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Select item 92292731.

Patients with Invasive Lobular Carcinoma Show a Significant Increase in IRS-4 Expression Compared to Infiltrative Ductal Carcinoma—A Histopathological Study

Miguel A. Ortega, Oscar Fraile-Martinez, Cielo García-Montero, Sandra Borja-Vergel, Diego Torres-Carranza, Leonel Pekarek, Coral Bravo Arribas, Juan A. De León-Luis, Cristina Sánchez-Rojo, Miguel Angel Alvarez-Mon, Natalio García-Honduvilla, Julia Buján, Santiago Coca, Melchor Alvarez-Mon, Miguel A. Saez, Luis G. Guijarro

Medicina (Kaunas) 2022 Jun; 58(6): 722. Published online 2022 May 28. doi: 10.3390/medicina58060722

PMCID:: PMC9229273

Abstract Article PDF–2.3M

Select item 84897642.

Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall

Miguel A Ortega, Oscar Fraile-Martínez, Cielo García-Montero, Fernando Ruiz-Grande, Silve Barrena, Hector Montoya, Leonel Pekarek, Sofia Zoullas, Miguel A Alvarez-Mon, Felipe Sainz, Angel Asúnsolo, Julio Acero, Melchor Álvarez-Mon, Julia Buján, Natalio García-Honduvilla, Luis G Guijarro

J Int Med Res. 2021 Sep; 49(9): 03000605211041275. Published online 2021 Sep 30. doi: 10.1177/03000605211041275

PMCID:: PMC8489764

Abstract Article PDF–600K

Select item 81768513.

Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4

Konrad Patyra, Kristiina Makkonen, Maria Haanpää, Sinikka Karppinen, Liisa Viikari, Jorma Toppari, Mary Pat Reeve, Jukka Kero

Front Endocrinol (Lausanne) 2021; 12: 658137. Published online 2021 May 21. doi: 10.3389/fendo.2021.658137

PMCID:: PMC8176851

Abstract Article PDF–1.1M

Select item 61616504.

Mutations in IRS4 are associated with central hypothyroidism

Charlotte A Heinen, Emmely M de Vries, Mariëlle Alders, Hennie Bikker, Nitash Zwaveling-Soonawala, Erica L T van den Akker, Boudewijn Bakker, Gera Hoorweg-Nijman, Ferdinand Roelfsema, Raoul C Hennekam, Anita Boelen, A S Paul van Trotsenburg, Eric Fliers

J Med Genet. 2018 Oct; 55(10): 693–700. Published online 2018 Jul 30. doi: 10.1136/jmedgenet-2017-105113

PMCID:: PMC6161650

Abstract Article PDF–699K

Select item 37692815.

Effect of IRS4 Levels on PI 3-Kinase Signalling

Gerta Hoxhaj, Kumara Dissanayake, Carol MacKintosh

PLoS One. 2013; 8(9): e73327. Published online 2013 Sep 10. doi: 10.1371/journal.pone.0073327

PMCID:: PMC3769281

Abstract Article PDF–2.8M

Select item 57918826.

Pan-cancer analysis of somatic copy number alterations implicates IRS4 and IGF2 in enhancer hijacking

Joachim Weischenfeldt, Taronish Dubash, Alexandros P. Drainas, Balca R. Mardin, Yuanyuan Chen, Adrian M. Stütz, Sebastian M. Waszak, Graziella Bosco, Ann Rita Halvorsen, Benjamin Raeder, Theocharis Efthymiopoulos, Serap Erkek, Christine Siegl, Hermann Brenner, Odd Terje Brustugun, Sebastian M. Dieter, Paul A. Northcott, Iver Petersen, Stefan M. Pfister, Martin Schneider, Steinar K. Solberg, Erik Thunissen, Wilko Weichert, Thomas Zichner, Roman Thomas, Martin Peifer, Aslaug Helland, Claudia R. Ball, Martin Jechlinger, Rocio Sotillo, Hanno Glimm, Jan O. Korbel

Nat Genet. Author manuscript; available in PMC 2018 Jan 31.

Published in final edited form as: Nat Genet. 2017 Jan; 49(1): 65–74. Published online 2016 Nov 21. doi: 10.1038/ng.3722

PMCID:: PMC5791882

Abstract Article PDF–1.6M

Select item 90982227.

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells

Yanchun Zhang, Xuexue Xiong, Qi Zhu, Jiali Zhang, Shengmiao Chen, Yuetong Wang, Jian Cao, Li Chen, Linjun Hou, Xi Zhao, Piliang Hao, Jian Chen, Min Zhuang, Dake Li, Gaofeng Fan

eLife. 2022; 11: e76183. Published online 2022 May 12. doi: 10.7554/eLife.76183

PMCID:: PMC9098222

Abstract Article PDF–2.3M

Select item 60370258.

Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway

Xinchun Li, Li Zhong, Zhuo Wang, Huiming Chen, Dan Liao, Ruhua Zhang, Hongyu Zhang, Tiebang Kang

Theranostics. 2018; 8(13): 3643–3653. Published online 2018 Jun 7. doi: 10.7150/thno.26021

PMCID:: PMC6037025

Abstract Article PDF–1.3M

Select item 850689.

IRS-4 Mediates Protein Kinase B Signaling during Insulin Stimulation without Promoting Antiapoptosis

Tohru Uchida, Martin G. Myers, Jr., Morris F. White

Mol Cell Biol. 2000 Jan; 20(1): 126–138. doi: 10.1128/mcb.20.1.126-138.2000

PMCID:: PMC85068

Abstract Article PDF–2.3M

Select item 417624010.

