cfh complement factor H [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cfhprovided by ZNC
Official Full Name: complement factor Hprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-661
See related: Ensembl:ENSDARG00000100442 AllianceGenome:ZFIN:ZDB-GENE-050208-661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7147412; si:ch211-207o17.2
Summary: Is expressed in several structures, including digestive system; eye; fin; gill; and heart. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (23641995..23668335, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (23615431..23641771, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1-4) in Danio rerio.
Title: Zebrafish complement factor H and its related genes: identification, evolution, and expression.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fumarate hydratase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: complement factor H

NP_001186119.1

EC 4.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199190.1 → NP_001186119.1 complement factor H precursor

See identical proteins and their annotated locations for NP_001186119.1

Status: PROVISIONAL

Source sequence(s)

HM149232

UniProtKB/TrEMBL

E2FHP4

Related

ENSDARP00000136634.1, ENSDART00000167106.2

Conserved Domains (4) summary

cd00033
Location:383 → 430

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00032
Location:604 → 658

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

PHA02927
Location:375 → 718

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:664 → 718

Sushi; Sushi repeat (SCR repeat)