Abstract
N-acylated or D enantiomer peptide derivatives based on the sequence RRWQWRMKK in lactoferricin B demonstrated antimicrobial activities greater than those of lactoferricin B against bacteria and fungi. The most potent peptide, conjugated with an 11-carbon-chain acyl group, showed two to eight times lower MIC than lactoferricin B.
MeSH terms
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Acetylation
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Amino Acid Sequence
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology*
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Bacteria / drug effects
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Candida / drug effects
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Lactoferrin / analogs & derivatives*
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Lactoferrin / chemistry
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Lactoferrin / pharmacology
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Molecular Sequence Data
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Peptide Fragments
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Peptides / chemistry
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Peptide Fragments
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Peptides
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lactoferricin B
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Lactoferrin