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Conserved domains on  [gi|767943414|ref|XP_011534360|]
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proto-oncogene tyrosine-protein kinase ROS isoform X12 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10637190)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-27 subunit beta that associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 211-290 2.05e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 2.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  211 NIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQK-----LDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAE 285
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*
gi 767943414  286 SSITT 290
Cdd:cd00063    88 SVTVT 92
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
103-297 1.80e-10

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.41  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  103 EVLENADLPTAP---FASSIGSHNMTLRWKSANFSGVK-YIIQWKYAQLlGSWTYTKTVSRPSYVVKPLHPFTEYIFRVV 178
Cdd:COG3401   225 SVTTPTTPPSAPtglTATADTPGSVTLSWDPVTESDATgYRVYRSNSGD-GPFTKVATVTTTSYTDTGLTNGTTYYYRVT 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  179 WIFTAQLQlySPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPqfPGGPILGYNL----RLISKNQKLDAGTQR 254
Cdd:COG3401   304 AVDAAGNE--SAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVyrstSGGGTYTKIAETVTT 379

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767943414  255 TSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQ 297
Cdd:COG3401   380 TSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1051-1157 6.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414 1051 PSAPENPRIfilpsgKCCNKNEVVVefRWNKPKHENGVLTKFEIFYNISNQsitnktcEDWIAVNVTP-SVMSFQLEGMS 1129
Cdd:cd00063     1 PSPPTNLRV------TDVTSTSVTL--SWTPPEDDGGPITGYVVEYREKGS-------GDWKEVEVTPgSETSYTLTGLK 65

                          90       100
                  ....*....|....*....|....*...
gi 767943414 1130 PRCFIAFQVRAFTSKGPGPYADVVKSTT 1157
Cdd:cd00063    66 PGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 567-677 8.61e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 8.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  567 PGRPQELSVLF-GSHQALVQWKPPALAIGAnvilISD-IIELFELGPSAWQNWTYEVkvstqdppevthiflnISGTMLN 644
Cdd:cd00063     1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGP----ITGyVVEYREKGSGDWKEVEVTP----------------GSETSYT 60

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767943414  645 VPELQSAMKYKVSVRASSPKRPGPWSEPSVGTT 677
Cdd:cd00063    61 LTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 971-1038 8.74e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 8.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943414  971 NASSFQILWNGPPAVDWGVVFYSVEF----SAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGP 1038
Cdd:cd00063    13 TSTSVTLSWTPPEDDGGPITGYVVEYrekgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 211-290 2.05e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 2.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  211 NIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQK-----LDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAE 285
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*
gi 767943414  286 SSITT 290
Cdd:cd00063    88 SVTVT 92
fn3 pfam00041
Fibronectin type III domain;
206-283 1.44e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414   206 APLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKN-----QKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGE 280
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsgepwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 767943414   281 GPE 283
Cdd:pfam00041   82 GPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
103-297 1.80e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.41  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  103 EVLENADLPTAP---FASSIGSHNMTLRWKSANFSGVK-YIIQWKYAQLlGSWTYTKTVSRPSYVVKPLHPFTEYIFRVV 178
Cdd:COG3401   225 SVTTPTTPPSAPtglTATADTPGSVTLSWDPVTESDATgYRVYRSNSGD-GPFTKVATVTTTSYTDTGLTNGTTYYYRVT 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  179 WIFTAQLQlySPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPqfPGGPILGYNL----RLISKNQKLDAGTQR 254
Cdd:COG3401   304 AVDAAGNE--SAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVyrstSGGGTYTKIAETVTT 379

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767943414  255 TSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQ 297
Cdd:COG3401   380 TSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 206-281 1.13e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.13e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414    206 APLIRNIESSSPDTVEVSWDPPQFPG--GPILGYNLRLISKN---QKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGE 280
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 767943414    281 G 281
Cdd:smart00060   83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1051-1157 6.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414 1051 PSAPENPRIfilpsgKCCNKNEVVVefRWNKPKHENGVLTKFEIFYNISNQsitnktcEDWIAVNVTP-SVMSFQLEGMS 1129
Cdd:cd00063     1 PSPPTNLRV------TDVTSTSVTL--SWTPPEDDGGPITGYVVEYREKGS-------GDWKEVEVTPgSETSYTLTGLK 65

