIAAVISLPPLIYKGKQ--KDEQGGLPQCKLNEEAW---YILSSSIGSFFAPCLIMILVY----- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rLRgVRLLSGSREKdrnlrRITRLVLVVVAVFVGCWTPvqvFVLAQGLGVQPSSETAV--AILRFCTALGYVNSCLNPIL 237
Cdd:cd15321  187 -LR-IYLIAKNREK-----RFTFVLAVVIGVFVLCWFP---FFFSYSLGAICPELCKVphSLFQFFFWIGYCNSSLNPVI 256
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15321  257 YTIFNQDFRRAF 268
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
2-246 3.85e-19

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 84.81  E-value: 3.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14991   32 WKANTVYLFNLVLADFLLLICLPFRIDYYLRGeHWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIptpqDYWGPVFAICI----FLFSFIVPVLVISVCYSL 156
Cdd:cd14991  112 MSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFS----SYTKPSLSIRWhnalFLLEFFLPLGLIVFCSVR 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLRgvrlLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLA----QGLGVQPSSETAVAILRFCTALGYVNSC 232
Cdd:cd14991  188 IACNLR----IRQSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAGLLalvfKNLGSCRCLNSVAQLFHISLAFTYLNSA 263
                        250
                 ....*....|....
gi 768017218 233 LNPILYAFLDENFK 246
Cdd:cd14991  264 LDPVIYCFSSPWFR 277
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
1-249 5.33e-19

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 84.33  E-value: 5.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKT--ATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRA 77
Cdd:cd15201   29 LKSwkSSTVYLFNLAVADFLLIICLPFRTDYYLRGKhWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKAQAVNVAIWALasvvgvpvAIMGSAQVEDEEIECLVEIPTPQDywgpVFAIC------------IFLFSFIV 145
Cdd:cd15201  109 INSISVRKAAIIACGLWLL--------TIAMTVYLLTKKHLFPRGNATQCE----SFNICtgtdsssnwheaMFLLEFFL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 146 PVLVISVCYSLMIRRLRGVRLlsgsrEKDRNLRRITRLVLVVVAVFVGCWTP-----VQVFVLAQGLGVQPSSETAVAIL 220
Cdd:cd15201  177 PLAIILYCSVRIIWQLRGRQL-----DRHAKIKRAVQFIMVVAIVFIICFLPsnvtrIAIWILKHTSNEDCQYYRSVDLA 251
                        250       260       270
                 ....*....|....*....|....*....|
gi 768017218 221 RFCT-ALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15201  252 FYITiSFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
3-246 5.80e-19

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 84.58  E-value: 5.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLP------FQGTDillgfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15377   33 SGISVYMFNLALADFLYVLTLPalifyyFNKTD-----WIFGDAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLK 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  77 ALDVRTSSKAQAVNVAIWALASVVGVPVAIM-GSAQVEDEEIECLveiPTPQDYWGP---VFAICIFLFSFIVPVLVISV 152
Cdd:cd15377  108 SLGRLKKKNAICISVLVWLIVVVAISPILFYsGTGVRKNKTITCY---DTTSDEYLRsyfIYSMCTTVAMFCVPFILILG 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRLRgVRLLSGSREKDRNLRRITRLVLVVVAVFVGC-WTPVQVFV---LAQGLGVQPSSETAV-----AILRFC 223
Cdd:cd15377  185 CYGLIVRALI-YKDMKYTEENNAPLRRKSIYLVIIVLTVFAVsYLPFHVMKtlnLRARLDFQTPAMCAFndrvyATYQVT 263
                        250       260
                 ....*....|....*....|...
gi 768017218 224 TALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15377  264 RGLASLNSCVDPILYFLAGDTFR 286
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
1-249 9.47e-19

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 83.89  E-value: 9.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15048   31 LRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE---CLVEIptpQDYWGPVFAICIflFSFIVPVLVISVCYSL 156
Cdd:cd15048  111 KQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIVPtgdCEVEF---FDHFYFTFITSV--LEFFIPFISVSFFNLL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 M---------IRRLRGVRLLSGSREKDRNL-----------RRITRLVLVVVAVFVGCWTPVQVFVLAqgLGVQPSSETA 216
Cdd:cd15048  186 IylnirkrsrRRPLRSVPILPASQNPSRARsqreqvklrrdRKAAKSLAILVLVFLICWAPYTILTII--RSFCSGSCVD 263
                        250       260       270
                 ....*....|....*....|....*....|...
gi 768017218 217 VAILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15048  264 SYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
6-240 1.00e-18

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 83.44  E-value: 1.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLL--TLPFQGTDILLGFWPfGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15196   36 HLFILHLSVADLLVALfnVLPQLIWDITYRFYG-GDLLCRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAiWALASVVGVP-VAIMGSAQVEDEEIECLVEIPTPqdyWGPVFAICIFLFS-FIVPVLVISVCYSLMIR-- 159
Cdd:cd15196  115 RVHLMVAIA-WVLSLLLSIPqLFIFSYQEVGSGVYDCWATFEPP---WGLRAYITWFTVAvFVVPLIILAFCYGRICYvv 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 ---RLRGVRLlsgsrekdrnlrritrlVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILrfCTALGYVNSCLNPI 236
Cdd:cd15196  191 wraKIKTVKL-----------------TLVVVACYIVCWTPFFVVQMWAAWDPTAPIEGPAFVI--IMLLASLNSCTNPW 251

                 ....
gi 768017218 237 LYAF 240
Cdd:cd15196  252 IYLA 255
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
1-249 1.15e-18

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 83.72  E-value: 1.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALD 79
Cdd:cd15399   31 MRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLTVIALDRHRCI---VYHLE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAI-WALASVVGVPVAIMGSAQVEDEEIE-----CLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15399  108 SKISKKISFLIIGLtWAASALLASPLAIFREYSVIEISPDfkiqaCSEKWPNGTLNDGTIYSVSMLLIQYVLPLAIISYA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRLLSGSREKDRNLRR-ITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSS-------ETAVAILRFCTA 225
Cdd:cd15399  188 YIRIWTKLKNHVSPGGGNDHYHQRRRkTTKMLVCVVVVFAVSWLPFHAFQLASDIDSKVLDlkeykliYTIFHVIAMCST 267
                        250       260
                 ....*....|....*....|....
gi 768017218 226 LgyvnscLNPILYAFLDENFKACF 249
Cdd:cd15399  268 F------ANPLLYGWMNNNYRTAF 285
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
1-249 1.19e-18

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 84.05  E-value: 1.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQgtdiLLGFW---PF--GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHP 74
Cdd:cd15358   31 MRTPTNYYLFSLAVSDLLVLLLgMPLE----LYEMWsnyPFllGAGGCYFKTLLFETVCFASILNVTALSVERYIAVVHP 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  75 IRALDVRTSSKAQAVNVAIWALASVVGVP---------VAIMGSAQVEDEEIECLVEiptPQDYWGPVFAICIFLFsFIV 145
Cdd:cd15358  107 LKAKYVVTRTHAKRVIGAVWVVSILCSIPntslhgifqLTVPCRGPVPDSATCMLVK---PRWMYNLIIQITTLLF-FFL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 146 PVLVISVCYSLMIRRLRGVRLLSG----------------SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGV 209
Cdd:cd15358  183 PMGTISVLYLLIGLQLKREKMLLVleakgskagdsyqhrrIQQEKRRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFIS 262
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 768017218 210 QPSSETAVAILRFCTALG---YVNSCLNPILYAFLDENFKACF 249
Cdd:cd15358  263 QWTGELHLAFQYVHIISGvffYLSSAANPVLYNLMSTRFREMF 305
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
1-249 1.30e-18

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 83.14  E-value: 1.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15049   31 LRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPvAIMGSAQVEDE----EIECLVeiptpQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15049  111 KRTPKRAILMIALAWVISFVLWAP-AILGWQYFVGErtvpDGQCYI-----QFLDDPAITFGTAIAAFYLPVLVMTILYW 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMirrlrgvrllsgSREKDRNlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFctaLGYVNSCLNP 235
Cdd:cd15049  185 RI------------YRETARE-RKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLWSFGYW---LCYINSTINP 248
                        250
                 ....*....|....
gi 768017218 236 ILYAFLDENFKACF 249
Cdd:cd15049  249 FCYALCNKTFRKTF 262
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
3-240 1.39e-18

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 83.69  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLL-----------TLPFQGTDillgfwpfgnALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAI 71
Cdd:cd15386   33 SRMHLFVLHLALTDLVVALfqvlpqliweiTYRFQGPD----------LLCRAVKYLQVLSMFASTYMLIMMTVDRYIAV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  72 CHPIRALDvRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEE---IECLVEIPTPqdyWGPVFAICIFLFS-FIVPV 147
Cdd:cd15386  103 CHPLRTLQ-QPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQGsgvLDCWADFGFP---WGAKAYITWTTLSiFVLPV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 148 LVISVCYSLMIRRL-RGVRLLS-GSREKDRNLR-------------------RITRLVLVVVAVFVGCWTPvqvFVLAQG 206
Cdd:cd15386  179 AILIVCYSLICYEIcKNLKGKTqTSRSEGGGWRtqgmpsrvssvrtisrakiRTVKMTFVIVLAYIACWAP---FFSVQM 255
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 768017218 207 LGV----QPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15386  256 WSVwdenAPDEDSSDFAFTITMLLASLSSCCNPWIYMF 293
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
2-246 1.39e-18

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 83.28  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15368   32 KTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRW 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMG-SAQVEDEEI----ECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15368  112 RKKRYAVAACIGMWLLVLTALSPLERTDlTYYVKELNIttcfDVLKWTMLPNIAAWAAFLFTLFILLFLIPFIITVYCYV 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSREKdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNP 235
Cdd:cd15368  192 LIILKLVQTSERYGREQK----RRAIYLALIVLLVFITCFAPNNFILLAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDP 267
                        250
                 ....*....|.
gi 768017218 236 ILYAFLDENFK 246
Cdd:cd15368  268 FIYYFASKEFR 278
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
3-251 1.95e-18

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 82.99  E-value: 1.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15055   33 TPTNLLLLSLAVADFLVgLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVaIMGSAQVEDEEI------ECLVEIPTPqdyWGpvfaICIFLFSFIVPVLVISVCYS 155
Cdd:cd15055  113 TIRRVKICICLCWFVSALYSSVL-LYDNLNQPGLIRynscygECVVVVNFI---WG----VVDLVLTFILPCTVMIVLYM 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 ---LMIRR-LRGVRLLSGSREKDRNLRRITRLVLVVVAVFVG--------CWTPVQVFVLaqglgVQPSSETAVAILRFC 223
Cdd:cd15055  185 rifVVARSqARAIRSHTAQVSLEGSSKKVSKKSERKAAKTLGivvgvfllCWLPYYIVSL-----VDPYISTPSSVFDVL 259
                        250       260
                 ....*....|....*....|....*...
gi 768017218 224 TALGYVNSCLNPILYAFldenFKACFRK 251
Cdd:cd15055  260 IWLGYFNSCLNPLIYAL----FYPWFRK 283
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
1-249 1.99e-18

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 82.68  E-value: 1.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15323   31 LRAPQNLFLVSLASADILVaTLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI-ECLVEiptpQDYWgPVFAICIflFSFIVPVLVISVCYSLMI 158
Cdd:cd15323  111 KRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYpQCKLN----DETW-YILSSCI--GSFFAPCLIMILVYIRIY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RrlrgvrlLSGSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPsSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15323  184 R-------VAKAREK-----RFTFVLAVVMGVFVVCWFPFFFSYSLYGICREA-CEVPEPLFKFFFWIGYCNSSLNPVIY 250
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15323  251 TIFNQDFRRSF 261
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
1-249 2.07e-18

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 82.54  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15063   31 LRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITRPIRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVE-------DEEIECLVEIPTpqdywGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15063  111 LMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDgimdysgSSSLPCTCELTN-----GRGYVIYSALGSFYIPMLVMLF 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRrlrgvrllSGSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVLaqglgVQPSSETAVAILRFCTA--LGYVN 230
Cdd:cd15063  186 FYFRIYR--------AARMET-----KAAKTVAIIVGCFIFCWLPFFTVYL-----VRAFCEDCIPPLLFSVFfwLGYCN 247
                        250
                 ....*....|....*....
gi 768017218 231 SCLNPILYAFLDENFKACF 249
Cdd:cd15063  248 SALNPCIYALFSRDFRFAF 266
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
7-249 2.30e-18

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 82.82  E-value: 2.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15375   37 IIMLNLALTDLLYVTSLPFLIYYYINGeSWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRW 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECL--VEIPTPQDYWgpVFAICIFLFSFIVPVLVISVCYSLMIRRL-R 162
Cdd:cd15375  117 AIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLdfTSSDNLNTIW--WYNWILTVLGFLLPLVIVTLCYTRIIYTLaK 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 163 GVRLLSGSREKDRnlrritRLVLVVVAVFVGCWTPVQVFVLA----QGLGVQPSSETAV-AILRFCTALGYVNSCLNPIL 237
Cdd:cd15375  195 GPHTGSASKQKAR------RLIILILLVFYVCFLPFHILRVVrietRLPPVSCCLKHQVhAIYIITRPLAALNTFGNLLL 268
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15375  269 YVVSGDNFQQAF 280
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
1-249 2.97e-18

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 82.64  E-value: 2.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALD 79
Cdd:cd15124   31 MRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAI---VRPMD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVA---IWALASVVGVPVAIMGSAQVEDEE------IEClVEIPTPQDYWGPVFAICIFLFSFIVPVLVI 150
Cdd:cd15124  108 IQASNALMKICLKaalIWILSMLLAIPEAVFSDLHPFYDKstnktfVSC-APYPHSNELHPKIHSMASFLIFYVIPLSII 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 151 SVCYSLMIRRL------RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVqpsSETAVAILRFCT 224
Cdd:cd15124  187 SVYYYFIAKNLirsaynLPVEGNVHVRRQIESRKRLAKTVLVFVGLFAFCWLPNHIIYLYRSYHY---SEVDTSMLHFVS 263
                        250       260       270
                 ....*....|....*....|....*....|
gi 768017218 225 A-----LGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15124  264 SicariLAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
2-246 4.00e-18

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 82.54  E-value: 4.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAID----YYNMFTSTFTLTAMSVDRYVAICH--- 73
Cdd:cd14996   32 KTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFyWKYQSTQCRIANFFGtlviHVSMCVSILILSWIAISRYATLMKhds 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  74 ----PIRALDV---------RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECL-----VEIPTPQDYWGPVFA 135
Cdd:cd14996  112 atqkQSCYEKIfyghflkrfRQPKFARYLCIYIWGVVLCIIIPVVVYYSVREADEDGESLcynrqVELGAKGSQIAGLIA 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 136 ICIFLFSFIVPVLVisvcYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVF-----VLAQGLGVQ 210
Cdd:cd14996  192 TTFFFLFFLVVLLS----YYSFVNHLRRIQKNTCISEKDLIYRSVKRNILIIQALLVVCFLPYHIFkpvfyVLHQREDCQ 267
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 768017218 211 PSSeTAVAILRFCTALGYVNSCLNPILYAFLDENFK 246
Cdd:cd14996  268 QLN-YLIETKNILTCLASARSSTDPIMYLLLDKTFK 302
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
1-249 4.29e-18

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 82.18  E-value: 4.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRalD 79
Cdd:cd15981   31 MRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFR--Q 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI------------ECLVEIPTPQdyWGPVFAICIFLFSFIVPV 147
Cdd:cd15981  109 KLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHFmvddynnsyplySCWEAWPDTE--MRKIYTTVLFSHIYLAPL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 148 LVISVCYSLMIRRL-RGVRLLSGSREKDRNLRRITR-------LVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSE---TA 216
Cdd:cd15981  187 TLIVIMYARIAFKLfKSSAPIRGSQGEEEEGRRVSKrkikvinMLIIVALFFTLSWLPLWTLMLLTDYGHLSEDQlnlVT 266
                        250       260       270
                 ....*....|....*....|....*....|...
gi 768017218 217 VAILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15981  267 VYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
1-249 5.24e-18

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 81.25  E-value: 5.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGT-DILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15067   30 LRTVTNYFIVSLAVADLLVgSIVMPFSILhEMTGGYWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYP 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWgpVFAICIflfSFIVPVLVISVCYSLMI 158
Cdd:cd15067  110 SRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCLFTDDSGYL--IFSSCV---SFYIPLVVMLFTYYRIY 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RrlrgvrllSGSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15067  185 R--------AAAKE-----QKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCVSNPDILFPLVTWLGYINSGMNPIIY 251
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15067  252 ACSSRDFRRAF 262
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
1-246 6.33e-18

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 81.49  E-value: 6.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15402   31 LRNAGNIFVVSLAVADLVVaIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYwgpvfAICIFLFSFIVPVLVISVCY----S 155
Cdd:cd15402  111 LYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSSAY-----TIAVVFFHFILPIIIVTFCYlriwI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVgCWTPVQVFvlaqGLGVQPSSETAVAILR---FCTA--LGYVN 230
Cdd:cd15402  186 LVIQVRRRVKPDNKPKLKPHDFRNFVTMFVVFVLFAV-CWAPLNFI----GLAVAVDPETIVPRIPewlFVASyyMAYFN 260
                        250
                 ....*....|....*.
gi 768017218 231 SCLNPILYAFLDENFK 246
Cdd:cd15402  261 SCLNAIIYGLLNQNFR 276
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
5-249 6.56e-18

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 81.63  E-value: 6.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15065   34 SNLFIVSLAVADLLVaLLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVG-VPV----------AIMGSAQVEDEEIECLVEIPtpqdywgPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15065  114 RRALVVIASVWILSALISfLPIhlgwhrlsqdEIKGLNHASNPKPSCALDLN-------PTYAVVSSLISFYIPCLVMLL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSlmirrlrgvRLLSGSREKDRNLRRITRLVLVVVAVFVG-----------------------------CWTPVqvFVL 203
Cdd:cd15065  187 IYS---------RLYLYARKHVVNIKSQKLPSESGSKFQVPslsskhnnqgvsdhkaavtlgiimgvfliCWLPF--FII 255
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 768017218 204 AQglgVQPSSETAVAILRF--CTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15065  256 NI---IAAFCKTCIPPKCFkiLTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
1-249 7.00e-18

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 81.17  E-value: 7.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15297   31 LQTVNNYFLFSLACADLIIgVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVA-----IMGSAQVEDEeiECLVeiptpQDYWGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15297  111 KRTTKMAGMMIAAAWVLSFILWAPAIlfwqfIVGGRTVPEG--ECYI-----QFFSNAAVTFGTAIAAFYLPVIIMTVLY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRrlrgvrllSGSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVLaqgLGVQPSSETAVAILRFCTALGYVNSCLN 234
Cdd:cd15297  184 WQISR--------ASSREK-----KVTRTILAILLAFIITWTPYNVMVL---INTFCASCIPNTVWTIGYWLCYINSTIN 247
                        250
                 ....*....|....*
gi 768017218 235 PILYAFLDENFKACF 249
Cdd:cd15297  248 PACYALCNATFKKTF 262
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
3-162 1.41e-17

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 80.38  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFqgtdILLGFWP--FGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15164   33 TETRVYMINLAVADCCLLFSLPF----VLYFLKHswPDDELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALasvVGVPVAIMGSAQVEDEEIeCLVEIPTPQDYWGPVFaiciFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15164  109 RSPRKAALTCGLLWVL---VIISVSLRLAWEEQEENF-CFGKTSTRPSKRTLIF----SLLGFFIPLIILSFCSIQVIRS 180

