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Conserved domains on  [gi|1907196565|ref|XP_036010720|]
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sentrin-specific protease 6 isoform X3 [Mus musculus]

Protein Classification

C48 family peptidase( domain architecture ID 581147)

C48 family peptidase similar to sentrin-specific proteases (SUMO proteases) that catalyze the processing of small ubiquitin-like modifier (SUMO) propeptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Peptidase_C48 super family cl23802
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
581-693 1.10e-15

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


The actual alignment was detected with superfamily member pfam02902:

Pssm-ID: 420019  Cd Length: 202  Bit Score: 76.73  E-value: 1.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  581 EFLNDVIIDFYLKYLvLEKLKKEDAD--RIHIFSSFFYKRLNQRERrnpetTNLSIQQKRHGRVKTWTR--HVDIFEKDF 656
Cdd:pfam02902    1 EWLNDTVIDFYLKLL-AHRLESEDYKneRVHFLNSFFYSKLTSKVS-----FKWGKKKDFYNGVRRWTRknKKWLFDVDI 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907196565  657 IFVPLNEAA-HWFLAVVCfpgLEKPK---YEPNPHYHENAV 693
Cdd:pfam02902   75 IYIPINWDGkHWVLLIIN---LPKKTitiLDSLISLHTDKE 112
Peptidase_C48 super family cl23802
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
873-949 5.36e-09

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


The actual alignment was detected with superfamily member pfam02902:

Pssm-ID: 420019  Cd Length: 202  Bit Score: 57.08  E-value: 5.36e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  873 ILLMDSLRGPSRSNV----VKILREYLEVEWEVKKGSKRSFSKDVMKgSNPKVPQQNNFSDCGVYVLQYVESFFENPVLN 948
Cdd:pfam02902   98 ITILDSLISLHTDKEyirpINAMLPYLMSEALKKEQDDPDLTPFEIK-RLTKVPQQPNSGDCGPYVLKFIELLAEGVPFE 176

                   .
gi 1907196565  949 F 949
Cdd:pfam02902  177 F 177
 
Name Accession Description Interval E-value
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
581-693 1.10e-15

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 76.73  E-value: 1.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  581 EFLNDVIIDFYLKYLvLEKLKKEDAD--RIHIFSSFFYKRLNQRERrnpetTNLSIQQKRHGRVKTWTR--HVDIFEKDF 656
Cdd:pfam02902    1 EWLNDTVIDFYLKLL-AHRLESEDYKneRVHFLNSFFYSKLTSKVS-----FKWGKKKDFYNGVRRWTRknKKWLFDVDI 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907196565  657 IFVPLNEAA-HWFLAVVCfpgLEKPK---YEPNPHYHENAV 693
Cdd:pfam02902   75 IYIPINWDGkHWVLLIIN---LPKKTitiLDSLISLHTDKE 112
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
873-949 5.36e-09

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 57.08  E-value: 5.36e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  873 ILLMDSLRGPSRSNV----VKILREYLEVEWEVKKGSKRSFSKDVMKgSNPKVPQQNNFSDCGVYVLQYVESFFENPVLN 948
Cdd:pfam02902   98 ITILDSLISLHTDKEyirpINAMLPYLMSEALKKEQDDPDLTPFEIK-RLTKVPQQPNSGDCGPYVLKFIELLAEGVPFE 176

                   .
gi 1907196565  949 F 949
Cdd:pfam02902  177 F 177
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
567-672 9.21e-09

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 59.09  E-value: 9.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  567 ISVTNEDLHCLSEGEFLNDVIIDFYLKyLVLEKLKKEDAD--RIHIFSSFFYKRLNQrerrnpettnlSIQQKRHGRVKT 644
Cdd:PLN03189   288 IDITGEILRCLKPGAWLNDEVINLYLE-LLKEREAREPKKflKCHFFNTFFYKKLVS-----------GKSGYDYKAVRR 355
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1907196565  645 WT--RHVDIFEK--DFIFVPLNEAAHWFLAVV 672
Cdd:PLN03189   356 WTtqKKLGYHLIdcDKIFVPIHQEIHWTLAVI 387
 
Name Accession Description Interval E-value
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
581-693 1.10e-15

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 76.73  E-value: 1.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  581 EFLNDVIIDFYLKYLvLEKLKKEDAD--RIHIFSSFFYKRLNQRERrnpetTNLSIQQKRHGRVKTWTR--HVDIFEKDF 656
Cdd:pfam02902    1 EWLNDTVIDFYLKLL-AHRLESEDYKneRVHFLNSFFYSKLTSKVS-----FKWGKKKDFYNGVRRWTRknKKWLFDVDI 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907196565  657 IFVPLNEAA-HWFLAVVCfpgLEKPK---YEPNPHYHENAV 693
Cdd:pfam02902   75 IYIPINWDGkHWVLLIIN---LPKKTitiLDSLISLHTDKE 112
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
873-949 5.36e-09

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 57.08  E-value: 5.36e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  873 ILLMDSLRGPSRSNV----VKILREYLEVEWEVKKGSKRSFSKDVMKgSNPKVPQQNNFSDCGVYVLQYVESFFENPVLN 948
Cdd:pfam02902   98 ITILDSLISLHTDKEyirpINAMLPYLMSEALKKEQDDPDLTPFEIK-RLTKVPQQPNSGDCGPYVLKFIELLAEGVPFE 176

                   .
gi 1907196565  949 F 949
Cdd:pfam02902  177 F 177
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
567-672 9.21e-09

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 59.09  E-value: 9.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907196565  567 ISVTNEDLHCLSEGEFLNDVIIDFYLKyLVLEKLKKEDAD--RIHIFSSFFYKRLNQrerrnpettnlSIQQKRHGRVKT 644
Cdd:PLN03189   288 IDITGEILRCLKPGAWLNDEVINLYLE-LLKEREAREPKKflKCHFFNTFFYKKLVS-----------GKSGYDYKAVRR 355
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1907196565  645 WT--RHVDIFEK--DFIFVPLNEAAHWFLAVV 672
Cdd:PLN03189   356 WTtqKKLGYHLIdcDKIFVPIHQEIHWTLAVI 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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