FRU FER-like regulator of iron uptake [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: FRU
Gene description: FER-like regulator of iron uptake
Primary source: Araport:AT2G28160
Locus tag: AT2G28160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS FE-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1; ATBHLH029; ATBHLH29; ATFIT1; BASIC HELIX-LOOP-HELIX PROTEIN 29; BHLH029; F24D13.5; F24D13_5; FE-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1; FER-like regulator of iron uptake; FIT1
Summary: Encodes a putative transcription factor that regulates iron uptake responses. mRNA is detected in the outer cell layers of the root and accumulates in response to iron deficiency. The expression of many iron-regulated genes is dependent on FIT1. It specifically regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation.Similar to FER in tomato and is a regulator of iron uptake. It is post-transcriptionally controlled.
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Genomic context

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Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (12004658..12006276)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FER-like iron deficiency-induced transcription factor (FIT) accumulates in nuclear condensates.
Title: FER-like iron deficiency-induced transcription factor (FIT) accumulates in nuclear condensates.
The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana.
Title: The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana.
FIT and bHLH Ib transcription factors modulate iron and copper crosstalk in Arabidopsis.
Title: FIT and bHLH Ib transcription factors modulate iron and copper crosstalk in Arabidopsis.
Reactive oxygen species coordinate the transcriptional responses to iron availability in Arabidopsis.
Title: Reactive oxygen species coordinate the transcriptional responses to iron availability in Arabidopsis.
bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis.
Title: bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis.
Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR.
Title: Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR.
propose that Ca(2+)-triggered CBL1/9-mediated activation of CIPK11 and subsequent phosphorylation of FIT shifts inactive into active FIT, allowing regulatory protein interactions in the nucleus
Title: CIPK11-Dependent Phosphorylation Modulates FIT Activity to Promote Arabidopsis Iron Acquisition in Response to Calcium Signaling.
The authors provide evidence that subgroup transcription factor bHLH039 transcription factor is involved in FIT transcriptional regulation.
Title: Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.
Plant hormone jasmonic acid (JA) negatively affects iron acquisition by repressing the expression of iron uptake regulatory gene FIT and promoting its protein degradation via the 26S proteasome pathway. The subgroup IVa bHLH transcription factors (bHLH18, bHLH19, bHLH20, and bHLH25) are FIT interactors that function in JA-mediated FIT protein degradation.
Title: Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis.
34 genes were robustly FIT-regulated in root and seedling samples and included 13 novel FIT-dependent genes.
Title: Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001336147.1

Supported by ESTs:

NM_179783.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to iron ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: FER-like regulator of iron uptake

NP_850114.1

FER-like regulator of iron uptake (FRU); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of iron ion transport, response to cytokinin stimulus, response to iron ion, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: root; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT2G16910.1); Has 2366 Blast hits to 2362 proteins in 114 species: Archae - 2; Bacteria - 0; Metazoa - 3; Fungi - 9; Plants - 2350; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12004658..12006276

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179783.2 → NP_850114.1 FER-like regulator of iron uptake [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850114.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0V7X4, Q8S3E9, Q9ZUV8

UniProtKB/TrEMBL

A0A178VTK6, A0A5S9X263, C0SV65

Conserved Domains (1) summary

cd11450
Location:126 → 201

bHLH_AtFIT_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced transcription factor 1 (FIT) and similar proteins
NM_001336147.1 → NP_001323907.1 FER-like regulator of iron uptake [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VTK6, A0A1P8AYH9