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    OR4F16 olfactory receptor family 4 subfamily F member 16 [ Homo sapiens (human) ]

    Gene ID: 81399, updated on 2-May-2024

    Summary

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    Official Symbol
    OR4F16provided by HGNC
    Official Full Name
    olfactory receptor family 4 subfamily F member 16provided by HGNC
    Primary source
    HGNC:HGNC:15079
    See related
    Ensembl:ENSG00000284662 AllianceGenome:HGNC:15079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR1-1; OR7-21
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    1p36.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (676076..720101, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111940..112877, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (621096..622034, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:569139-570114 Neighboring gene MT-ATP6 pseudogene 1 Neighboring gene MT-CO3 pseudogene 12 Neighboring gene NANOG hESC enhancer GRCh37_chr1:581712-582213 Neighboring gene WBP1L pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr1:632454-632965 Neighboring gene septin 14 pseudogene 14 Neighboring gene uncharacterized LOC100288069 Neighboring gene capicua transcriptional repressor pseudogene 3 Neighboring gene RNA, U6 small nuclear 1199, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    3. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 4F3/4F16/4F29
    Names
    olfactory receptor OR1-1
    olfactory receptor OR4F16
    olfactory receptor OR7-21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005277.1 → NP_001005277.1  olfactory receptor 4F3/4F16/4F29

      See identical proteins and their annotated locations for NP_001005277.1

      Status: VALIDATED

      Source sequence(s)
      AC114498
      Consensus CDS
      CCDS41221.1
      UniProtKB/Swiss-Prot
      B2RPQ6, Q6IEY1
      UniProtKB/TrEMBL
      A0A126GV92, Q6IFP3
      Related
      ENSP00000329982.2, ENST00000332831.5
      Conserved Domains (1) summary
      cd15226
      Location:35 → 291
      7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      676076..720101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449992.2 → XP_024305760.1  olfactory receptor 4F3/4F16/4F29 isoform X1

      UniProtKB/Swiss-Prot
      B2RPQ6, Q6IEY1
      UniProtKB/TrEMBL
      A0A126GV92, Q6IFP3
      Conserved Domains (1) summary
      cd15226
      Location:35 → 291
      7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017002410.2 → XP_016857899.1  olfactory receptor 4F3/4F16/4F29 isoform X1

      UniProtKB/Swiss-Prot
      B2RPQ6, Q6IEY1
      UniProtKB/TrEMBL
      A0A126GV92, Q6IFP3
      Conserved Domains (1) summary
      cd15226
      Location:35 → 291
      7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_017002408.2 → XP_016857897.1  olfactory receptor 4F3/4F16/4F29 isoform X1

      UniProtKB/Swiss-Prot
      B2RPQ6, Q6IEY1
      UniProtKB/TrEMBL
      A0A126GV92, Q6IFP3
      Conserved Domains (1) summary
      cd15226
      Location:35 → 291
      7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_047431162.1 → XP_047287118.1  olfactory receptor 4F3/4F16/4F29 isoform X1

      UniProtKB/Swiss-Prot
      B2RPQ6, Q6IEY1
      UniProtKB/TrEMBL
      A0A126GV92

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      111940..112877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IEY1.1 GenPept UniProtKB/Swiss-Prot:Q6IEY1

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