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Dnah14 dynein, axonemal, heavy chain 14 [ Mus musculus (house mouse) ]

Gene ID: 240960, updated on 5-Mar-2024

Summary

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Official Symbol
Dnah14provided by MGI
Official Full Name
dynein, axonemal, heavy chain 14provided by MGI
Primary source
MGI:MGI:2444525
See related
Ensembl:ENSMUSG00000047369 AllianceGenome:MGI:2444525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm980; Dnahc14; Gm18554; A230079K17Rik
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of dynein complex. Orthologous to human DNAH14 (dynein axonemal heavy chain 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.8) and cortex adult (RPKM 0.1) See more
Orthologs
human all
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Genomic context

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Location:
1 H4- H5; 1 84.83 cM
Exon count:
87
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (181404158..181642306)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181576593..181814932)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 121, retrogene 1 Neighboring gene STARR-seq mESC enhancer starr_03239 Neighboring gene STARR-positive B cell enhancer mm9_chr1:183475630-183475931 Neighboring gene predicted gene, 32767 Neighboring gene STARR-seq mESC enhancer starr_03241 Neighboring gene predicted gene, 33612 Neighboring gene STARR-seq mESC enhancer starr_03242 Neighboring gene predicted gene, 23690 Neighboring gene STARR-positive B cell enhancer ABC_E5877 Neighboring gene STARR-positive B cell enhancer ABC_E3345 Neighboring gene lamin B receptor Neighboring gene predicted gene 5533

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 14
Names
dynein, axonemal, heavy chain 14 pseudogene
NP_001363968.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377039.1 → NP_001363968.1  dynein axonemal heavy chain 14

    Status: VALIDATED

    Source sequence(s)
    AC113509, AC120366, AC165229
    UniProtKB/TrEMBL
    A0A571BGC3
    Related
    ENSMUSP00000158787.3, ENSMUST00000238412.3
    Conserved Domains (6) summary
    COG5245
    Location:1202 → 4193
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:973 → 1378
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1511 → 1845
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12781
    Location:3348 → 3563
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:4202 → 4595
    Dynein_C; Dynein heavy chain C-terminal domain
    pfam13767
    Location:328 → 391
    DUF4168; Domain of unknown function (DUF4168)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    181404158..181642306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_018673.1: Suppressed sequence

    Description
    NG_018673.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.

  2. NM_172846.2: Suppressed sequence

    Description
    NM_172846.2: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version

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