                          90       100
                  ....*....|....*....|....*...
gi 767943414 1130 PRCFIAFQVRAFTSKGPGPYADVVKSTT 1157
Cdd:cd00063    66 PGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 111-178 9.74e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 9.74e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943414    111 PTAPFASSIGSHNMTLRWKSANFSG-VKYIIQWK--YAQLLGSW-TYTKTVSRPSYVVKPLHPFTEYIFRVV 178
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRveYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 111-194 9.78e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 9.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  111 PTAPFASSIGSHNMTLRWKSANFSG---VKYIIQWKYAQLLGSWTYTKT-VSRPSYVVKPLHPFTEYIFRVVWIFTAQlq 186
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGGG-- 81


                  ....*...
gi 767943414  187 lYSPPSPS 194
Cdd:cd00063    82 -ESPPSES 88
fn3 pfam00041
Fibronectin type III domain;
1052-1149 3.70e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 3.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  1052 SAPENPRIfilpsgkcCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSitnktcEDWIAVNVTPSVMSFQLEGMSPR 1131
Cdd:pfam00041    1 SAPSNLTV--------TDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG------EPWNEITVPGTTTSVTLTGLKPG 66

                           90
                   ....*....|....*...
gi 767943414  1132 CFIAFQVRAFTSKGPGPY 1149
Cdd:pfam00041   67 TEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 567-677 8.61e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 8.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  567 PGRPQELSVLF-GSHQALVQWKPPALAIGAnvilISD-IIELFELGPSAWQNWTYEVkvstqdppevthiflnISGTMLN 644
Cdd:cd00063     1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGP----ITGyVVEYREKGSGDWKEVEVTP----------------GSETSYT 60

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767943414  645 VPELQSAMKYKVSVRASSPKRPGPWSEPSVGTT 677
Cdd:cd00063    61 LTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1051-1147 1.18e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.18e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414   1051 PSAPENPRIfilpsgKCCNKNEVVVefRWNKPKHENGvlTKFEIFYNISNQSitnkTCEDWIAVNVTPSVMSFQLEGMSP 1130
Cdd:smart00060    1 PSPPSNLRV------TDVTSTSVTL--SWEPPPDDGI--TGYIVGYRVEYRE----EGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 767943414   1131 RCFIAFQVRAFTSKGPG 1147
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
111-178 1.08e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 1.08e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767943414   111 PTAPFASSIGSHNMTLRWKSANFSG---VKYIIQWKYAQLLGSWTyTKTVSRP--SYVVKPLHPFTEYIFRVV 178
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPWN-EITVPGTttSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
568-670 3.65e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414   568 GRPQELSVLF-GSHQALVQWKPPalaiganvilisdiielfELGPSAWQNwtYEVKVSTQDPPEVTHIFlNISGT--MLN 644
Cdd:pfam00041    1 SAPSNLTVTDvTSTSLTVSWTPP------------------PDGNGPITG--YEVEYRPKNSGEPWNEI-TVPGTttSVT 59

                           90       100
                   ....*....|....*....|....*.
gi 767943414   645 VPELQSAMKYKVSVRASSPKRPGPWS 670
Cdd:pfam00041   60 LTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 567-667 8.14e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 8.14e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414    567 PGRPQELSVLF-GSHQALVQWKPPALAIGANVILisdiielfelgpsawqnwTYEVKVSTQDPPEVTHIFlNISGTMLNV 645
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIV------------------GYRVEYREEGSEWKEVNV-TPSSTSYTL 61

                            90       100
                    ....*....|....*....|..
gi 767943414    646 PELQSAMKYKVSVRASSPKRPG 667
Cdd:smart00060   62 TGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 971-1038 8.74e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 8.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943414  971 NASSFQILWNGPPAVDWGVVFYSVEF----SAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGP 1038
Cdd:cd00063    13 TSTSVTLSWTPPEDDGGPITGYVVEYrekgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 211-290 2.05e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 2.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  211 NIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQK-----LDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAE 285
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*
gi 767943414  286 SSITT 290
Cdd:cd00063    88 SVTVT 92
fn3 pfam00041
Fibronectin type III domain;
206-283 1.44e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414   206 APLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKN-----QKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGE 280
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsgepwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 767943414   281 GPE 283
Cdd:pfam00041   82 GPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
103-297 1.80e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.41  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  103 EVLENADLPTAP---FASSIGSHNMTLRWKSANFSGVK-YIIQWKYAQLlGSWTYTKTVSRPSYVVKPLHPFTEYIFRVV 178
Cdd:COG3401   225 SVTTPTTPPSAPtglTATADTPGSVTLSWDPVTESDATgYRVYRSNSGD-GPFTKVATVTTTSYTDTGLTNGTTYYYRVT 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  179 WIFTAQLQlySPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPqfPGGPILGYNL----RLISKNQKLDAGTQR 254
Cdd:COG3401   304 AVDAAGNE--SAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVyrstSGGGTYTKIAETVTT 379

