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Items: 1 to 20 of 227

1.
eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation
Tobias Schmidt, Adrianna Dabrowska, Joseph A Waldron, Kelly Hodge, Grigorios Koulouras, Mads Gabrielsen, June Munro, David C Tack, Gemma Harris, Ewan McGhee, David Scott, Leo M Carlin, Danny Huang, John Le Quesne, Sara Zanivan, Ania Wilczynska, Martin Bushell
Nucleic Acids Res. 2023 Feb 28; 51(4): 1859–1879. Published online 2023 Feb 2. doi: 10.1093/nar/gkad030
PMCID:
PMC9976904
AbstractArticlePDF–1.9M
2.
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma
Sara M. Steinmann, Anabel Sánchez-Martín, Elisabeth Tanzer, Antonio Cigliano, Giovanni M. Pes, Maria M. Simile, Laurent Desaubry, Jose J.G. Marin, Matthias Evert, Diego F. Calvisi
Int J Mol Sci. 2023 Feb; 24(3): 2055. Published online 2023 Jan 20. doi: 10.3390/ijms24032055
PMCID:
PMC9917075
AbstractArticlePDF–28M
3.
Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer
Chao Wang, Jonathan Leavenworth, Chao Zhang, Zhichao Liu, Katherine Y. Yuan, Yichun Wang, Guangxin Zhang, Shuaibin Wang, Xuelian Cui, Yue Zhang, Sejong Bae, Jiangbing Zhou, Lizhong Wang, Runhua Liu
Oncogene. Author manuscript; available in PMC 2022 Sep 30.
Published in final edited form as: Oncogene. 2022 May; 41(19): 2778–2785. Published online 2022 Mar 31. doi: 10.1038/s41388-022-02272-3
PMCID:
PMC9215223
AbstractArticlePDF–2.1M
4.
Targeting eIF4A Dependent Translation of KRAS Signaling Molecules
Kamini Singh, Jianan Lin, Nicolas Lecomte, Prathibha Mohan, Askan Gokce, Viraj R. Sanghvi, Man Jiang, Olivera Grbovic-Huezo, Antonija Burčul, Stefan G. Stark, Paul B. Romesser, Qing Chang, Jerry P. Melchor, Rachel K. Beyer, Mark Duggan, Yoshiyuki Fukase, Guangli Yang, Ouathek Ouerfelli, Agnes Viale, Elisa de Stanchina, Andrew W. Stamford, Peter T. Meinke, Gunnar Rätsch, Steven D. Leach, Zhengqing Ouyang, Hans-Guido Wendel
Cancer Res. Author manuscript; available in PMC 2021 Oct 15.
Published in final edited form as: Cancer Res. 2021 Apr 15; 81(8): 2002–2014. Published online 2021 Feb 25. doi: 10.1158/0008-5472.CAN-20-2929
PMCID:
PMC8137674
AbstractArticlePDF–2.6M
5.
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions
Jutta Steinberger, Leo Shen, Stephen J. Kiniry, Sai Kiran Naineni, Regina Cencic, Mehdi Amiri, Sarah A E Aboushawareb, Jennifer Chu, Rayelle Itoua Maïga, Brahm J Yachnin, Francis Robert, Nahum Sonenberg, Pavel V Baranov, Jerry Pelletier
Nucleic Acids Res. 2020 Sep 25; 48(17): 9521–9537. Published online 2020 Aug 7. doi: 10.1093/nar/gkaa662
PMCID:
PMC7515738
AbstractArticlePDF–4.0M
6.
A comparative study of small molecules targeting eIF4A
Sai Kiran Naineni, Rayelle Itoua Maïga, Regina Cencic, Andrea A. Putnam, Luis A. Amador, Abimael D. Rodriguez, Eckhard Jankowsky, Jerry Pelletier
RNA. 2020 May; 26(5): 541–549. doi: 10.1261/rna.072884.119
PMCID:
PMC7161356
AbstractArticlePDF–1.1M
7.