                 ..
gi 768017218 161 LR 162
Cdd:cd15164  181 LK 182
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
1-249 1.65e-17

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 80.17  E-value: 1.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15060   31 LRIVQNFFIVSLAVADlAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIECLVEIPTPQDywgpVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15060  111 KRTLKRVLLMIVVVWALSALISVP-PLIGWNDWPENFTETTPCTLTEEK----GYVIYSSSGSFFIPLLIMTIVYVKIFI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgvrllSGSREkdrnlRRITRLVLVVVAVFVGCWTPvqVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15060  186 --------ATSKE-----RRAARTLGIIMGVFVVCWLP--FFLMYVILPFCETCSPSAKVVNFITWLGYVNSALNPVIYT 250
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15060  251 IFNLDFRRAF 260
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
2-246 1.90e-17

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 80.23  E-value: 1.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIrALDV 80
Cdd:cd15370   32 KHPAVIYMANLALADLLFVIWFPLKIAYHINGnNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPM-SHSR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMG-SAQVEDEEIECLVEIPTPQDYWGPVFA--ICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15370  111 KKANIAIGISLAIWLLILLVTIPLYLVKqTVFIPALDITTCHDVLPEQLLVGDMFNyfLSLAIGVFLFPAFLTAVAYVLM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSgSREKDRNlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCT-ALGYVNSCLNPI 236
Cdd:cd15370  191 IRALKSSINDE-SIEKKRK--RAIKLIVTVLVMYLICFTPSNLLLVVHYFLLKNQGQSSVYAFYITAlCLSTLNSCIDPF 267
                        250
                 ....*....|
gi 768017218 237 LYAFLDENFK 246
Cdd:cd15370  268 VYYFVSHDFR 277
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
6-254 3.27e-17

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 80.33  E-value: 3.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTLPFQGTDILlGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALDVRTSSK 85
Cdd:PHA02834  63 DVYLFNIAMSDLMLVFSFPFIIHNDL-NEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILV---VNATKIKNKSI 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAV--NVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRG 163
Cdd:PHA02834 139 SLSVllSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKN 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 164 VRllsgsrekDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGL---GVQPSS----ETAVAILRFCTALGYVNSCLNPI 236
Cdd:PHA02834 219 CK--------NKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLqsvGLIDIGcyhfKKIVYSIDIAELISFVHCCVNPI 290
                        250
                 ....*....|....*...
gi 768017218 237 LYAFLDENFKACFRKFCC 254
Cdd:PHA02834 291 IYAFVGKNFKKVFKNMFC 308
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
5-254 3.33e-17

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 79.48  E-value: 3.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15295   35 SNYFFLNLAISDFFVgAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 -SKAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIEClveipTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLR 162
Cdd:cd15295  115 tLRIVTQMVAVWVLAFLVHGP-AILVSDSWKTEDGEC-----EPEFFSNWYILAITSVLEFLVPVILVAYFNTQIYWSLW 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 163 gvrllsgSREKDrnlRRITRLVLVVVAVFVGCWTPVQVF-VLAQGLGVQPSSetavAILRFCTALGYVNSCLNPILYAFL 241
Cdd:cd15295  189 -------KRLRD---RKLAKSLAIILGTFAICWAPYSLFtIIRAACEKHRGS----PWYNFAFWLQWFNSFINPFLYPLC 254
                        250
                 ....*....|...
gi 768017218 242 DENFKACFRKFCC 254
Cdd:cd15295  255 HKRFRKAFLKIFC 267
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
1-249 3.83e-17

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 79.55  E-value: 3.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRalD 79
Cdd:cd15980   31 MRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPFK--Q 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECL-VEIPTPQDYW----------GPVFAICIFLFSFIVPVL 148
Cdd:cd15980  109 KLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLgSQNKTSPVYWcredwpnqemRKIYTTVLFANIYLAPLS 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 149 VISVCYSLMIRRLRGVRLLSGSREK-------DRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVA--- 218
Cdd:cd15980  189 LIVIMYARIGITLFKTAMPHTGKHNqeqrhvvSRKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYANLSPNQLQIIniy 268
                        250       260       270
                 ....*....|....*....|....*....|.
gi 768017218 219 ILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15980  269 IYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
1-252 3.84e-17

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 79.18  E-value: 3.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15305   31 LQNATNFFLMSLAVADMLVgILVMPVSLIAILYDYaWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGsaqVEDEEIECLVEIPTPQDywgPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15305  111 RFNSRTKAMMKIAAVWTISIGISMPIPVIG---LQDDEKVFVNGTCVLND---ENFVLIGSFVAFFIPLIIMVITYCLTI 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRgvrllsgSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSET-AVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15305  185 QVLQ-------RQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKlMEELLNVFVWVGYVSSGINPLV 257
                        250
                 ....*....|....*
gi 768017218 238 YAFLDENFKACFRKF 252
Cdd:cd15305  258 YTLFNKTYRRAFSNY 272
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
10-249 4.52e-17

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 79.37  E-value: 4.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  10 FNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQA 88
Cdd:cd15922   40 FNLALSDAIITPAAPLLIAYFSLGShWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKK 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  89 VNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLM---IRRLrGVR 165
Cdd:cd15922  120 LCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSLLYFVWNFVLLILGFLLPFGVSLTCYALLgasIAKM-NSN 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 166 LLSGSREKDRNLRRITRLVLVVVAvfvgCWTPVQVfVLAQGLGVQPSSETAVAILRFCTALGY-------VNSCLNPILY 238
Cdd:cd15922  199 NARGRAMKAKSLQMIGISLVIFII----CFVPLHV-TRTVGVVVKLFYPESCTLLHKVEVAYYiswvltgVNCCLDPLLY 273
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15922  274 CFASEKFRKSF 284
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
1-249 5.77e-17

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 78.34  E-value: 5.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLP-FQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15308   31 LKTTTNYFIVSLAVADLLLaLLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYN 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVaIMGSAQVEDEEIE-CLVEiptpQDYWGPVFAICiflfSFIVPVLVISVCYSLM 157
Cdd:cd15308  111 RRQGSVRQLLLISATWILSFAVASPV-IFGLNNVPNRDPAvCKLE----DNNYVVYSSVC----SFFIPCPVMLVLYCAM 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLrgvrllsgSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGvqPSSETAVAILRFCTALGYVNSCLNPIL 237
Cdd:cd15308  182 FRGL--------GRE-----RKAMRVLPVVVGAFLFCWTPFFVVHITRALC--ESCSIPPQLISIVTWLGYVNSALNPVI 246
                        250
                 ....*....|..
gi 768017218 238 YAFLDENFKACF 249
Cdd:cd15308  247 YTVFNAEFRNVF 258
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 6.74e-17

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 79.11  E-value: 6.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15133   31 MRTPTNYYLFSLAVSDLLVLLLgMPLELYELWQNYpFLLGSGGCYFKTFLFETVCLASILNVTALSVERYIAVVHPLAAR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVP-VAIMGSAQ----VEDEEIECLVEiptPQDYWGPVFAICIFLFsFIVPVLVISVC 153
Cdd:cd15133  111 TCSTRPRVTRVLGCVWGVSMLCALPnTSLHGIKFlgsgVPASAQCTVRK---PQAIYNMIPQHTGHLF-FVLPMAVISVL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRLLS-------------GSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgVQPSSETAVAIL 220
Cdd:cd15133  187 YLLMALRLARERGLDatgagskigtrtgQLLQHPRTRAQVTKMLFILVVVFAICWAPFHIDRLMWSF-ISDWTDNLHEVF 265
                        250       260       270
                 ....*....|....*....|....*....|...
gi 768017218 221 RFCTALG----YVNSCLNPILYAFLDENFKACF 249
Cdd:cd15133  266 QYVHIISgvffYLSSAVNPILYNLMSTRFREMF 298
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-247 9.51e-17

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 78.30  E-value: 9.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15132   31 MRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRpWIFGEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVP------VAIMGSAQVEDEEIECLveiPTPQDYWGPVFAICIFLFS--FIVPVLVIS 151
Cdd:cd15132  111 LVTRRRVKCVIAALWAFALLSAGPflflvgVEQDNNIHPDDFSRECK---HTPYAVSSGLLGIMIWVTTtyFFLPMLCLS 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 152 VCYSLMIRRL-RGVRLLSG--SREKDRNLRRITRLVLVVVAVFVGCWTPVQV--FVLAQglgvqpSSETAVAILR----- 221
Cdd:cd15132  188 FLYGFIGRKLwKSKNDLRGpnAAARERSHRQTVRILAVVVLAFIICWLPFHIgrILFAN------TEDYRTMMFSqyfni 261
                        250       260
                 ....*....|....*....|....*.
gi 768017218 222 FCTALGYVNSCLNPILYAFLDENFKA 247
Cdd:cd15132  262 VAMQLFYLSASINPILYNLISRKYRA 287
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
1-249 1.01e-16

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 78.36  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTL-VLLTLPFQGTDILLGFWPFGNA-----LCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHP 74
Cdd:cd15975   31 MRNGPNALIASLALGDLIyIVIDIPINVYKLLAQKWPFDDSsfgvfLCKLVPFLQKASVGITVLNLCALSVDRYRAVASW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  75 IRALDVRTSSKAQAVNVAIWALASVVGVPVAI---MGSAQVEDEEIE-CLVEIPTP--------QDYWgpvfaicIFLFS 142
Cdd:cd15975  111 SRVQGIGIPLITAIEIFSIWVLSFILAIPEAIgfvMVPFEYNGEQYRtCMLNATTKfmnfyvdaKDWW-------LFGFY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 143 FIVPVLVISVCYSLMI-----RRLRGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAV 217
Cdd:cd15975  184 FCVPLACTAIFYTLMTcemlnRRKGSLRIALSEHLKQR--REVAKTVFCLVVIFALCWFPLHLSRILKKTVYNENDPRRC 261
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 768017218 218 AILRFCTALGY-------VNSCLNPILYAFLDENFKACF 249
Cdd:cd15975  262 ELLSFLLVMDYisinlatMNSCINPIALYFVSKKFKNCF 300
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
2-249 1.20e-16

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 78.21  E-value: 1.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLV-LLTLPfqgTDILLGF---WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRA 77
Cdd:cd15195   32 KSHIQILIMHLALADLMVtFFNMP---MDAVWNYtveWLAGDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKaQAVNVAiWALASVVGVPVAIMGSAQVEDEEIECLVE------IPTPQDyWGPVFAICIFLfSFIVPVLVIS 151
Cdd:cd15195  109 NQARKRVK-IMLTVA-WVLSALCSIPQSFIFSVLRKMPEQPGFHQcvdfgsAPTKKQ-ERLYYFFTMIL-SFVIPLIITV 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 152 VCYSLMI----RRLRGVRLLSGSREKDRNLRRITRL-------VLVVVAVFVGCWTPVQV------FVLAQGLGVQPSSE 214
Cdd:cd15195  185 TCYLLILfeisKMAKRARDTPISNRRRSRTNSLERArmrtlrmTALIVLTFIVCWGPYYVlglwywFDKESIKNLPPALS 264
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768017218 215 TAVAIlrfctaLGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15195  265 HIMFL------LGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
6-249 1.34e-16

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 77.81  E-value: 1.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15967   36 NVFVLNLGLADLLYLLTLPFLVVYYLKGRkWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTT 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVPvaIMGSAQVEDEEIECLVEipTPQDYWGP--VFAICIFLFSFIVPVLVISVCYSLMirrlr 162
Cdd:cd15967  116 HSVVISALVWLLVVIQSLP--DLFFSKTNSNGTKCFDT--TFNDYLESylTYSLGWTVTGFVIPLLIILGCYGHV----- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 163 gVRLLSGSREKDRNLR-RITRLVLVVVAVFVGCWTPVQVF----VLAQGLGVQPSSET---AVAILRFCT-ALGYVNSCL 233
Cdd:cd15967  187 -VVVLCRNNNVDKGLKqRCLKLVIILIVLFSVCYIPYHVFrnlnLLSRILQKQGSCTQwfrGIYIAHQVSrGLVCLNSAL 265
                        250
                 ....*....|....*.
gi 768017218 234 NPILYAFLDENFKACF 249
Cdd:cd15967  266 NPLVYLMGSEDILSRI 281
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
2-239 1.66e-16

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 77.62  E-value: 1.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVr 81
Cdd:cd15079   32 RTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPL- 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVA--IMGSAQVEDEEIECLVEIPTpQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15079  111 TRGKALLLILFIWLYALPWALLPLlfGWGRYVPEGFLTSCSFDYLT-RDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVK 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLR--------------GVRLLSGSREKDRNLR-RITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCT 224
Cdd:cd15079  190 AVFahekalreqakkmnVVSLRSNADANKQSAEiRIAKVALTNVFLWFIAWTPYAVVALIGAFGNQSLLTPLVSMIPALF 269
                        250
                 ....*....|....*
gi 768017218 225 AlgYVNSCLNPILYA 239
Cdd:cd15079  270 A--KTAACYNPIVYA 282
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
1-246 1.80e-16

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 77.47  E-value: 1.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIralD 79
Cdd:cd15397   31 KTNVTNILIANLSFSDILVcLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSILSLVLIALERHQLIINPT---G 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTS-SKAQAVNVAIWALASVVGVPvaIMGSAQVEDEEIECLVEIPTP-------QDYWGP-----VFAICIFLFSFIVP 146
Cdd:cd15397  108 WKPSvSQAYLAVVVIWMLACFISLP--FLAFHILTDEPYKNLSHFFAPladkavcTESWPSehhklAYTTWLLLFQYCLP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 147 VLVISVCYSLMIRRLRGVRLL----SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVF-VLAQGLGVQPSSETAVAILR 221
Cdd:cd15397  186 LLFILVCYLRIYLRLRRRKDMlerrGEYNRRAGHSKRINVMLVSLVAAFALCWLPLNVFnAIADWNHEAIPHCQHNLIFS 265
                        250       260
                 ....*....|....*....|....*
gi 768017218 222 FCTALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15397  266 LCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-238 1.86e-16

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 77.63  E-value: 1.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15958   31 LQTLTNLFITSLACADLVMgLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVG-VPVAIMGSAQVEDEEIECLvEIPTPQDY-WGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15958  111 LLTRARAKGIVCTVWAISALVSfLPIMMHWWRDEDDQALKCY-EDPGCCDFvTNRAYAIASSIISFYIPLLIMIFVYLRV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IR--------------RLRGVRLLSGSREKdRNLRRITRLVLVVVAVFVG--------CWTPvqvFVLAQGLGVQPSSET 215
Cdd:cd15958  190 YReakkqikkidkcegRFHNTLTGLGRKCK-RRPSRILALREQKALKTLGiimgvftlCWLP---FFLVNVVNVFNRELV 265
                        250       260
                 ....*....|....*....|...
gi 768017218 216 AVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15958  266 PDWLFVFFNWLGYANSAFNPIIY 288
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
5-163 1.96e-16

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 77.14  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15371   34 TAIFYANLAISDLLFCITLPFKIVYHLNGNnWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVGVPVAIMG-SAQVEDEEIEC---LVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15371  114 TYAVLICALVWTIVFLYMLPFFILKqTYYLKELNITTchdVLPECEQNSNFQFYYFISMAVFGFLIPLVITIFCYISIIR 193

                 ....
gi 768017218 160 RLRG 163
Cdd:cd15371  194 TLNA 197
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
1-252 2.02e-16

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 77.18  E-value: 2.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILL-GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15306   31 LQYATNYFLMSLAVADLLVgLFVMPIALLTILFeAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQAS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVED--EEIECLVEIPTPQDywgpvFAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd15306  111 QYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDnpNNITCVLTKERFGD-----FILFGSLAAFFTPLAIMIVTYFL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLRgvrllsgsREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPI 236
Cdd:cd15306  186 TIHALR--------KQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTLQMLMEIFVWIGYVSSGVNPL 257
                        250
                 ....*....|....*.
gi 768017218 237 LYAFLDENFKACFRKF 252
Cdd:cd15306  258 VYTLFNKTFRDAFGRY 273
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-249 2.34e-16

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 76.91  E-value: 2.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15322   31 LKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEcLVEIPTPQDYwgpVFAICIflFSFIVPVLVISVCYslmIR 159
Cdd:cd15322  111 KRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGP-ICKINDEKWY---IISSCI--GSFFAPCLIMVLVY---IR 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgVRLLSGSREKdrnlrRITRLVLVVVAVFVGCWTPvqvFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15322  182 ----IYQIAKNREK-----RFTFVLAVVIGVFVICWFP---FFFTYTLTAVCDCSVPETLFKFFFWFGYCNSSLNPVIYT 249
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15322  250 IFNHDFRRAF 259
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
1-246 2.47e-16

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 77.13  E-value: 2.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15209   31 LRNAGNIFVVSLSVADLVVaIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEClveipTPQDYWGPVFAICIFLFSFIVPVLVISVCY----S 155
Cdd:cd15209  111 LYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSC-----TFAQTVSTVYTITVVVIHFLLPLLIVSFCYlriwV 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVgCWTPVQVFVLAqgLGVQPSsETAVAILR--FCTA--LGYVNS 231
Cdd:cd15209  186 LVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFVLFAV-CWAPLNFIGLA--VAINPK-EMAPKIPEwlFVASyfMAYFNS 261
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15209  262 CLNAIIYGLLNQNFR 276
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
1-238 2.75e-16

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 77.49  E-value: 2.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15058   31 LQTMTNIFITSLACADLVMgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVG-VPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15058  111 LLTKRRARVIVCVVWIVSALVSfVPIMNQWWRANDPEANDCYQDPTCCDFRTNMAYAIASSVVSFYIPLLIMIFVYARVF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 R-RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVG---------------------------CWTPVQVFVLAQGLGVQ 210
Cdd:cd15058  191 LiATRQLQLIDKRRLRFQSECPAPQTTSPEGKRSSGrrpsrltvvkehkalktlgiimgtftlCWLPFFIANIINVFNRN 270
                        250       260
                 ....*....|....*....|....*...
gi 768017218 211 PSSETAVAILRFctaLGYVNSCLNPILY 238
Cdd:cd15058  271 LPPGEVFLLLNW---LGYINSGLNPIIY 295
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
1-249 2.83e-16

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 76.70  E-value: 2.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15050   31 LHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPV----AIMGSAQVEDEEIECLVEIPTpqDYWgpvFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15050  111 YRTKTRASLMISGAWLLSFLWVIPIlgwhHFARGGERVVLEDKCETDFHD--VTW---FKVLTAILNFYIPSLLMLWFYA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRgvrllsgsREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETavaILRFCTALGYVNSCLNP 235
Cdd:cd15050  186 KIFKAVN--------RE-----RKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCCNEN---LHMFTIWLGYINSTLNP 249
                        250
                 ....*....|....
gi 768017218 236 ILYAFLDENFKACF 249
Cdd:cd15050  250 FIYPLCNENFKKTF 263
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 3.60e-16

