Yes1 YES proto-oncogene 1, Src family tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Yes1provided by MGI
Official Full Name: YES proto-oncogene 1, Src family tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:99147
See related: Ensembl:ENSMUSG00000014932 AllianceGenome:MGI:99147
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Yes; p61-Yes
Summary: Predicted to enable several functions, including non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including cellular response to growth factor stimulus; cellular response to retinoic acid; and positive regulation of nitrogen compound metabolic process. Located in actin filament and plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; pancreas; placenta; and vagal nerve trunk. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 4.0), CNS E11.5 (RPKM 3.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.33 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (32768502..32844410)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (32611171..32687066)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue.
Title: Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue.
AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
Title: AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in ice.
Title: Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in mice.
Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.
Title: Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.
MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1.
Title: MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1.
a novel insight into the molecular mechanisms underlying lung development and contribute to a better understanding of the characteristics of TAZ-transcriptional coactivator with PDZ-binding motif and YAP
Title: Epithelial Expression of YAP and TAZ Is Sequentially Required in Lung Development.
results suggest that Yes-associated protein fine-tunes the expression of genes associated with spermatogonial fate commitment, but that its loss is not sufficient to alter spermatogenesis in vivo
Title: Yes-associated protein expression in germ cells is dispensable for spermatogenesis in mice.
Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase.
Title: Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP/TEAD pathway
Title: Serum Inter-α-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells.
Differentiation of embryonic stem cells is driven by c-Src is antagonized by c-Yes.
Title: c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa54a9.seq (e-PCR)
- UniSTS:125205

RH27881 (e-PCR)
- UniSTS:87601

AI323763 (e-PCR)
- UniSTS:179147

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase Yes

Names: Yamaguchi sarcoma viral (v-yes) oncogene homolog 1; proto-oncogene c-Yes; proto-oncogene tyrosine-protein kinase Yes; viral oncogene yes homolog

NP_001192061.1

EC 2.7.10.2

NP_001192062.1

EC 2.7.10.2

NP_033561.1

EC 2.7.10.2

XP_036020892.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205132.1 → NP_001192061.1 tyrosine-protein kinase Yes

See identical proteins and their annotated locations for NP_001192061.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC091274, AC166934

Consensus CDS

CCDS39061.1

UniProtKB/Swiss-Prot

Q04736

UniProtKB/TrEMBL

Q3TJI7, Q8C762, Q8CBP1

Related

ENSMUSP00000144001.2, ENSMUST00000202543.4

Conserved Domains (4) summary

cd09933
Location:152 → 251

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:92 → 149

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:262 → 540

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

pfam07714
Location:275 → 524

Pkinase_Tyr; Protein tyrosine kinase
NM_001205133.1 → NP_001192062.1 tyrosine-protein kinase Yes

See identical proteins and their annotated locations for NP_001192062.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in both the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC091274, AC166934

Consensus CDS

CCDS39061.1

UniProtKB/Swiss-Prot

Q04736

UniProtKB/TrEMBL

Q3TJI7, Q8C762, Q8CBP1

Related

ENSMUSP00000132161.3, ENSMUST00000168707.6

Conserved Domains (4) summary

cd09933
Location:152 → 251

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:92 → 149

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:262 → 540

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

pfam07714
Location:275 → 524

Pkinase_Tyr; Protein tyrosine kinase
NM_009535.3 → NP_033561.1 tyrosine-protein kinase Yes

See identical proteins and their annotated locations for NP_033561.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC091274, AC166934, AK167420

Consensus CDS

CCDS39061.1

UniProtKB/Swiss-Prot

Q04736

UniProtKB/TrEMBL

Q3TJI7, Q8C762, Q8CBP1

Related

ENSMUSP00000072154.7, ENSMUST00000072311.13

Conserved Domains (4) summary

cd09933
Location:152 → 251

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:92 → 149

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:262 → 540

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

pfam07714
Location:275 → 524

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

32768502..32844410

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164999.1 → XP_036020892.1 tyrosine-protein kinase Yes isoform X1

Conserved Domains (3) summary

cd09933
Location:152 → 251

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:92 → 149

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cl21453
Location:262 → 351

PKc_like; Protein Kinases, catalytic domain