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity
Joseph A. Waldron, David C. Tack, Laura E. Ritchey, Sarah L. Gillen, Ania Wilczynska, Ernest Turro, Philip C. Bevilacqua, Sarah M. Assmann, Martin Bushell, John Le Quesne
Genome Biol. 2019; 20: 300. Published online 2019 Dec 30. doi: 10.1186/s13059-019-1901-2
PMCID:
PMC6936103
AbstractArticlePDF–5.0M
8.
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco, Jr., Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
Nat Commun. 2019; 10: 5151. Published online 2019 Nov 13. doi: 10.1038/s41467-019-13086-5
PMCID:
PMC6853918
AbstractArticlePDF–1.9M
9.
Target-Based Screening Against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Anti-Tumor Activity
Tara L. Peters, Joseph Tillotson, Alison Yeomans, Sarah C. Wilmore, Elizabeth Lemm, Carlos Jiménez-Romero, Luis A. Amador, Lingxiao Li, Amit D. Amin, Praechompoo Pongtornpipat, Christopher J. Zerio, Andrew J. Ambrose, Gillian Paine-Murrieta, Patricia Greninger, Francisco Vega, Cyril H. Benes, Graham Packham, Abimael D. Rodríguez, Eli Chapman, Jonathan H. Schatz
Clin Cancer Res. Author manuscript; available in PMC 2019 Sep 1.
Published in final edited form as: Clin Cancer Res. 2018 Sep 1; 24(17): 4256–4270. Published online 2018 May 29. doi: 10.1158/1078-0432.CCR-17-3645
PMCID:
PMC6500731
AbstractArticlePDF–1.7M
10.
The Translation Inhibitor Rocaglamide Targets a Biomolecular Cavity between eIF4A and Polypurine RNA
Shintaro Iwasaki, Wakana Iwasaki, Mari Takahashi, Ayako Sakamoto, Chiduru Watanabe, Yuichi Shichino, Stephen N. Floor, Koichi Fujiwara, Mari Mito, Kosuke Dodo, Mikiko Sodeoka, Hiroaki Imataka, Teruki Honma, Kaori Fukuzawa, Takuhiro Ito, Nicholas T. Ingolia
Mol Cell. Author manuscript; available in PMC 2020 Feb 21.
Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 738–748.e9. Published online 2018 Dec 27. doi: 10.1016/j.molcel.2018.11.026
PMCID:
PMC6386617
AbstractArticlePDF–2.8M
11.
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape
A Modelska, E Turro, R Russell, J Beaton, T Sbarrato, K Spriggs, J Miller, S Gräf, E Provenzano, F Blows, P Pharoah, C Caldas, J Le Quesne
Cell Death Dis. 2015 Jan; 6(1): e1603. Published online 2015 Jan 22. doi: 10.1038/cddis.2014.542
PMCID:
PMC4669741
AbstractArticlePDF–3.1M
12.
Factor-dependent processivity in human eIF4A DEAD-box helicase
Cuauhtémoc García-García, Kirsten L. Frieda, Kateryna Feoktistova, Christopher S. Fraser, Steven M. Block
Science. Author manuscript; available in PMC 2016 Jun 26.
Published in final edited form as: Science. 2015 Jun 26; 348(6242): 1486–1488. doi: 10.1126/science.aaa5089
PMCID:
PMC4605566
AbstractArticlePDF–414K
13.
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Andrew L. Wolfe, Kamini Singh, Yi Zhong, Philipp Drewe, Vinagolu K. Rajasekhar, Viraj R. Sanghvi, Konstantinos J. Mavrakis, Man Jiang, Justine E. Roderick, Joni Van der Meulen, Jonathan H. Schatz, Christina M. Rodrigo, Chunying Zhao, Pieter Rondou, Elisa de Stanchina, Julie Teruya-Feldstein, Michelle A. Kelliher, Frank Speleman, John A. Porco, Jr., Jerry Pelletier, Gunnar Rätsch, Hans-Guido Wendel
Nature. Author manuscript; available in PMC 2015 Jul 6.
