Ces1f carboxylesterase 1F [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ces1fprovided by RGD
Full Name: carboxylesterase 1Fprovided by RGD
Primary source: RGD:1642419
See related: Ensembl:ENSRNOG00000015438 AllianceGenome:RGD:1642419
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables carboxylic ester hydrolase activity. Predicted to be involved in lipid catabolic process. Located in intracellular membrane-bounded organelle. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 2521.7) and Liver (RPKM 1002.6) See more
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Genomic context

Location:: 19p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (29969633..29995119)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (13796623..13822113)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (15081117..15126629)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

establish ES-4 as a bona fide endogenous nCEH that can account for the majority of cholesteryl ester hydrolysis in transformed rat hepatic cells and primary rat hepatocytes.
Title: Rat carboxylesterase ES-4 enzyme functions as a major hepatic neutral cholesteryl ester hydrolase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables carboxylesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty-acyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: liver carboxylesterase 1F

Names: carboxyesterase ES-4; carboxylesterase ES-4; kidney microsomal carboxylesterase; liver carboxylesterase 4; microsomal palmitoyl-CoA hydrolase

NP_001096829.2

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103359.2 → NP_001096829.2 liver carboxylesterase 1F precursor

See identical proteins and their annotated locations for NP_001096829.2

Status: PROVISIONAL

Source sequence(s)

BC128711, FM041665

UniProtKB/Swiss-Prot

A2VCW1, Q62679, Q64573

UniProtKB/TrEMBL

A6KD46

Related

ENSRNOP00000024187.6, ENSRNOT00000024187.7

Conserved Domains (2) summary

COG0657
Location:121 → 234

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:24 → 545

COesterase; Carboxylesterase family