magi-1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;PDZ domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: magi-1
Gene description: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;PDZ domain-containing protein
Locus tag: CELE_K01A6.2
See related: AllianceGenome:WB:WBGene00010444
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables beta-catenin binding activity and glutamate receptor binding activity. Involved in habituation; long-term memory; and regulation of protein localization. Located in adherens junction and synapse. Is expressed in several structures, including anus; egg-laying apparatus; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to several human genes including MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2) and MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See magi-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 17

Sequence:: Chromosome: IV; NC_003282.8 (11715039..11729281)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study demonstrates novel physical interactions between MAGI-1, AFD-1/afadin and SAX-7/L1CAM, which are part of a functional interactome that includes components of the core cadherin-catenin complex; results suggest MAGI-1 helps to partition and maintain a stable, spatially ordered apical junction during morphogenesis
Title: A genome-wide functional screen shows MAGI-1 is an L1CAM-dependent stabilizer of apical junctions in C. elegans.
MAGI-1 functions as an "organizer" that ensures the correct segregation of different cell adhesion complexes into distinct domains along the lateral plasma membrane.
Title: The C. elegans MAGI-1 protein is a novel component of cell junctions that is required for junctional compartmentalization.
MAGI-1 has a role in neuron-specific regulation of associative learning and memory in C. elegans
Title: Neuron-specific regulation of associative learning and memory by MAGI-1 in C. elegans.
MAGI-1L interacts with AMPARs through the intracellular domain of the GLR-2 subunit, which is required for the modulation of AMPAR synaptic localization by mechanical stimulation.
Title: MAGI-1 modulates AMPA receptor synaptic localization and behavioral plasticity in response to prior experience.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K01A6.1 (e-PCR)
- UniSTS:321542

K01A6.3 (e-PCR)
- UniSTS:314575

K01A6.2 (e-PCR)
- UniSTS:319470

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;PDZ domain-containing protein

NP_001255577.1

Confirmed by transcript evidence

NP_001255579.1

Partially confirmed by transcript evidence

NP_001255581.1

Partially confirmed by transcript evidence

NP_001370254.1

Partially confirmed by transcript evidence

NP_001379500.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11715039..11729281

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268648.3 → NP_001255577.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255577.1

Status: REVIEWED

UniProtKB/TrEMBL

C1P633

Conserved Domains (5) summary

smart00456
Location:294 → 323

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:421 → 510

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:263 → 293

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:968 → 1049

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl17190
Location:180 → 244

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001383205.1 → NP_001370254.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

C1P635

Conserved Domains (5) summary

smart00456
Location:294 → 323

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:421 → 510

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:263 → 293

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:717 → 800

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl17190
Location:180 → 244

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001268650.4 → NP_001255579.1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255579.1

Status: REVIEWED

UniProtKB/TrEMBL

C1P634
NM_001392402.1 → NP_001379500.1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

C6KRJ8

Conserved Domains (4) summary

smart00456
Location:42 → 71

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:169 → 258

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:11 → 41

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:716 → 797

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001268652.3 → NP_001255581.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255581.1

Status: REVIEWED

UniProtKB/TrEMBL

D3YT29

Conserved Domains (2) summary

smart00228
Location:196 → 285

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:743 → 824

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...