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Nmt1 N-myristoyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 18107, updated on 21-Apr-2024

Summary

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Official Symbol
Nmt1provided by MGI
Official Full Name
N-myristoyltransferase 1provided by MGI
Primary source
MGI:MGI:102579
See related
Ensembl:ENSMUSG00000020936 AllianceGenome:MGI:102579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables glycylpeptide N-tetradecanoyltransferase activity. Acts upstream of or within N-terminal protein myristoylation and in utero embryonic development. Predicted to be located in cytosol and plasma membrane. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; heart; liver; lung; and metanephros. Orthologous to human NMT1 (N-myristoyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 40.2), testis adult (RPKM 33.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 66.71 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102919163..102959734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103028344..103068912)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34620 Neighboring gene STARR-seq mESC enhancer starr_30823 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene microRNA 6931 Neighboring gene STARR-positive B cell enhancer ABC_E8458 Neighboring gene STARR-positive B cell enhancer ABC_E7071 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102889625-102889808 Neighboring gene STARR-seq mESC enhancer starr_30825 Neighboring gene predicted gene, 42090 Neighboring gene phospholipase C, delta 3 Neighboring gene STARR-seq mESC enhancer starr_30831 Neighboring gene STARR-positive B cell enhancer ABC_E204 Neighboring gene acyl-Coenzyme A binding domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway. Zou W, et al. Pharmacology, 2022. PMID 35732157
  2. Requirement of N-myristoyltransferase 1 in the development of monocytic lineage. Shrivastav A, et al. J Immunol, 2008 Jan 15. PMID 18178842
  3. Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation. Rampoldi F, et al. J Immunol, 2015 Nov 1. PMID 26423150
  4. Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells. Rampoldi F, et al. J Leukoc Biol, 2017 Apr. PMID 28062573
  5. Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hance N, et al. Hum Mol Genet, 2005 Jul 1. PMID 15888483

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway.
    Title: NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway.
  2. NMT1 is essential for proper monocytic differentiation of the mouse bone marrow cells.
    Title: Requirement of N-myristoyltransferase 1 in the development of monocytic lineage.
  3. Nmt1 is not essential for the viability of mammalian cells but is required for development and is the principal N-myristoyltransferase in early embryogenesis
    Title: N-myristoyltransferase 1 is essential in early mouse development.
  4. NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation
    Title: Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycylpeptide N-tetradecanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glycylpeptide N-tetradecanoyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-lysine N6-myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-terminal peptidyl-glycine N-myristoylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in N-terminal peptidyl-glycine N-myristoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within N-terminal protein myristoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular ketone metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycylpeptide N-tetradecanoyltransferase 1
Names
NMT 1
myristoyl-CoA:protein N-myristoyltransferase 1
peptide N-myristoyltransferase 1
type I N-myristoyltransferase
NP_032733.1
XP_006532508.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008707.4 → NP_032733.1  glycylpeptide N-tetradecanoyltransferase 1

    See identical proteins and their annotated locations for NP_032733.1

    Status: VALIDATED

    Source sequence(s)
    AL731805
    Consensus CDS
    CCDS25511.1
    UniProtKB/Swiss-Prot
    O70310
    UniProtKB/TrEMBL
    Q3UJC3
    Related
    ENSMUSP00000021314.8, ENSMUST00000021314.8
    Conserved Domains (1) summary
    COG5092
    Location:86 → 484
    NMT1; N-myristoyl transferase [Lipid metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102919163..102959734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532445.5 → XP_006532508.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006532508.1

    UniProtKB/Swiss-Prot
    O70310
    UniProtKB/TrEMBL
    Q3UJC3
    Conserved Domains (1) summary
    COG5092
    Location:86 → 484
    NMT1; N-myristoyl transferase [Lipid metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70310.1 GenPept UniProtKB/Swiss-Prot:O70310

Gene LinkOut

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