Published in final edited form as: Nature. 2014 Sep 4; 513(7516): 65–70. Published online 2014 Jul 27. doi: 10.1038/nature13485
PMCID:
PMC4492470
AbstractArticlePDF–2.8M
14.
Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A
Woo Jae Kim, Joon Hyun Kim, Sung Key Jang
EMBO J. 2007 Dec 12; 26(24): 5020–5032. Published online 2007 Nov 22. doi: 10.1038/sj.emboj.7601920
PMCID:
PMC2140107
AbstractArticlePDF–529K
15.
Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.
Mark X Du, Robert B Johnson, Xin-Lai Sun, Kirk A Staschke, Joseph Colacino, Q May Wang
Biochem J. 2002 Apr 1; 363(Pt 1): 147–155. doi: 10.1042/0264-6021:3630147
PMCID:
PMC1222461
SummaryPDF–244K
16.
Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI.
N S Kim, T Kato, N Abe, S Kato
Nucleic Acids Res. 1993 Apr 25; 21(8): 2012. doi: 10.1093/nar/21.8.2012
PMCID:
PMC309447
SummaryPage BrowsePDF–175K
17.
eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model
Alina González-Ortiz, Angel Pulido-Capiz, César Y. Castañeda-Sánchez, Esmeralda Ibarra-López, Octavio Galindo-Hernández, Maritza Anahí Calderón-Fernández, Leslie Y. López-Cossio, Raul Díaz-Molina, Brenda Chimal-Vega, Nicolás Serafín-Higuera, Iván Córdova-Guerrero, Victor García-González
Cells. 2022 Dec; 11(24): 4069. Published online 2022 Dec 15. doi: 10.3390/cells11244069
PMCID:
PMC9776898
AbstractArticlePDF–2.6M
18.
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
Jasmine George, Yongsheng Li, Ishaque P. Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S. Rader, Anil K. Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Cell Rep. Author manuscript; available in PMC 2021 Dec 16.
Published in final edited form as: Cell Rep. 2021 Nov 2; 37(5): 109934. doi: 10.1016/j.celrep.2021.109934
Correction in:
Cell Rep. 2023 Mar 28; 42(3): 112228.
PMCID:
PMC8675433
AbstractArticlePDF–1.9M
19.
Differential regulation of the melanoma proteome by eIF4A1 and eIF4E
Cailin E. Joyce, Adrienne G. Yanez, Akihiro Mori, Akinori Yoda, Johanna S. Carroll, Carl D. Novina
Cancer Res. Author manuscript; available in PMC 2018 Feb 1.
Published in final edited form as: Cancer Res. 2017 Feb 1; 77(3): 613–622. Published online 2016 Nov 22. doi: 10.1158/0008-5472.CAN-16-1298
Correction in:
Cancer Res. 2017 Mar 15; 77(6): 1505.
PMCID:
PMC5362820
AbstractArticlePDF–1.3M
20.
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase
James J. Steinhardt, Raymond J. Peroutka, Krystyna Mazan-Mamczarz, Qing Chen, Simone Houng, Carol Robles, Rolf N. Barth, Joseph DuBose, Brandon Bruns, Ronald Tesoriero, Deborah Stein, Raymond Fang, Nader Hanna, Jason Pasley, Carlos Rodriguez, Mark D. Kligman, Matthew Bradley, Joseph Rabin, Stacy Shackelford, Bojie Dai, Ari L. Landon, Thomas Scalea, Ferenc Livak, Ronald B. Gartenhaus
Blood. 2014 Dec 11; 124(25): 3758–3767. Prepublished online 2014 Oct 15. doi: 10.1182/blood-2014-07-589689
PMCID:
PMC4263984
AbstractArticle

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