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Hivep3 human immunodeficiency virus type I enhancer binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 16656, updated on 4-May-2024

Summary

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Official Symbol
Hivep3provided by MGI
Official Full Name
human immunodeficiency virus type I enhancer binding protein 3provided by MGI
Primary source
MGI:MGI:106589
See related
Ensembl:ENSMUSG00000028634 AllianceGenome:MGI:106589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rc; Krc; KBP1; Shn3; Zas3; KBP-1; A130075N07; Schnurri-3; 2900056N03Rik; E030045D18Rik
Summary
Enables DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in bone; brain; ganglia; genitourinary system; and hemolymphoid system. Orthologous to human HIVEP3 (HIVEP zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 3.7), cortex adult (RPKM 2.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.1; 4 55.51 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119590982..119992608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119733759..120138045)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:119342138-119342339 Neighboring gene predicted gene, 35761 Neighboring gene STARR-positive B cell enhancer ABC_E1653 Neighboring gene predicted gene, 35957 Neighboring gene STARR-positive B cell enhancer ABC_E11252 Neighboring gene STARR-positive B cell enhancer ABC_E4655 Neighboring gene STARR-positive B cell enhancer ABC_E9594 Neighboring gene STARR-seq mESC enhancer starr_11240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:119569908-119570109 Neighboring gene STARR-positive B cell enhancer mm9_chr4:119631902-119632203 Neighboring gene STARR-positive B cell enhancer ABC_E522 Neighboring gene predicted gene, 38632 Neighboring gene predicted gene, 36215 Neighboring gene STARR-seq mESC enhancer starr_11242 Neighboring gene predicted gene, 36134 Neighboring gene predicted gene, 36073 Neighboring gene endothelin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis. Stavre Z, et al. Proc Natl Acad Sci U S A, 2023 May 9. PMID 37141171, Free PMC Article
  2. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Harsha Krovi S, et al. Nat Commun, 2020 Dec 7. PMID 33288744, Free PMC Article
  3. Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development. Allen CE, et al. Gene Expr, 2007. PMID 18257392, Free PMC Article
  4. Schnurri-3: a key regulator of postnatal skeletal remodeling. Jones DC, et al. Adv Exp Med Biol, 2007. PMID 17966382
  5. KRC transcripts: identification of an unusual alternative splicing event. Mak CH, et al. Immunogenetics, 1998 Jun. PMID 9601941

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
    Title: Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
  2. Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.
    Title: Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.
  3. Thus, Alg2, as a downstream mediator of Hivep3, suppresses osteogenesis, whereas it promotes chondrogenesis.
    Title: Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.
  4. Knockdown of Shn3 in adult mice results in a high-bone mass phenotype.
    Title: Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
  5. Shn3 expression in mesenchymal cells directly controls osteoblastic bone formation and indirectly regulates osteoclastic bone resorption.
    Title: Control of bone resorption in mice by Schnurri-3.
  6. ZAS3 was a crucial molecule in osteoclast differentiation.
    Title: The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.
  7. report that mice bearing parallel null mutations in the adapter proteins Schnurri2 (Shn2) and Schnurri3 (Shn3) exhibit defects in patterning of the axial skeleton during embryogenesis.
    Title: Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.
  8. Gel mobility shift assays showed altered DNA binding activities of NF-kappaB and AP-1 proteins in ZAS3-deficient tissues, including the thymus. Lymphocyte analysis suggested a subtle function of ZAS3 in regulating T-cell development and activation
    Title: Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.
  9. study reveals an essential role for Shn3 as a regulator of postnatal bone mass
    Title: Schnurri-3: a key regulator of postnatal skeletal remodeling.
  10. results show Schnurri-3 (Shn3) is an essential regulator of adult bone formation; Shn3 was found to control levels of Runx2, by promoting its degradation through recruitment of WWP1 to Runx2
    Title: Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor HIVEP3
Names
KB-binding and recognition component
KB-binding and regognition component
human immunodeficiency virus type I enhancer-binding protein 3 homolog
kappa B and Rss recognition component
kappa-B and V(D)J recombination signal sequences-binding protein
kappa-binding protein 1
recombinant component
zinc finger protein ZAS3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010657.3 → NP_034787.2  transcription factor HIVEP3

    See identical proteins and their annotated locations for NP_034787.2

    Status: VALIDATED

    Source sequence(s)
    AL606916, AL606930, AL607142
    Consensus CDS
    CCDS38863.1
    UniProtKB/Swiss-Prot
    A2A884, A2MZW0, Q69ZG6, Q6SNP9
    Related
    ENSMUSP00000101914.3, ENSMUST00000106307.9
    Conserved Domains (6) summary
    smart00451
    Location:1745 → 1778
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:1845 → 2315
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1722 → 1742
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1720 → 1742
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 224
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    119590982..119992608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502817.4 → XP_006502880.1  transcription factor HIVEP3 isoform X1

    See identical proteins and their annotated locations for XP_006502880.1

    UniProtKB/Swiss-Prot
    A2A884, A2MZW0, Q69ZG6, Q6SNP9
    Conserved Domains (6) summary
    smart00451
    Location:1745 → 1778
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:1845 → 2315
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1722 → 1742
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1720 → 1742
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 224
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036163749.1 → XP_036019642.1  transcription factor HIVEP3 isoform X1

    UniProtKB/Swiss-Prot
    A2A884, A2MZW0, Q69ZG6, Q6SNP9
    Conserved Domains (6) summary
    smart00451
    Location:1745 → 1778
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:1845 → 2315
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1722 → 1742
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1720 → 1742
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 224
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011240452.3 → XP_011238754.1  transcription factor HIVEP3 isoform X1

    See identical proteins and their annotated locations for XP_011238754.1

    UniProtKB/Swiss-Prot
    A2A884, A2MZW0, Q69ZG6, Q6SNP9
    Conserved Domains (6) summary
    smart00451
    Location:1745 → 1778
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:1845 → 2315
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1722 → 1742
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1720 → 1742
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 224
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006502815.4 → XP_006502878.1  transcription factor HIVEP3 isoform X1

    See identical proteins and their annotated locations for XP_006502878.1

    UniProtKB/Swiss-Prot
    A2A884, A2MZW0, Q69ZG6, Q6SNP9
    Conserved Domains (6) summary
    smart00451
    Location:1745 → 1778
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:1845 → 2315
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1722 → 1742
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1720 → 1742
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 224
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011240453.3 → XP_011238755.1  transcription factor HIVEP3 isoform X1

    See identical proteins and their annotated locations for XP_011238755.1

    UniProtKB/Swiss-Prot
    A2A884, A2MZW0, Q69ZG6, Q6SNP9
    Related
    ENSMUSP00000130249.3, ENSMUST00000166542.3
    Conserved Domains (6) summary
    smart00451
    Location:1745 → 1778
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:1845 → 2315
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1722 → 1742
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1720 → 1742
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 224
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_867814.3 RNA Sequence

  2. XR_003954883.2 RNA Sequence

  3. XR_001784097.2 RNA Sequence

  4. XR_003954884.2 RNA Sequence

  5. XR_004941818.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A884.1 GenPept UniProtKB/Swiss-Prot:A2A884

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