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Vmn2r65 vomeronasal 2, receptor 65 [ Mus musculus (house mouse) ]

Gene ID: 100009609, updated on 21-Apr-2024

Summary

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Official Symbol
Vmn2r65provided by MGI
Official Full Name
vomeronasal 2, receptor 65provided by MGI
Primary source
MGI:MGI:3642776
See related
Ensembl:ENSMUSG00000066372 AllianceGenome:MGI:3642776
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
V2ro
Summary
Enables G protein-coupled olfactory receptor activity. Acts upstream of or within neuron differentiation. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
7 D3; 7 48.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (84589377..84613217, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (84940169..84964009, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AE member 1 Neighboring gene ubiquitin specific peptidase 46 pseudogene Neighboring gene predicted gene, 17985 Neighboring gene STARR-seq mESC enhancer starr_19444 Neighboring gene vomeronasal 2, receptor 66 Neighboring gene vomeronasal 2, receptor, pseudogene 64

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multisensory Logic of Infant-Directed Aggression by Males. Isogai Y, et al. Cell, 2018 Dec 13. PMID 30550786, Free PMC Article
  2. Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons. Kimoto H, et al. Nature, 2005 Oct 6. PMID 16208374
  3. Subpopulations of vomeronasal sensory neurons with coordinated coexpression of type 2 vomeronasal receptor genes are differentially dependent on Vmn2r1. Akiyoshi S, et al. Eur J Neurosci, 2018 Apr. PMID 29465786, Free PMC Article
  4. Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species. Tonelli Gombalová Z, et al. J Comp Neurol, 2020 Oct 15. PMID 32212159
  5. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled olfactory receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vomeronasal 2, receptor 65
Names
vomeronasal 2 receptor o
vomeronasal receptor Vmn2r65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105180.1 → NP_001098650.1  vomeronasal 2, receptor 65 precursor

    See identical proteins and their annotated locations for NP_001098650.1

    Status: PROVISIONAL

    Source sequence(s)
    AC163494
    Consensus CDS
    CCDS52288.1
    UniProtKB/TrEMBL
    G3X931
    Related
    ENSMUSP00000036551.9, ENSMUST00000044583.10
    Conserved Domains (4) summary
    cd06365
    Location:36 → 492
    PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:587 → 820
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:75 → 435
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:501 → 552
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    84589377..84613217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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