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 76.87  E-value: 3.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTL-VLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15977   31 MRNGPNVLIASLALGDLLyILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAVASWSRIRG 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSaqvedeeiecLVEIPtpqdYWGPVFAIC---------------------I 138
Cdd:cd15977  111 IGIPVWKAVEVTLIWAVAIIVAVPEAIAFD----------MVEID----YRGQTLLVCmlpmeqtssfmrfyqdvkdwwL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 139 FLFSFIVPVLVISVCYSL----MIRRLRGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSE 214
Cdd:cd15977  177 FGFYFCLPLACTGVFYTLmsceMLSIKNGMRIALNDHMKQR--REVAKTVFCLVVIFALCWLPLHLSRILKKTIYDVKDP 254
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 768017218 215 TAVAILRFCTALGYV-------NSCLNPILYAFLDENFKACF 249
Cdd:cd15977  255 QRCELLSFLLVMDYTginmaslNSCINPVALYFVSRKFKNCF 296
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
2-246 4.30e-16

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 76.35  E-value: 4.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14988   32 KNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYtWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQ 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIECLVEIP-TPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd14988  112 HQHRIRRALCAGIWVLSAIIPLP-EVVHMQLLDGVEPMCLFLAPfETYDEWALAVSLLTLIIGFLIPFSIIAVFNVLTAR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRgvrllSGSREKDrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETA--VAILRF------CTALgyVNS 231
Cdd:cd14988  191 YIR-----TAGRPES---RRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHISLHCnlVHFLYFfydvidCFSL--LHC 260
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd14988  261 VANPILYNFLSKSFR 275
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-238 4.40e-16

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 76.83  E-value: 4.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15957   31 LQTVTNYFITSLACADLVMgLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVG-VPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15957  111 LLTKNKARVIILMVWIVSGLTSfLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 ----RRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVG--------------------CWTPvqvFVLAQGLGVQPSSE 214
Cdd:cd15957  191 qeakRQLQKIDKSEGRFHNQNIDQNGSGGGGGNRRRSKFclkehkalktlgiimgtftlCWLP---FFIVNIVHVIQDNL 267
                        250       260
                 ....*....|....*....|....
gi 768017218 215 TAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15957  268 IRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
7-243 5.72e-16

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 75.99  E-value: 5.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQgTDILLGF--WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15366   37 VYLLNLSVSDLLYIATLPLW-IDYFLHRdnWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALaSVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGv 164
Cdd:cd15366  116 TAVAVSAVVWAI-EIGANSAPLFHDELFRDRYNHTFCFEKYPMEDWVAWMNLYRVFVGFLFPWVLMLFSYRGILRAVRG- 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 165 rllSGSREKdRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLG--VQPSS----ETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15366  194 ---NVSTEQ-QEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVylGKPCDcgfeERVFTAYHVSLALTSLNCVADPILY 269

                 ....*
gi 768017218 239 AFLDE 243
Cdd:cd15366  270 CLVNE 274
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
1-246 6.48e-16

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 76.04  E-value: 6.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIrALD 79
Cdd:cd15400   31 LRNSGNVFVVSLALADLVVaLYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICHSF-AYD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVA-IWALASVVGVPVAIMGSAQVEDEEIECLVeIPTPQDYwgpvFAICIFLFSFIVPVLVISVCY---- 154
Cdd:cd15400  110 KLYSRWNTLLYVClIWALTVVAIVPNFFVGSLEYDPRIYSCTF-VQTASSS----YTIAVVVIHFIVPITVVSFCYlriw 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVgCWTPVQVFVLAQGLGVQ---PSSETAVAILRFCTAlgYVNS 231
Cdd:cd15400  185 VLVIQVRRKVKSESKPRLKPSDFRNFLTMFVVFVIFAI-CWAPLNLIGLAVAINPQemaPKVPEWLFVVSYFMA--YFNS 261
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15400  262 CLNAIIYGLLNQNFR 276
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-238 6.83e-16

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 76.10  E-value: 6.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15959   31 LQTMTNVFVTSLACADLVMgLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVG-VPVAIMGSAQVEDEEIECLVEIPTPQDYWGPV-FAICIFLFSFIVPVLVISVCYS-L 156
Cdd:cd15959  111 LVTKRRARTAVCLVWAISAAISfLPIMNQWWRDGADEEAQRCYDNPRCCDFVTNMpYAIVSSTVSFYVPLLVMIFVYVrV 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLRGVRLLSG------------SREKDRNLRRITRLVLVVVAVFVG-----------CWTPvqvFVLAQGLGVQPSS 213
Cdd:cd15959  191 FVVATRQVRLIRKdkvrfppeesppAESRPACGRRPSRLLAIKEHKALKtlgiimgtftlCWLP---FFVANIIKVFCRS 267
                        250       260
                 ....*....|....*....|....*
gi 768017218 214 ETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15959  268 LVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
2-246 7.80e-16

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 75.56  E-value: 7.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQ-GTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15924   31 KSSFIIYLKNTVVADLLMILTFPFKiLSDAGLGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFP 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15924  111 KSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCSFLKSELGLKWHEIVNYICQVIFWIVFLLMIVCYTAITKK 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 L-RGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQV----FVLAQGLGVqpSSETAVAILRFCTA----LGYVNS 231
Cdd:cd15924  191 VyRSYRRVFRSSSSRR--KKSNVKIFIIVAVFFVCFVPYHFaripYTLSQTRDV--FDCTAENILFYVKEatlfLSALNV 266
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15924  267 CLDPIIYFFLCKSFR 281
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
1-249 8.05e-16

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 75.35  E-value: 8.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15304   31 LQNATNYFLMSLAIADMLLgFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGVPVAIMG---SAQVEDEEiECLVEIPTpqdywgpvFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15304  111 RFNSRTKAFLKIIAVWTISVGISMPIPVFGlqdDSKVFKEG-SCLLADEN--------FVLIGSFVAFFIPLTIMVITYF 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLrgvrllsgsREKDRNLRRITRLVLVVVAVFVGCWTPvqvFVLAQGLGV--QPSSETAV--AILRFCTALGYVNS 231
Cdd:cd15304  182 LTIKSL---------QQSISNEQKASKVLGIVFFLFVVMWCP---FFITNVMAVicKESCNEVVigGLLNVFVWIGYLSS 249
                        250
                 ....*....|....*...
gi 768017218 232 CLNPILYAFLDENFKACF 249
Cdd:cd15304  250 AVNPLVYTLFNKTYRSAF 267
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 8.09e-16

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 76.05  E-value: 8.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTL-VLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRY--VAICHPIRA 77
Cdd:cd15976   31 MRNGPNILIASLALGDLLhIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYraVASWSRIKG 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVrtsSKAQAVNVA-IWALASVVGVPVAIMGSAQVEDEEIE----CLVE----------IPTPQDYWgpvfaicIFLFS 142
Cdd:cd15976  111 IGV---PKWTAVEIVlIWVVSIILAVPEAIGFDMITMDYKGEllriCLLHpiqktafmqfYKTAKDWW-------LFSFY 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 143 FIVPVLVISVCYSLM----IRRLRGVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVA 218
Cdd:cd15976  181 FCLPLACTAVFYTLMtcemLRKKNGMQIALNDHLKQR--REVAKTVFCLVLVFALCWLPLHLSRILKLTIYDEKDPNRCE 258
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 768017218 219 ILRFCTALGYV-------NSCLNPILYAFLDENFKACF 249
Cdd:cd15976  259 LLSFFLVLDYIginmaslNSCINPIALYLVSKRFKNCF 296
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
1-249 8.18e-16

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 76.04  E-value: 8.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVL-LTLPFQgtdiLLGF------WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICH 73
Cdd:cd15355   34 LQSTVHYHLASLALSDLLILlLAMPVE----LYNFiwvhhpWAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  74 PIRALDVRTSSKAQAVNVAIWALASVVGVP-VAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15355  110 PFKAKSLMSRSRTKKFISAIWLASALLAIPmLFTMGEQNRSGTHPGGLICTPIVDTSTLKVVIQVNAFLSFLFPMLVISV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRL----------------RGVR-LLSGSREKDR--NLRRITRLVLVVVAVFVGCWTPVQVFVLaqgLGVQPSS 213
Cdd:cd15355  190 LNTLIANQLtvmvnqaeqenqvctiGGQRtVLSVSMEPGRvqSLRHGVLVLRAVVIAFVVCWLPYHVRRL---MFCYVSD 266
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 768017218 214 ETAVAIL--------RFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15355  267 EQWTTFLydfyhyfyMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
3-246 9.15e-16

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 75.25  E-value: 9.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGnALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRT 82
Cdd:cd14989   33 TIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDIA-VLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLRT 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  83 SSKAQAVNVAIWaLASVVG--VPVAIMgSAQVEDEEIECLVEIPTPQdyWGPVfaicifLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd14989  112 MQHARLSCGLIW-MASISAtlLPFTAV-QAQHTGEVHFCFADVREIQ--WLEV------TLGFIIPFSIIGLCYSLIVRV 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LrgVRllsgsREKDRNLR----RITRLVLVVVAVFVGCWTPVQVFVLAQGL-GVQPSSETAVAILRFCTAL--------G 227
Cdd:cd14989  182 L--VR-----AQKHRRLRprrqKALRMILVVVLVFFICWLPENVFISIQLLqGTQEPSESYDESFRHNHPLtghivnlaA 254
                        250
                 ....*....|....*....
gi 768017218 228 YVNSCLNPILYAFLDENFK 246
Cdd:cd14989  255 FSNSCLNPLIYSFLGETFR 273
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
1-246 9.47e-16

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 74.99  E-value: 9.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTL-VLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15210   31 LRTRTNAFIINLSISDLLfCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWA--LASVVGVPVAIMGSAQVEDEEIECLVEiptpQDYWGPVFAICIFLFSFIVPVLVISVCYSLm 157
Cdd:cd15210  111 IYTRRGLALMIAGTWIfsFGSFLPLWLGIWGRFGLDPKVCSCSIL----RDKKGRSPKTFLFVFGFVLPCLVIIICYAR- 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 irrlrgvrllsgsrekdRNLRRITRLVLVVVAVFVGCWTPVQVFVLAqglgvqpSSETAVAILRFCTA-LGYVNSCLNPI 236
Cdd:cd15210  186 -----------------REDRRLTRMMLVIFLCFLVCYLPITLVNVF-------DDEVAPPVLHIIAYvLIWLSSCINPI 241
                        250
                 ....*....|
gi 768017218 237 LYAFLDENFK 246
Cdd:cd15210  242 IYVAMNRQYR 251
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
1-238 1.27e-15

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 74.71  E-value: 1.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALD 79
Cdd:cd15213   31 MRSAINLLLANLAFSDIMLsLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLII---VQRQD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAI-MGSAQVEDEEIECLVEIPTPQDYwgPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15213  108 KLNPHRAKILIAVSWVLSFCVSFPPLVgWGKYEFPPRAPQCVLGYTESPAD--RIYVVLLLVAVFFIPFLIMLYSYFCIL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRGVrllsgsreKDRNLRRITRLVLVVVAvfvgCWTPVQVFVLAQGLgVQPSSETAVaILRFCTALGYVNSCLNPILY 238
Cdd:cd15213  186 NTVRSF--------KTRAFTTILILFIGFSV----CWLPYTVYSLLSVF-SRYSSSFYV-ISTCLLWLSYLKSAFNPVIY 251
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
1-249 1.48e-15

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 74.63  E-value: 1.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15330   31 LQNVANYLIGSLAVTDLMVsVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVN 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIECLVEIptPQDywgPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15330  111 KRTPRRAAVLISLTWLIGFSISIP-PMLGWRTPEDRSDPDACTI--SKD---PGYTIYSTFGAFYIPLILMLVLYGRIFK 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgvrllSGSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLaqglgVQPSSETAVAILRFCTA----LGYVNSCLNP 235
Cdd:cd15330  185 --------AAARE-----RKTVKTLGIIMGTFILCWLPFFIVAL-----VLPFCESTCHMPELLGAiinwLGYSNSLLNP 246
                        250
                 ....*....|....
gi 768017218 236 ILYAFLDENFKACF 249
Cdd:cd15330  247 IIYAYFNKDFQSAF 260
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
2-249 1.90e-15

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 74.60  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLV-LLTLPFQGTdILLGF-WPFGNALCKTVIAIdyynMFT--STFTLTAMSVDRYVAICHPIRA 77
Cdd:cd14968   32 RTVTNYFIVSLAVADILVgALAIPLAIL-ISLGLpTNFHGCLFMACLVL----VLTqsSIFSLLAIAIDRYLAIKIPLRY 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKAQAVNVAIWALASVVGVpVAIMG-------SAQVEDEEIECLVEIPTPQDYWgpVFAicIFLFSFIVPVLVI 150
Cdd:cd14968  107 KSLVTGRRAWGAIAVCWVLSFLVGL-TPMFGwnngaplESGCGEGGIQCLFEEVIPMDYM--VYF--NFFACVLVPLLIM 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 151 SVCYS---LMIRR-LRGVRLLSGSREKDRNLRR---ITRLVLVVVAVFVGCWTPVQV---FVLAQGLGVQPSSETAVAIL 220
Cdd:cd14968  182 LVIYLrifRVIRKqLRQIESLLRSRRSRSTLQKevkAAKSLAIILFLFALCWLPLHIincITLFCPECKVPKILTYIAIL 261
                        250       260
                 ....*....|....*....|....*....
gi 768017218 221 rfctaLGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd14968  262 -----LSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
5-246 1.99e-15

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 74.87  E-value: 1.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPiRALDVRTS 83
Cdd:cd15396   35 TNILIANLSLSDVLVcVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAIERYQLIVNP-RGWKPSAS 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVnVAIWALASVVGVPVAImgSAQVEDEEIE--------------CLVEIPTPQDYWgpVFAICIFLFSFIVPVLV 149
Cdd:cd15396  114 HAYWGI-VLIWLFSLMISIPFLI--FHQLTDEPFRnlsshsdfykdkvvCIEAWPSETERL--IFTTSLLVFQYFVPLGF 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 150 ISVCY---SLMIRRLRGvrLLSGSREKDRNL---RRITRLVLVVVAVFVGCWTPVQVF--VLAQGLGVQPSSETAVAiLR 221
Cdd:cd15396  189 IFICYlkiFVCLKKRNS--KIDRMRENESRLsenKRINTMLISIVVTFAACWLPLNIFnvVFDWNHEVLMSCHHNLV-FT 265
                        250       260
                 ....*....|....*....|....*
gi 768017218 222 FCTALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15396  266 LCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
6-246 2.05e-15

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 74.37  E-value: 2.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15378   36 NIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKKRS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGvr 165
Cdd:cd15378  116 AVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDATNSLIYSLFLTVTGFLIPLCVMCFFYYKIALFLKN-- 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 166 lLSGSREKDRNLRRITRLVLVVVAVFVGCWTP------VQVFVLAQGLGVQPSSETAVAILRFCT-ALGYVNSCLNPILY 238
Cdd:cd15378  194 -RNRQLANATSFEKPLTLVILAVVIFSVLFTPyhvmrnVRIASRLDSIGVSECTLIIIKSLYIVTrPIAFLNSVINPVFY 272

                 ....*...
gi 768017218 239 AFLDENFK 246
Cdd:cd15378  273 FLMGDHFR 280
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
6-249 2.11e-15

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 74.44  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15199   36 AVYLLNLVLADVLLLICLPFKAYFYLNGnRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQ 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALasVVGVPVAIMGSAQVEDEEiECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGV 164
Cdd:cd15199  116 AAPYISFLVWLL--LVGLTIPTLLASQPKNFT-ECNSFSPKDDEDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKR 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 165 RLLSGSREKdrnLRRITRLVLVVVAVFVGCWTPV----QVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAF 240
Cdd:cd15199  193 LRDVGKQPK---LQRAMALVTSVVVVFGFCFLPCflarVLMLIFQNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCF 269

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15199  270 SSPTFRSSY 278
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
6-250 2.85e-15

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 73.83  E-value: 2.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15334   36 NYLICSLAVTDFLVaVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIECLVEiptpQDYWgpVFAICIFLFSFIVPVLVISVCYSLMIRrlrgv 164
Cdd:cd15334  116 HAGIMIAVVWIISIFISMP-PLFWRHQTTSREDECIIK----HDHI--VFTIYSTFGAFYIPLALILILYYKIYR----- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 165 rllSGSREkdrnlRRITRLVLVVVAVFVGCWTPvqVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDEN 244
Cdd:cd15334  184 ---AATRE-----RKAATTLGLILGAFVICWLP--FFVKEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNED 253

                 ....*.
gi 768017218 245 FKACFR 250
Cdd:cd15334  254 FKKAFQ 259
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
3-251 3.61e-15

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 73.81  E-value: 3.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRaldVR 81
Cdd:cd15314   33 TPTNYLILSLAVADLLVgGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLL---YR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAI---WALASVVGVPVAIMGSAQVEDEEI------ECLVeiptpqdYWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15314  110 SKITVRVVLVMIlisWSVSALVGFGIIFLELNIKGIYYNhvacegGCLV-------FFSKVSSVVGSVFSFYIPAVIMLC 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYS--LMIRRlRGVRLLSGSREKD-RNLRRITRLVLVVVAVFVG----CWTPVQVFVLAQGLGvqpSSETAVAILRFCTA 225
Cdd:cd15314  183 IYLkiFLVAQ-RQARSIQSARTKSgASSSKMERKATKTLAIVMGvfllCWTPFFLCNIIDPFI---NYSIPPVLIEVLNW 258
                        250       260
                 ....*....|....*....|....*.
gi 768017218 226 LGYVNSCLNPILYAFldenFKACFRK 251
Cdd:cd15314  259 LGYSNSTLNPFIYAF----FYSWFRK 280
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
3-161 4.50e-15

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 73.75  E-value: 4.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15379   33 SRTTIYMLNLATADLLYVCSLPLLIYNYTQKdYWPFGDFTCRLVRFQFYTNLHGSILFLTCISVQRYLGICHPLASWHKK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSK-AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLvEIPTPQ---DYWGpvFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15379  113 KGKKlTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCY-DLSPPArstAYFP--YGITLTRTGFLLPFAARLACYCSM 189

                 ....
gi 768017218 158 IRRL 161
Cdd:cd15379  190 ATIL 193
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
1-249 6.19e-15

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 72.74  E-value: 6.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15298   31 LQTVNNYFLFSLACADLIIgAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVA-----IMGSAQVEDEeiECLVE-IPTPQDYWGPVFAiciflfSFIVPVLVISVC 153
Cdd:cd15298  111 RRTTKMAGLMIAAAWVLSFVLWAPAIlfwqfVVGKRTVPDN--QCFIQfLSNPAVTFGTAIA------AFYLPVVIMTVL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIrrlrgvrlLSGSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFctaLGYVNSCL 233
Cdd:cd15298  183 YIHIS--------LASARER-----KVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYW---LCYVNSTI 246
                        250
                 ....*....|....*.
gi 768017218 234 NPILYAFLDENFKACF 249
Cdd:cd15298  247 NPACYALCNATFKKTF 262
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
1-246 6.22e-15

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 73.02  E-value: 6.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15401   31 LRNAGNIFVVSLSVADLVVaVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYwgpvfAICIFLFSFIVPVLVISVCY----S 155
Cdd:cd15401  111 LYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSY-----TITVVVVHFIVPLSIVTFCYlriwV 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVgCWTPVQVFVLA---QGLGVQPSSETAVAILRFCTAlgYVNSC 232
Cdd:cd15401  186 LVIQVKHRVRQDSKQKLKANDIRNFLTMFVVFVLFAV-CWGPLNFIGLAvaiNPLKVAPKIPEWLFVLSYFMA--YFNSC 262
                        250
                 ....*....|....
gi 768017218 233 LNPILYAFLDENFK 246
Cdd:cd15401  263 LNAVIYGVLNQNFR 276
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 6.83e-15

