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Select item 101845531.

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance

Megan L. Insco, Brian J. Abraham, Sara J. Dubbury, Ines H. Kaltheuner, Sofia Dust, Constance Wu, Kevin Y. Chen, David Liu, Stanislav Bellaousov, Anna M. Cox, Benjamin J.E. Martin, Tongwu Zhang, Calvin G. Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E. Esgdaille, Telmo Henriques, Kevin M. Brown, Stephen J. Chanock, Matthias Geyer, Karen Adelman, Phillip A. Sharp, Richard A. Young, Paul L. Boutz, Leonard I. Zon

Science. Author manuscript; available in PMC 2023 May 15.

Published in final edited form as: Science. 2023 Apr 21; 380(6642): eabn7625. Published online 2023 Apr 21. doi: 10.1126/science.abn7625

PMCID:: PMC10184553

Abstract Article PDF–2.1M

Select item 84729242.

Wolfram-like syndrome with bicuspid aortic valve due to a homozygous missense variant in CDK13

Anushree Acharya, Syed Irfan Raza, Muhammad Zeeshan Anwar, Thashi Bharadwaj, Khurram Liaqat, Muhammad Akram Shahzad Khokhar, Jenna L. Everard, Abdul Nasir, University of Washington Center for Mendelian Genomics, Deborah A. Nickerson, Michael J. Bamshad, Muhammad Ansar, Isabelle Schrauwen, Wasim Ahmad, Suzanne M. Leal

J Hum Genet. 2021; 66(10): 1009–1018. Published online 2021 Apr 21. doi: 10.1038/s10038-021-00922-0

Correction in:: J Hum Genet. 2021; 66(10): 1019.

PMCID:: PMC8472924

Abstract Article PDF–1.2M

Select item 47575663.

CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment

Yasmine Even, Marie-Line Escande, Claire Fayet, Anne-Marie Genevière

PLoS One. 2016; 11(2): e0149184. Published online 2016 Feb 17. doi: 10.1371/journal.pone.0149184

PMCID:: PMC4757566

Abstract Article PDF–7.9M

Select item 84249814.

An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks

Julia Ramírez-Moya, Christos Miliotis, Allison R. Baker, Richard I. Gregory, Frank J. Slack, Pilar Santisteban

Mol Cancer. 2021; 20: 115. Published online 2021 Sep 8. doi: 10.1186/s12943-021-01401-y

PMCID:: PMC8424981

Abstract Article PDF–3.1M

Select item 66025665.

Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium

Arno L. Greenleaf

Transcription. 2019; 10(2): 91–110. Published online 2018 Oct 22. doi: 10.1080/21541264.2018.1535211

PMCID:: PMC6602566

Abstract Article PDF–2.0M

Select item 57493036.

Heterozygous mutations affecting the protein kinase domain of CDK13 cause a syndromic form of developmental delay and intellectual disability

Mark J Hamilton, Richard C Caswell, Natalie Canham, Trevor Cole, Helen V Firth, Nicola Foulds, Ketil Heimdal, Emma Hobson, Gunnar Houge, Shelagh Joss, Dhavendra Kumar, Anne Katrin Lampe, Isabelle Maystadt, Victoria McKay, Kay Metcalfe, Ruth Newbury-Ecob, Soo-Mi Park, Leema Robert, Cecilie F Rustad, Emma Wakeling, Andrew O M Wilkie, The Deciphering Developmental Disorders Study, Stephen R F Twigg, Mohnish Suri

J Med Genet. 2018 Jan; 55(1): 28–38. Published online 2017 Oct 11. doi: 10.1136/jmedgenet-2017-104620

PMCID:: PMC5749303

Abstract Article PDF–1.3M

Select item 55570757.