Insulin Receptor Substrate-4 Binds to Slingshot-1 Phosphatase and Promotes Cofilin Dephosphorylation

Yuta Homma, Shin-ichiro Kanno, Kazutaka Sasaki, Michiru Nishita, Akira Yasui, Tomoichiro Asano, Kazumasa Ohashi, Kensaku Mizuno

J Biol Chem. 2014 Sep 19; 289(38): 26302–26313. Published online 2014 Aug 6. doi: 10.1074/jbc.M114.565945

PMCID:: PMC4176240

Abstract Article PDF–2.5M

Select item 319267711.

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

Ji-Yao Li, Biaoxin Chai, Weizhen Zhang, Xiaobin Wu, Chao Zhang, Danielle Fritze, Zefeng Xia, Cam Patterson, Michael W Mulholland

BMC Neurosci. 2011; 12: 95. Published online 2011 Sep 28. doi: 10.1186/1471-2202-12-95

PMCID:: PMC3192677

Abstract Article PDF–7.8M

Select item 541954612.

Insulin Receptor Substrate 4 Couples the Leptin Receptor to Multiple Signaling Pathways

Joris Wauman, Anne-Sophie De Smet, Dominiek Catteeuw, Denise Belsham, Jan Tavernier

Mol Endocrinol. April 1, 2008; 22(4): 965–977. doi: 10.1210/me.2007-0414

PMCID:: PMC5419546

Abstract Article

Select item 825770813.

FBXL6 degrades phosphorylated p53 to promote tumor growth

Yajun Li, Kaisa Cui, Qiang Zhang, Xu Li, Xingrong Lin, Yi Tang, Edward V. Prochownik, Youjun Li

Cell Death Differ. 2021 Jul; 28(7): 2112–2125. Published online 2021 Feb 10. doi: 10.1038/s41418-021-00739-6

PMCID:: PMC8257708

Abstract Article PDF–5.1M

Select item 588628214.

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways

Tishani Methsala Wijesuriya, Leentje De Ceuninck, Delphine Masschaele, Matthea R Sanderson, Karin Vanessa Carias, Jan Tavernier, Rachel Wevrick

Hum Mol Genet. 2017 Nov 1; 26(21): 4215–4230. Published online 2017 Aug 14. doi: 10.1093/hmg/ddx311

PMCID:: PMC5886282

Abstract Article PDF–1.1M

Select item 291078915.

Insulin-like Growth Factor Axis Gene Polymorphisms and Clinical Outcome in Pancreatic Cancer

Xiaoqun Dong, Milind Javle, Kenneth R. Hess, Rachna Shroff, James L. Abbruzzese, Donghui Li

Gastroenterology. Author manuscript; available in PMC 2011 Aug 1.

Published in final edited form as: Gastroenterology. 2010 Aug; 139(2): 464–473.e3. Published online 2010 Apr 21. doi: 10.1053/j.gastro.2010.04.042

PMCID:: PMC2910789

Abstract Article PDF–403K

Select item 825766016.

USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription

Xiaohua Jie, William Pat Fong, Rui Zhou, Ye Zhao, Yingchao Zhao, Rui Meng, Sheng Zhang, Xiaorong Dong, Tao Zhang, Kunyu Yang, Gang Wu, Shuangbing Xu

Cell Death Differ. 2021 Jul; 28(7): 2095–2111. Published online 2021 Feb 8. doi: 10.1038/s41418-021-00740-z

PMCID:: PMC8257660

Abstract Article PDF–6.4M

Select item 384306817.

WD Repeat Protein WDR48 in Complex with Deubiquitinase USP12 Suppresses Akt-dependent Cell Survival Signaling by Stabilizing PH Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1)

Narmadha Reddy Gangula, Subbareddy Maddika

J Biol Chem. 2013 Nov 29; 288(48): 34545–34554. Published online 2013 Oct 21. doi: 10.1074/jbc.M113.503383

PMCID:: PMC3843068

Abstract Article PDF–3.8M

Select item 660664918.

The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

Tongde Du, Hongchang Li, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui, Chuanchun Han, Lingqiang Zhang

Nat Commun. 2019; 10: 2914. Published online 2019 Jul 2. doi: 10.1038/s41467-019-10824-7

PMCID:: PMC6606649

Abstract Article PDF–4.7M

Select item 573969019.

Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway

Baihai Jiao, Xuezhen Shi, Yanzhao Chen, Haiyan Ye, Min Yao, Wenxu Hong, Shilin Li, Xiaoqiong Duan, Yujia Li, Yancui Wang, Limin Chen

Oncotarget. 2017 Dec 1; 8(62): 105923–105935. Published online 2017 Nov 18. doi: 10.18632/oncotarget.22510

PMCID:: PMC5739690

Abstract Article PDF–5.3M

Select item 450550620.

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28

Woo Jae Kim, Ben S. Wittner, Arnaud Amzallag, Brian W. Brannigan, David T. Ting, Sridhar Ramaswamy, Shyamala Maheswaran, Daniel A. Haber

J Biol Chem. 2015 Jun 5; 290(23): 14381–14390. Published online 2015 Apr 16. doi: 10.1074/jbc.M114.631945

PMCID:: PMC4505506

Abstract Article PDF–2.0M

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