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Select item 104493091.

miR-926-3p influences myocardial injury in septic mice through regulation of mTOR signaling pathway by targeting TSC1

Feng Yan, Qian Wang, Huiyu Yang, Hui Lv, Weiwei Qin

Aging (Albany NY) 2023 May 15; 15(9): 3826–3838. Published online 2023 May 11. doi: 10.18632/aging.204716

PMCID:: PMC10449309

Abstract Article PDF–1.4M

Select item 94813622.

Possible Involvement of DNA Methylation in TSC1 Gene Expression in Neuroprotection Induced by Hypoxic Preconditioning

Ruifang Qi, Yabin Xie, Xiaolu Zhang, Shuyuan Jiang, Xiaolei Liu, Wei Xie, Xiaoe Jia, Rengui Bade, You Liu, Kerui Gong, Wenjie Yang, Guanghui Guo, Kai Sun, Chunyang Zhang, Ruijuan Han, Guo Shao

Oxid Med Cell Longev. 2022; 2022: 9306097. Published online 2022 Sep 9. doi: 10.1155/2022/9306097

PMCID:: PMC9481362

Abstract Article PDF–2.5M

Select item 94452003.

Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass

Yuan Liang, Ruili Yu, Rui He, Lijun Sun, Chao Luo, Lu Feng, Hong Chen, Yue Yin, Weizhen Zhang

Front Endocrinol (Lausanne) 2022; 13: 891379. Published online 2022 Aug 23. doi: 10.3389/fendo.2022.891379

PMCID:: PMC9445200

Abstract Article PDF–2.8M

Select item 90187814.

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtmann, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg

Nat Commun. 2022; 13: 2025. Published online 2022 Apr 19. doi: 10.1038/s41467-022-29714-6

Correction in:: Nat Commun. 2022; 13: 2410.

PMCID:: PMC9018781

Abstract Article PDF–8.3M

Select item 86752025.

Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis

Linda M.C. Koene, Eva Niggl, Ilse Wallaard, Martina Proietti-Onori, Diana C. Rotaru, Ype Elgersma

JCI Insight. 2021 Dec 8; 6(23): e150120. Published online 2021 Dec 8. doi: 10.1172/jci.insight.150120

PMCID:: PMC8675202

Abstract Article PDF–1.8M

Select item 85439256.

Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses

Yuan-Lynn Hsieh, Xiaoxi Wei, Yating Wang, Honghao Zhang, Shuqun Qi, Di Xie, Yuji Mishina, Daniela Mendonça, Nan Hatch, Fei Liu

Bone. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Bone. 2021 Dec; 153: 116142. Published online 2021 Aug 5. doi: 10.1016/j.bone.2021.116142

PMCID:: PMC8543925

Abstract Article PDF–3.6M

Select item 81010347.

Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice

Yafei Deng, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Shuju Zhang, Baige Yao, Shuhui Li, Yuan Gao, Xiaohui Li, Liping Li, Youcai Deng

J Neuroinflammation. 2021; 18: 107. Published online 2021 May 6. doi: 10.1186/s12974-021-02153-8

PMCID:: PMC8101034

Abstract Article PDF–2.7M

Select item 80971698.

Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis

Lanman Xu, Xiaofang Wang, Yan Chen, Lynn Soong, Yongping Chen, Jiyang Cai, Yuejin Liang, Jiaren Sun

Front Immunol. 2021; 12: 638575. Published online 2021 Apr 21. doi: 10.3389/fimmu.2021.638575

PMCID:: PMC8097169

Abstract Article PDF–3.5M

Select item 79852659.

TSC1 Affects the Process of Renal Ischemia-Reperfusion Injury by Controlling Macrophage Polarization

Xiao Hu, Yanan Xu, Zhaoqi Zhang, Zuofu Tang, Jinhua Zhang, You Luo, Weiming Deng, Zhanwen Dong, Yong Zhao, Ning Na

Front Immunol. 2021; 12: 637335. Published online 2021 Mar 9. doi: 10.3389/fimmu.2021.637335

PMCID:: PMC7985265

Abstract Article PDF–2.7M

Select item 781127910.

MTOR-initiated Metabolic Switch and Degeneration in the Retinal Pigment Epithelium

Young-Mi Go, Jing Zhang, Jolyn Fernandes, Christopher Litwin, Rui Chen, Theodore G. Wensel, Dean P. Jones, Jiyang Cai, Yan Chen

FASEB J. Author manuscript; available in PMC 2021 Jan 16.

Published in final edited form as: FASEB J. 2020 Sep; 34(9): 12502–12520. Published online 2020 Jul 28. doi: 10.1096/fj.202000612R

PMCID:: PMC7811279

Abstract Article PDF–2.5M

Select item 748386111.

Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

Elyza Kelly, Fantao Meng, Hirofumi Fujita, Felipe Morgado, Yasaman Kazemi, Laura C. Rice, Chongyu Ren, Christine Ochoa Escamilla, Jennifer M. Gibson, Sanaz Sajadi, Robert J. Pendry, Tommy Tan, Jacob Ellegood, M. Albert Basson, Randy D. Blakely, Scott V. Dindot, Christelle Golzio, Maureen K. Hahn, Nicholas Katsanis, Diane M. Robins, Jill L. Silverman, Karun K. Singh, Rachel Wevrick, Margot J. Taylor, Christopher Hammill, Evdokia Anagnostou, Brad E. Pfeiffer, Catherine J. Stoodley, Jason P. Lerch, Sascha du Lac, Peter T. Tsai

Nat Neurosci. Author manuscript; available in PMC 2021 Jan 13.

Published in final edited form as: Nat Neurosci. 2020 Sep; 23(9): 1102–1110. Published online 2020 Jul 13. doi: 10.1038/s41593-020-0665-z

PMCID:: PMC7483861

Abstract Article PDF–3.3M

Select item 748125112.

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg

Nat Commun. 2020; 11: 4510. Published online 2020 Sep 9. doi: 10.1038/s41467-020-18140-1

PMCID:: PMC7481251

Abstract Article PDF–8.4M

Select item 740629213.

Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex–associated cystic kidney disease

Morris Nechama, Yaniv Makayes, Elad Resnick, Karen Meir, Oded Volovelsky

JCI Insight. 2020 Jul 9; 5(13): e136857. Published online 2020 Jul 9. doi: 10.1172/jci.insight.136857

PMCID:: PMC7406292

Abstract Article PDF–10M

Select item 718244014.

Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma

Ting Li, Guohong Zhang, Linlin Wang, Susu Li, Xiaoping Xu, Yi Gao

Front Cell Dev Biol. 2020; 8: 225. Published online 2020 Apr 7. doi: 10.3389/fcell.2020.00225

PMCID:: PMC7182440

Abstract Article PDF–4.1M

Select item 714012115.

Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

Cheng Yang, Jianwen Liao, Pinglin Lai, Hai Huang, Shicai Fan, Yuhui Chen, Xiaochun Bai

Biomed Res Int. 2020; 2020: 4572687. Published online 2020 Mar 26. doi: 10.1155/2020/4572687

PMCID:: PMC7140121

Abstract Article PDF–1.6M

Select item 688290116.

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Polina Kosillo, Natalie M. Doig, Kamran M. Ahmed, Alexander H.C.W. Agopyan-Miu, Corinna D. Wong, Lisa Conyers, Sarah Threlfell, Peter J. Magill, Helen S. Bateup

Nat Commun. 2019; 10: 5426. Published online 2019 Nov 28. doi: 10.1038/s41467-019-13396-8

PMCID:: PMC6882901

Abstract Article PDF–3.0M

Select item 682959817.

Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

Mahsa Zarei, Heng Du, Amin H. Nassar, Rachel E. Yan, Krinio Giannikou, Sneha H. Johnson, Hilaire C. Lam, Elizabeth P. Henske, Yubao Wang, Tinghu Zhang, John Asara, David J. Kwiatkowski

J Exp Med. 2019 Nov 4; 216(11): 2635–2652. Published online 2019 Sep 10. doi: 10.1084/jem.20190251

PMCID:: PMC6829598

Abstract Article PDF–4.3M

Select item 668753818.

Nutrient sensing in CD11c cells alters the gut microbiota to regulate food intake and body mass

D. Nyasha Chagwedera, Qi Yan Ang, Jordan E. Bisanz, Yew Ann Leong, Kirthana Ganeshan, Jingwei Cai, Andrew D. Patterson, Peter J. Turnbaugh, Ajay Chawla

Cell Metab. Author manuscript; available in PMC 2020 Aug 6.

Published in final edited form as: Cell Metab. 2019 Aug 6; 30(2): 364–373.e7. Published online 2019 May 23. doi: 10.1016/j.cmet.2019.05.002

PMCID:: PMC6687538

Abstract Article PDF–1.7M

Select item 640140819.

Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration

Jiancheng Huang, Shun Gu, Meng Chen, Shu-jie Zhang, Zhichun Jiang, Xue Chen, Chao Jiang, Guohua Liu, Roxana A Radu, Xiantao Sun, Douglas Vollrath, Jianhai Du, Biao Yan, Chen Zhao

Theranostics. 2019; 9(4): 1170–1180. Published online 2019 Jan 30. doi: 10.7150/thno.26281

PMCID:: PMC6401408

Abstract Article PDF–1.9M

Select item 624888820.

Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β-Catenin Cascade

Han Kyoung Choi, Hebao Yuan, Fang Fang, Xiaoxi Wei, Lu Liu, Qing Li, Jun-Lin Guan, Fei Liu

J Bone Miner Res. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: J Bone Miner Res. 2018 Nov; 33(11): 2021–2034. Published online 2018 Jul 19. doi: 10.1002/jbmr.3530

PMCID:: PMC6248888

Abstract Article PDF–2.7M

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