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Dad1 defender against cell death 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192275, updated on 13-Apr-2024

Summary

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Official Symbol
Dad1provided by RGD
Official Full Name
defender against cell death 1provided by RGD
Primary source
RGD:621028
See related
Ensembl:ENSRNOG00000009090 AllianceGenome:RGD:621028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme activator activity. Involved in response to nutrient and response to xenobiotic stimulus. Predicted to be integral component of membrane. Predicted to be part of oligosaccharyltransferase complex. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 271.8), Kidney (RPKM 261.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dad1 in Genome Data Viewer
Location:
15p13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (31647326..31667159, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (27677286..27697120, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (32868136..32887933, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene T cell receptor delta constant like Neighboring gene T-cell receptor alpha chain V region Neighboring gene abhydrolase domain containing 4, N-acyl phospholipase B Neighboring gene uncharacterized LOC134482120

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Rosen MB, et al. Reprod Toxicol, 2005 Jan-Feb. PMID 15686871
  2. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Fischer A, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444866
  3. Deletion of Dad1 in mice induces an apoptosis-associated embryonic death. Brewster JL, et al. Genesis, 2000 Apr. PMID 10748466
  4. The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation. Roboti P, et al. J Cell Sci, 2012 Jul 15. PMID 22467853
  5. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. Kelleher DJ, et al. Mol Cell, 2003 Jul. PMID 12887896

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in blastocyst development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation via asparagine IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Names
DAD-1
oligosaccharyl transferase subunit DAD1
NP_001380736.1
NP_620265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393807.1 → NP_001380736.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8L2Q6I7
    Related
    ENSRNOP00000012233.3, ENSRNOT00000012233.6
    Conserved Domains (1) summary
    pfam02109
    Location:7 → 130
    DAD; DAD family

  2. NM_138910.4 → NP_620265.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform 2

    See identical proteins and their annotated locations for NP_620265.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P61805
    UniProtKB/TrEMBL
    A6KGR8
    Related
    ENSRNOP00000092852.1, ENSRNOT00000098684.1
    Conserved Domains (1) summary
    pfam02109
    Location:7 → 113
    DAD; DAD family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    31647326..31667159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61805.3 GenPept UniProtKB/Swiss-Prot:P61805

Gene LinkOut

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