Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

D Ribatti; A Vacca; B Nico; F Quondamatteo; R Ria; M Minischetti; A Marzullo; R Herken; L Roncali; F Dammacco

doi:10.1038/sj.bjc.6690070

Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

Br J Cancer. 1999 Feb;79(3-4):451-5. doi: 10.1038/sj.bjc.6690070.

Authors

D Ribatti¹, A Vacca, B Nico, F Quondamatteo, R Ria, M Minischetti, A Marzullo, R Herken, L Roncali, F Dammacco

Affiliation

¹ Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy.

Abstract

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Bone Marrow / blood supply*
Disease Progression
Female
Humans
Male
Mast Cells / cytology*
Middle Aged
Monoclonal Gammopathy of Undetermined Significance / physiopathology
Multiple Myeloma / physiopathology*
Neovascularization, Pathologic / physiopathology*