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Inhibition of human PAI1 by immunofluorescence staining based microscopic assay
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Surface Plasmon Resonance (SPR) Assay from US Patent US9120744: "Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorometric Plate Assay from US Patent US9120744: "Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism"
Assay data:15 Active, 11 Activity ≤ 1 µM, 37 Tested
Enzymatic Assay from Article 10.1074/jbc.M109.067967: "Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1."
Assay data:12 Active, 9 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorometric PAI-1/tPA IC50 Plate Assay at pH 7.8 from US Patent US9718760: "Plasminogen activator inhibitor-1 inhibitors and methods of use thereof"
Assay data:8 Active, 3 Activity ≤ 1 µM, 11 Tested
Fluorometric PAI-1/uPA IC50 Plate Assay (10% plasma buffer) from US Patent US9718760: "Plasminogen activator inhibitor-1 inhibitors and methods of use thereof"
Assay data:53 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Fluorometric PAI-1/uPA IC50 Plate Assay (1.5% BSA buffer) from US Patent US9718760: "Plasminogen activator inhibitor-1 inhibitors and methods of use thereof"
Fluorometric PAI-1/uPA IC50 Plate Assay from US Patent US9718760: "Plasminogen activator inhibitor-1 inhibitors and methods of use thereof"
Assay data:37 Active, 16 Activity ≤ 1 µM, 133 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 24.5 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release pre-incubated for 15 mins before 2 nM Spectrozyme tPA substrate addition for 15 mins using 5 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Assay data:17 Active, 1 Activity ≤ 1 µM, 21 Tested
Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Assay data:5 Active, 8 Tested
Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release at 2.5 uM pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release at 10 uM pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release at 20 uM pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Assay data:36 Tested
Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release at 50 uM pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of basal level PAI-1 phosphorylation in human MDA-MB-231 cells at 1 uM by ELISA
Inhibition of EGF-induced phosphorylated PAI-1 in human MDA-MB-231 cells at 1 uM by ELISA
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
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