Phenotypic and molecular characterisation of CDK13-related congenital heart defects, dysmorphic facial features and intellectual developmental disorders

Bret L. Bostwick, Scott McLean, Jennifer E. Posey, Haley E. Streff, Karen W. Gripp, Alyssa Blesson, Nina Powell-Hamilton, Jessica Tusi, David A. Stevenson, Ellyn Farrelly, Louanne Hudgins, Yaping Yang, Fan Xia, Xia Wang, Pengfei Liu, Magdalena Walkiewicz, Marianne McGuire, Dorothy K. Grange, Marisa V. Andrews, Marybeth Hummel, Suneeta Madan-Khetarpal, Elena Infante, Zeynep Coban-Akdemir, Karol Miszalski-Jamka, John L. Jefferies, Members of the Undiagnosed Diseases Network, Jill A. Rosenfeld, Lisa Emrick, Kimberly M. Nugent, James R. Lupski, John W. Belmont, Brendan Lee, Seema R. Lalani

Genome Med. 2017; 9: 73. Published online 2017 Aug 14. doi: 10.1186/s13073-017-0463-8

PMCID:: PMC5557075

Abstract Article PDF–5.6M

Select item 43330968.

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

Kaiwei Liang, Xin Gao, Joshua M. Gilmore, Laurence Florens, Michael P. Washburn, Edwin Smith, Ali Shilatifard

Mol Cell Biol. 2015 Mar; 35(6): 928–938. Prepublished online 2015 Jan 5. Published online 2015 Feb 18. doi: 10.1128/MCB.01426-14

PMCID:: PMC4333096

Abstract Article PDF–3.2M

Select item 482829.

Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.

Y Lapidot-Lifson, D Patinkin, C A Prody, G Ehrlich, S Seidman, R Ben-Aziz, F Benseler, F Eckstein, H Zakut, H Soreq

Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2): 579–583. doi: 10.1073/pnas.89.2.579

PMCID:: PMC48282

Summary Page Browse PDF–1.4M

Select item 1028790110.

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1

Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

Nucleic Acids Res. 2023 Jun 23; 51(11): 5512–5526. Published online 2023 Apr 7. doi: 10.1093/nar/gkad258

PMCID:: PMC10287901

Abstract Article PDF–3.4M

Select item 838564511.

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

Qingqing Chai, Sunan Li, Morgan K. Collins, Rongrong Li, Iqbal Ahmad, Silas F. Johnson, Dylan A. Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F. Hultquist, B. Matija Peterlin, Yong-Hui Zheng

Cell Rep. Author manuscript; available in PMC 2021 Aug 25.

Published in final edited form as: Cell Rep. 2021 Aug 10; 36(6): 109514. doi: 10.1016/j.celrep.2021.109514

PMCID:: PMC8385645

Abstract Article PDF–2.1M

Select item 659351312.

Novel pathogenic variants and multiple molecular diagnoses in neurodevelopmental disorders

Joanne Trinh, Krishna Kumar Kandaswamy, Martin Werber, Maximilian E. R. Weiss, Gabriela Oprea, Shivendra Kishore, Katja Lohmann, Arndt Rolfs

J Neurodev Disord. 2019; 11: 11. Published online 2019 Jun 25. doi: 10.1186/s11689-019-9270-4

PMCID:: PMC6593513

Abstract Article PDF–1.1M

Select item 567500013.

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

Sheng Chih Jin, Jason Homsy, Samir Zaidi, Qiongshi Lu, Sarah Morton, Steven R. DePalma, Xue Zeng, Hongjian Qi, Weni Chang, Michael C. Sierant, Wei-Chien Hung, Shozeb Haider, Junhui Zhang, James Knight, Robert D. Bjornson, Christopher Castaldi, Irina R. Tikhonoa, Kaya Bilguvar, Shrikant M. Mane, Stephan J. Sanders, Seema Mital, Mark Russell, William Gaynor, John Deanfield, Alessandro Giardini, George A. Porter, Jr., Deepak Srivastava, Cecelia W. Lo, Yufeng Shen, W. Scott Watkins, Mark Yandell, H. Joseph Yost, Martin Tristani-Firouzi, Jane W. Newburger, Amy E. Roberts, Richard Kim, Hongyu Zhao, Jonathan R. Kaltman, Elizabeth Goldmuntz, Wendy K. Chung, Jonathan G. Seidman, Bruce D. Gelb, Christine E. Seidman, Richard P. Lifton, Martina Brueckner

Nat Genet. Author manuscript; available in PMC 2018 Apr 9.

