BioAssay by Target (List) for Gene (Select 6098) - PubChem BioAssay - NCBI

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Select item 19559091.

Inhibition of ROS (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1955909

Summary Related BioAssays by Target

Select item 19202102.

Inhibitory Activity of the Compounds of the Invention Against ROS1, NTRK and ALK and their Drug-Resistant Kinases from US Patent US20240025908: "COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 3

Assay data:29 Active, 14 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested

AID:: 1920210

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19136963.

Selectivity interaction (KinaseProfiler? (Millipore)) EUB0000640a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1913696

Summary Related BioAssays by Target

Select item 19135704.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000147b ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1913570

Summary Related BioAssays by Target

Select item 19131425.

Affinity Biochemical interaction (Microfluidic mobility shift assay) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913142

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19128916.

Affinity On-target Cellular interaction (Sandwich ELISA (cell-based ROS1-fusion assay)) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912891

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127257.

Affinity Phenotypic Cellular interaction (Free plasma tumor growth inhibition assay) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912725

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19006198.

Inhibition of ROS1 (unknown origin) at 0.1 uM relative to control

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1900619

Summary PubMed Citation Related BioAssays by Target

Select item 18890709.

Inhibition of ROS1 (unknown origin) by radiometric assay

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1889070

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188901110.

Inhibition of ROS1 (unknown origin) at 1.0 uM relative to control

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1889011

Summary PubMed Citation Related BioAssays by Target

Select item 188393111.

Inhibition of ROS1 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1883931

Summary PubMed Citation Related BioAssays by Target

Select item 188005312.

Inhibition of ROS (unknown origin) at 1 uM by kinase-profiling analysis

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1880053

Summary PubMed Citation Related BioAssays by Target

Select item 187809613.

Inhibition of ROS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1878096

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186815914.

Inhibition of ROS1 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:2 Tested

AID:: 1868159

Summary PubMed Citation Related BioAssays by Target

Select item 186287815.

Inhibition of ROS (unknown origin)

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1862878

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186198916.

Inhibition of Ros (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:2 Tested

AID:: 1861989

Summary PubMed Citation Related BioAssays by Target

Select item 185557917.

Inhibition of ROS1 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1855579

Summary PubMed Citation Related BioAssays by Target

Select item 183578918.

ROS1 DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1835789

Summary Related BioAssays by Target

Select item 183514119.

Ros(h) Kinase panel

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1835141

Summary Related BioAssays by Target

Select item 183479020.

Ros(h) Millipore kinase panel

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Tested

AID:: 1834790

Summary Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (90)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (33)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (79)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (93)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (287)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (45)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (250)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (78)
BioAssays deposited by other experimentalists

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