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767943414  255 TSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQ 297
Cdd:COG3401   380 TSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 206-281 1.13e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.13e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414    206 APLIRNIESSSPDTVEVSWDPPQFPG--GPILGYNLRLISKN---QKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGE 280
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 767943414    281 G 281
Cdd:smart00060   83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1051-1157 6.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414 1051 PSAPENPRIfilpsgKCCNKNEVVVefRWNKPKHENGVLTKFEIFYNISNQsitnktcEDWIAVNVTP-SVMSFQLEGMS 1129
Cdd:cd00063     1 PSPPTNLRV------TDVTSTSVTL--SWTPPEDDGGPITGYVVEYREKGS-------GDWKEVEVTPgSETSYTLTGLK 65

                          90       100
                  ....*....|....*....|....*...
gi 767943414 1130 PRCFIAFQVRAFTSKGPGPYADVVKSTT 1157
Cdd:cd00063    66 PGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 111-178 9.74e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 9.74e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943414    111 PTAPFASSIGSHNMTLRWKSANFSG-VKYIIQWK--YAQLLGSW-TYTKTVSRPSYVVKPLHPFTEYIFRVV 178
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRveYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 111-194 9.78e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 9.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  111 PTAPFASSIGSHNMTLRWKSANFSG---VKYIIQWKYAQLLGSWTYTKT-VSRPSYVVKPLHPFTEYIFRVVWIFTAQlq 186
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGGG-- 81


                  ....*...
gi 767943414  187 lYSPPSPS 194
Cdd:cd00063    82 -ESPPSES 88
fn3 pfam00041
Fibronectin type III domain;
1052-1149 3.70e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 3.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  1052 SAPENPRIfilpsgkcCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSitnktcEDWIAVNVTPSVMSFQLEGMSPR 1131
Cdd:pfam00041    1 SAPSNLTV--------TDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG------EPWNEITVPGTTTSVTLTGLKPG 66

                           90
                   ....*....|....*...
gi 767943414  1132 CFIAFQVRAFTSKGPGPY 1149
Cdd:pfam00041   67 TEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 567-677 8.61e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 8.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414  567 PGRPQELSVLF-GSHQALVQWKPPALAIGAnvilISD-IIELFELGPSAWQNWTYEVkvstqdppevthiflnISGTMLN 644
Cdd:cd00063     1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGP----ITGyVVEYREKGSGDWKEVEVTP----------------GSETSYT 60

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767943414  645 VPELQSAMKYKVSVRASSPKRPGPWSEPSVGTT 677
Cdd:cd00063    61 LTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1051-1147 1.18e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.18e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414   1051 PSAPENPRIfilpsgKCCNKNEVVVefRWNKPKHENGvlTKFEIFYNISNQSitnkTCEDWIAVNVTPSVMSFQLEGMSP 1130
Cdd:smart00060    1 PSPPSNLRV------TDVTSTSVTL--SWEPPPDDGI--TGYIVGYRVEYRE----EGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 767943414   1131 RCFIAFQVRAFTSKGPG 1147
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
111-178 1.08e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 1.08e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767943414   111 PTAPFASSIGSHNMTLRWKSANFSG---VKYIIQWKYAQLLGSWTyTKTVSRP--SYVVKPLHPFTEYIFRVV 178
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPWN-EITVPGTttSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
568-670 3.65e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414   568 GRPQELSVLF-GSHQALVQWKPPalaiganvilisdiielfELGPSAWQNwtYEVKVSTQDPPEVTHIFlNISGT--MLN 644
Cdd:pfam00041    1 SAPSNLTVTDvTSTSLTVSWTPP------------------PDGNGPITG--YEVEYRPKNSGEPWNEI-TVPGTttSVT 59

                           90       100
                   ....*....|....*....|....*.
gi 767943414   645 VPELQSAMKYKVSVRASSPKRPGPWS 670
Cdd:pfam00041   60 LTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 567-667 8.14e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 8.14e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943414    567 PGRPQELSVLF-GSHQALVQWKPPALAIGANVILisdiielfelgpsawqnwTYEVKVSTQDPPEVTHIFlNISGTMLNV 645
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIV------------------GYRVEYREEGSEWKEVNV-TPSSTSYTL 61

                            90       100
                    ....*....|....*....|..
gi 767943414    646 PELQSAMKYKVSVRASSPKRPG 667
Cdd:smart00060   62 TGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 971-1038 8.74e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 8.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943414  971 NASSFQILWNGPPAVDWGVVFYSVEF----SAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGP 1038
Cdd:cd00063    13 TSTSVTLSWTPPEDDGGPITGYVVEYrekgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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