NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034617490|ref|XP_016860706|]
View 

kynureninase isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
kynureninase super family cl31141
kynureninase; This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a ...
30-301 7.07e-141

kynureninase; This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen. [Energy metabolism, Amino acids and amines]


The actual alignment was detected with superfamily member TIGR01814:

Pssm-ID: 130873 [Multi-domain]  Cd Length: 406  Bit Score: 403.35  E-value: 7.07e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490  30 ALHLDEEDKLRHFRECFYIPKIQDlppvdlslvnkdENAIYFL-GNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRP 108
Cdd:TIGR01814   1 ALELDEADPLRALRDEFHLPKIGD------------ENAVIYLdGNSLGLMPKAARNALKEELDKWAKIAIRGHNTGKAP 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 109 WITGDESIVGLMKdiVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMR 188
Cdd:TIGR01814  69 WFTLDESLLKLRL--VGAKEDEVVVMNTLTINLHLLLASFYKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLTVEESMV 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 189 MIKPREgEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVD 268
Cdd:TIGR01814 147 QIEPRE-EETLRLEDILDTIEKNGDDIAVILLSGVQYYTGQLFDMAAITRAAHAKGALVGFDLAHAVGNVPLDLHDWGVD 225
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1034617490 269 FACWCSYKYLNagAGGIAGAFIHEKHAHTIKPA 301
Cdd:TIGR01814 226 FACWCTYKYLN--AGPGAGAFVHEKHAHTERPR 256
 
Name Accession Description Interval E-value
kynureninase TIGR01814
kynureninase; This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a ...
30-301 7.07e-141

kynureninase; This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen. [Energy metabolism, Amino acids and amines]


Pssm-ID: 130873 [Multi-domain]  Cd Length: 406  Bit Score: 403.35  E-value: 7.07e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490  30 ALHLDEEDKLRHFRECFYIPKIQDlppvdlslvnkdENAIYFL-GNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRP 108
Cdd:TIGR01814   1 ALELDEADPLRALRDEFHLPKIGD------------ENAVIYLdGNSLGLMPKAARNALKEELDKWAKIAIRGHNTGKAP 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 109 WITGDESIVGLMKdiVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMR 188
Cdd:TIGR01814  69 WFTLDESLLKLRL--VGAKEDEVVVMNTLTINLHLLLASFYKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLTVEESMV 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 189 MIKPREgEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVD 268
Cdd:TIGR01814 147 QIEPRE-EETLRLEDILDTIEKNGDDIAVILLSGVQYYTGQLFDMAAITRAAHAKGALVGFDLAHAVGNVPLDLHDWGVD 225
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1034617490 269 FACWCSYKYLNagAGGIAGAFIHEKHAHTIKPA 301
Cdd:TIGR01814 226 FACWCTYKYLN--AGPGAGAFVHEKHAHTERPR 256
Bna5 COG3844
Kynureninase [Amino acid transport and metabolism];
30-300 1.27e-102

Kynureninase [Amino acid transport and metabolism];


Pssm-ID: 443054 [Multi-domain]  Cd Length: 420  Bit Score: 306.66  E-value: 1.27e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490  30 ALHLDEEDKLRHFRECFYIPkiqdlppvdlslvnkDENAIYFLGNSLGLQPKMVKTYLEEEL-DKWAKIAAYGHEvgKRP 108
Cdd:COG3844     8 ARALDAADPLAAFRDRFHLP---------------DDGVIYLDGNSLGLLPKAAAARLAEVLeEEWGELLIRGWN--EAP 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 109 WITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLniEESMR 188
Cdd:COG3844    71 WFDLPERLGDKLARLVGAAPGEVVVMDSTTVNLHKLLVAAYRPRPGRTKILSEADNFPTDRYALEGQARLHGL--DEELR 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 189 MIKPREGEeTLRIEDILEVIEkegDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVD 268
Cdd:COG3844   149 LVEPRDGE-TLRPEDIEAALD---DDVALVLLSHVNYRTGQLFDMAAITAAAHAAGALVGWDLAHSAGAVPVDLHDWGVD 224
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1034617490 269 FACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP 300
Cdd:COG3844   225 FAVGCTYKYLNGGPGAPAFLYVHERHQDRLLQ 256
 
Name Accession Description Interval E-value
kynureninase TIGR01814
kynureninase; This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a ...
30-301 7.07e-141

kynureninase; This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen. [Energy metabolism, Amino acids and amines]


Pssm-ID: 130873 [Multi-domain]  Cd Length: 406  Bit Score: 403.35  E-value: 7.07e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490  30 ALHLDEEDKLRHFRECFYIPKIQDlppvdlslvnkdENAIYFL-GNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRP 108
Cdd:TIGR01814   1 ALELDEADPLRALRDEFHLPKIGD------------ENAVIYLdGNSLGLMPKAARNALKEELDKWAKIAIRGHNTGKAP 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 109 WITGDESIVGLMKdiVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMR 188
Cdd:TIGR01814  69 WFTLDESLLKLRL--VGAKEDEVVVMNTLTINLHLLLASFYKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLTVEESMV 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 189 MIKPREgEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVD 268
Cdd:TIGR01814 147 QIEPRE-EETLRLEDILDTIEKNGDDIAVILLSGVQYYTGQLFDMAAITRAAHAKGALVGFDLAHAVGNVPLDLHDWGVD 225
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1034617490 269 FACWCSYKYLNagAGGIAGAFIHEKHAHTIKPA 301
Cdd:TIGR01814 226 FACWCTYKYLN--AGPGAGAFVHEKHAHTERPR 256
Bna5 COG3844
Kynureninase [Amino acid transport and metabolism];
30-300 1.27e-102

Kynureninase [Amino acid transport and metabolism];


Pssm-ID: 443054 [Multi-domain]  Cd Length: 420  Bit Score: 306.66  E-value: 1.27e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490  30 ALHLDEEDKLRHFRECFYIPkiqdlppvdlslvnkDENAIYFLGNSLGLQPKMVKTYLEEEL-DKWAKIAAYGHEvgKRP 108
Cdd:COG3844     8 ARALDAADPLAAFRDRFHLP---------------DDGVIYLDGNSLGLLPKAAAARLAEVLeEEWGELLIRGWN--EAP 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 109 WITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLniEESMR 188
Cdd:COG3844    71 WFDLPERLGDKLARLVGAAPGEVVVMDSTTVNLHKLLVAAYRPRPGRTKILSEADNFPTDRYALEGQARLHGL--DEELR 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034617490 189 MIKPREGEeTLRIEDILEVIEkegDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVD 268
Cdd:COG3844   149 LVEPRDGE-TLRPEDIEAALD---DDVALVLLSHVNYRTGQLFDMAAITAAAHAAGALVGWDLAHSAGAVPVDLHDWGVD 224
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1034617490 269 FACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP 300
Cdd:COG3844   225 FAVGCTYKYLNGGPGAPAFLYVHERHQDRLLQ 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH