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Inhibition of human DNA topoisomerase I mediated supercoiled pHOT1 plasmid DNA relaxation upto 100 uM incubated for 30 mins by ethidium bromide staining based agarose gel electrophoresis analysis
Assay data:6 Tested
SummaryRelated BioAssays by Target
Inhibition of topoisomerase 1 in human HCT-116 cells assessed as suppression of Topo 1 protein expression at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of topoisomerase 1 (unknown origin) mediated DNA relaxation assessed as delay in pBR322 DNA migration by gel electrophoresis assay
Inhibition of topoisomerase 1 (unknown origin) assessed as effect on DNA by gel electrophoresis
Assay data:1 Tested
Inhibition of topoisomerase 1 in human HCT-116 cells assessed as suppression of Topo 1 protein expression incubated for 24 hrs by Western blot analysis
Inhibition of human DNA topoisomerase 1 assessed as reduction in pBR322 DNA relaxation upto 100 uM by gel electrophoresis method
Assay data:2 Tested
Inhibition of human DNA topoisomerase 1 assessed as reduction in pBR322 DNA relaxation at 10 to 20 uM by gel electrophoresis method
Assay data:2 Active, 2 Tested
Inhibition of topoisomerase 1 (unknown origin) assessed as relaxation of supercoiled kDNA incubated for 30 mins ethidium bromide staining based UV transilluminator analysis
Inhibition of Topoisomerase 1 (unknown origin)
Assay data:3 Active, 4 Tested
Inhibition of human topoisomerase 1 incubated for 2 hrs by ELISA analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human topoisomerase 1
Inhibition of topoisomerase 1 (unknown origin)
Inhibition of topoisomerase 1 (unknown origin) at 100 uM incubated for 30 mins by gel electrophoresis analysis relative to control
Inhibition of topoisomerase 1 (unknown origin) at 200 uM incubated for 30 mins by gel electrophoresis analysis relative to control
Inhibition of DNA topoisomerase 1 (unknown origin) at 50 uM measured by agar gel electrophoresis
Inhibition of human DNA topoisomerase 1 incubated for 2 hrs by ELISA
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Top1 (unknown origin) assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 12.5 uM incubated for 25 mins by ethidium bromide staining based agarose gel electrophoresis analysis relative to control
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Top1 (unknown origin) assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 50 uM incubated for 25 mins by ethidium bromide staining based agarose gel electrophoresis analysis relative to control
Poison activity at human topoisomerase I assessed as stabilization of enzyme-DNA cleavage complex by measuring nicked DNA formation at 100 uM after 60 mins by agarose gel electrophoresis method
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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