1V6F,3L50


Conserved Protein Domain Family
ADF_GMF-beta_like
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cd11283: ADF_GMF-beta_like 
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ADF-homology domain of glia maturation factor beta and related proteins
Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. Most of these proteins enhance the turnover rate of actin and interact with actin monomers as well as actin filaments. The glia maturation factor (GMF), however, does not bind actin but interacts with the Arp2/3 complex (which contains actin-related proteins, amongst others) and suppresses Arp2/3 activity, inducing the dissociation of branched daughter filaments from their mother filaments. This family includes both mammalian GMF isoforms, GMF-beta and GMF-gamma. GMF-beta regulates cellular growth, fission, differentiation and apoptosis. GMF-gamma is important in myeloid cell development and is an important regulator for cell migration and polarity in neutrophils.
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Statistics
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PSSM-Id: 200439
Aligned: 30 rows
Threshold Bit Score: 132.746
Created: 17-Aug-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1V6F_A        15 DVAEDLVEKLRKFRFRKEth--nAAIIMKIDKd-ERLVVLDEELEGv----------------SPDELKDELPERQPRFI 75  house mouse
NP_001134255   9 TFSGETKQQLRKFRLTTSrakdpQAVIYMIDKn-THEIRQALDDYDear-----------vykSLEEVGEDLPDHSPRFV 76  Atlantic salmon
6320268        6 KIGTETRNKIKKFRTSTArtdsiKALSIKIEPkpSYEIIVDEDEQEeld-----------eieDLSELAEILPDNSPRFV 74  baker's yeast
XP_655710      6 TLSADAAAQFKKFKIKRNpe--nCALILKINRs-NSLIEVEEELDNt----------------PLLDLQDYLPTTEPRFI 66  Entamoeba histo...
XP_002174602   9 SISAETTGLIDRFRLRLKkt-nlYVLLLKINKn-TQEVVPDGDIEQl---------------eSIEELADELPDTNLRYV 71  Schizosaccharom...
XP_001731261   7 DIEPSLQSELRSFRLSKSts-knAALVVKINKp-KLLLEKEELIDPi----------------TPEELAEELPEHSPRFV 68  Malassezia glob...
O13808         9 TISDTTMKEIDRFRLRLKks-vmYAFILKVDKa-TKEIVPDGEIMDl---------------qSIEEVADELSETNPRFI 71  fission yeast
XP_757415      9 DIPSSVVVRIQKFRLTPSka-aiTALVFKIDRk-TLTLEIEEELTTgltcvedliqeapedtkLICKVCTELPENSPRFL 86  Ustilago maydis...
XP_568204      6 DIPQDVLDALKQFRFKNSkg--tTAISVKIIKn-SLTMAVDEEFEGq----------------SIEEIAEELPENAPRYV 66  Cryptococcus ne...
NP_986635      6 QLSDHTRAAIRQFRLATSradalQTLVLAIRPrpSYEIVVDNDATEeaag----------evsGLEDLAEVLPDNTPRFV 75  Ashbya gossypii...

1V6F_A        76 VYSYKYQHd-----------DGRVSYPLCFIFSSPvgc-kpEQQMMYAGSKNKLVQTAe-lTKVFEIRNTEDLT 136 house mouse
NP_001134255  77 LLSYPVTTs-----------DGRLSVPYVLLYYLPitc-naEVRMLYAGAKELMRSTSe-aGSVIDVESVDDLE 137 Atlantic salmon
6320268       75 LTAYPTTTk-----------DGFKQTPLVLVYWKPmtvvsqEWKMLYAGALEMIREECg-tFKLIEVSSGLEDD 136 baker's yeast
XP_655710     67 VYSYKFETr-----------DGRITYPLVLIYSSPtgi-npQFSMIYTSCVASLQSSLpgvQRNYTVKDVEDLT 128 Entamoeba histolytica...
XP_002174602  72 LVSYPMKTk-----------DGRLSTPMFLLYWRPgav-sgEMSMLYASAKVWFQNQAq-vQKVIEFNEQDEIT 132 Schizosaccharomyces j...
XP_001731261  69 LLSYEMKHa-----------DGRISYPLVLVYWAPest-nmELSTLYTSALPTFCTLAd-vGKVIDIRDGNITT 129 Malassezia globosa CB...
O13808        72 LVSYPTKTt-----------DGRLSTPLFMIYWRPsat-pnDLSMIYASAKVWFQDVSq-vHKVFEARDSEDIT 132 fission yeast
XP_757415     87 IVNYKLNHrdgrvsylanarVSRTPQPLFLLYWAPqts-plDLSTLYASALSNFSVKSd-vAKVIDVRDAEIST 158 Ustilago maydis 521
XP_568204     67 LLSHELKHk-----------DGRISYPLLLINWAPtts-piELMTLHASSLSYFQQVSe-tAKVLEARDGAEGL 127 Cryptococcus neoforma...
NP_986635     76 LLAYPLSS------------DGRQRTALVLLHWKPatvvsqEWKMLYAGATELVRSECa-pNKFLEVSSGLEED 136 Ashbya gossypii ATCC ...
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