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ACO1 aconitate hydratase ACO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851013, updated on 5-May-2024

Summary

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Gene symbol
ACO1
Gene description
aconitate hydratase ACO1
Primary source
SGD:S000004295
Locus tag
YLR304C
See related
AllianceGenome:SGD:S000004295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GLU1
Summary
Enables aconitate hydratase activity and nucleic acid binding activity. Involved in mitochondrial genome maintenance and tricarboxylic acid cycle. Located in cytosol and mitochondrial nucleoid. Used to study central nervous system disease; neurodegenerative disease; and optic nerve disease. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (735212..737548, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Neighboring gene tRNA-Ile Neighboring gene 1-phosphatidylinositol 4-kinase STT4 Neighboring gene NEDD8-conjugating protein UBC12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The aconitase C-terminal domain is an independent dual targeting element. Ben-Menachem R, et al. J Mol Biol, 2011 Jun 3. PMID 21440554
  2. Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells. Klinger H, et al. Exp Gerontol, 2010 Aug. PMID 20382214
  3. Reduced stability and enhanced surface hydrophobicity drive the binding of apo-aconitase with GroEL during chaperone assisted refolding. Gupta P, et al. Int J Biochem Cell Biol, 2010 May. PMID 20060926
  4. Effect of calorie restriction on the metabolic history of chronologically aging yeast. Goldberg AA, et al. Exp Gerontol, 2009 Sep. PMID 19539741
  5. Enhancement of over expression and chaperone assisted yield of folded recombinant aconitase in Escherichia coli in bioreactor cultures. Gupta P, et al. J Biosci Bioeng, 2009 Feb. PMID 19217544

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast ACO1 mitochondrial import is modulated by interactions of its C and N terminal domains and SSA1/SSA2.
    Title: Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70).
  2. Lack of the ACO1 gene results in increased zinc tolerance.
    Title: On the molecular relationships between high-zinc tolerance and aconitase (Aco1) in Saccharomyces cerevisiae.
  3. mitochondria are opportunistic organelles that seize proteins, such as metabolic enzymes, for construction of the nucleoid, an mitochondrial DNA maintenance/segregation apparatus
    Title: Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.
  4. essential for mtDNA maintenance independent of its catalytic activity; may integrate metabolic signals and mtDNA maintenance
    Title: Aconitase couples metabolic regulation to mitochondrial DNA maintenance.
  5. Yeast aconitase isoenzymes distribute between two distinct subcellular compartments and participate in two separate metabolic pathways: the glyoxylate shunt in the cytosol and the tricarboxylic acid cycle in mitochondria.
    Title: Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing.
  6. frataxin is an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation
    Title: Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aconitate hydratase ACO1
NP_013407.1
  • Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; mutation in human homolog ACO2 is associated with dominant optic nerve atrophy; human homolog ACO2 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    735212..737548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182192.1 → NP_013407.1  TPA: aconitate hydratase ACO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013407.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYU7, P19414
    UniProtKB/TrEMBL
    A0A6A5PUD7, A7A1I8, B3RHI2, C7GUC7, C8ZDR7, G2WJC5, N1P1J9
    Conserved Domains (1) summary
    TIGR01340
    Location:41 → 772
    aconitase_mito; aconitate hydratase, mitochondrial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19414.2

Gene LinkOut

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