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HIP Hsc/Hsp70-interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318211, updated on 10-May-2024

Summary

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Official Symbol
HIPprovided by FlyBase
Official Full Name
Hsc/Hsp70-interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0260484
Locus tag
Dmel_CG32789
See related
AllianceGenome:FB:FBgn0260484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe1A9; CG32789; Dmel\CG32789; Hip
Old locus tag
CG32789
Summary
Predicted to enable Hsp70 protein binding activity and chaperone binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein-containing complex assembly. Located in cytoplasm. Is expressed in organism. Orthologous to several human genes including ST13 (ST13 Hsp70 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See HIP in Genome Data Viewer
Location:
3F2-3F2; 1-5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3799150..3801570)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3693183..3695607)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Circadianly Regulated Gene Neighboring gene long non-coding RNA:CR44118 Neighboring gene pseudo Neighboring gene forkhead domain 3F Neighboring gene transfer RNA:Glutamine-CTG 2-1 Neighboring gene echinus

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Wang AM, et al. Nat Chem Biol, 2013 Feb. PMID 23222885, Free PMC Article
  2. Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus. Hogan CC, et al. J Mol Evol, 2009 Apr. PMID 19333534
  3. Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Zhang G, et al. Nat Commun, 2022 Feb 14. PMID 35165263, Free PMC Article
  4. Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex. Gilfillan GD, et al. Genes Dev, 2006 Apr 1. PMID 16547172, Free PMC Article
  5. Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Lee SY, et al. Cell Mol Life Sci, 2014 Jul. PMID 24292889, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heat shock protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Hsc/Hsp70-interacting protein
Names
CG32789-PA
HIP-PA
anon-fast-evolving-1A9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    3799150..3801570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130718.5 → NP_570074.3  Hsc/Hsp70-interacting protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570074.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0L9I4, C0L9I8, C4NYP8, C9QP24, Q86DR2, Q86DR3, Q86DR4, Q86DR5, Q86DR6, Q86DR7, Q86DR8, Q86DR9, Q86DS0, Q86DS1, Q86DS2, Q86DS3, Q8IRT4
    UniProtKB/TrEMBL
    E2QD63
    Conserved Domains (4) summary
    smart00727
    Location:299 → 336
    STI1; Heat shock chaperonin-binding motif
    PLN03088
    Location:126 → 235
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    cd14438
    Location:10 → 47
    Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
    sd00006
    Location:126 → 154
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C4NYP8.2 C4NYP8
Q86DS1.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials