GEO DataSets

(Submitter supplied) αβ T cell receptor (TCR) V(D)J genes code for billions of TCR combinations. However only some appear on peripheral T cells in any individual because, to mature, thymocytes must react with low affinity but not high affinity with thymus expressed MHC/peptides. MHC proteins are very polymorphic. Different alleles bind different peptides. Therefore any individual might express many different MHC alleles to ensure that some peptides from an invader are bound to MHC and activate T cells. more...

Organism:

Mus musculus

Type:

Other

4 related Platforms

70 Samples

Download data: CSV

(Submitter supplied) Neuroinflammation plays important role in neurodegenerative diseases including ALS. We used single nucleus RNA sequencing (SnRNA-seq) to analyze the function of microglia and their subclusters in the progression of disease.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

4 Samples

Download data

(Submitter supplied) RNA sequencing(seq-RNA) was used to analyze the underlying mechanism of immature dendritic cells (imDCs) response to extracellular reactive oxygen species (ROS). The oxidative stress model of imDCswas constructed by simulating ROS with H2O2. The final H2O2 concentration was determined by CCK8 and Annexin V-FITC/ PI double staining methods. The free migration of imDCs was analyzed by cell real-time imaging. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28330

6 Samples

Download data: TXT

(Submitter supplied) Unmodulated 40 Hz (u40Hz) stimulation, imperceptible to the human ear, which has been reported to improve cognitive function in human and mice. However, research on the effects of u40Hz stimulation is still limited. This study is the first to report the effects of u40Hz stimulation on glucose tolerance and muscle strength in SAMP-10 mice, an aging-accelerated model. SAMP-10 mice underwent five weeks of u40Hz stimulation, followed by glucose tolerance tests, cognitive and behavioral assessments, and frailty evaluations. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL24676 GPL30209 GPL30215

28 Samples

Download data: TDF

(Submitter supplied) Nutrient sensing and adaptation in the placenta are essential for pregnancy viability and proper fetal growth. Our recent research demonstrates that the placenta adapts to nutrient insufficiency through mTOR inhibition-mediated trophoblast differentiation toward syncytiotrophoblasts (STBs), a highly specialized multinucleated trophoblast subtype directing extensive maternal-fetal interactions. However, the underlying mechanism remains elusive. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30215

10 Samples

Download data: XLSX

(Submitter supplied) In this study endothelial cells of the forebrain, cerebellum, spinal cord, lungs and liver were acutely purified by FACS. RNA-Seq was performed on isolated endothelial cells and their transcriptome was compared to identify regional blood-brain barrier specific transcripts.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

8 Samples

Download data: XLSX

(Submitter supplied) Abstract Objective: JianPiHuaTan Formula (JPHTF), a traditional Chinese medicine (TCM), has been utilized as an adjunctive therapy for colorectal cancer (CRC). The study aims to evaluate the potential clinical benefits of JPHTF and its effectiveness in inhibiting tumor growth. Methods: 300 stage II/III CRC patients and 412 advanced CRC patients were enrolled to verify the clinical value of JPHTF in CRC treatment. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21273

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL24247

30 Samples

Download data: BW, TXT

(Submitter supplied) Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on the core histones, balancing histone acetyltransferase (HAT) activity. Despite this apparent repressive function, suppression of HDAC activity causes both up and downregulation of gene expression. Here we exploit the degradation tag (dTAG) system to rapidly degrade HDAC1 in embryonic stem cells (ESCs) lacking the paralog, HDAC2. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

12 Samples

Download data: TXT

(Submitter supplied) Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on the core histones, balancing histone acetyltransferase (HAT) activity. Despite this apparent repressive function, suppression of HDAC activity causes both up and downregulation of gene expression. Here we exploit the degradation tag (dTAG) system to rapidly degrade HDAC1 in embryonic stem cells (ESCs) lacking the paralog, HDAC2. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL24247

18 Samples

Download data: BW

(Submitter supplied) Mycobacterium tuberculosis infects two billion people across the globe, and results in 8-9 million new tuberculosis (TB) cases and 1-1.5 million deaths each year. Most patients have no known genetic basis that predisposes them to disease. Here, we investigate the complex genetic basis of pulmonary TB by modelling human genetic diversity with the Diversity Outbred mouse population. When infected with M. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL34456

134 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32068

134 Samples

Download data: CEL

(Submitter supplied) Humans are highly genetically diverse, and most are resistant to Mycobacterium tuberculosis. However, lung tissue from genetically resistant humans is not readily available to identify potential mechanisms of resistance. To address this, we model M. tuberculosis infection in Diversity Outbred mice. Like humans, Diversity Outbred mice also exhibit genetically determined susceptibility to M. tuberculosis infection: Progressors who succumb within 60 days of a low dose aerosol infection due to acute necrotizing granulomas, and Controllers who maintain asymptomatic infection for at least 60 days, and then develop chronic pulmonary TB with occasional necrosis and cavitation, over months to greater than 1 year. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32068

88 Samples

Download data: CEL

(Submitter supplied) Humans are highly genetically diverse, and most are resistant to Mycobacterium tuberculosis. However, lung tissue from genetically resistant humans is not readily available to identify potential mechanisms of resistance. To address this, we model M. tuberculosis infection in Diversity Outbred mice. Like humans, Diversity Outbred mice also exhibit genetically determined susceptibility to M. tuberculosis infection: Progressors who succumb within 60 days of a low dose aerosol infection due to acute necrotizing granulomas, and Controllers who maintain asymptomatic infection for at least 60 days, and then develop chronic pulmonary TB with occasional necrosis and cavitation, over months to greater than 1 year. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32068

46 Samples

Download data: CEL

(Submitter supplied) We used the CCl 4 -induced ALI model and employed flow cytometry, microscopy imaging and qRT-PCR to examine intrahepatic neutrophil subpopulations during the necroinflammatory and early and late repair phases of the wound healing response. We also analyzed intrahepatic neutrophils for their transcriptional profiles using RNA-seq. Finally, we evaluated their protein translation, mitochondrial function and cell metabolism using the Seahorse Mito Stress Test. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

12 Samples

Download data: TXT

(Submitter supplied) Unprogrammed macrophage polarization, is associated with diabetic wound ulcers. Nevertheless, development of corresponding drugs is still a challenge. Here, exosomes are isolated from naive bone marrow-derived macrophages (BMDMs) (M0-Exos), inflammatory BMDMs (M1-Exos), and anti-inflammatory BMDMs (M2-Exos), with the aim of pinpointing the exosomes functionality and identify global miRNAs expression profiles.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL17021

9 Samples

Download data: TXT

(Submitter supplied) RNA sequencing to compare gene expression between NOD.g7 and NOD.L7 mice in order to identify a gene that may influence pre-mNK cell number

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

2 Samples

Download data: TXT

(Submitter supplied) We tested the hypothesis that increase dosage of Ube3a may exert its influence on transcriptomic organization in a sex-biased manner

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

38 Samples

Download data: CSV

(Submitter supplied) Harmful algal blooms (HABs) arise from the rapid growth of algae in both marine and freshwater ecosystems due to the continuous global temperature rise and anthropogenic eutrophication. Humans are at a great risk of exposure to toxins released from HABs through drinking water, food, and recreational activities, making HAB toxins contaminants of emerging concern (CECs). The impact of HAB toxins on women’s reproductive health, however, remains poorly understood. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

15 Samples

Download data: XLSX