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 72.95  E-value: 6.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAld 79
Cdd:cd16004   31 MRTVTNYFIVNLALADLSMaAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIYSMTAIAADRYMAIIHPFKP-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vRTSSKAQAVNVA-IWALASVVGVPVAIMGSAQVEDEEIECLVEipTPQDYWGP---VFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd16004  109 -RLSAGSTKVVIAgIWLVALALAFPQCFYSTVTMDQGRTKCIVA--WPGDSGGKhqlTYHLAVIVLIYLLPLAVMFVTYS 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRGvRLLSGSREKDRNL------RRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYV 229
Cdd:cd16004  186 IIGITLWR-SAVPGHQAHGAYHrqlqakKKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVYLAIFWLAM 264
                        250       260
                 ....*....|....*....|.
gi 768017218 230 NSCL-NPILYAFLDENFKACF 249
Cdd:cd16004  265 SSTMyNPIIYCCLNQRFRSGF 285
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
6-249 9.50e-15

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 72.26  E-value: 9.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15335   36 NYLICSLAVTDFLVaVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEiptpQDYWGpvFAICIFLFSFIVPVLVISVCYSLMIRrlrgv 164
Cdd:cd15335  116 RAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQ----HDHVI--YTIYSTFGAFYIPLTLILILYYRIYH----- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 165 rllSGSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQ-PSSETAvailRFCTALGYVNSCLNPILYAFLDE 243
Cdd:cd15335  185 ---AASRE-----RKAARILGLILGAFILSWLPFFIKELIVGLSVMtVSPEVA----DFLTWLGYVNSLVNPLLYTSFNE 252

                 ....*.
gi 768017218 244 NFKACF 249
Cdd:cd15335  253 DFKLAF 258
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
1-249 1.17e-14

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 72.08  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15302   31 IRQPSNYFIASLAVSDLLIgLESMPFYTVYVLNGdYWPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVgVPVAIMG----SAQVED-EEIECLVEIPTpqdywGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15302  111 NWRTPRKVLLIIAITWIIPALL-FFISIFGwqyfTGQGRSlPEGECYVQFMT-----DPYFNMGMYIGYYWTTLIVMLIL 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRllsgsrekdRNLRRITrlvlVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVaILRFCTALGYVNSCL 233
Cdd:cd15302  185 YAGIYRAANRAR---------KALRTIT----FILGAFVICWTPYHILATIYGFCEAPPCVNET-LYTISYYLCYMNSPI 250
                        250
                 ....*....|....*.
gi 768017218 234 NPILYAFLDENFKACF 249
Cdd:cd15302  251 NPFCYALANQQFKKTF 266
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
1-245 1.25e-14

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 72.67  E-value: 1.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT---------LPFQGTDILLGFWPFgnaLCKTVIAIDYYNMFTSTFTLTAMSVDRYVAI 71
Cdd:cd14978   30 MRSSTNVYLAALAVSDILVLLSalplfllpyIADYSSSFLSYFYAY---FLPYIYPLANTFQTASVWLTVALTVERYIAV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  72 CHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQV--EDEEIECLVEIPTPQDYWGPVFA----ICIFLFSFIV 145
Cdd:cd14978  107 CHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVEceNCNNNSYYYVIPTLLRQNETYLLkyyfWLYAIFVVLL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 146 PVLVISVCYSLMIRRLR--------GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAV 217
Cdd:cd14978  187 PFILLLILNILLIRALRkskkrrrlLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIY 266
                        250       260
                 ....*....|....*....|....*....
gi 768017218 218 AILR-FCTALGYVNSCLNPILYAFLDENF 245
Cdd:cd14978  267 QLLGdISNLLVVLNSAVNFIIYCLFSSKF 295
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
7-244 1.40e-14

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 72.10  E-value: 1.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15367   37 IYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVpVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSlmiRRLRGVR 165
Cdd:cd15367  117 ATLVSTVIWLKELMTCV-FFFLHGEISKDKENHSVCFEHYPIKAWEHNINYYRFYAGFLFPIFLLSFSYC---RILRAVR 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 166 LLSGSREKDRNlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLgVQPSSETAVAIL---RFCTALGYVNSCLNPILYAFLD 242
Cdd:cd15367  193 KSHGTQKSQKI--QIKRLVLSTVVIFLVCFGPYHILLLVRSV-FERDCNFAEGIFnyyHFSLLLTSFNCVADPVLYCFAS 269

                 ..
gi 768017218 243 EN 244
Cdd:cd15367  270 ES 271
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-240 1.73e-14

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 72.16  E-value: 1.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  11 NLALADTLVLL--TLPFQGTDILLGFWPfGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQa 88
Cdd:cd15387   41 HLSIADLVVAVfqVLPQLIWDITFRFYG-PDFLCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYV- 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  89 vnVAIWALASVVGVP-VAIMGSAQVEDEEIECLVEIPTPqdyWGP-VFAICIFLFSFIVPVLVISVCYSL---------- 156
Cdd:cd15387  119 --LFSWLLSLVFSIPqVHIFSLREVGNGVYDCWADFIQP---WGPkAYITWITLSVYIIPVLILSVCYGLisfkiwqnvk 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 -------------------MIRRLRGVRLLSGSRekdrnlRRITRLVLVVVAVFVGCWTP---VQVFVLAQGLGVQPSSE 214
Cdd:cd15387  194 lktrretktplssaasggaALARVSSVKLISKAK------IRTVKMTFVIVLAYIVCWTPfffVQMWSVWDPNAPKEASP 267
                        250       260
                 ....*....|....*....|....*.
gi 768017218 215 TAVAILrfctaLGYVNSCLNPILYAF 240
Cdd:cd15387  268 FIIAML-----LASLNSCCNPWIYMF 288
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 1.83e-14

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 72.17  E-value: 1.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTL-VLLTLPFQGTDILLGFWPF-----GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHP 74
Cdd:cd15128   31 MRNGPNALIASLALGDLLyIVIDLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKASVGITVLNLCALSVDRYRAVASW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  75 IRALDVRTSSKAQAVNVAIWALASVVGVPVAI---MGSAQVEDEEIE-CLVEIPTP--------QDYWgpvfaicIFLFS 142
Cdd:cd15128  111 SRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIgfdMVRFNYKGVTLRtCLLRPETSfmkfyidvKDWW-------LFGFY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 143 FIVPVLVISVCYSLM----IRRLRG-VRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAV 217
Cdd:cd15128  184 FCLPLVCTAIFYTLMtcemLRKRNGmLRIALNEHLKQR--REVAKTVFCLVVIFALCWLPLHLSRILKLTVYDQNDPNRC 261
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 768017218 218 AILRFCTALGY-------VNSCLNPILYAFLDENFKACF 249
Cdd:cd15128  262 ELLSFLLVLDYfginlatLNSCINPIALYFVSRKFKNCF 300
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
1-249 2.13e-14

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 71.44  E-value: 2.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15324   31 LRAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMgsaqVEDEEIECLVEiptpQDYWGPVFAICIflfSFIVPVLVISVCYSLMIR 159
Cdd:cd15324  111 KRTPKRIKRMIAVVWVISAVISFPPLLM----TKHDEWECLLN----DETWYILSSCTV---SFFAPGLIMILVYCKIYR 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 rlrgvrlLSGSREKdrnlrRITRLVLVVVAVFVGCWTPVqVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15324  180 -------VAKMREK-----RFTFVLAVVMGVFVLCWFPF-FFTYSLHAVCRKRCGIPDALFNLFFWIGYCNSSVNPIIYT 246
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15324  247 IFNRDFRKAF 256
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
1-246 2.63e-14

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 71.39  E-value: 2.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15301   31 LQTISNYFLFSLAVADFAIgVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVP-----VAIMGSAQVEDEeiECLVEIPTPQDYwgpvFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15301  111 RRTTKKAAVMIASAWIISLLLWPPwiyswPYIEGKRTVPAG--TCYIQFLETNPY----VTFGTALAAFYVPVTIMCILY 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRgvrllsgsREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglGVQPSSETAVAIL-RFCTALGYVNSCL 233
Cdd:cd15301  185 WRIWRETK--------KRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIK--AFFPCSDTIPTELwDFSYYLCYINSTI 254
                        250
                 ....*....|...
gi 768017218 234 NPILYAFLDENFK 246
Cdd:cd15301  255 NPLCYALCNAAFR 267
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
1-249 4.83e-14

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 70.38  E-value: 4.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVL-LTLPFQ-GTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15310   31 LQTTTNYLVVSLAVADLLVAtLVMPWVvYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNV---AIWALASVVGVPVaIMGSAQVEDeeieclveiPTPQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15310  111 HGTGQSSCRRVSLmitAVWVLAFAVSCPL-LFGFNTTGD---------PTVCSISNPDFVIYSSVVSFYLPFGVTLLVYV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLrgvrllsgSREKdrnlrRITRLVLVVVAVFVGCWTPvqvFVLAQGLGVQ-PSSETAVAILRFCTALGYVNSCLN 234
Cdd:cd15310  181 RIYVVL--------LREK-----KATQMLAIVLGAFIVCWLP---FFLTHILNTHcQACHVPPELYSATTWLGYVNSALN 244
                        250
                 ....*....|....*
gi 768017218 235 PILYAFLDENFKACF 249
Cdd:cd15310  245 PVIYTTFNIEFRRAF 259
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
1-246 6.86e-14

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 70.44  E-value: 6.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCktviaiDYYNM------FTSTFTLTAMSVDRYVAICH 73
Cdd:cd15083   31 LRTPANYLIINLAISDfLMCILNCPLMVISSFSGRWIFGKTGC------DMYGFsgglfgIMSINTLAAIAVDRYLVITR 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  74 PIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDE-EIECLVEIpTPQDYWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15083  105 PMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGlLTSCSFDY-LSRDDANRSYVICLLIFGFVLPLLIIIY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRLR------------GVRLLSGSREKDRNLR-RITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPS-SETAVA 218
Cdd:cd15083  184 CYSFIFRAVRrhekamkemakrFSKSELSSPKARRQAEvKTAKIALLLVLLFCLAWTPYAVVALIGQFGYLEVlTPLATA 263
                        250       260
                 ....*....|....*....|....*...
gi 768017218 219 IlrfCTALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15083  264 I---PAAFAKTSAIYNPVIYAFSHPKFR 288
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
7-240 7.72e-14

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 70.19  E-value: 7.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLL-----TLPFQGTDILLGfwpfGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15388   37 VFMLHLCIADLVVAFfqvlpQLVWDITDRFRG----PDVLCRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKG 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAiWALASVVGVP-VAIMGSAQVEDEEIECLVEIPTPqdyWGP-VFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15388  113 RARWNGPVCVA-WAISLILSLPqVFIFSKVEVAPGVYECWACFIEP---WGLkAYVTWITLVVFVLPTLIITVCQVLIFK 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RL--------------RGVRLLSGSREKDRN-----LRRITRLVLVVVAVFVGCWTPvqvFVLAQGLGV-QPSSETAVAI 219
Cdd:cd15388  189 EIhiniylksqiivavVKKKQLLSSRASSVAevskaMIKTVKMTLVIVLVYVLCWAP---FFLVQLWSVwDPKAPTEGAT 265
                        250       260
                 ....*....|....*....|.
gi 768017218 220 LRFCTALGYVNSCLNPILYAF 240
Cdd:cd15388  266 FTILMLLASLNSCTNPWIYMA 286
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
7-246 8.72e-14

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 69.75  E-value: 8.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKA 86
Cdd:cd15152   37 IFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDV 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  87 QaVNVAIWALASVVGVPVAIMGSAQVEDEEIeCLVEIPTPQ-DYWGPVFAICIF-LFSFIVPVLVISVCYSLMIRRLR-G 163
Cdd:cd15152  117 Y-ISIAGWLVVCVGCLPFPLLRQSQDTNPTC-CFADLPLRNvGLTTSVIMLTIAeLTGFVTPLLIVLYCSWKTVMSLReK 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 164 VRLLSGSREKDRNLRRITRLVLVVVAvfvgCWTPVQV-----FVLAQGLGVQPSSETAVAILRFCT-ALGYVNSCLNPIL 237
Cdd:cd15152  195 TPVLQDLGEKKKALKMILTCAVVFLI----CFAPYHIsfpldFLVKSNKIKSCTARKVILIFHPVAlCLASLNSCLDPVI 270

                 ....*....
gi 768017218 238 YAFLDENFK 246
Cdd:cd15152  271 YYFTTDEFK 279
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
2-247 8.90e-14

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 69.80  E-value: 8.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLL-TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRalDV 80
Cdd:cd15398   32 KTIINFLIGNLAFSDILVVLfCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAIVRYHMIKHPLS--NH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSA-------QVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15398  110 LTANHGYFLLGTVWTLGFTICSPLPVFHKIvdlsetfNLESLKNKYLCIESWPSDSYRIAFTISLLFVQYILPLVCLTVS 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRllsgsrekdRNLRRITRLVLVVVAVfvgcWTPVQVFVLAQGL-GVQPSSETAVAILRFCTALGYVNSC 232
Cdd:cd15398  190 HTSVCRSVKRSR---------SVFYRLTIVILAFAVS----WMPLHLFHLVTDFnANLISNRHFKLVYCICHLLGMLSCC 256
                        250
                 ....*....|....*
gi 768017218 233 LNPILYAFLDENFKA 247
Cdd:cd15398  257 LNPILYGFLNNGIKS 271
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
1-249 9.31e-14

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 69.83  E-value: 9.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPirALD 79
Cdd:cd15056   31 LRKKTNYFVVSLAVADLLVaVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAICCQ--PLV 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDeeIECLVEIPTPQDYWGPVF------AICIFLFSFIVPVLVISVC 153
Cdd:cd15056  109 YKMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIG--IEDLIAFNCASGSTSCVFmvnkpfAIICSTVAFYIPALLMVLA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 Y----------SLMIRRLRGVRLLSGSREKDRNLR-RITRLVLVVVAVFVGC----WTPVQVFVLaqglgVQPSSETAVA 218
Cdd:cd15056  187 YyriyvaareqAHQIRSLQRAGSSNHEADQHRNSRmRTETKAAKTLGIIMGCfcvcWAPFFVTNI-----VDPFIGYRVP 261
                        250       260       270
                 ....*....|....*....|....*....|...
gi 768017218 219 --ILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15056  262 ylLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
1-248 9.40e-14

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 69.88  E-value: 9.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTlpfqGTDILL-----GFWPFGNALCK-TVIAIDYYNMfTSTFTLTAMSVDRYVAICHP 74
Cdd:cd15085   31 LRNPINIFILNLSFSDLMMALC----GTTIVTvtnyeGYFYLGDAFCIfQGFAVNYFGI-VSLWSLTLLAYERYNVVCKP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  75 IRALDVRTSSKAQAVnVAIWALASVVGVpVAIMGSAQVEDEEIECLVEIPTPQDYWGPV-FAICIFLFSFIVPVLVISVC 153
Cdd:cd15085  106 MGGLKLSTKRGYQGL-LFIWLFCLFWAV-APLFGWSSYGPEGVQTSCSIGWEERSWSNYsYLILYFLMCFVIPVAIIGFS 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRL---LSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAqgLGVQPSSETAVAILRFCTALGYVN 230
Cdd:cd15085  184 YGNVLRSLHKLNKkieQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALI--VVVNPELSISPLAATMPTYFAKTS 261
                        250
                 ....*....|....*...
gi 768017218 231 SCLNPILYAFLDENFKAC 248
Cdd:cd15085  262 PVYNPIIYIFLNKQFRES 279
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
1-246 1.01e-13

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 69.84  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPiRALd 79
Cdd:cd15395   31 MHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERHQLIINP-RGW- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vRTSSKAQAVNVA-IWALASVVGVPVAIMgsAQVEDEEIE--------------CLVEIPTpqDYWGPVFAICIFLFSFI 144
Cdd:cd15395  109 -RPNNRHAYVGIAvIWVLAVLTSLPFLIF--QVLTDEPFKnvnvsldaykgkyvCLDQFPS--DTIRLSYTTCLLVLQYF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 145 VPVLVISVCY-SLMIRRLRGVRLLSGSRE---KDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAIL 220
Cdd:cd15395  184 GPLCFIFICYlKIYIRLKRRNNMMDKMRDnkyRSSETKRINIMLISIVVAFAVCWLPLNIFNAVFDWNHEAIATCNHNLL 263
                        250       260
                 ....*....|....*....|....*..
gi 768017218 221 -RFCTALGYVNSCLNPILYAFLDENFK 246
Cdd:cd15395  264 fLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
2-247 1.17e-13

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 69.47  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15166   32 RTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKELK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI-ECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15166  112 NTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFtTCLKMLDIIHLKEVNVLNFTRLIFFFLIPLFIMIGCYLVIIHN 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 LRGVRLlsgSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAIlrFCTALGYVNSCLNPILYAF 240
Cdd:cd15166  192 LVHGRT---SKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQNGDNSYNPWAA--FTTFLMNLSTCLDVILYYI 266

                 ....*..
gi 768017218 241 LDENFKA 247
Cdd:cd15166  267 VSKQFQA 273
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
1-249 1.17e-13

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 69.58  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTdILLGFwpfgnalCKTVIAIDYYNMF------TSTFTLTAMSVDRYVAICH 73
Cdd:cd15069   31 LQTPTNYFLVSLAAADVAVgLFAIPFAIT-ISLGF-------CTDFHSCLFLACFvlvltqSSIFSLLAVAVDRYLAIKV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  74 PIRALDVRTSSKAQAVNVAIWALASVVGVpVAIMG-----SAQVEDEE------------IECLVEIPTPQDYWGPV-FA 135
Cdd:cd15069  103 PLRYKSLVTGKRARGVIAVLWVLAFGIGL-TPFLGwnkamSATNNSTNpadhgtnhscclISCLFENVVPMSYMVYFnFF 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 136 ICIFLFSFIVPVLVISVcYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQV------FVLAQGlGV 209
Cdd:cd15069  182 GCVLPPLLIMLVIYIKI-FLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCWLPVHIlncitlFQPEFS-KS 259
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 768017218 210 QPSSETAVAILrfctaLGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15069  260 KPKWAMNVAIL-----LSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
7-240 1.32e-13

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 69.46  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLL--TLPFQGTDILLGFWPfGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTsS 84
Cdd:cd15385   37 LFIKHLSLADLVVAFfqVLPQLCWDITYRFYG-PDFLCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPT-K 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAVNVAIWALASVVGVP---VAIMGSAQVEDEEIECLVEIPTPqdyWGP-VFAICIFLFSFIVPVLVISVCYSLMIRR 160
Cdd:cd15385  115 RSYLMIGSAWALSFILSTPqyfIFSLSEIENGSGVYDCWANFIVP---WGIkAYITWITISIFVVPVIILLTCYGFICYN 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 161 L-RGVRLLSGSREKDR------------NLRRITRL-------VLVVVAVFVGCWTP---VQVF-VLAQGLGVQPSSETA 216
Cdd:cd15385  192 IwRNIKCKTRRGLSDNalknillavcvsSVKTISRAkirtvkmTFVIVLAYIVCWAPfftIQMWsVWDQNFPWDESENTA 271
                        250       260
                 ....*....|....*....|....*
gi 768017218 217 VAIlrfcTA-LGYVNSCLNPILYAF 240
Cdd:cd15385  272 VTI----TAlLASLNSCCNPWIYMF 292
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
1-249 1.33e-13

