Abstract
An assessment of the current status of marine anticancer compounds is presented along with a case study on the aquaculture of Lissodendoryx n. sp. 1, a sponge that produces the antimitotic agents halichondrin B and isohomohalichondrin B. The use of polymer therapeutics to enhance the properties of marine natural products is considered.
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Aquaculture
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Drug Design*
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Drug Screening Assays, Antitumor
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Ethers, Cyclic / isolation & purification*
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Ethers, Cyclic / pharmacology
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Humans
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Macrolides
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Porifera / chemistry*
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Porifera / metabolism
Substances
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Antineoplastic Agents
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Ethers, Cyclic
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Macrolides
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halichondrin B