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    fhaB FHA domain-containing protein FhaB [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887079, updated on 6-Oct-2023

    Summary

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    Gene symbol
    fhaB
    Gene description
    FHA domain-containing protein FhaB
    Locus tag
    Rv0019c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (23270..23737, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase PknA Neighboring gene penicillin-binding protein PbpA Neighboring gene cell division protein RodA Neighboring gene phosphoserine/threonine phosphatase PstP Neighboring gene FHA domain-containing protein FhaA Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis. Gupta M, et al. J Biol Chem, 2009 Dec 11. PMID 19826007, Free PMC Article
    2. Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. Villarino A, et al. J Mol Biol, 2005 Jul 29. PMID 15978616
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data provides initial clues for a possible regulation of PapA5 and hence the phthiocerol dimycocerosate biosynthesis by PknB, either by direct phosphorylation of PapA5 or indirectly through Rv0019c.
      Title: Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis.
    2. model of PknB-GarA interactions suggests a substrate recruitment mechanism that might apply to other mycobacterial kinases bearing multiple phosphorylation sites in their activation loops
      Title: Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    FHA domain-containing protein FhaB
    NP_214533.1
    • FtsZ-interacting protein A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      23270..23737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214533.1 FHA domain-containing protein FhaB [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214533.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M1D1
      Conserved Domains (1) summary
      COG1716
      Location:1 → 152
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WJB5.1

    Gene LinkOut

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