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 69.23  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd17790   31 LKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIE---CLVeiptpQDYWGPVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd17790  111 KRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTVLagqCYI-----QFLSQPIITFGTAIAAFYLPVTIMIILYWR 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLrgvrllsgSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETavaILRFCTALGYVNSCLNPI 236
Cdd:cd17790  186 IYRET--------IKEK-----KAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPKT---LWELGYWLCYVNSTVNPM 249
                        250
                 ....*....|...
gi 768017218 237 LYAFLDENFKACF 249
Cdd:cd17790  250 CYALCNKSFRDTF 262
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
2-247 1.35e-13

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 69.05  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPfqgTDILLgFWPFGNAL-CKTVIAIDYY-NMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15163   32 KTTSVIYTINLVVTDLLVGLSLP---TRIVM-YYSAGNCLtCSFVHIFSYFvNMYCSILFLTCICVDRYLAIVQVEASRR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVgvPVAIMGSAqvedeeieclveIPTPQDYWGPVFAICIFlfSFIVPVLVISVCYSLMIR 159
Cdd:cd15163  108 WRNPNYAKGICVFIWLFAIVV--TFSILTTA------------IKFASCCLSKLFALTVF--EFFLPLLIITFFTIRIMC 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRGVRLLSGSREKDRnlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15163  172 ALSRPGLMHQSRERRM---RAVQLLITVLIIFMICFTPFHVRQVAVAFNPDIPHHTSLIVYHVTVTLSSLNSCMDPIVYC 248

                 ....*...
gi 768017218 240 FLDENFKA 247
Cdd:cd15163  249 FVTNNFQS 256
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 1.76e-13

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 69.12  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd16002   31 MRTVTNYFLVNLAFAEaSMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQPRL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKaqAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIP-TPQDYWGPVFAICIFLFSFIVPVLVIsVCYSLMI 158
Cdd:cd16002  111 SATATK--VVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPeHEERKYETVYHVCVTVLIYFLPLLVI-GCAYTVV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRGVRLLSG-----SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgvQPSSETAVAILRFCTA---LGYVN 230
Cdd:cd16002  188 GITLWASEIPGdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYF--HPELYEQKFIQQVYLAimwLAMSS 265
                        250
                 ....*....|....*....
gi 768017218 231 SCLNPILYAFLDENFKACF 249
Cdd:cd16002  266 TMYNPIIYCCLNDRFRVGF 284
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
2-246 2.37e-13

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 68.67  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQgtdILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15920   32 ETSISVYMRNLALADLLLVLCLPFR---VAYQNTAGPLSFCKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIH 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAImGSAQVEDEEIECLVEipTPQDYWGPVFAICIFLFSFIVPVLVISVcYSLMIRRL 161
Cdd:cd15920  109 TVPWSSAASGGVWLLLLACMIPFLF-ESRNEGPCDNKCFHF--RSKGLTAGGINLTAVVIFYILSLLFLYF-YAKISHKL 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 162 RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQV----FVLAQgLGV---QPSSETAVAILRFCTALGYVNSCLN 234
Cdd:cd15920  185 YKVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHIvrvpYVLAQ-IDVissLPWKQTLHIANELVLCLSALNSCLD 263
                        250
                 ....*....|..
gi 768017218 235 PILYAFLDENFK 246
Cdd:cd15920  264 PIIYFFLSSSFR 275
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
1-247 4.14e-13

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 68.12  E-value: 4.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15337   31 LRTPSNMFIINLAISDFGFSAVngFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAM 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAIWALASVVGV-PVAIMGSAQVEDEEIECLVEIPTpQDYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15337  111 KKMTFKRAFIMIIIIWLWSLLWSIpPFFGWGRYVPEGFQTSCTFDYLS-RDLNNRLFILGLFIFGFLCPLLIIIFCYVNI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLR------------GVRLLSGSREKDRNLR-RITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCT 224
Cdd:cd15337  190 IRAVRnhekemtqtaksGMGKDTEKNDARKKAEiRIAKVAIILISLFLLSWTPYAVVALLGQFGPAYWITPYVSELPVMF 269
                        250       260
                 ....*....|....*....|...
gi 768017218 225 AlgYVNSCLNPILYAFLDENFKA 247
Cdd:cd15337  270 A--KASAIYNPIIYALSHPKFRA 290
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
1-249 7.37e-13

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 66.97  E-value: 7.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15300   31 LKTVNNYYLLSLACADLIIgIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAI-----MGSAQVEDEEIEClveiptpQDYWGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15300  111 KRTPKRAGIMIGLAWLISFILWAPPILcwqyfVGKRTVPERECQI-------QFLSEPTITFGTAIAAFYIPVSVMTILY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRrlrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGvqpSSETAVAILRFCTALGYVNSCLN 234
Cdd:cd15300  184 CRIYK-------------ETIKERKAAQTLSAILLAFIITWTPYNIMVLVSTFC---SDCIPLTLWHLGYWLCYVNSTVN 247
                        250
                 ....*....|....*
gi 768017218 235 PILYAFLDENFKACF 249
Cdd:cd15300  248 PMCYALCNKTFRKTF 262
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
1-250 8.90e-13

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 66.90  E-value: 8.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15299   34 LKTVNNYFLLSLACADLIIgVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRA 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI---ECLVEIPTPqdywgPVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd15299  114 KRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVppdECFIQFLSE-----PIITFGTAIAAFYLPVTIMTILYWR 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLrgvrllsgSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFctaLGYVNSCLNPI 236
Cdd:cd15299  189 IYKET--------IKEK-----KAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYW---LCYINSTVNPV 252
                        250
                 ....*....|....
gi 768017218 237 LYAFLDENFKACFR 250
Cdd:cd15299  253 CYALCNKTFRTTFK 266
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
5-240 1.09e-12

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 66.95  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15382   36 VNILLMHLAIADLLVtFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVCISLDRYFAILKPLRLSDARRR 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKaQAVNVAiWALASVVGVPVAIMGSAQVEDEE---IECLV--EIPTPQDywgpVFAICIF--LFSFIVPVLVISVCYSL 156
Cdd:cd15382  116 GR-IMLAVA-WVISFLCSIPQSFIFHVESHPCVtwfSQCVTfnFFPSHDH----ELAYNIFnmITMYALPLIIIVFCYSL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 ----MIRRLRGVRLLSGSREKDRNLRRIT------------RLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAIL 220
Cdd:cd15382  190 ilceISRKSKEKKEDVSEKSSSVRLRRSSvgllerarsrtlKMTIVIVLVFIICWTPYFIMSLWYWFDRESASKVDPRIQ 269
                        250       260
                 ....*....|....*....|
gi 768017218 221 RFCTALGYVNSCLNPILYAF 240
Cdd:cd15382  270 KGLFLFAVSNSCMNPIVYGY 289
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
1-248 1.22e-12

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 66.39  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPfGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15171   31 LKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSL-GNPTCKVLVALSSVGLHSEALFNVLLTVQASRVFFHGRLASSA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 -RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVE----IPTPQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15171  110 rRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSrphfLPAEETFWKYFLTLKMNIVVLVFPLLVFIICCV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRgvrllsgSREKDRNLRRITRLVLVVVAVFvgcWTPVQ-VFVLAQ-----GLGVQPSSETAVAILRFCTALGYV 229
Cdd:cd15171  190 QLRKTQR-------FRERQRDLSKLVFAIMVVFLLM---WAPYNiALFLSAfkehfSLRDCKSSYHLDASVQVTKLIATT 259
                        250
                 ....*....|....*....
gi 768017218 230 NSCLNPILYAFLDENFKAC 248
Cdd:cd15171  260 HCCVNPLLYALLDPAFRRR 278
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
6-247 1.24e-12

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 66.62  E-value: 1.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSS 84
Cdd:cd15383   37 RILILHLAAADLLVtFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRN 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  85 KAQAvnVAIWALASVVGVPVAIM---GSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMI--- 158
Cdd:cd15383  117 RIML--CAAWGLSALLALPQLFLfhtVTATPPVNFTQCATHGSFPAHWQETLYNMFTFFCLFLLPLLIMIFCYTRILlei 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 -RRLRGVRLLSG------------SREKDRNLrritRLVLVVVAVFVGCWTPVQV------FVLAQGLGVQPSSETAVAI 219
Cdd:cd15383  195 sRRMKEKKDSAKnevalrsssdniPKARMRTL----KMTIVIVSSFIVCWTPYYLlglwywFSPEMLEQTVPESLSHILF 270
                        250       260
                 ....*....|....*....|....*...
gi 768017218 220 LrfctaLGYVNSCLNPILYAFLDENFKA 247
Cdd:cd15383  271 L-----FGLLNACLDPLIYGLFTISFRR 293
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
3-161 1.78e-12

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 66.13  E-value: 1.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15170   34 TPIDILLLNLTVSDLIFLLFLPFKMAEAASGMiWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALAS-----VVGVPVAIMGSAQVEDEEIECLVEIPTPQ-DYWGPVFaICIFLFSFIVPVLVISVCYS 155
Cdd:cd15170  114 RPLYAVIASVFFWVLAFshcsiVYIVEYHIDSENTSVTNNSRCYDNFTPEQlKILLPVR-LELFLVLFCIPFLITCFCYI 192

                 ....*.
gi 768017218 156 LMIRRL 161
Cdd:cd15170  193 NFIRIL 198
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
8-249 1.79e-12

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 66.12  E-value: 1.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   8 YIFNLALADTLVLLT-LPFQgtdiLLGF------WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15130   41 HLGSLALSDLLILLLaMPVE----LYNFiwvhhpWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVA-IMGSAQVEDEEIE--CLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15130  117 MSRSRTKKFISAIWLASALLAIPMLfTMGLQNESDDGTHpgGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVTSILNTVI 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRgvrllsgsrekdRNLRRITRLVLVVVAVFVGCWTPVQVFVLAqgLGVQPSSETAVAILRF-------CTALGYVN 230
Cdd:cd15130  197 ANKLV------------QALRRGVLVLRAVVIAFVVCWLPYHVRRLM--FCYISDEQWTTFLFDFyhyfymlTNALFYVS 262
                        250
                 ....*....|....*....
gi 768017218 231 SCLNPILYAFLDENFKACF 249
Cdd:cd15130  263 SAINPILYNLVSANFRQVF 281
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
7-159 2.17e-12

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 65.87  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFqgtdiLLGF------WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15376   38 VFSFNLAVSDLLYALSLPL-----LAAYyyppknWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSH 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVaiMGSAQVEDEEIECLVEIPTPQDYWGPV-FAICIFL--FSFIVPVLVISVCYSLM 157
Cdd:cd15376  113 VRPKHAKLVSLAVWLLVAALSAPV--LSFSHLEVERHNKTECLGTAVDSRLPTyLPYSLFLavVGCGLPFLLTLASYLAI 190

                 ..
gi 768017218 158 IR 159
Cdd:cd15376  191 VW 192
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
7-246 2.62e-12

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 65.64  E-value: 2.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQ-GTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15149   36 VYLKNIVFADLLMSLTFPFKiLSDVELGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGY 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVR 165
Cdd:cd15149  116 SKALSVVVWMLMAVLSVPNIILTNQSFHEANYTKCARLKSELGIQWHKASNYICVSIFWVVFLLLIIFYVAISRKIYKSN 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 166 LLSgSREKDRNLRRITRLVLVVVAVFVGCWTPVQV----FVLAQgLGVQ---PSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15149  196 QKF-RRNSTNMKAKSSRNIFSILFVFFVCFVPYHAlripYTLSQ-TGADyscQSKTILYYMKEFTLLLSAANVCLDPIIY 273

                 ....*...
gi 768017218 239 AFLDENFK 246
Cdd:cd15149  274 FFLCQPFR 281
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
3-245 2.63e-12

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 65.56  E-value: 2.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15200   33 KSNTMYLLSLVVADFFLIINLPFRIDYYLRNeVWRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQvedEEIECLV----EIPTPQDYWGPVfaicIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15200  113 SVGCAAKVAAGLWILILLLNIHLLLLDHVQ---SNSTCLSydhgTDPSASDRWHRI----LFFLEFFLPLGIILFCIFSI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGSRekdrnLRRITRLVLVVVAVFVGCWTPVQVF----VLAQGLGVQPSSETAVAILRFCTALGYVNSCL 233
Cdd:cd15200  186 ILTLKQRKLAKQAG-----PQRAVKVLAVIVLVYTVCFLPSILFalasLVAFKVSQCRSLDLCTQLFHGSLAFTYLNSAL 260
                        250
                 ....*....|..
gi 768017218 234 NPILYAFLDENF 245
Cdd:cd15200  261 DPVLYCFSSPSF 272
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
5-162 2.76e-12

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 65.25  E-value: 2.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTL-VLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15215   34 ANRFIFNLLVADLLqTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTP 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIECLVEIptpqdYWG--PVFAICIFLFSFIVPVLVISVCYSLMIRRL 161
Cdd:cd15215  114 RRGYLLIYGTWIVSVLQSTP-PLYGWGQAAFDERNALCSV-----IWGssYSYTILSVVSSFVLPVIIMLACYSMVFRAA 187

                 .
gi 768017218 162 R 162
Cdd:cd15215  188 R 188
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
5-249 4.42e-12

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 64.70  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15066   34 TNYFVVSLAMADMLVaLCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVGVpVAIMGSAQVEDEEIECLVEIPTPQDYW-GPVFAICIFLFSFIVPVLVISVCYSLMIRRLR 162
Cdd:cd15066  114 RRVAIMLANVWISPALISF-LPIFLGWYTTEEHLQYRKTHPDQCEFVvNKIYALISSSVSFWIPCIVMIFTYYRIYLEAK 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 163 gvrllsgsREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGL--GVQPSSETAVAILRFctaLGYVNSCLNPILYAF 240
Cdd:cd15066  193 --------RE-----HKAAKTLGIIMGAFILCWLPFFLWYVTTTLcgDACPYPPILVSILFW---IGYFNSTLNPLIYAY 256

                 ....*....
gi 768017218 241 LDENFKACF 249
Cdd:cd15066  257 FNRDFREAF 265
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
1-244 4.73e-12

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 64.79  E-value: 4.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTL-VLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15212   31 LRTVTNAFILSLSLSDLLtALLCLPFAFLTLFSRpGWLFGDRLCLANGFFNACFGIVSTLTMTLISFDRYYAIVRQPQGK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSkAQAVnVAIWALASVVGVPVAIMGSAQVEDEEI---ECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15212  111 IGRRRA-LQLL-AAAWLTALGFSLPWYLLASAPEYYEKLgfyHCLYVLHSGPSRLGAAYSSVLIVLCYLLPFALMCFCHY 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRgvrlLSGSREKDRN-----LR-----RITRLVLVVVAVFVGCWTPVQVFVLAQGLG-VQ-PSSETAVAILrfc 223
Cdd:cd15212  189 NICKTVR----LSESRVRPVTtyahlLRfysemRTATTVLIMIVFIICCWGPYCLLGLVAAAGgYQfPPLMDTVAIW--- 261
                        250       260
                 ....*....|....*....|.
gi 768017218 224 taLGYVNSCLNPILYAFLDEN 244
Cdd:cd15212  262 --MAWANGAINPLIYAIRNPN 280
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
1-249 6.94e-12

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 64.05  E-value: 6.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15333   35 LHTPANYLIASLAVTDLLVsILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEipTPQDYWgPVFAICiflFSFIVPVLVISVCYSLMIR 159
Cdd:cd15333  115 KRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVN--TDHILY-TVYSTV---GAFYIPTLLLIALYGRIYV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRgvrllsgSREkdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgVQPSSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15333  189 EAR-------ARE-----RKATKTLGIILGAFIVCWLPFFIISLVLPI-CKDACWFHLAIFDFFTWLGYLNSLINPIIYT 255
                        250
                 ....*....|
gi 768017218 240 FLDENFKACF 249
Cdd:cd15333  256 MSNEDFKQAF 265
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
5-249 9.97e-12

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 64.25  E-value: 9.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGnALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRaLDVRTS 83
Cdd:cd15320   37 TNFFVISLAVSDLLVaVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFR-YERKMT 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAI-WALASVVG-VPVAIM-----------GSAQVEDEEIEclveipTPQDYWGPVFAICIFLFSFIVPVLVI 150
Cdd:cd15320  115 PKVAFIMISVaWTLSVLISfIPVQLNwhkakptsfldLNASLRDLTMD------NCDSSLNRTYAISSSLISFYIPVAIM 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 151 SVCYSLMIR----RLRGVRLLSGSREKDRNLR--------------------------RITRLVLVVVAVFVGCWTPvqV 200
Cdd:cd15320  189 IVTYTRIYRiaqkQIRRISALERAAVHAKNCQnstgnrgsgdcqqpessfkmsfkretKVLKTLSVIMGVFVCCWLP--F 266
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768017218 201 FVLAQGLGVQPSSETAVAILRFCTA-----LGYVNSCLNPILYAFlDENFKACF 249
Cdd:cd15320  267 FILNCMVPFCKPTSTEPFCISSTTFdvfvwFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
5-249 1.10e-11

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 64.21  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   5 TNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGnALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15319   36 TNIFIVSLAVSDLFVaLLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQ 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVG-VPVAI-----MGSAQVEDEEIECLVEIPTPQD-YWGPVFAICIFLFSFIVPVLVISVCYS- 155
Cdd:cd15319  115 RVALVMISVAWTLSVLISfIPVQLnwhkdSGDDWVGLHNSSISRQVEENCDsSLNRTYAISSSLISFYIPVAIMIVTYTr 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 ------LMIRRL----------RGVRLLSGSREKDRNLR-------RITRLVLVVVAVFVGCWTPvqVFVL--------- 203
Cdd:cd15319  195 iyriaqIQIRRIssleraaehaQSCRSNRIDCHHHTSLRtsikketKVLKTLSVIMGVFVCCWLP--FFILncmvpfcdr 272
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 768017218 204 ---AQGLGVQPSSETAVAILRFctaLGYVNSCLNPILYAFlDENFKACF 249
Cdd:cd15319  273 ppaDPDAGLPCVSETTFDVFVW---FGWANSSLNPIIYAF-NADFRKVF 317
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
2-245 1.11e-11

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 63.66  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQ-GTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15969   31 KTSFIFYLKNIVIADLLMTLTFPFKiIQDSGLGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRM 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTP--QDYWGPVFAICIFLfsFIVPVLVISVCYSLMI 158
Cdd:cd15969  111 YSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCSKLKSPlgVKWHTAVSYINICI--FVAVLVILIVCYISIS 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRL-----RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgvqpsSETAVAILRFCTA----LGYV 229
Cdd:cd15969  189 RYIyksskQFISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFSQLDKIL-----DCTIKTILYYCKEatlfLSAC 263
                        250
                 ....*....|....*.
gi 768017218 230 NSCLNPILYAFLDENF 245
Cdd:cd15969  264 NVCLDPIIYFFMCRSF 279
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
6-249 1.21e-11

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 63.66  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADTLVLLTlpfQGTDILL----GFWPFGNALCKTV-IAIDYYNMfTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15082   49 NYIIVNLSVADFLVSLT---GGTISFLtnarGYFFLGVWACVLEgFAVTFFGI-VALWSLAVLAFERFFVICRPLGNIRL 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVnVAIWALASVVGVPvAIMGSAQVEDEEIECLVEiptPQDYWGPV----FAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd15082  125 QGKHAALGL-LFVWTFSFIWTIP-PVLGWSSYTVSKIGTTCE---PNWYSGNMhdhtYIITFFTTCFILPLGVIFVSYGK 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 157 MIRRLRGVRLLSGSREKDRNL-RRITRLVLVVVAVFVGCWTPVQVF-VLAQGLGVQPSSETAVAILRFCTALGYVnscLN 234
Cdd:cd15082  200 LLQKLRKVSNTQGRLGNARKPeRQVTRMVVVMIVAFMVCWTPYAAFsILVTAHPTIHLDPRLAAIPAFFSKTAAV---YN 276
                        250
                 ....*....|....*
gi 768017218 235 PILYAFLDENFKACF 249
Cdd:cd15082  277 PIIYVFMNKQFRKCL 291
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
54-249 1.88e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 63.03  E-value: 1.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  54 FTSTFTLTAMSVDRYVAICHPIRALDVRTSSkAQAVNVAIWALASV-VGVPVaIMGSAQVEDEEIECLVEIPTPQDYWGP 132
Cdd:cd14980   93 LMSVLMMLLITLDRYICIVYPFSNKRLSYKS-AKIILILGWLFSIIfAAIPI-LYSINQPGDNRLYGYSSICMPSNVSNP 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 133 VFA---ICIFLFSFIVpVLVISVCYSLMIRRLRGVRlLSGSREKDRNLRRITRLVLVVVAVFVGCWTP---VQVFVLAQG 206
Cdd:cd14980  171 YYRgwlIAYLLLTFIA-WIIICILYILIFISVRKSR-KSARRSSSKRDKRIAIRLALILITDLICWLPyyiVIFSGLLTS 248
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 768017218 207 LGVQPSSETAVAILrfctALGyVNSCLNPILYAFLDENFKACF 249
Cdd:cd14980  249 TEIDIHVLQFIAIL----ALP-LNSAINPYLYTLTTPTFKRDF 286
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
2-238 2.74e-11

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 62.84  E-value: 2.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALdv 80
Cdd:cd15384   32 RRTIYSLLLHLAIADLLVtFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYPMKRN-- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIM---GSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLM 157
Cdd:cd15384  110 QAPERVRRMVTVAWILSPIFSIPQAVIfhvERGPFVEDFHQCVTYGFYTAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRL----RGV-RLLSGSREKDRNLRRI--------TRLVLVVVAVFVGCWTPVQV-FVLAQGLGVQPSSETAVAILRFc 223
Cdd:cd15384  190 FITLskssRDFqGLEIYTRNRGPNRQRLfhkakvksLRMSAVIVTAFILCWTPYYViMIWFLFFNPYPLNDILFDVIFF- 268
                        250
                 ....*....|....*
gi 768017218 224 taLGYVNSCLNPILY 238
Cdd:cd15384  269 --FGMSNSCVNPLIY 281
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
1-246 4.13e-11

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 62.06  E-value: 4.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADT-LVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15073   31 LRTPTNALIINLAVTDLgVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAV-----NVAIWALASVVGvpvaiMGSAQVEDEEIECLVEIpTPQDYWGPVFAICIFLFSFIVPVLVISVCY 154
Cdd:cd15073  111 MTTNTYTVMIllawtNAFFWAAMPLVG-----WASYALDPTGATCTINW-RKNDSSFVSYTMSVIVVNFIVPLAVMFYCY 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 ---SLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILrfCTALGYVNS 231
Cdd:cd15073  185 ynvSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEPKKIPPWMAII--PPLFAKSST 262
                        250
                 ....*....|....*
gi 768017218 232 CLNPILYAFLDENFK 246
Cdd:cd15073  263 FYNPCIYVIANKKFR 277
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
2-242 4.53e-11

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 61.67  E-value: 4.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN-ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd14964   30 PRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPqALCYLIYLLWYGANLASIWTTLVLTYHRYFALCGPLKYTRL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVE-IPTPQDYWgpvFAICifLFSFIVPVLVISVCYSLMIR 159
Cdd:cd14964  110 SSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYlICTTIYLT---WGFL--LVSFLLPLVAFLVIFSRIVL 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 160 RLRG---VRLLSGSREKDRNLRRiTRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFctALGYVNSCLNPI 236
Cdd:cd14964  185 RLRRrvrAIRSAASLNTDKNLKA-TKSLLILVITFLLCWLPFSIVFILHALVAAGQGLNLLSILAN--LLAVLASTLNPF 261

                 ....*.
gi 768017218 237 LYAFLD 242
Cdd:cd14964  262 IYCLGN 267
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
1-162 5.93e-11

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 61.66  E-value: 5.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15336   31 LRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLASIR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQV-EDEEIECLVE--IPTPQDYwgpVFAICIFLFSFIVPVLVISVCYSL 156
Cdd:cd15336  111 WVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVpEGLLTSCTWDymTFTPSVR---AYTMLLFCFVFFIPLGIIIYCYLF 187

                 ....*.
gi 768017218 157 MIRRLR 162
Cdd:cd15336  188 IFLAIR 193
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
3-251 7.18e-11

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 61.69  E-value: 7.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15317   33 SPTNMLVLSLATADFLLgLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVvgVPVAIMGSAQVEDEEIECLVEIP---TPQDYWGPVFAICIFLfSFIVPVLVISVCYS-LM 157
Cdd:cd15317  113 TVQVAWRFIAIGWLVPGI--YTFGLIYTGANDEGLEEYSSEIScvgGCQLLFNKIWVLLDFL-TFFIPCLIMIGLYAkIF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 158 IRRLRGVRLLSGSREKDRNL--------RRITRLVLVVVAVFVG----CWTPvqvFVLAQGLGVQPSSETAVAILRFCTA 225
Cdd:cd15317  190 LVARRQARKIQNMEDKFRSSeensskasASRERKAAKTLAIVMGiflfCWLP---YFIDTIVDEYSNFITPAIVFDAVIW 266
                        250       260
                 ....*....|....*....|....*.
gi 768017218 226 LGYVNSCLNPILYAFldenFKACFRK 251
Cdd:cd15317  267 LGYFNSAFNPFIYAF----FYPWFRK 288
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
1-240 9.55e-11

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 61.03  E-value: 9.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15318   31 LHTPTNFLLLSLALADMLLgLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGvpVAIMGSAQVEDEEIECLVEIPTP-------QDYWG----PVFAI-CIFLFSFIVPV 147
Cdd:cd15318  111 KFTIRVACIFIAAGWLVPTVYT--SVFLYTKAVEEGLAELLTSVPCVgscqllyNKLWGwlnfPVFFIpCLIMIGLYVKI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 148 LVISVCYSLMIrrlrgVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgvqPSSETAVAILRFCTALG 227
Cdd:cd15318  189 FIVAKRQARAI-----ASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSL---LNFITPPLLFDIIIWFA 260
                        250
                 ....*....|...
gi 768017218 228 YVNSCLNPILYAF 240
Cdd:cd15318  261 YFNSACNPLIYVF 273
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
3-241 1.16e-10

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 60.91  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRT 82
Cdd:cd14983   34 TPNVIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  83 SSKAQAVNVAIWALASVVGVPVAIMGSAQVE-------DEEIECLVEIPTPQ-DYWGPV-FAICIFLfsFIVPVLVISVC 153
Cdd:cd14983  114 PLYSCLVCVAIWALVIFHVTLVFILETSGGTldintpvGNSSTCYENFTPEQlALLAPVrLELSLVL--FFLPLAITAFC 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YslmirrLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILrfCTALgyvNSCL 233
Cdd:cd14983  192 Y------VRCIRILVRSRLHERRKRRAVRVAVSTLLTFVVCFGPYNISHVVGFVRHESVWWRKLALL--TSTC---NAFL 260

                 ....*...
gi 768017218 234 NPILYAFL 241
Cdd:cd14983  261 DPLIFYFL 268
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
2-173 2.50e-10

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 59.71  E-value: 2.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQgtdILLGF----WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRA 77
Cdd:cd15148   32 RNSVRIFLINVAIADLLLIICLPFR---ILYHVnnnqWTLGPLLCKVVGNLFYMNMYISIILLGFISLDRYLKINRSSRR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKAQAVNVAIWALASVVGVPVAIMgsAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVIsVCYSLM 157
Cdd:cd15148  109 QKFLTRKWSIVACGVLWAVALVGFVPMIVL--TEKNEESTKCFQYKDRKNAKGKAIFNFLIVAMFWLVFLLLI-LSYGKI 185
                        170
                 ....*....|....*.
gi 768017218 158 irrlrGVRLLSGSREK 173
Cdd:cd15148  186 -----AKKLLRISRDK 196
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
3-249 3.84e-10

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 59.31  E-value: 3.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNA-LCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15104   33 TKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKvLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIM 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEC---LVEIPTPQDY-----WGPVFAICIFLFSFIvpvLVISVC 153
Cdd:cd15104  113 TGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCsffAAFHPRVLLVlscmvFFPALLLFVFCYCDI---LKIARV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgvqpSSETAVA--ILRFCTALGYVNS 231
Cdd:cd15104  190 HSRAIYKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITGLVQAL----CDECKLYdvLEDYLWLLGLCNS 265
                        250
                 ....*....|....*...
gi 768017218 232 CLNPILYAFLDENFKACF 249
Cdd:cd15104  266 LLNPWIYAFWQKEVRRAL 283
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
7-150 5.28e-10

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 59.02  E-value: 5.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15364   37 VYLFSLSLCELLYLGTLPLWTIYVSNNHkWPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAVVYALESRGRRRQRI 116
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEiECLVEIPTPQDYWGPVFAicIFLFSFIVPVLVI 150
Cdd:cd15364  117 AAFISFLIFIVVGLVHSPVFIMREGQTEGSH-TCFETLQMDTQVAGFYYA--RFCIGFAIPLAIL 178
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
3-249 1.04e-09

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 58.13  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15312   33 SPTNFLILSLAITDFLLgFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVE-----IPTPQDYWGPVfaicIFLFSFIVPVLVISVCYS- 155
Cdd:cd15312  113 TTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVSctgscVLIFNKLWGVI----ASLIAFFIPGTVMIGIYIk 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 -LMIRRlRGVRLLSG------SREKDRNLRRITRLVLVVVAVFVG----CWTPVQVFVLaqglgVQP--SSETAVAILRF 222
Cdd:cd15312  189 iFFVAR-KHAKVINNrpsvtkGDSKNKLSKKKERKAAKTLSIVMGvfllCWLPFFVATL-----IDPflNFSTPVDLFDA 262
                        250       260
                 ....*....|....*....|....*..
gi 768017218 223 CTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15312  263 LVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
1-249 1.55e-09

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 57.36  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHpIRALD 79
Cdd:cd15331   31 LQGVSNYLILSLAVADLMVaVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVTN-IDYIR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPvAIMGSAQVED-----EEIECLVEiptpQDYWGPVFAICIflfSFIVPVLVISVCY 154
Cdd:cd15331  110 RRTAKRILIMIAVVWFVSLIISIA-PLFGWKDEDDldrvlKTGVCLIS----QDYGYTIFSTVG---AFYVPLLLMIIIY 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRgvrllsgsREKD--RNLRRITRLVLVvvavfvgCWTPVqvFVLAQGLGVQPSSETAVAILRFCTALGYVNSC 232
Cdd:cd15331  182 WKIYQAAK--------RERKaaRTLAIITGAFVV-------CWLPF--FLVALVMPFCGAWQISRFLESFFLWLGYFNSL 244
                        250
                 ....*....|....*..
gi 768017218 233 LNPILYAFLDENFKACF 249
Cdd:cd15331  245 LNPIIYTIFSPDFRGAF 261
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
1-249 1.64e-09

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 57.44  E-value: 1.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLP--FQGTDILLGFwPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15000   30 LRTPTNLLIGNMALADLLTLLVCPwmFLVHDFFQNY-VLGSVGCKLEGFLEGSLLLASVLALCAVSYDRLTAIVLPSEAR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 dvRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVED----EEIECLVEIPTPQDYWGPVFAICIFLfsfivPVLVISVCY 154
Cdd:cd15000  109 --LTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQwknfLETYCAENTQVLPIYWHVIITVLVWL-----PLGIMLICY 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGVRLLSGSREKDRNLR---RITRLVLVVVAVFVGCWTPVQVFV-----LAQGLGVQPSSETAVAILRFCT-A 225
Cdd:cd15000  182 SAIFWKLDKYERRVLRREHPSVVRykkKAAKTLFIVLITFVVCRIPFTALIfyrykLVPNDNTQNSVSGSFHILWFASkY 261
                        250       260
                 ....*....|....*....|....
gi 768017218 226 LGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15000  262 LMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
7-240 1.66e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 57.30  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIF--NLALADTLV--------LLTLPFQGTDIllgfwPFGNALCKTVIAIdyyNMFTSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd14972   33 MYILiaNLAAADLLAgiafvftfLSVLLVSLTPS-----PATWLLRKGSLVL---SLLASAYSLLAIAVDRYISIVHGLT 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  77 ALDVRTSSKAQAVNVAIWALASVVGVpVAIMGSAQVEDEEIECLVEIP-TPQDYwgpvfAICIFLFsFIVPVLVISVCYS 155
Cdd:cd14972  105 YVNNVTNKRVKVLIALVWVWSVLLAL-LPVLGWNCVLCDQESCSPLGPgLPKSY-----LVLILVF-FFIALVIIVFLYV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRL--RGVRLLSGSREKDRNLRRITRLVLVVVAVFVG----CWTPVQVFVLAQGLGvqPSSETAVAILRFCTALGYV 229
Cdd:cd14972  178 RIFWCLwrHANAIAARQEAAVPAQPSTSRKLAKTVVIVLGvflvCWLPLLILLVLDVLC--PSVCDIQAVFYYFLVLALL 255
                        250
                 ....*....|.
gi 768017218 230 NSCLNPILYAF 240
Cdd:cd14972  256 NSAINPIIYAF 266
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
1-249 1.90e-09

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 56.97  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15309   31 LQTTTNYLIVSLAVADLLVaTLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVA-IWALASVVGVPVAImgsAQVEDEEIECLVEiptpqdywGPVFAICIFLFSFIVPVLVISVCYSLMI 158
Cdd:cd15309  111 RYSSKRRVTVMISvVWVLSFAISCPLLF---GLNNTDQNECIIA--------NPAFVVYSSIVSFYVPFIVTLLVYVQIY 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRgvrllsgsREKdrnlrRITRLVLVVVAVFVGCWTPvqvFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILY 238
Cdd:cd15309  180 IVLQ--------KEK-----KATQMLAIVLGVFIICWLP---FFITHILNMHCDCNIPPALYSAFTWLGYVNSAVNPIIY 243
                        250
                 ....*....|.
gi 768017218 239 AFLDENFKACF 249
Cdd:cd15309  244 TTFNIEFRKAF 254
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
7-161 1.96e-09

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 57.45  E-value: 1.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQ-GTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15147   39 IFMVNLTIADLLFLITLPFWiVYYHNEGNWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKR 118
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWG--PVFAICIFL-FSFIVPVLVISVCYSLMIRRL 161
Cdd:cd15147  119 GIIISVAIWVIIVASASYFLFMDSTNTVKIDSGNFTRCFEGYEKDNskPVLIIHFIIiGLFFLVFLLILVCNLVIARTL 197
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
8-249 2.76e-09

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 56.80  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   8 YIFNLALADTLVLL-TLPFQgtdiLLGF------WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15356   41 HLVSLALSDLLILLiSVPIE----LYNFvwfhypWVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVA-IMGsaqvEDEEIECLVEIPTPQDYWGPVF----AICIF-----LFSFIVPVLVI 150
Cdd:cd15356  117 LSKRRTKWLLALIWASSLGFALPMAfIMG----QKYELETADGEPEPSSRVCTVLvsraTLKVFiqvnaFVSFVLPLALI 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 151 SVCYSLMIRRLRgvrllsgsrekDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAqgLGVQPSSETAVAILRF-------C 223
Cdd:cd15356  193 AFLNGVTVSHLR-----------IQSLQHSVQVLRAIVIAYVICWLPYHARRLM--FCYVPDDAWTDSLYNFyhyfymlT 259
                        250       260
                 ....*....|....*....|....*.
gi 768017218 224 TALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15356  260 NTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
1-249 5.68e-09

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 56.10  E-value: 5.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFqGTDILLGFwpfgnalCKTVIAIDYYNMF------TSTFTLTAMSVDRYVAICH 73
Cdd:cd15068   31 LQNVTNYFVVSLAAADIAVgVLAIPF-AITISTGF-------CAACHGCLFIACFvlvltqSSIFSLLAIAIDRYIAIRI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  74 PIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEE------------IECLVEIPTPQDYwgpvFAICIFLF 141
Cdd:cd15068  103 PLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEgknhsqgcgegqVACLFEDVVPMNY----MVYFNFFA 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 142 SFIVPVLVISVCYSLMI----RRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVG----CWTPVQVfVLAQGLGVQPSS 213
Cdd:cd15068  179 CVLVPLLLMLGVYLRIFlaarRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGlfalCWLPLHI-INCFTFFCPDCS 257
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 768017218 214 ETAVAILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15068  258 HAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
1-162 6.39e-09

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 55.44  E-value: 6.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPiraldv 80
Cdd:cd15072   31 LRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGFFTALASICSSAAIAWDRYHHYCTR------ 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 rtsSKAQAVNVAIWA----LASVVGVPVAIMGSAQVEDEEIECLVEIPTPQ---DYWGPVFAICIFlfSFIVPVLVISVC 153
Cdd:cd15072  105 ---SKLQWSTAISLVlfvwLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKgdrNYVSYLFTMAFF--NFILPLFILLTS 179

                 ....*....
gi 768017218 154 YSLMIRRLR 162
Cdd:cd15072  180 YSSIEQKLK 188
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
55-246 9.44e-09

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 55.28  E-value: 9.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  55 TSTFTLTAMSVDRYVAICHPIRALDVrTSSKAQAVNVAIWALASVVGV-PVAIM-------GSAQVedeeieCL-----V 121
Cdd:cd15137   93 VSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLAVlPLLPWdyfgnfyGRSGV------CLplhitD 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 122 EIPTPQDYWGPVFaICIFLFSFivpvLVISVCYSLMIRRLRGVRLLSGSREKDRNlRRITRLVLVVVAVFVGCWTPVQVF 201
Cdd:cd15137  166 ERPAGWEYSVFVF-LGLNFLAF----VFILLSYIAMFISIRRTRKAAASRKSKRD-MAVAKRFFLIVLTDFLCWIPIIVI 239
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 768017218 202 VLAQGLGVQPSSE----TAVAILRfctalgyVNSCLNPILYAFLDENFK 246
Cdd:cd15137  240 GILALSGVPIPGEvyawVAVFVLP-------INSALNPILYTLSTPKFR 281
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
56-246 1.38e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 54.53  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  56 STFTLTAMSVDRYVAICHPIRaLDVRTS-SKAQAVNVAIWALASVVGVpVAIMGSAQVEDEEIeCL-VEIPTPQDywgpv 133
Cdd:cd15136   94 SVFTLTVITLERWYAITHAMH-LNKRLSlRQAAIIMLGGWIFALIMAL-LPLVGVSSYSKTSI-CLpFETETPVS----- 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 134 FAICIFLFSF-IVPVLVISVCYSLMIRRLRGvrllsGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPS 212
Cdd:cd15136  166 KAYVIFLLLFnGLAFLIICGCYIKIYLSVRG-----SGRAANSNDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGLPLI 240
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 768017218 213 SETAVAILrfcTALGY-VNSCLNPILYAFLDENFK 246
Cdd:cd15136  241 SVSNAKIL---LVFFYpLNSCANPFLYAIFTKQFR 272
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
7-246 4.27e-08