Published in final edited form as: Nat Genet. 2017 Nov; 49(11): 1593–1601. Published online 2017 Oct 9. doi: 10.1038/ng.3970

PMCID:: PMC5675000

Abstract Article PDF–1.2M

Select item 341823614.

Frequent Amplification of CENPF, GMNN and CDK13 Genes in Hepatocellular Carcinomas

Hye-Eun Kim, Dae-Ghon Kim, Kyung Jin Lee, Jang Geun Son, Min-Young Song, Young-Mi Park, Jae-Jung Kim, Sung-Won Cho, Sung-Gil Chi, Hyun Sub Cheong, Hyoung Doo Shin, Sang-Wook Lee, Jong-Keuk Lee

PLoS One. 2012; 7(8): e43223. Published online 2012 Aug 13. doi: 10.1371/journal.pone.0043223

PMCID:: PMC3418236

Abstract Article PDF–2.0M

Select item 753068115.

Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Tianyun Wang, Kendra Hoekzema, Davide Vecchio, Huidan Wu, Arvis Sulovari, Bradley P. Coe, Madelyn A. Gillentine, Amy B. Wilfert, Luis A. Perez-Jurado, Malin Kvarnung, Yoeri Sleyp, Rachel K. Earl, Jill A. Rosenfeld, Madeleine R. Geisheker, Lin Han, Bing Du, Chris Barnett, Elizabeth Thompson, Marie Shaw, Renee Carroll, Kathryn Friend, Rachael Catford, Elizabeth E. Palmer, Xiaobing Zou, Jianjun Ou, Honghui Li, Hui Guo, Jennifer Gerdts, Emanuela Avola, Giuseppe Calabrese, Maurizio Elia, Donatella Greco, Anna Lindstrand, Ann Nordgren, Britt-Marie Anderlid, Geert Vandeweyer, Anke Van Dijck, Nathalie Van der Aa, Brooke McKenna, Miroslava Hancarova, Sarka Bendova, Marketa Havlovicova, Giovanni Malerba, Bernardo Dalla Bernardina, Pierandrea Muglia, Arie van Haeringen, Mariette J. V. Hoffer, Barbara Franke, Gerarda Cappuccio, Martin Delatycki, Paul J. Lockhart, Melanie A. Manning, Pengfei Liu, Ingrid E. Scheffer, Nicola Brunetti-Pierri, Nanda Rommelse, David G. Amaral, Gijs W. E. Santen, Elisabetta Trabetti, Zdeněk Sedláček, Jacob J. Michaelson, Karen Pierce, Eric Courchesne, R. Frank Kooy, The SPARK Consortium, Magnus Nordenskjöld, Corrado Romano, Hilde Peeters, Raphael A. Bernier, Jozef Gecz, Kun Xia, Evan E. Eichler

Nat Commun. 2020; 11: 4932. Published online 2020 Oct 1. doi: 10.1038/s41467-020-18723-y

Correction in:: Nat Commun. 2020; 11: 5398.

PMCID:: PMC7530681

Abstract Article PDF–1.7M

Select item 598803716.

