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Select item 67440481.

Retinal transcriptome profile in mice following dexamethasone treatment for endotoxin-induced uveitis

Peng YU, Yiguo QIU, Ru LIN, Xinyu FU, Bingtao HAO, Bo LEI

Nan Fang Yi Ke Da Xue Xue Bao. 2018 Aug 20; 38(8): 901–909. doi: 10.3969/j.issn.1673-4254.2018.08.01

PMCID:: PMC6744048

Abstract Article PDF–857K

Select item 66084582.

A Critical Role for Interferon Regulatory Factor 9 in Cerebral Ischemic Stroke

Hou-Zao Chen, Sen Guo, Zuo-Zhi Li, Yanyun Lu, Ding-Sheng Jiang, Ran Zhang, Hao Lei, Lu Gao, Xiaofei Zhang, Yan Zhang, Lang Wang, Li-Hua Zhu, Mei Xiang, Yan Zhou, Qi Wan, Hailong Dong, De-Pei Liu, Hongliang Li

J Neurosci. 2014 Sep 3; 34(36): 11897–11912. doi: 10.1523/JNEUROSCI.1545-14.2014

PMCID:: PMC6608458

Abstract Article PDF–7.6M

Select item 65949703.

Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Dongwon Kim, Ruosi Chen, Mary Sheu, Noori Kim, Sooah Kim, Nasif Islam, Eric M. Wier, Gaofeng Wang, Ang Li, Angela Park, Wooyang Son, Benjamin Evans, Victoria Yu, Vicky P. Prizmic, Eugene Oh, Zixiao Wang, Jianshi Yu, Weiliang Huang, Nathan K. Archer, Zhiqi Hu, Nashay Clemetson, Amanda M. Nelson, Anna Chien, Ginette A. Okoye, Lloyd S. Miller, Gabriel Ghiaur, Sewon Kang, Jace W. Jones, Maureen A. Kane, Luis A. Garza

Nat Commun. 2019; 10: 2811. Published online 2019 Jun 26. doi: 10.1038/s41467-019-10811-y

PMCID:: PMC6594970

Abstract Article PDF–3.5M

Select item 65059384.

Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA

Janelle M. Veazey, Timothy J. Chapman, Timothy R. Smyth, Sara E. Hillman, Sophia I. Eliseeva, Steve N. Georas

PLoS One. 2019; 14(5): e0216056. Published online 2019 May 8. doi: 10.1371/journal.pone.0216056

PMCID:: PMC6505938

Abstract Article PDF–748K

Select item 63106845.

Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

Qin Yu, Kun Qu, Yorgo Modis

Mol Cell. 2018 Dec 20; 72(6): 999–1012.e6. doi: 10.1016/j.molcel.2018.10.012

PMCID:: PMC6310684

Abstract Article PDF–7.0M

Select item 62807916.

ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity

Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl R Walkley, Yukio Kawahara

EMBO Rep. 2018 Dec; 19(12): e46303. Published online 2018 Oct 25. doi: 10.15252/embr.201846303

PMCID:: PMC6280791

Abstract Article PDF–3.2M

Select item 59337157.

A direct link between MITF, innate immunity, and hair graying

Melissa L. Harris, Temesgen D. Fufa, Joseph W. Palmer, Sandeep S. Joshi, Denise M. Larson, Arturo Incao, Derek E. Gildea, Niraj S. Trivedi, Autumne N. Lee, Chi-Ping Day, Helen T. Michael, Thomas J. Hornyak, Glenn Merlino, NISC Comparative Sequencing Program, William J. Pavan

PLoS Biol. 2018 May; 16(5): e2003648. Published online 2018 May 3. doi: 10.1371/journal.pbio.2003648

PMCID:: PMC5933715

Abstract Article PDF–20M

Select item 57529988.

Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection

Wen-Yu Cheng, Huai-Jie Jia, Xiao-Bing He, Guo-Hua Chen, Yuan Feng, Chun-Yan Wang, Xiao-Xia Wang, Zhi-Zhong Jing

Biomed Res Int. 2017; 2017: 6456180. Published online 2017 Dec 21. doi: 10.1155/2017/6456180

PMCID:: PMC5752998

Abstract Article PDF–1.4M

Select item 56979009.

The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity

Jacquelyn A. Gorman, Christian Hundhausen, John S. Errett, Amy E. Stone, Eric J. Allenspach, Yan Ge, Tanvi Arkatkar, Courtnee Clough, Xuezhi Dai, Socheath Khim, Kathleen Pestal, Denny Liggitt, Karen Cerosaletti, Daniel B. Stetson, Richard G. James, Mohamed Oukka, Patrick Concannon, Michael Gale, Jr., Jane H. Buckner, David J. Rawlings

Nat Immunol. Author manuscript; available in PMC 2017 Nov 29.