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 53.28  E-value: 4.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQ-GTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15150   36 IFLKNTVISDLLMILTFPFKiLSDAKLGSWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLG 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDY-WGPVFA-ICIFLfsFIVPVLVISVCYSLMIRRL-R 162
Cdd:cd15150  116 AKILSTVIWASMFALSLPNMILTNRQPTPKNVKKCSLLKSEFGLvWHEIVNyICQVI--FWVNFLIVIVCYTLITKELyK 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 163 GVRLLSGSREKDRnlRRITRLVLVVVAVFVGCWTPVQV----FVLAQGLGVQ--PSSETAVAILRFCTALGYVNSCLNPI 236
Cdd:cd15150  194 SYKRTRGVGKVSR--KKVNVKVFIIIAVFFICFVPFHFaripYTLSQTRDVFdcTAKNTLFYVKESTLWLTSLNACLDPF 271
                        250
                 ....*....|
gi 768017218 237 LYAFLDENFK 246
Cdd:cd15150  272 IYFFLCKSFR 281
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
2-246 6.73e-08

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 52.46  E-value: 6.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQ-GTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15167   32 RKCINIYLINLLTADFLLTLALPVKiAVDLGIAPWKLKIFHCQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSSKLYRI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFA--ICIFLFSFIVPVLVISVCysLMI 158
Cdd:cd15167  112 QEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGCADFKTEFGRHWHVLTnfICMAIFLNFSAIILISNF--LVI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 159 RRLRGVRllsgSREKDRNLRRITRLVLVVVAVFVGCWTPVQV----FVLAQGLGVQPSS-ETAVAILRFCTALGYV-NSC 232
Cdd:cd15167  190 RKLYRNK----DSEEYRNARQALVNILLVTAGYVICFVPYHIvripYTLSQSEVITDCSlKRSLFLAKESTLLLAVlNLC 265
                        250
                 ....*....|....
gi 768017218 233 LNPILYAFLDENFK 246
Cdd:cd15167  266 FDPILYFHLSKAFR 279
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
7-246 7.85e-08

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 52.48  E-value: 7.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQG-TDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15151   36 VYLKNTLVADLIMTLMLPFKIlSDSGLGPWQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRF 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  86 AQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYW--GPVFAICIFLFsFIVPVLVIsVCYSLMIRRLrg 163
Cdd:cd15151  116 AKILSGAVWLVMFLLSVPNMILSNKPATPISVKKCASLKSPLGLKwhEVVNYICQFIF-WGVFALMV-LFYTIISKKV-- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 164 VRLLSGSREKDRNLRRITRLVL-VVVAVFVGCWTPVQV----FVLAQ-GLGVQPSSETAVAILRFCTA-LGYVNSCLNPI 236
Cdd:cd15151  192 YESYKKSRSKDNKASKKTKAKVfIIVAVFFVCFAPFHFvrvpYTLSQtGKITDCQLQNLLYIAKEITLwLAATNVCLDPL 271
                        250
                 ....*....|
gi 768017218 237 LYAFLDENFK 246
Cdd:cd15151  272 IYIFLCKSFR 281
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
1-249 9.59e-08

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 52.05  E-value: 9.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKtviaidYYNMFTSTF------TLTAMSVDRYVAICH 73
Cdd:cd15086   31 LRSPINLLLLNISLSDLLVcVLGTPFSFAASTQGRWLIGEHGCR------WYGFANSLFgivsliSLAVLSYERYCTLLR 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  74 PIRAlDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQ-VEDEEIECLVEIpTPQDYWGPVFAICIFLFSFIVPVLVISV 152
Cdd:cd15086  105 PTEA-DVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYgPEGPGTTCSVQW-TSRSANSISYIICLFIFCLLLPFLVMVY 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYS---LMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAvfvgCWTPVQVFVLAQGLGvQPSSETAVAILrFCTALGYV 229
Cdd:cd15086  183 CYGrllYAIKQVGKINKSTARKREQHVLLMVVTMVICYLL----CWLPYGVMALLATFG-KPGLVTPVASI-VPSILAKS 256
                        250       260
                 ....*....|....*....|
gi 768017218 230 NSCLNPILYAFLDENFKACF 249
Cdd:cd15086  257 STVVNPIIYVFMNKQFYRCF 276
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
33-248 1.43e-07

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 51.74  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  33 GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVrTSSKAQAVNVAIWALASVVGVPvAIMGSAQV 112
Cdd:cd15076   64 GYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFGNFRF-GSKHALGAVVATWIIGIGVSLP-PFFGWSRY 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 113 EDEEIECLVE---IPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGV---RLLSGSREKDRnlRRITRLVLV 186
Cdd:cd15076  142 IPEGLQCSCGpdwYTVGTKYRSEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVaaqQQESASTQKAE--REVSRMVVV 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768017218 187 VVAVFVGCWTPVQVFVLAQGLGVQPSSEtavaiLRFCTALGYVN--SCL-NPILYAFLDENFKAC 248
Cdd:cd15076  220 MVGSFCLCYVPYAALAMYMVNNRDHGLD-----LRLVTIPAFFSksSCVyNPIIYCFMNKQFRAC 279
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
7-241 1.75e-07

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 51.10  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPI---RALDVRTS 83
Cdd:cd14973   36 VYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPIwyrCHRPKHLS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVnvaIWALASVVGVPVAIM-GSAQVEDEEIECLVeiptpqdywgpVFAICIFLFSFIVPVLVISvcySLMIRrlr 162
Cdd:cd14973  116 AVVCAL---LWALSLLLSVLESYFcGFLFWKFNESACRT-----------FNFLSALLFLLLFLVMCVS---SLTLL--- 175
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017218 163 gVRLLSGSREkdRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTAlgyVNSCLNPILYAFL 241
Cdd:cd14973  176 -IRVQCSSQR--RPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFSNYLFHTFHPISDLLSC---VNSSANPIIYFFV 248
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
7-242 2.91e-07

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 50.53  E-value: 2.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGtdILLGFWPF-----GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15220   34 AFVCHLCVVDLLAALLLMPLG--ILSSSPFFlgvvfGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKM 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIW------ALASVVGVPVAIMGSAQVEDeeiECLVeiptpqdYWGP-----VFAICIFLFSFIVPVLVI 150
Cdd:cd15220  112 TIGLVAAVLVGVWvkalllGLLPVLGWPSYGGPAPIAAR---HCSL-------HWSHsghrgVFVVLFALVCFLLPLLLI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 151 SVCYSLMIRRLRGvrllsgsrekdrnlRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSS----ETAVailrfcTAL 226
Cdd:cd15220  182 LVVYCGVFKVFGG--------------GKAALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSggeaEEVV------TWL 241
                        250
                 ....*....|....*.
gi 768017218 227 GYVNSCLNPILYAFLD 242
Cdd:cd15220  242 AYSCFAVNPFFYGLLN 257
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
1-254 3.83e-07

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 50.25  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLL---TLPFQGTdiLLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRa 77
Cdd:cd15084   41 LRSPLNYILVNLAVADLLVTLfgsSVSFSNN--IVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMG- 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 lDVRTSSKAQAVNVAI-WALASVVGVPVAIMGSAQVEdeeiECLVEIPTPQDYWGPV----FAICIFLFSFIVPVLVISV 152
Cdd:cd15084  118 -DFRFQQRHAVSGCAFtWGWSLLWTSPPLFGWSSYVP----EGLRTSCGPNWYTGGTnnnsYILALFVTCFALPLSTIIF 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CYSLMIRRLRGVRLLSGSREK-DRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRfcTALGYVNS 231
Cdd:cd15084  193 SYSNLLLTLRAVAAQQKESETtQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKDVVIQPTLASLP--SYFSKTAT 270
                        250       260
                 ....*....|....*....|...
gi 768017218 232 CLNPILYAFLDENFKACFRKFCC 254
Cdd:cd15084  271 VYNPIIYVFMNKQFRSCLLELLC 293
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
1-157 4.28e-07

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 50.22  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALD 79
Cdd:cd15404   31 MRSAINILLASLAFADMMLaVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISIDRFLII---VQKQD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAImGSA--QVEDEEIECLVEIPTPQDYwgPVFAICIFLFSFIVPVLVIsvCYSLM 157
Cdd:cd15404  108 KLNPYRAKVLIAVSWAVSFCVAFPLAV-GSPdlQIPSRAPQCVFGYTTNPGY--QAYVILIMLIFFFIPFMVM--LYSFM 182
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
1-248 4.55e-07

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 50.21  E-value: 4.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALC------KTVIAIdyynmfTSTFTLTAMSVDRYVAICH 73
Cdd:cd15078   31 LRTPTNLLLVNISLSDLLVsLLGVTFTFMSCVRGRWVFDVAGCvwdgfsNSLFGI------VSIMTLTVLAYERYIRVVH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  74 PiRALDVRTSSKAqAVNVAIWALASVvGVPVAIMGSAQVEDEEIECLVEIpTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15078  105 A-KVVNFSWSWRA-ITYIWLYSLAWT-GAPLLGWNRYTLEVHGLGCSFDW-KSKDPNDTSFVLLFFLGCLVVPLGIMAYC 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLM---IRRLRGVRLLSGSREKD--RNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGy 228
Cdd:cd15078  181 YGHIlyeIRMLRSVEDLQTFQVIKilKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGYSKLVTPTIAIIPSLFAKS- 259
                        250       260
                 ....*....|....*....|
gi 768017218 229 vNSCLNPILYAFLDENFKAC 248
Cdd:cd15078  260 -STAYNPVIYIFMIRKFRQC 278
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
3-96 5.77e-07

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 50.01  E-value: 5.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLVLLTLPFQGTDILL-GFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15169   34 TPSLVYALNLGCSDLLLTVSLPLKAVEALAsGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFR 113
                         90
                 ....*....|....*
gi 768017218  82 TSSKAQAVNVAIWAL 96
Cdd:cd15169  114 RPCYSWGVCAAIWAL 128
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
2-159 5.80e-07

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 49.83  E-value: 5.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPiraLDV 80
Cdd:cd15008   31 QSTTNYFVVSMACADLLLSVAsAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTIVYP---LSF 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  81 RTS-SKAQAVNVAIWALASVVGVPVAIMGSAQVEDEeieclVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR 159
Cdd:cd15008  108 KVSrEKAKKMIAASWLFDAAFVSPALFFYGSNWGPH-----CNFFLPDSWDGAAYAIIHLLVGFLVPSILIILFYQKVIK 182
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
1-249 7.31e-07

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 49.40  E-value: 7.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALD 79
Cdd:cd15296   31 LRTQGNFFFLNLAISDFLVgGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSV---TRAVS 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRT----SSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI---ECLVEIptpqdYWGPVFAICIFLFSFIVPvlVISV 152
Cdd:cd15296  108 YRAqkgmTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIIpegECYAEF-----FYNWYFLMTASTLEFFTP--FISV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 153 CY-----SLMIRRlRGVRLlsgSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVL----AQGLGVQPS-SETAVAILrf 222
Cdd:cd15296  181 TYfnlsiYLNIQK-RRFRL---SRDK-----KVAKSLAIIVCVFGLCWAPYTLLMIiraaCHGHCVPDYwYETSFWLL-- 249
                        250       260
                 ....*....|....*....|....*..
gi 768017218 223 ctalgYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15296  250 -----WVNSAINPVLYPLCHMSFRRAF 271
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
1-249 1.01e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 49.03  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15054   31 LRNTSNYFLVSLFMSDLMVgLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCVISLDRYLLIISPLRYKL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPT--PQDYWGP--VFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15054  111 RMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTveGQCRLLVslPYALVASCLTFFLPSGAICFTYC 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLRgvRLLSGSrekdrnlrritRLVLVVVAVFVGCWTPVQVFVLAQGLgvqpSSETAVAILRFCTALGYVNSCLNP 235
Cdd:cd15054  191 RILLAAR--KALKAS-----------LTLGILLGMFFVTWLPFFVANVVQAV----CDCVSPGLFDVLTWLGYCNSTMNP 253
                        250
                 ....*....|....
gi 768017218 236 ILYAFLDENFKACF 249
Cdd:cd15054  254 IIYPLFMRDFKRAL 267
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
8-122 1.43e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 48.99  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   8 YIFNLALADTL-VLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPiRALDVRTSSK 85
Cdd:cd15005   38 FLLDLCLADGLrSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHH-RFYAKRMTFW 116
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768017218  86 AQAVNVAI-WALASVVGV-PVAIMGSAQVEDEEIECLVE 122
Cdd:cd15005  117 TCLAVICMaWTLSVAMAFpPVFDVGTYTFIREEDQCTFE 155
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
1-251 2.06e-06

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 48.32  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15316   31 LHSPTNFLIASLACADFLVGVTvMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTDPLVYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGsaqVEDEEIECLV---------EIPTPQDYwgpvfaICIFLFSFIVPVLVI 150
Cdd:cd15316  111 KFTVSVSGICISVSWIFSLTYSFSVFYTG---VNDDGLEELVnalncvggcQIILNQNW------VLVDFLLFFIPTFAM 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 151 SVCYSLMI----RRLRGVRLLSGSRE------KDRNLRRITRLVLVVVAVFVG---CWTPVQVFVLAQGLgvqPSSETAV 217
Cdd:cd15316  182 IILYGKIFlvakQQARKIEMTSSKAEsssesyKDRVARRERKAAKTLGITVIAflvSWLPYLIDVLIDAF---MNFITPP 258
                        250       260       270
                 ....*....|....*....|....*....|....
gi 768017218 218 AILRFCTALGYVNSCLNPILYAFldenFKACFRK 251
Cdd:cd15316  259 YIYEICCWCAYYNSAMNPLIYAL----FYPWFRK 288
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
11-249 2.27e-06

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 48.02  E-value: 2.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  11 NLALADTLVL-LTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRaLDVRTSSKAQA 88
Cdd:cd15328   41 SMAVSDVLVAaLVMPLSLVHELSGrRWQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSITRHLE-YTLRTRRRISN 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  89 VNVAI-WALASVVGVPVAIMGSAQVEDEEIEclvEIPTPQDywgPVFAICIFLFSFIVPVLVISVCY------------- 154
Cdd:cd15328  120 VMIALtWALSAVISLAPLLFGWGETYSEDSE---ECQVSQE---PSYTVFSTFGAFYLPLCVVLFVYwkiykaaqkekra 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 155 SLMIRRLRGVRLLsgsrekdrnlrritrlvlvvvavfvgCWTPvqvFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLN 234
Cdd:cd15328  194 ALMVGILIGVFVL--------------------------CWIP---FFLTELISPLCSCDIPPIWKSIFLWLGYSNSFFN 244
                        250
                 ....*....|....*
gi 768017218 235 PILYAFLDENFKACF 249
Cdd:cd15328  245 PLIYTAFNKNYNNAF 259
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
3-163 2.80e-06

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 47.63  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd15214   32 TLSNKFVFSLTLSNLLLsVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  82 TSSKAQAVNVAIWaLASVVGVPVAIMGSAQVEDEEIE--CLVEIPTPQDYWGPVFAICIFLfsfivPVLVISVCYSLMIR 159
Cdd:cd15214  112 TGNRAVLALVYIW-LHSLIGCLPPLFGWSSLEFDRFKwmCVAAWHKEAGYTAFWQVWCALL-----PFVVMLVCYGFIFR 185

                 ....
gi 768017218 160 RLRG 163
Cdd:cd15214  186 VARA 189
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
1-248 5.53e-06

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 46.74  E-value: 5.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVLLtlpFQGTDILLGF----WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15077   31 LRSHLNYILVNLAVANLIVVC---FGSTTAFYSFsqmyFVLGPLACKIEGFTATLGGMVSLWSLAVVAFERFLVICKPLG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  77 ALDVRTSsKAQAVNVAIWALASVVGVPvAIMGSAQVEDEEIECLVE---IPTPQDYWGPVFAICIFLFSFIVPVLVISVC 153
Cdd:cd15077  108 NFTFRGT-HAIIGCIATWVFGLAASLP-PLFGWSRYIPEGLQCSCGpdwYTTNNKWNNESYVMFLFCFCFGVPLSIIVFS 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 154 YSLMIRRLRGV-RLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCtaLGYVNSC 232
Cdd:cd15077  186 YGRLLLTLRAVaKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALWVVTNRGEPFDLRLASIPSV--FSKASTV 263
                        250
                 ....*....|....*.
gi 768017218 233 LNPILYAFLDENFKAC 248
Cdd:cd15077  264 YNPVIYVFMNKQFRSC 279
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
35-253 5.66e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 46.86  E-value: 5.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  35 WPFGNALCKtviaidyYNMFTSTFT-------LTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVG-VPVAI 106
Cdd:cd14981   69 WDGGQPLCD-------YFGFMMSFFglsslliVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAsLPLLG 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 107 MGSAQVEDEEIECLveIPTPQDYWGPVFAICIFLFSFIVPVLVISVC-YSLMIRRLRGVRLLSGSREKDRNLRRITRLVL 185
Cdd:cd14981  142 LGSYVLQYPGTWCF--LDFYSKNTGDAAYAYLYSILGLLILLVTLLCnLLVIITLLRMRRRKKRHRRSRRSARRQKRNEI 219
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768017218 186 VVVAVFVG-------CWTPVQVFVLAQGLGVQPSSETAVAI-LRFCTalgyVNSCLNPILYAFLDenfKACFRKFC 253
Cdd:cd14981  220 QMVVLLLAitvvfsvCWLPLMIRVLINATGDSEKNGKTDLLaVRMAS----WNQILDPWVYILLR---KEVLRRLY 288
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
12-249 9.75e-06

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 46.33  E-value: 9.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  12 LALADTLVLLT-LPFQGTDILLG--FWPFGNALCKTviaidYYNMF-----TSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15135   45 LACSDLLVLLLgMPVELYSAIWDpfATPSGNIACKI-----YNFLFeacsyATILNVATLSFERYIAICHPFKYKALSGS 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVnVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFS------------FIVPVLVIS 151
Cdd:cd15135  120 RVRLLI-CFVWLTSALVALPLLFAMGTEDPLEAFPSYRGTRHHCQDQKSNLTICTSLSSkwtvfqasifsaFVLYLLVLA 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 152 V----CYSlMIRRLRG--------------VRLL--SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLgvQP 211
Cdd:cd15135  199 SvafmCRR-MMRALMGskkgavavkgpggsVQLLrkHESAEGKTARKQTILFLGLIVGTLAVCWMPNQIRRIMAAA--KP 275
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 768017218 212 SSETAVAILR-------FCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15135  276 KDDWTRSYFRayiillpIADTFFYLSSVLNPLLYNLSSQQFRSVF 320
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
6-248 1.22e-05

