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Inhibition of DNMT3L-mediated wild type full length recombinant human DNMT3A hetero tetramer expressed in NiCo21(DE3) competent Escherichia coli cells to DNMT3L protein-protein interaction assessed as DNA methylation using poly dl-dC as substrate incubated for 1 hr
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of wild type full length recombinant human DNMT3A expressed in NiCo21(DE3) competent Escherichia coli cells to DNMT3L protein-protein interaction
Assay data:2 Active, 2 Tested
Inhibition of DNMT3L-mediated wild type full length recombinant human DNMT3A homo tetramer expressed in NiCo21(DE3) competent Escherichia coli cells to DNMT3L protein-protein interaction assessed as DNA methylation using poly dl-dC as substrate incubated for 1 hr
Inhibition of wild type full length recombinant human DNMT3A expressed in NiCo21(DE3) competent Escherichia coli cells to DNMT3L (unknown origin) protein-protein interaction
Inhibition of DNMT3B/3L (unknown origin) at 50 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of DNMT3B/3L (unknown origin) at 10 uM
Inhibition of DNMT3B/3L (unknown origin) at 5 uM
Inhibition of DNMT3A/3L (unknown origin) at 5 uM
Inhibition of DNMT3A/3L (unknown origin) at 10 uM
Binding affinity to DNMT3A/3L (unknown origin) assessed as active protein binding by SPR assay
Steady state binding affinity to DNMT3A/3L (unknown origin) at 0.12 to 10 uM by SPR assay
Inhibition of DNMT3A/3L (unknown origin) up to 1 mM using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay
Non-competitive inhibition of DNMT3A/3L (unknown origin) after 1 hr in presence of SAM and varying concentrations of Poly dI-dC DNA substrate by scintillation proximity assay
Non-competitive inhibition of DNMT3A/3L (unknown origin) after 1 hr in presence of DNA substrate and varying concentrations of SAM by scintillation proximity assay
Inhibition of DNMT3B/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay
Inhibition of DNMT3A/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay
Inhibition of DNMT3a/3L (unknown origin) using poly(dIdC) as substrate at 5 uM incubated for 3 hrs in presence of 20 uM SAM by fluorescence analysis
Inhibition of human DNMT3B/3L up to 50 uM using poly(dI-dC) as substrate and in presence of [3H]-SAM incubated for 1 hr by filter-based assay
Inhibition of human DNMT3A/3L up to 50 uM using poly(dI-dC) as substrate and in presence of [3H]-SAM incubated for 1 hr by filter-based assay
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