BioAssays, Active for PubChem Compound (Select 5311) - PubChem BioAssay - NCBI

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Select item 3666421.

Inhibition of HDAC3 after 17 hrs

Source:: ChEMBL

Protein Target:: Histone deacetylase 3

Assay data:13 Active, 2 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested

AID:: 366642

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3666412.

Inhibition of HDAC2 after 17 hrs

Source:: ChEMBL

Protein Target:: Histone deacetylase 2

Assay data:13 Active, 8 Activity ≤ 1 µM, 13 Tested

AID:: 366641

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3666403.

Inhibition of HDAC1 after 17 hrs

Source:: ChEMBL

Protein Target:: Histone deacetylase 1

Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested

AID:: 366640

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3533564.

Inhibition of HDAC in human SHSY5Y cells by fluorimetric cellular activity assay

Source:: ChEMBL

Protein Targets:: Histone deacetylase 1; ...
Total:: 11

Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 353356

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3533545.

Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay

Source:: ChEMBL

Assay data:7 Active, 7 Tested

AID:: 353354

Summary Compounds, Active PubMed Citation

Select item 3527536.

Antiproliferative activity against human A549 cells after 72 hrs by celltiter-blue cell viability assay

Source:: ChEMBL

Assay data:2 Active, 2 Tested

AID:: 352753

Summary Compounds, Active PubMed Citation

Select item 3527527.

Antiproliferative activity against human HCT116 cells after 72 hrs by celltiter-blue cell viability assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 352752

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 3527518.

Inhibition of His-tagged HDAC8 catalytic domain expressed in Escherichia coli

Source:: ChEMBL

Protein Target:: Histone deacetylase 8

Assay data:1 Active, 2 Tested

AID:: 352751

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 3527509.

Inhibition of C-terminal FLAG tagged HDAC6

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 352750

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 35274810.

Inhibition of C-terminal FLAG tagged HDAC3

Source:: ChEMBL

Protein Target:: Histone deacetylase 3

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 352748

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 35274711.

Inhibition of C-terminal FLAG tagged HDAC2

Source:: ChEMBL

Protein Target:: Histone deacetylase 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 352747

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 35252512.

Antiproliferative activity against human SU-8686 cells by MTT assay

Source:: ChEMBL

Assay data:3 Active, 2 Activity ≤ 1 µM, 11 Tested

AID:: 352525

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 35252413.

Antiproliferative activity against human Panc 04.03 cells by MTT assay

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 11 Tested

AID:: 352524

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 35252314.

Antiproliferative activity against human MIAPaCa2 cells by MTT assay

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 µM, 11 Tested

AID:: 352523

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 35252215.

Antiproliferative activity against human HUPT3 cells by MTT assay

Source:: ChEMBL

Assay data:3 Active, 2 Activity ≤ 1 µM, 11 Tested

AID:: 352522

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 35252116.

Antiproliferative activity against human BxPC3 cells by MTT assay

Source:: ChEMBL

Assay data:3 Active, 11 Tested

AID:: 352521

Summary Compounds, Active PubMed Citation

Select item 35252017.

Inhibition of human recombinant HDAC10

Source:: ChEMBL

Protein Target:: Polyamine deacetylase HDAC10

Assay data:4 Active, 4 Activity ≤ 1 µM, 11 Tested

AID:: 352520

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 35251918.

Inhibition of human recombinant HDAC2

Source:: ChEMBL

Protein Target:: Histone deacetylase 2

Assay data:5 Active, 4 Activity ≤ 1 µM, 11 Tested

AID:: 352519

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 35251819.

Inhibition of human recombinant HDAC6

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:9 Active, 8 Activity ≤ 1 µM, 14 Tested

AID:: 352518

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 35251720.

Inhibition of human recombinant HDAC3

Source:: ChEMBL

Protein Target:: Histone deacetylase 3

Assay data:7 Active, 5 Activity ≤ 1 µM, 14 Tested

AID:: 352517

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (19)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (300)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (18)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (226)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (278)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (5)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (12)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (279)
BioAssays extracted from the literature
NIH MLP (11)
BioAssays deposited by the NIH Molecular Libraries Program
Other (10)
BioAssays deposited by other experimentalists

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