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 45.92  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   6 NIYIFNLALADtlvlltlpfqgtdilLGFWPFGNALCKTVIAIDYYNM---------FTSTF-------TLTAMSVDRYV 69
Cdd:cd15075   36 NYALVNLAVAD---------------LGTTVFGGLLSVVTNAVGYFNLgrvgcvlegFAVAFfgiaalcTVAVIAVDRLF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  70 AICHPIRALDVRTSSKAQAVNVA-----IWALASVVGvpvaiMGSAQVEDEEIECLVEIPTpQDYWGPVFAICIFLFSFI 144
Cdd:cd15075  101 VVCKPLGTLTFQTRHALAGIASSwlwslIWNTPPLFG-----WGSYQLEGVMTSCAPDWYS-RDPVNVSYILCYFSFCFA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 145 VPVLVISVCYSLMIRRLRGVRLL----SGSREKDRNlrRITRLVLVVVAVFVGCWTPVQVFVLAqgLGVQPSSETAVAIL 220
Cdd:cd15075  175 IPFAIILVSYGYLLWTLRQVAKLgvaeGGSTAKAEV--QVARMVVVMVMAFLLCWLPYAAFALT--VVSKPDVYINPLIA 250
                        250       260
                 ....*....|....*....|....*...
gi 768017218 221 RFCTALGYVNSCLNPILYAFLDENFKAC 248
Cdd:cd15075  251 TVPMYLAKSSTVYNPIIYIFMNKQFRDC 278
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
1-248 1.65e-05

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 45.21  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADtLVLLTLPFQGTDI--LLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRal 78
Cdd:cd15080   31 LRTPLNYILLNLAVAD-LFMVFGGFTTTMYtsMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMS-- 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  79 DVRTSSKAQAVNVAI-WALASVVGVPVAIMGSAQV-EDEEIECLVEIPTPQ-DYWGPVFAICIFLFSFIVPVLVISVCYS 155
Cdd:cd15080  108 NFRFGENHAIMGVAFtWVMALACAAPPLVGWSRYIpEGMQCSCGIDYYTLKpEVNNESFVIYMFVVHFTIPLIVIFFCYG 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 156 LMIRRLR-GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFV----LAQGLGVQPSSETAVAILRFCTALgyvn 230
Cdd:cd15080  188 RLVCTVKeAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAfyifTHQGSDFGPIFMTIPAFFAKSSAV---- 263
                        250
                 ....*....|....*...
gi 768017218 231 scLNPILYAFLDENFKAC 248
Cdd:cd15080  264 --YNPVIYILMNKQFRNC 279
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
8-246 2.55e-05

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 44.89  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   8 YIFNLALADTLVLLTLPFqgTDILLGFW----PFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 83
Cdd:cd15919   39 YLLALAAADILVLFFIVF--VDFLLEDFilnkQMPQVLDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYP 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  84 SKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTpqdyWGPVFAIciflfsFIVPVLVISVCYSLMIRRLrg 163
Cdd:cd15919  117 ARTRKVIVSVYITCFLTSIPYYWWPNIWIEDYTSTSMHHVLI----WIHCFTV------YLVPCSIFFVLNSIIVYKL-- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 164 vRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILR-FCTALGYVNSCLNPILYAFLD 242
Cdd:cd15919  185 -RRKSNFRLRGYSTGKTTAILFTITSIFAILWAPRIIMILYHLYVSPINNSWLVHIVSdIANMLALLNTAINFFLYCFIS 263

                 ....
gi 768017218 243 ENFK 246
Cdd:cd15919  264 KRFR 267
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
56-240 5.14e-05

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 44.00  E-value: 5.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  56 STFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVpVAIMGSAQVEDEEiECLVEIPTpqdYWGPVFA 135
Cdd:cd15349   86 STFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGF-LPLLGWNCLCDFR-SCSSLLPL---YSKSYIL 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 136 ICIFLFSFIVpvLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSET 215
Cdd:cd15349  161 FCLVIFFIIL--LTIIGLYFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRSCKP 238
                        170       180
                 ....*....|....*....|....*
gi 768017218 216 AVAiLRFCTALGYVNSCLNPILYAF 240
Cdd:cd15349  239 LFG-MEWVLALAVLNSAINPLIYSF 262
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
55-76 7.56e-05

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 43.24  E-value: 7.56e-05
                         10        20
                 ....*....|....*....|..
gi 768017218  55 TSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15912   86 TEFFLLAVMSFDRYVAICNPLH 107
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
60-107 8.07e-05

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 43.17  E-value: 8.07e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 768017218  60 LTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIM 107
Cdd:cd15950   91 LLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCL 138
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
1-248 1.08e-04

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 42.91  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALAD-TLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIchpIRALD 79
Cdd:cd15403   31 MRSAINLLLATLAFSDiMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVAILLIISVDRFLII---VQRQD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 VRTSSKAQAVNVAIWALASVVGVPVAIMGSaqvedeeiecLVEIPT--PQDYWG-------PVFAICIFLFSFIVPVLVI 150
Cdd:cd15403  108 KLNPHRAKVMIAISWVLSFCISFPSVVGWT----------LVEVPAraPQCVLGytespadRVYAVLLVVAVFFVPFSIM 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 151 SVCYSLMIRRLR---------------------GVRLLSGSREKDRNLRRITRLVLVVVAVFVG---CWTPVQVFVLAQG 206
Cdd:cd15403  178 LYSYLCILNTVRrnavrihnhadslclsqvsklGLMGLQRPHQMNVDMSFKTRAFTTILILFVGfslCWLPHTVFSLLSV 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 768017218 207 LGVQPSSETAVAILRFCTA-LGYVNSCLNPILYAFLDENFK-AC 248
Cdd:cd15403  258 FSRRFYYSSSFYPISTCVLwLSYLKSVFNPVIYCWRIKKFReAC 301
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
2-106 2.30e-04

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 41.70  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVR 81
Cdd:cd14994   32 RSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMHLTFLFYVIILVIRYLIFFQRKDKMEFY 111
                         90       100
                 ....*....|....*....|....*
gi 768017218  82 TSSKAQAVNVAIWALASVVGVPVAI 106
Cdd:cd14994  112 RKLHAVAASAVVWVLVLLIVVPVFV 136
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
58-156 2.48e-04

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 41.77  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  58 FTLTAMSVDRYVAICHPIRALdVRTSSKA-QAVNVAIWALASVVGVP--VAIMGSAQVEDEEIE---ClvEIP-----TP 126
Cdd:cd15421   89 LLLALMAYDRYVAICHPLRYP-VLMSPRVcLLMAAGSWLGGSLNSLIhtVYTMHFPYCGSREIHhffC--EVPallklSC 165
                         90       100       110
                 ....*....|....*....|....*....|...
gi 768017218 127 QD---YWGPVFAICIFLfsFIVPVLVISVCYSL 156
Cdd:cd15421  166 ADtsaYETVVYVSGVLF--LLIPFSLILASYAL 196
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
3-250 2.89e-04

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 42.11  E-value: 2.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   3 TATnIYIFNLALADTLVLLTLPFqgtdILLGFWPF--GNALCKTVIAIDYYNMFTSTF-TLTAMSVDRYVAICHPIRAld 79
Cdd:PHA03235  68 TPT-LYMTNLYLANLLTVFVLPF----IMLSNQGLlsGSVAGCKFASLLYYASCTVGFaTVALIAADRYRVIHQRTRA-- 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  80 vRTSSKAQ--AVNVAIWALASVVGVPVAIMGSAQVEDEeieclveiptpQDYWGPVFAICIFLFSF-------------- 143
Cdd:PHA03235 141 -RSSAYRStyKILGLTWFASLICSGPAPVYTTVVAHDD-----------VDPEAPGYETCVIYFRAdqvktvlstfkvll 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 144 -----IVPVLVISVCYSLMIRRLRgvrlLSGSREKDRNLRRITRLVLvvvavfvgCWTPVQV-FVL-----AQGLGVQPS 212
Cdd:PHA03235 209 tlvwgIAPVVMMTWFYTFFYRTLK----RASYKKRSRTLTFVCILLL--------SFLCLQTpFVAimifdSYATLIWPS 276
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 768017218 213 SETAVAILRfctALGYVNS------CL-NPILYAFLDENF----KACFR 250
Cdd:PHA03235 277 DCEHINLRD---AVSTLSRlvpnlhCLlNPILYAFLGNDFlkrfRQCFR 322
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
7-151 2.92e-04

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 41.62  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPFQGTDILLgfwPFGNALCKTVIAIDYYNMF------TSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15110   36 VYILHLAIADFTFLLCIFILSIMYIG---PFNFSHSRDYVAMLIFIILflfgynTGLYLLTAISVERCLSVLYPIWYRCH 112
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTpqdywgpvfaICIFLFSFIVPVLVIS 151
Cdd:cd15110  113 RPKHQSAIVCGLLWALSVLMTSLEYLMCIDEGFHVRNECRAVLIF----------IGILTFLVFTPLMLIS 173
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
58-76 3.30e-04

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 41.29  E-value: 3.30e-04
                         10
                 ....*....|....*....
gi 768017218  58 FTLTAMSVDRYVAICHPIR 76
Cdd:cd15225   89 FLLAAMAYDRYVAICNPLR 107
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
58-76 4.76e-04

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 40.90  E-value: 4.76e-04
                         10
                 ....*....|....*....
gi 768017218  58 FTLTAMSVDRYVAICHPIR 76
Cdd:cd15227   89 ALLTVMAYDRYVAICHPLH 107
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
55-76 1.20e-03

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 39.77  E-value: 1.20e-03
                         10        20
                 ....*....|....*....|..
gi 768017218  55 TSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15911   86 TECYLLAVMSYDRYLAICKPLH 107
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-76 1.23e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 39.77  E-value: 1.23e-03
                         10        20
                 ....*....|....*....|....*
gi 768017218  54 FTST--FTLTAMSVDRYVAICHPIR 76
Cdd:cd13954   83 LGGTecFLLAVMAYDRYVAICHPLH 107
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
60-107 1.34e-03

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 39.41  E-value: 1.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 768017218  60 LTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIM 107
Cdd:cd15222   91 LLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFL 138
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
59-107 1.66e-03

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 39.19  E-value: 1.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 768017218  59 TLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIM 107
Cdd:cd15917   90 VLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLL 138
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
56-249 1.90e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 39.07  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  56 STFTLTAMSVDRYVAICHPIRaLDVRTSSK-AQAVNVAIWALASVVGVpVAIMGSAQVEDEEIECLVEIPTPQDYWGPVF 134
Cdd:cd15360   94 SVYTLTVITLERWHTITYAMQ-LDRKVRLRhAAVIMVGGWIFAFTVAL-LPIFGISSYMKVSICLPMDIESPLSQAYIIF 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 135 AICIFLFSFivpvLVISVCYSLMIRRLRGVRLLSGSREKdrnlrRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSE 214
Cdd:cd15360  172 ILVLNVLAF----LIICACYIKIYLTVRNPNFVSSNSDT-----KIAKRMAVLIFTDFLCMAPISFFAISASLKVPLITV 242
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 768017218 215 TAVAILrfcTALGY-VNSCLNPILYAFLDENFKACF 249
Cdd:cd15360  243 SKSKIL---LVLFYpINSCANPFLYAIFTKTFRRDF 275
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
55-76 1.90e-03

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 39.13  E-value: 1.90e-03
                         10        20
                 ....*....|....*....|..
gi 768017218  55 TSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15235   87 TDSFLLAVMAYDRYVAICHPLH 108
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
8-109 2.47e-03

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 38.81  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   8 YIF--NLALAD-TLVLLTLPfqgtDILLGFWPFGNAL----CKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV 80
Cdd:cd15223   36 YILlgILAAVDiVLATTILP----KMLAIFWFDANTIslpgCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPSI 111
                         90       100
                 ....*....|....*....|....*....
gi 768017218  81 RTSSKAQAVNVAIWALASVVGVPVAIMGS 109
Cdd:cd15223  112 ITKSFILKLVLFALIRSGLLVLPIVVLAS 140
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
140-249 3.06e-03

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 38.26  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 140 LFSFIVPVLVISVCYSLMIRRL-RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGvqPSSETAVA 218
Cdd:cd15101  166 LVTFLVMVVVYARIFVYVRRRTnRMSPHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLC--CRQCNVLA 243
                         90       100       110
                 ....*....|....*....|....*....|.
gi 768017218 219 ILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15101  244 VEKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
8-93 3.33e-03

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 38.43  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   8 YIFNLALADTLVLL---TLPfqgtDILLGFW------PFGNalCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRAL 78
Cdd:cd15221   36 YLFLSMLAVTDLLLsttTVP----KMLAIFWfgageiSFDG--CLTQMFFVHFVFVTESAILLAMAFDRYVAICYPLRYT 109
                         90
                 ....*....|....*
gi 768017218  79 DVRTSSKAQAVNVAI 93
Cdd:cd15221  110 TILTHSVIGKIGVAA 124
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
57-76 3.92e-03

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 37.94  E-value: 3.92e-03
                         10        20
                 ....*....|....*....|
gi 768017218  57 TFTLTAMSVDRYVAICHPIR 76
Cdd:cd15234   88 NFLLAVMAYDRYVAICHPLH 107
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
7-249 4.12e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 38.08  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   7 IYIFNLALADTLVLLTLPfqgTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKA 86
Cdd:cd15961   37 LLIGSLALADLLAGIGLI---LNFIFAYLLQSEAAKLVTVGLIVASFSASVCSLLAITVDRYLSLYYALTYNSERTVTFT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  87 QAVNVAIWALASVVGVpVAIMGSAQVEDEEIeCLVEIPTPQDYWGPVFAICIFLFSFIVPvLVISVCySLMIRRLRGVRL 166
Cdd:cd15961  114 YVMLVLLWGASICLGL-LPVMGWNCLADEST-CSVVRPLTKNNAAILSVSFLLMFALMLQ-LYIQIC-KIVMRHAHQIAL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 167 LSG--SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAqglgvqpSSETAVAILRFCTAL-GYVNSCLNPILYAFLDE 243
Cdd:cd15961  190 QHHflATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLI-------ADYTYPSIYTYATLLpATYNSIINPVIYAFRNQ 262

                 ....*.
gi 768017218 244 NFKACF 249
Cdd:cd15961  263 EIQKAL 268
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
60-99 4.16e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 38.01  E-value: 4.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768017218  60 LTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV 99
Cdd:cd15232   91 LTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGML 130
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
1-246 4.27e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 37.84  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIdyynMFT--STFTLTAMSVDRYVAICHPIRA 77
Cdd:cd15070   31 LRTTTFYFIVSLALADIAVgVLVIPLAIVVSLGVTIHFYSCLFMSCLLV----VFThaSIMSLLAIAVDRYLRVKLTVRY 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  78 LDVRTSSKAQAVNVAIWALASVVG-VPVA----IMGSAQVEDEEIECLVEIPTPQDYwgpvfaicIFLFSFI----VPVL 148
Cdd:cd15070  107 RIVTTQRRIWLALGLCWLVSFLVGlTPMFgwnrKPSLESVNTTPLQCQFTSVMRMDY--------MVYFSFFtwilIPLV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 149 VISVCYSLMIRRLRG--VRLLSGSREKDRNLRR---ITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQ-PSSETAVAILrf 222
Cdd:cd15070  179 IMCALYVDIFYIIRNklSQNATGFRETGAFYGRefkTAKSLALVLFLFAVCWLPLSIINCVVYFNPKvPKIALYLGIL-- 256
                        250       260
                 ....*....|....*....|....
gi 768017218 223 ctaLGYVNSCLNPILYAFLDENFK 246
Cdd:cd15070  257 ---LSHANSMMNPIVYACKIKKFK 277
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
55-76 4.31e-03

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 37.96  E-value: 4.31e-03
                         10        20
                 ....*....|....*....|..
gi 768017218  55 TSTFTLTAMSVDRYVAICHPIR 76
Cdd:cd15229   86 TEAFLLSAMAYDRYAAICHPLH 107
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
55-107 4.64e-03

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 37.69  E-value: 4.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768017218  55 TSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIM 107
Cdd:cd15420   86 TECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVL 138
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
62-203 5.17e-03

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 37.83  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  62 AMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALA-SVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAIcifL 140
Cdd:cd15144  101 AMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVAlAVALLPLFRFGRYKPQFPGTWCFIKVQPPGSWADVAFAL---L 177
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 141 FSF--IVPVLVISVC-----YSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVgCWTPVQVFVL 203
Cdd:cd15144  178 FSLlgLASLLVSLVCntisgLTLVRARLRKKCSCSNRRAKSHDIEMVVQLVGIMVVSCI-CWSPLLIFVL 246
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
1-125 5.55e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 37.91  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   1 MKTATNIYIFNLALADTLVL-LTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD 79
Cdd:cd15127   31 MRSISNSLLANLAFWDFLIIfFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYE 110
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768017218  80 VRTSSKAQAVNVA-IWALASVVGVPVAIMGSAQVEDEEIE------CLVEIPT 125
Cdd:cd15127  111 MIENCTSTTAKLAvIWVGALLLALPEVVLRQLSKEDGGSGappaerCVVKIST 163
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
194-249 5.58e-03

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 37.47  E-value: 5.58e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768017218 194 CWTPVQVFVLAQGLGVQpsSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACF 249
Cdd:cd15342  221 CWTPGQVVLLLDGLGCE--SCNVLAYEKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
55-239 6.17e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 37.51  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218  55 TSTFT-----LTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVpVAIMGsAQVEDEEIECLVEIP-TPQD 128
Cdd:cd15099   81 TMAFTasvgsLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISF-LPLMG-WRCKTWDSPCSRLFPyIDRH 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218 129 YWGPVFAICIFLFSFIVpvlvisVCYSLMIRRL-RGVRLLSGSREKDRNLRRITRL---------VLVVVAVFVGCWTPV 198
Cdd:cd15099  159 YLASWTGLQLVLLFLII------YAYPYILWKAhRHEANMGGPKLGRQQVKGQARMrmdirlaktLSLILLVLAICWLPV 232
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 768017218 199 QVFVLAQGLGVQpsSETAVAILRFCTALGYVNSCLNPILYA 239
Cdd:cd15099  233 LAFMLVDVRVTL--TNKQKRMFAFCSMLCLVNSCVNPIIYA 271
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
51-74 6.50e-03

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 37.49  E-value: 6.50e-03
                         10        20
                 ....*....|....*....|....*.
gi 768017218  51 YNMFTST--FTLTAMSVDRYVAICHP 74
Cdd:cd15230   80 FAVFGTTecFLLAAMAYDRYVAICNP 105
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
58-76 6.91e-03

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 37.21  E-value: 6.91e-03
                         10
                 ....*....|....*....
gi 768017218  58 FTLTAMSVDRYVAICHPIR 76
Cdd:cd15918   89 FLLAVMAYDRYVAICHPLH 107
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
53-102 7.70e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 37.08  E-value: 7.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 768017218  53 MFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGV 102
Cdd:cd15103   90 LLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGI 139
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
2-103 7.96e-03

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 37.06  E-value: 7.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   2 KTATNIYIFNLALADTLVLLTLPFQG----TDILLGFWPfgNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRA 77
Cdd:cd15129   33 KKSSYYYLLALTASDILTQVFIIFVGfilqTAILAREVP--HALIHTVSVLEFAANHASIWITVLLTVDRYVALCHPLRY 110
                         90       100
                 ....*....|....*....|....*.
gi 768017218  78 LDVRTSSKAQAVNVAIWALASVVGVP 103
Cdd:cd15129  111 RAVSYPERTRRIIAAVFVAALATGIP 136
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
8-122 9.21e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 37.24  E-value: 9.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017218   8 YIFNLALADTL-VLLTLPFQGTDILLG-FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSK 85
Cdd:cd15217   38 FLLDLCLADTIrSAVCFPFVLVSIRNGsAWTYSVLSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWT 117
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 768017218  86 AQAVNVAIWALASVVGV-PVAIMGSAQVEDEEIECLVE 122
Cdd:cd15217  118 CIAVICMVWTLSVAMAFpPVFDVGTYKFIREEDQCIFE 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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