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Copg1 coatomer protein complex, subunit gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 54161, updated on 21-Apr-2024

Summary

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Official Symbol
Copg1provided by MGI
Official Full Name
coatomer protein complex, subunit gamma 1provided by MGI
Primary source
MGI:MGI:1858696
See related
Ensembl:ENSMUSG00000030058 AllianceGenome:MGI:1858696
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Copg; D6Wsu16e; D6Ertd71e
Summary
Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Predicted to act upstream of or within protein transport. Located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human COPG1 (COPI coat complex subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 31.9), limb E14.5 (RPKM 28.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 39.13 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87864801..87890577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87887819..87913595)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene ISY1 splicing factor homolog Neighboring gene cellular nucleic acid binding protein Neighboring gene STARR-seq mESC enhancer starr_16568 Neighboring gene STARR-positive B cell enhancer ABC_E2793 Neighboring gene STARR-positive B cell enhancer ABC_E1704 Neighboring gene 5-hydroxymethylcytosine (hmC) binding, ES cell specific Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene ribosomal protein S19, pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex. Bainter W, et al. J Clin Invest, 2021 Feb 1. PMID 33529166, Free PMC Article
  2. mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles. Yamasaki A, et al. Mol Biol Cell, 2009 Oct. PMID 19656848, Free PMC Article
  3. Differential localization of coatomer complex isoforms within the Golgi apparatus. Moelleken J, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360540
  4. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. Hahn Y, et al. FEBS Lett, 2000 Sep 29. PMID 11018518
  5. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combined immunodeficiency due to a mutation in the gamma1 subunit of the coat protein I complex.
    Title: Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.
  2. Data show Trs130 (mTrs130) is a component of an analogous TRAPP complex that this complex is enriched on COPI (Coat Protein I)-coated vesicles it specifically activates Rab1.
    Title: mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.
  3. analysis of differential localization of coatomer complex isoforms within the Golgi apparatus
    Title: Differential localization of coatomer complex isoforms within the Golgi apparatus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC66965

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organelle transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit gamma-1
Names
coatomer subunit gamma
gamma-1-COP
gamma-1-coat protein
gamma-COP
gamma-coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017477.2 → NP_059505.1  coatomer subunit gamma-1 isoform 1

    See identical proteins and their annotated locations for NP_059505.1

    Status: PROVISIONAL

    Source sequence(s)
    AC153872
    Consensus CDS
    CCDS39549.1
    UniProtKB/Swiss-Prot
    Q3U9F4, Q8BP96, Q8R1A7, Q922C6, Q9QZE5
    Related
    ENSMUSP00000109237.4, ENSMUST00000113607.10
    Conserved Domains (2) summary
    COG5240
    Location:7 → 869
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    sd00044
    Location:398 → 423
    HEAT; HEAT repeat [structural motif]

  2. NM_201244.1 → NP_957696.1  coatomer subunit gamma-1 isoform 2

    See identical proteins and their annotated locations for NP_957696.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056168
    Consensus CDS
    CCDS39550.1
    UniProtKB/TrEMBL
    Q7TNQ1
    Related
    ENSMUSP00000050858.6, ENSMUST00000049966.6
    Conserved Domains (1) summary
    COG5240
    Location:7 → 107
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87864801..87890577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001785155.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZE5.1 GenPept UniProtKB/Swiss-Prot:Q9QZE5

Gene LinkOut

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