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    pstP phosphoserine/threonine phosphatase PstP [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887070, updated on 6-Oct-2023

    Summary

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    Gene symbol
    pstP
    Gene description
    phosphoserine/threonine phosphatase PstP
    Locus tag
    Rv0018c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (21637..23181, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene anthranilate synthase component II Neighboring gene serine/threonine-protein kinase PknB Neighboring gene serine/threonine-protein kinase PknA Neighboring gene penicillin-binding protein PbpA Neighboring gene cell division protein RodA Neighboring gene FHA domain-containing protein FhaB Neighboring gene FHA domain-containing protein FhaA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serine/Threonine Protein Phosphatase PstP of Mycobacterium tuberculosis Is Necessary for Accurate Cell Division and Survival of Pathogen. Sharma AK, et al. J Biol Chem, 2016 Nov 11. PMID 27758870, Free PMC Article
    2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest an important role for PstP in establishing and maintaining infection, possibly via the modulation of cell division events.
      Title: Serine/Threonine Protein Phosphatase PstP of Mycobacterium tuberculosis Is Necessary for Accurate Cell Division and Survival of Pathogen.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    phosphoserine/threonine phosphatase PstP
    NP_214532.1
    • Experimental studies have shown that PstP specifically dephosporylates model phospho-Ser/Thr substrates and it is likely that PknB (Rv0014c) and PstP may act as a functional pair in vivo to control mycobacterial cell growth.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      21637..23181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214532.1 phosphoserine/threonine phosphatase PstP [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214532.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4LTI1
      Conserved Domains (2) summary
      NF033484
      Location:13 → 228
      Stp1_PP2C_phos; Stp1/IreP family PP2C-type Ser/Thr phosphatase
      NF033761
      Location:422 → 498
      gliding_GltJ; adventurous gliding motility protein GltJ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WHW5.1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials