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Elastase Serine protease panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to recombinant human neutrophil elastase assessed as increase in fluorescence using H2-OPT as substrate at 1 uM by SDS-PAGE based gel fluorescence scanning analysis
Assay data:3 Active, 6 Tested
Time-dependent inhibition of human leukocyte elastase assessed as observed binding constant
Assay data:4 Tested
Inhibition of elastase in human neutrophil using N-(OMe-succinyl)-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30s for 30 mins by absorbance based analysis relative to tutuilamide A
Inhibition of elastase in human neutrophil using N-(OMe-succinyl)-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30s for 30 mins by absorbance based analysis relative to sivelestat
Inhibition of elastase in human neutrophil using N-(OMe-succinyl)-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30s for 30 mins by absorbance based analysis relative to symplostatin 5
Inhibition of elastase in human neutrophil using N-(OMe-succinyl)-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30s for 30 mins by absorbance based analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of elastase in human neutrophil using MeOSuc-AAPV-AMC as substrate by fluorescence based analysis relative to sivelestat
Inhibition of elastase in human neutrophil using MeOSuc-AAPV-AMC as substrate by fluorescence based analysis
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human NE
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human neutrophil elastase
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human neutrophil elastase activity assessed as reduction in elastase release
Assay data:1 Active, 1 Tested
Inhibition of human neutrophil elastase activity assessed as reduction in superoxide anion generation
Affinity Biochemical interaction (Microtiter-based biochemical assay) EUB0000737a ELANE
Affinity Biochemical interaction (Microtiter-based biochemical assay) EUB0000735a ELANE
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Potency index, ratio of JO146 IC50 to test compound IC50 for inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins
Assay data:17 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins
Assay data:18 Active, 18 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of native full length human neutrophil elastase using N-succinyl-Ala-Ala-Pro-Val-pNA as substrate at 5 uM incubated for 30 mins followed by substrate addition by fluorescence based analysis
Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pnitroanilide as substrate by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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