Published in final edited form as: Nat Immunol. 2017 Jul; 18(7): 744–752. Published online 2017 May 29. doi: 10.1038/ni.3766

PMCID:: PMC5697900

Abstract Article PDF–1.0M

Select item 545386610.

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

Karine Cambon, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, Maria Rey, Raymonde Hassig, Noelle Dufour, Gwenaelle Auregan, Philippe Hantraye, Anselme L. Perrier, Nicole Déglon

Mol Ther Methods Clin Dev. 2017 Jun 16; 5: 259–276. Published online 2017 May 11. doi: 10.1016/j.omtm.2017.05.001

PMCID:: PMC5453866

Abstract Article PDF–2.7M

Select item 487336911.

Activation of the MDA5-IPS1 viral sensing pathway induces cancer cell death and type I interferon-dependent antitumor immunity

Xiaofei Yu, Hongxia Wang, Xia Li, Chunqing Guo, Fang Yuan, Paul B. Fisher, Xiang-Yang Wang

Cancer Res. Author manuscript; available in PMC 2017 Apr 15.

Published in final edited form as: Cancer Res. 2016 Apr 15; 76(8): 2166–2176. Published online 2016 Feb 18. doi: 10.1158/0008-5472.CAN-15-2142

PMCID:: PMC4873369

Abstract Article PDF–1.5M

Select item 483589412.

Blockage of indoleamine 2,3-dioxygenase regulates Japanese encephalitis via enhancement of type I/II IFN innate and adaptive T-cell responses

Seong Bum Kim, Jin Young Choi, Erdenebileg Uyangaa, Ajit Mahadev Patil, Ferdaus Mohd Altaf Hossain, Jin Hur, Sang-Youel Park, John-Hwa Lee, Koanhoi Kim, Seong Kug Eo

J Neuroinflammation. 2016; 13: 79. Published online 2016 Apr 18. doi: 10.1186/s12974-016-0551-5

PMCID:: PMC4835894

Abstract Article PDF–2.7M

Select item 465719713.

Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6C^hi monocyte differentiation

Seong Bum Kim, Jin Young Choi, Jin Hyoung Kim, Erdenebelig Uyangaa, Ajit Mahadev Patil, Sang-Youel Park, John Hwa Lee, Koanhoi Kim, Young Woo Han, Seong Kug Eo

J Neuroinflammation. 2015; 12: 216. Published online 2015 Nov 24. doi: 10.1186/s12974-015-0438-x

PMCID:: PMC4657197

Abstract Article PDF–3.7M

Select item 464925414.

Innate Immune Mechanisms in Japanese Encephalitis Virus Infection: Effect on Transcription of Pattern Recognition Receptors in Mouse Neuronal Cells and Brain Tissue

Prachi Rahul Fadnis, Vasanthapuram Ravi, Anita Desai, Lance Turtle, Tom Solomon

Viral Immunol. 2013 Dec 1; 26(6): 366–377. doi: 10.1089/vim.2013.0016

PMCID:: PMC4649254

Abstract Article PDF–514K

Select item 435014015.

Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery

Li-Fong Wang, You-Sheng Lin, Nan-Chieh Huang, Chia-Yi Yu, Wei-Lun Tsai, Jih-Jung Chen, Toru Kubota, Mayumi Matsuoka, Siang-Ru Chen, Chih-Shiang Yang, Ruo-Wei Lu, Yi-Ling Lin, Tsung-Hsien Chang

J Interferon Cytokine Res. 2015 Mar 1; 35(3): 143–156. doi: 10.1089/jir.2014.0038

PMCID:: PMC4350140

Abstract Article PDF–2.0M

Select item 408558116.

Aicardi-Goutières Syndrome Is Caused by IFIH1 Mutations

Hirotsugu Oda, Kenji Nakagawa, Junya Abe, Tomonari Awaya, Masahide Funabiki, Atsushi Hijikata, Ryuta Nishikomori, Makoto Funatsuka, Yusei Ohshima, Yuji Sugawara, Takahiro Yasumi, Hiroki Kato, Tsuyoshi Shirai, Osamu Ohara, Takashi Fujita, Toshio Heike

Am J Hum Genet. 2014 Jul 3; 95(1): 121–125. doi: 10.1016/j.ajhg.2014.06.007

PMCID:: PMC4085581

Abstract Article PDF–644K

Select item 399621517.

Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E₂ EP4 Receptor Signaling

Nathaniel S. Woodling, Qian Wang, Prachi G. Priyam, Paul Larkin, Ju Shi, Jenny U. Johansson, Irene Zagol-Ikapitte, Olivier Boutaud, Katrin I. Andreasson

J Neurosci. 2014 Apr 23; 34(17): 5882–5894. doi: 10.1523/JNEUROSCI.0410-14.2014