Lypla2 lysophospholipase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lypla2provided by RGD
Official Full Name: lysophospholipase 2provided by RGD
Primary source: RGD:620210
See related: Ensembl:ENSRNOG00000010067 AllianceGenome:RGD:620210
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lysophospholipase activity and palmitoyl-(protein) hydrolase activity. Predicted to be involved in acylglycerol catabolic process; prostaglandin catabolic process; and protein depalmitoylation. Predicted to be located in Golgi stack. Predicted to be active in cytoplasm. Orthologous to human LYPLA2 (lysophospholipase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 128.6), Kidney (RPKM 124.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (153481973..153486692, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (148198466..148203062, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (154315033..154319629, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-(protein) hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in acylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in macromolecule depalmitoylation	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein depalmitoylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-protein thioesterase 2

Names: APT-2; LPL-II; lysoPLA II; lysophospholipase II; palmitoyl-protein hydrolase

NP_112632.1

EC 3.1.2.22

XP_063144548.1

EC 3.1.2.22

XP_063144549.1

EC 3.1.2.22

XP_063144550.1

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429118.1 → NP_001416047.1 acyl-protein thioesterase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005
NM_031342.2 → NP_112632.1 acyl-protein thioesterase 2

See identical proteins and their annotated locations for NP_112632.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9QYL8

UniProtKB/TrEMBL

A0A8I6AKR5, A6IT88

Related

ENSRNOP00000014415.3, ENSRNOT00000014415.6

Conserved Domains (1) summary

pfam02230
Location:11 → 228

Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

153481973..153486692 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288478.1 → XP_063144548.1 acyl-protein thioesterase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6AB78
XM_063288480.1 → XP_063144550.1 acyl-protein thioesterase 2 isoform X2

UniProtKB/Swiss-Prot

Q9QYL8

UniProtKB/TrEMBL

A6IT88
XM_063288479.1 → XP_063144549.1 acyl-protein thioesterase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6AB78