The discovery and development of marine compounds with pharmaceutical potential

J Biotechnol. 1999 Apr 30;70(1-3):15-25. doi: 10.1016/s0168-1656(99)00052-8.

Abstract

An assessment of the current status of marine anticancer compounds is presented along with a case study on the aquaculture of Lissodendoryx n. sp. 1, a sponge that produces the antimitotic agents halichondrin B and isohomohalichondrin B. The use of polymer therapeutics to enhance the properties of marine natural products is considered.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Aquaculture
  • Drug Design*
  • Drug Screening Assays, Antitumor
  • Ethers, Cyclic / isolation & purification*
  • Ethers, Cyclic / pharmacology
  • Humans
  • Macrolides
  • Porifera / chemistry*
  • Porifera / metabolism

Substances

  • Antineoplastic Agents
  • Ethers, Cyclic
  • Macrolides
  • halichondrin B