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

Alejandro Sifrim, Marc-Phillip Hitz, Anna Wilsdon, Jeroen Breckpot, Saeed H. Al Turki, Bernard Thienpont, Jeremy McRae, Tomas W Fitzgerald, Tarjinder Singh, Ganesh Jawahar Swaminathan, Elena Prigmore, Diana Rajan, Hashim Abdul-Khaliq, Siddharth Banka, Ulrike M. M. Bauer, Jamie Bentham, Felix Berger, Shoumo Bhattacharya, Frances Bu'Lock, Natalie Canham, Irina-Gabriela Colgiu, Catherine Cosgrove, Helen Cox, Ingo Daehnert, Allan Daly, John Danesh, Alan Fryer, Marc Gewillig, Emma Hobson, Kirstin Hoff, Tessa Homfray, The INTERVAL Study, Anne-Karin Kahlert, Ami Ketley, Hans-Heiner Kramer, Katherine Lachlan, Anne Katrin Lampe, Jacoba J. Louw, Ashok Kumar Manickara, Dorin Manase, Karen P. McCarthy, Kay Metcalfe, Carmel Moore, Ruth Newbury-Ecob, Seham Osman Omer, Willem H. Ouwehand, Soo-Mi Park, Michael J. Parker, Thomas Pickardt, Martin O. Pollard, Leema Robert, David J. Roberts, Jennifer Sambrook, Kerry Setchfield, Brigitte Stiller, Chris Thornborough, Okan Toka, Hugh Watkins, Denise Williams, Michael Wright, Seema Mital, Piers E. F. Daubeney, Bernard Keavney, Judith Goodship, The UK10K Consortium, Riyadh Mahdi Abu-Sulaiman, Sabine Klaassen, Caroline F. Wright, Helen V. Firth, Jeffrey C. Barrett, Koenraad Devriendt, David R. FitzPatrick, J. David Brook, The Deciphering Developmental Disorders Study, Matthew Hurles

Nat Genet. Author manuscript; available in PMC 2018 Jun 5.

Published in final edited form as: Nat Genet. 2016 Sep; 48(9): 1060–1065. Published online 2016 Aug 1. doi: 10.1038/ng.3627

PMCID:: PMC5988037

Abstract Article PDF–1.1M

Select item 778041417.

CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis

Jin-Chun Qi, Zhan Yang, Tao Lin, Long Ma, Ya-Xuan Wang, Yong Zhang, Chun-Cheng Gao, Kai-Long Liu, Wei Li, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang, Xiao-Lu Wang, Jin-Kun Wen, Chang-Bao Qu

J Exp Clin Cancer Res. 2021; 40: 2. Published online 2021 Jan 4. doi: 10.1186/s13046-020-01814-5

PMCID:: PMC7780414

Abstract Article PDF–4.0M

Select item 244698318.

CDK13, a New Potential Human Immunodeficiency Virus Type 1 Inhibitory Factor Regulating Viral mRNA Splicing

Reem Berro, Caitlin Pedati, Kylene Kehn-Hall, Weilin Wu, Zachary Klase, Yasmine Even, Anne-Marie Genevière, Tatiana Ammosova, Sergei Nekhai, Fatah Kashanchi

J Virol. 2008 Jul; 82(14): 7155–7166. Published online 2008 May 14. doi: 10.1128/JVI.02543-07

PMCID:: PMC2446983

Abstract Article PDF–1.1M

Select item 320558619.

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

Dalibor Blazek, Jiri Kohoutek, Koen Bartholomeeusen, Eric Johansen, Petra Hulinkova, Zeping Luo, Peter Cimermancic, Jernej Ule, B. Matija Peterlin

Genes Dev. 2011 Oct 15; 25(20): 2158–2172. doi: 10.1101/gad.16962311

PMCID:: PMC3205586

Abstract Article PDF–1.9M

Select item 291410420.

Cyclin-dependent kinases: a family portrait

Marcos Malumbres, Edward Harlow, Tim Hunt, Tony Hunter, Jill M. Lahti, Gerard Manning, David O. Morgan, Li-Huei Tsai, Debra J. Wolgemuth

Nat Cell Biol. Author manuscript; available in PMC 2010 Aug 2.

Published in final edited form as: Nat Cell Biol. 2009 Nov; 11(11): 1275–1276. doi: 10.1038/ncb1109-1275

PMCID:: PMC2914104

Article PDF–146K

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