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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 30, 2015 |
| Title |
Comparative analysis of genome-wide gene expression profiles in heart, liver, spleen, ears and bone marrow in the murine strains of MRL/MpJ, C57B/6J, and Balb/C |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The MRL/MpJ mouse strain is known as a model of mammalian regeneration. The strain exhibits an unusual capacity in regenerative wound healing manifested by scarless ear-hole closure and enhanced regeneration response reported in other organs. A significant feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. As the regenerative response after injury is rather limited in mammals the MRL/MpJ mouse is a great model to study the molecular and cellular basis of scarless wound healing. We report here the analysis of genome-wide transcriptomic profiles in the heart, ear, spleen, liver and bone marrow of the MRL/MpJ mouse. We used gene expression microarray, which interrogates 44.170 of mouse transcripts, in order to identify the genes exhibiting remarkable differences in expression in the MRL/MpJ mouse compared to two reference strains: C57BL/6J and BALB/c. The comparison revealed hundreds of differentially expressed transcripts. Significant enrichments of genes engaged in retinol metabolism, peroxisome proliferator-activated receptor (PPAR), wound healing, and homeobox pathways distinguishes the differentially expressed transcripts up-regulated in the MRL/MpJ mouse, whereas the genes related to immune response, including including response to wounding are greatly enriched among those down-regulated. The same functional categories were associated with remarkable parallels between the transcriptomic patterns in murine neonates and the adult MRL/MpJ mouse.
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| Overall design |
15 samples, each sample is a poll representing three animals
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| Contributor(s) |
Sachadyn P |
| Citation(s) |
26572684 |
| Submission date |
Jan 02, 2015 |
| Last update date |
Mar 31, 2016 |
| Contact name |
Pawel Sachadyn |
| E-mail(s) |
psach@pg.gda.pl
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| Phone |
+48 583471605
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| Organization name |
Gdansk University of Technology
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| Department |
Molecular Biotechnology and Microbiology
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| Street address |
Narutowicza 11/12
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| City |
Gdansk |
| ZIP/Postal code |
80-233 |
| Country |
Poland |
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| Platforms (1) |
| GPL15887 |
NimbleGen Mouse gene expression array [100718_MM9_EXP] (gene-level version) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA271474 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE64624_RAW.tar |
52.3 Mb |
(http)(custom) |
TAR (of PAIR) |
| Processed data included within Sample table |
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