Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research

Vet Res Commun. 1999 Oct;23(6):343-60. doi: 10.1023/a:1006333608012.

Abstract

Some of the recent publications on the pharmacological, therapeutic and toxicological properties of the antimicrobial agent furazolidone (FZ) are briefly reviewed. In animals, most of the recently published papers focus on (1) the methodology of measuring the residues of the drug and its metabolites in edible tissues; (2) the carcinogenicity and genotoxicity of FZ; (3) the cellular and molecular basis of FZ-induced cardiomyopthy, and the action of different cardioprotectant drugs thereon; and (4) hormonal effects. In humans, the use of FZ as an anti-ulcer drug and in controlling infectious diseases, especially opportunistic infections in AIDS patients, is described.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology*
  • Anti-Infective Agents / therapeutic use
  • Anti-Infective Agents / toxicity
  • Antioxidants / metabolism
  • Free Radicals
  • Furazolidone / pharmacology*
  • Furazolidone / therapeutic use
  • Furazolidone / toxicity
  • Monoamine Oxidase Inhibitors / pharmacology
  • Monoamine Oxidase Inhibitors / therapeutic use
  • Monoamine Oxidase Inhibitors / toxicity

Substances

  • Anti-Infective Agents
  • Antioxidants
  • Free Radicals
  • Monoamine Oxidase Inhibitors
  • Furazolidone