Abstract
Several Gram-negative pathogenic bacteria have evolved a complex protein secretion system termed type III to deliver bacterial effector proteins into host cells that then modulate host cellular functions. These bacterial devices are present in both plant and animal pathogenic bacteria and are evolutionarily related to the flagellar apparatus. Although type III secretion systems are substantially conserved, the effector molecules they deliver are unique for each bacterial species. Understanding the biology of these devices may allow the development of novel prevention and therapeutic approaches for several infectious diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Flagella / metabolism
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Genes, Bacterial
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Gram-Negative Bacteria / genetics
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Gram-Negative Bacteria / metabolism*
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Gram-Negative Bacteria / pathogenicity
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Gram-Negative Bacterial Infections / microbiology*
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Humans
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Plants / microbiology
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Protein Biosynthesis
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Transcription, Genetic
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Virulence
Substances
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Bacterial Outer Membrane Proteins
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Bacterial Proteins